59 results about "Pituitary gland" patented technology

The invention relates generally to methods and apparatus for inducing hypothermia in an animal. Known methods for inducing hypothermia all involve cooling the outside or inside of an animal, sometimes in conjuction with drugs that disable the animal's homeostatic responses. The present invention is directed to a method and apparatus for applying heat to the hypothalamus of a warm-blooded animal in order to utilize the physiological mechanisms that regulate body temperature to effect a compensatory cooling response, thereby lowering body temperature. It is new and unsuggested in the art to apply heat in an effort to reduce body temperature. The invention effects the desired lowering of body temperature by the method od raising the temperature of the hypothalamus, a brain structure situated in humans just above the pituitary gland responsible for temperature regulation, by warming a nasal passage, or a sinus, such as the sphenoid sinus that is nearest to the hypothalamus, or by direct warming of the hypothalamus, or a combination of these.

The invention relates to a method for treating, controlling, or preventing cancerous cell phenotypes and growths in an animal involving the administration of gaseous nitric oxide to one or administration sites in a body. The invention generally is capable of treating cancers found in or on the adrenal gland, bladder, bones, brain, breast, cervix, colon, colorectum, esophagus, gastrointestinal tract, heart, kidney, liver, large intestine, lungs, mouth, ovaries, pancreas, parathyroid, pituitary gland, prostate, salivary gland, skin, small intestine, spleen, stomach, thymus, thyroid, testicles, urinary tract, uterus, vagina, and so forth.

The invention discloses a culturing method for sex reversal of a female carp to a male carp. The culturing method comprises the following steps that A. squeezing an abdomen of a 10-11-month-old carp, and separating a male carp with out-flown semen and a carp with no out-flown semen; B. inserting a copper roe digging device in a genital pore of the carp from which semen can not be squeezed, and selecting the carp capable of obtaining roe particles to cultivate the carp in a cement pond; C. according to the weight of the carp, feeding the carp with dosing fodders containing 17 alpha- methyltestosterone every day, and mix-injecting domperidone, luteinizing hormone releasing hormone and carp pituitary gland in the thoracic cavity of the carp in each five days; and D. after continuously processing the test carp for 2 months, squeezing the abdomen of the carp, the test carp with out-flown milky white semen is the sex reversal carp which is a female on genotype and a male on physiology. The culturing method is easy and feasible and is convenient in operation, and can be used for sex reversing the female carp on genotype into a male carp on physiology. The growth speed of the filial generation cross bred by the sex reversal carp and the common carp is fast and the economic benefits are remarkable.

The invention relates to an artificial eel propagation method, which includes: a, ripening parent fishes, breeding catadromous parent reels for seven days, gradually increasing salinity of water, and subjecting the parent eels to back intramuscular injection of ripening agent-carp pituitary gland homogenate and HCG (human chorionic gonadotropin); b, performing induced spawning of the parent eels, subjecting female eels to injection of oxytocin 17 alpha-hydroxyl progesterone and HCG, subjecting sperm-producing male eels to injection of mixture of CPE (carp pituitary extract) with HCG, collecting naturally spawned fertilized eggs on the next day, and subjecting the female eels laying no eggs to semi-dry artificial insemination; and c, hatching the fertilized eggs, immediately transferring the fertilized eggs to a special-made hatching barrel for hatching, and slightly aerating, changing half of water every four hours until fry are hatched successfully. The artificial eel propagation method has the advantages that anesthetic loss and operational injury can be prevented, injection dosage of hormones is reduced, a great amount of eels can mate and lay eggs naturally under artificial induced spawning, artificial insemination can be complete securely in a planned way, level of high-quality fertilized eggs and alevin of eels artificially propagated is increased.

The invention discloses recombinant oral protein TAT-GH of tilapia, a preparation method for the recombinant oral protein TAT-GH and application of the recombinant oral protein TAT-GH. The method comprises the following steps of: extracting total messenger ribonucleic acid (mRNA) from a pituitary gland of male tilapia, performing reverse transcription-polymerase chain reaction (RT-PCR) to obtain complementary deoxyribonucleic acid (cDNA), performing PCR amplification to obtain a growth hormone (GH) gene of the tilapia, and amplifying a TAT-GH gene by a PCR overlap extension method; constructing a recombinant plasmid pET-32a(+)-TAT-GH; and transforming Escherichia coli BL21 (DE3) by using the recombinant plasmid pET-32a(+)-TAT-GH, efficiently expressing fusion protein TAT-GH in the form of an inclusion body under the induction of isopropyl thiogalactoside (IPTG), and purifying and renaturing to obtain active protein. The protein can effectively promote the growth and development of fries of the tilapia after being fed to the fries of the tilapia.

The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and / or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, neurological conditions, and diseases or disorders related to the pituitary gland, colon, breast, lungs, and prostate are illustrated.

