Growth hormone controlled-release coating and preparation method thereof

A growth hormone and coating technology, applied in the field of biomedicine, can solve the problems of inability to achieve sustained release effect, lack of human body structure, targeted biochemical reaction rules, single raw material combination, etc., achieve unique antioxidant capacity and reduce contact dissolution rate , improve the effect of gastric function

Inactive Publication Date: 2018-08-31
FOSHAN SHIRUI LEADING MATERIAL RES INST GENERAL PARTNERSHIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the existing growth hormone sustained-release microcapsule technology uses a relatively single combination of raw materials and a simple structure to make microcapsules. Although it has certain universality and slow-release effect, it lacks pertinence to human body structure and biochemical reaction rules. , can not achieve significant long-term sustained-release effect

Method used

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  • Growth hormone controlled-release coating and preparation method thereof
  • Growth hormone controlled-release coating and preparation method thereof
  • Growth hormone controlled-release coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A somatotropin controlled-release coating consists of three layers: the outermost layer of super-hydrophobic coating, the middle layer of silk fibroin peptide coating and the innermost layer of somatotropin controlled-release microspheres.

[0032] The structure of the superhydrophobic coating is a particle structure, and the particle size is 50nm; the thickness of the hydrophobic coating is 1mm, and the initial water contact angle on the coating surface is 150 °; the superhydrophobic coating is composed of the following raw materials in parts by weight: 6 parts of γ-polyglutamic acid, 9 parts of polylactic acid-glycolic acid copolymer, and 100 parts of ethanol.

[0033] The preparation method of described γ-polyglutamic acid is: a. the cultivation of Bacillus subtilis: get the Bacillus subtilis cultivated on the slant to the primary seed tank equipped with seed medium, the inoculum size is 10%, 37 DEG C Under 200r / min shaking culture for 8 hours, take out 1 / 10 of the v...

Embodiment 2

[0044] A somatotropin controlled-release coating consists of three layers: the outermost layer of superhydrophobic coating, the middle layer of silk fibroin peptide coating and the innermost layer of somatotropin controlled-release microspheres.

[0045] The structure of the superhydrophobic coating is a particle structure, and the particle size is 5 μm; the thickness of the hydrophobic coating is 2 μm, and the initial water contact angle on the coating surface is 175°; the superhydrophobic coating is composed of the following raw materials in parts by weight: 9 parts of γ-polyglutamic acid, 6 parts of polylactic acid-glycolic acid copolymer, and 100 parts of ethanol.

[0046] The preparation method of described γ-polyglutamic acid is: a. the cultivation of Bacillus subtilis: get the Bacillus subtilis cultivated on the slant to the primary seed tank equipped with seed medium, the inoculum size is 10%, 37 DEG C Under 200r / min shaking culture for 8h, take out 1 / 10 of the volume ...

Embodiment 3

[0052] A somatotropin controlled-release coating consists of three layers: the outermost layer of super-hydrophobic coating, the middle layer of silk fibroin peptide coating and the innermost layer of somatotropin controlled-release microspheres.

[0053] The structure of the super-hydrophobic coating is a particle structure, and the particle size is 2.5 μm; the thickness of the hydrophobic coating is 0.5 mm, and the initial water contact angle on the coating surface is 160°; the super-hydrophobic coating consists of the following raw materials in parts by weight Composition: 7.5 parts of γ-polyglutamic acid, 7.5 parts of polylactic acid-glycolic acid copolymer, and 100 parts of ethanol.

[0054] The preparation method of described γ-polyglutamic acid is: a. the cultivation of Bacillus subtilis: get the Bacillus subtilis cultivated on the slant to the primary seed tank equipped with seed medium, the inoculum size is 10%, 37 DEG C Under 200r / min shaking culture for 8 hours, tak...

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Abstract

The invention belongs to the technical field of biomedical technologies, and discloses a growth hormone controlled-release coating and a preparation method thereof. The coating comprises three layersof structures which are an outermost layer superhydrophobic coating, a middle layer silk fibroin peptide coating and an innermost layer growth hormone controlled-release microballoon sphere. The invention aims at providing a preparation method of an oral administration dosage form. The three layers of structures with different ingredients are targetedly arranged to serve as the coating of growth hormone according to the structure and reaction rules of human digestive tracts, an advanced electrostatic spraying technology is adopted for making the coating, the number of times of administration of a patient is reduced, the growth hormone medicine clinical application range is increased, and the coating has the wide market prospect.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a growth hormone controlled-release coating and a preparation method thereof. Background technique [0002] Human growth hormone (hGH) is a peptide hormone secreted by the anterior lobe of the human pituitary gland, with a relative molecular mass of about 22 kDa. As a somatoregulin with a wide range of physiological functions, hGH can affect almost all types of tissues and cells, the main function is to stimulate the growth and differentiation of bone and cartilage cells; promote protein synthesis, while reducing protein consumption, regulate fat and sugar metabolism. The growth hormone initially obtained for clinical treatment was mainly extracted from the bovine pituitary gland. Recombinant hGH widely used in clinical treatment is obtained by bioengineering, its molecular structure is completely consistent with human endogenous hGH, and has the same pharmacodynamics and p...

Claims

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Application Information

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IPC IPC(8): A61K38/27A61K9/50A61K47/36A61K47/42A61K47/34A61K47/32A61P3/00
CPCA61K9/0053A61K9/5026A61K9/5031A61K9/5036A61K9/5052A61K9/5089A61K38/27A61P3/00
Inventor 不公告发明人
Owner FOSHAN SHIRUI LEADING MATERIAL RES INST GENERAL PARTNERSHIP
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