Growth hormone controlled-release coating and preparation method thereof
A growth hormone and coating technology, applied in the field of biomedicine, can solve the problems of inability to achieve sustained release effect, lack of human body structure, targeted biochemical reaction rules, single raw material combination, etc., achieve unique antioxidant capacity and reduce contact dissolution rate , improve the effect of gastric function
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Embodiment 1
[0031] A somatotropin controlled-release coating consists of three layers: the outermost layer of super-hydrophobic coating, the middle layer of silk fibroin peptide coating and the innermost layer of somatotropin controlled-release microspheres.
[0032] The structure of the superhydrophobic coating is a particle structure, and the particle size is 50nm; the thickness of the hydrophobic coating is 1mm, and the initial water contact angle on the coating surface is 150 °; the superhydrophobic coating is composed of the following raw materials in parts by weight: 6 parts of γ-polyglutamic acid, 9 parts of polylactic acid-glycolic acid copolymer, and 100 parts of ethanol.
[0033] The preparation method of described γ-polyglutamic acid is: a. the cultivation of Bacillus subtilis: get the Bacillus subtilis cultivated on the slant to the primary seed tank equipped with seed medium, the inoculum size is 10%, 37 DEG C Under 200r / min shaking culture for 8 hours, take out 1 / 10 of the v...
Embodiment 2
[0044] A somatotropin controlled-release coating consists of three layers: the outermost layer of superhydrophobic coating, the middle layer of silk fibroin peptide coating and the innermost layer of somatotropin controlled-release microspheres.
[0045] The structure of the superhydrophobic coating is a particle structure, and the particle size is 5 μm; the thickness of the hydrophobic coating is 2 μm, and the initial water contact angle on the coating surface is 175°; the superhydrophobic coating is composed of the following raw materials in parts by weight: 9 parts of γ-polyglutamic acid, 6 parts of polylactic acid-glycolic acid copolymer, and 100 parts of ethanol.
[0046] The preparation method of described γ-polyglutamic acid is: a. the cultivation of Bacillus subtilis: get the Bacillus subtilis cultivated on the slant to the primary seed tank equipped with seed medium, the inoculum size is 10%, 37 DEG C Under 200r / min shaking culture for 8h, take out 1 / 10 of the volume ...
Embodiment 3
[0052] A somatotropin controlled-release coating consists of three layers: the outermost layer of super-hydrophobic coating, the middle layer of silk fibroin peptide coating and the innermost layer of somatotropin controlled-release microspheres.
[0053] The structure of the super-hydrophobic coating is a particle structure, and the particle size is 2.5 μm; the thickness of the hydrophobic coating is 0.5 mm, and the initial water contact angle on the coating surface is 160°; the super-hydrophobic coating consists of the following raw materials in parts by weight Composition: 7.5 parts of γ-polyglutamic acid, 7.5 parts of polylactic acid-glycolic acid copolymer, and 100 parts of ethanol.
[0054] The preparation method of described γ-polyglutamic acid is: a. the cultivation of Bacillus subtilis: get the Bacillus subtilis cultivated on the slant to the primary seed tank equipped with seed medium, the inoculum size is 10%, 37 DEG C Under 200r / min shaking culture for 8 hours, tak...
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