The invention discloses a silurus asotus growth hormone (saGH)-cell penetrating peptide trans-activating transcriptional activator (TAT) fusion protein and its preparation method and use. The saGH-TAT fusion protein can be used for promoting bony fish growth and resisting osmotic pressure. The preparation method of the saGH-TAT fusion protein comprises the following steps of extracting RNA from the pituitary gland of a live silurus asotusm, carrying out a reverse transcription-polymerase chain reaction (RT-PCR) process to obtain a cDNA fragment containing a GH gene mature peptide encoding segment, connecting GH and TAT, introducing the complex of GH and TAT into an expression vector pET22b (+), and carrying out expression in an escherichia coli expression strain BL21(DE3) to obtain the purified saGH-TAT fusion protein. Through a feeding, injection or immersion method, the saGH-TAT fusion protein can improve a fish growth rate to different degrees and improve strong saline water tolerance. Compared with a single GH expression protein used for fishes, the saGH-TAT fusion protein has better effects.

A method of improving health in an animal includes administering to the animal a nutritional supplement comprising an amino acid secretagogue composition, which stimulates the pituitary gland in the animal to produce growth hormone. The nutritional supplement may be administered orally. The nutritional supplement may comprise L-arginine hydrochloride, L-pyroglutamic acid, L-lysine hydrochloride, and cysteine. When desired, the nutritional supplement may consist essentially of L-arginine hydrochloride, L-pyroglutamic acid, L-lysine hydrochloride, N-acetyl-L-cysteine, L-glutamine, and schizonepeta powder.

The invention discloses a method for artificially breeding Plagiognathops microlepis, belonging to the field of aquacultures. The method comprises the steps of stocking in the earlier stage, stocking in the later stage, carrying out artificial induced spawning and un-sticking fertilized ovum. The protein content in parent fish compound feed in the stocking process is 26-34%. The charging amount in the stocking process in the later stage is 3-5% of the weight of parent fishes in a pool. The artificial induced spawning medicine is a composition of PG (pituitary gland), LRH-A2 (luteinizing hormone releasing hormone A2) and 0.7% of sodium chloride solution. The fertilized ovum is un-stuck by using yellow mud slurry. According to the method disclosed by the invention, a scientific parent fish artificial culturing and proper artificial medicine induced spawning technology is adopted, therefore, the oestrous rate of parent fishes of Plagiognathops microlepis is up to 95% during 18 h, the artificial induced spawning rate is 95%, the artificial fertilization rate is 95%, and the artificial fry breeding effect is obvious.

The invention relates to the effect of a morinda officinalis extract on improving or treating sexual disorder, and an application thereof. The substance for treating or improving the sexual disorder has an effect on integrally regulating the hypothalamus, the pituitary gland, the sex gland and the adrenocortical function to improve or treat the sexual disorder, and simultaneously has selective specificity on different 5-HT receptors, i.e., the substance can selectively excite the 5-HT1 receptor, but has no excitation on the 5-HT2 receptor and the 5-HT3 receptor. The morinda officinalis extract can be used as a medicament and / or food for treating or assisting to improve the sexual disorder.

Novel peptide hormones which influence the release of gonadotropins by the pituitary gland in fish are disclosed. Methods in which such peptides may be administered to fish to control their reproduction are also described. Furthermore, novel isolated cDNA encoding the precursor of the novel gonadotropin-releasing hormone is disclosed. The use of such cDNA in controlling the gonadal development and spawning of fish is also described.

The invention belongs to the technical field of medical images and computers, and relates to a convolutional neural network-based periocular organ segmentation method and device, and a storage medium,and the method comprises the following steps: inputting a to-be-segmented medical image into a trained convolutional neural binary classification network, and obtaining a cross section containing eyes in the medical image; positioning an approximate eye area in the cross section of the eye; finding out the center of the head in the cross section of the eye after segmenting the head; according tothe anatomical size of the human body, positioning an approximate eye area through the center of the skull; segmenting an eye delineation eyeball at the positioned eye approximate position by using the trained convolutional neural network for delineating the eyeball; respectively positioning crystalline lenses, optic nerves and pituitary gland according to the positions of the eyes and the anatomical structure of the human body; and respectively drawing a crystalline lens, an optic nerve and a pituitary gland through corresponding convolutional neural networks.

The invention discloses a Chinese herbal medicine heightening insole which is composed of an insole body and a Chinese herbal medicine acupoint plaster, wherein the Chinese herbal medicine acupoint plaster is obtained by preparing medicine bags from Chinese herbal medicine preparations and applying the medicine bags on positions on the insole corresponding to acupoints and reflecting regions of a vola. Bulk drugs for the medicine bags in the heightening insole comprise manchurian wildginger, borneol, safflower, clematis root, dahurian angelica root, dragon's blood, frankincense, myrrh, lightyellow sophora root, Sichuan lovage rhizome, peony root, common bletilla, Chinese angelica, amur cork-tree bark, argy worwood and common cnidium fruit. The Chinese herbal medicine heightening insole provided by the invention has a simple structure, can stimulate acupoints at reflecting regions of a vola, stimulates secretion of human growth hormone, accelerates division of bone cells, promotes growth of bones, is applicable to short teenagers and exerts effects on sterilization, invigoration of the circulation of blood, recovery from fatigue, deodorizing, absorption of sweat and the like. The Chinese herbal medicine bags used in the invention are easily and conveniently prepared, can stimulate reflecting regions of pituitary gland, Yongquan aperture and a sleeping aperture at both feet and can effectively promote secretion and release of growth hormone by anterior pituitary, thereby promoting growth of bones of a body. Moreover, raw materials for the insole are cheap, a preparation method for the insole is simple and can be widely applied in production, so good social values and economic benefits are obtained.

The invention provides a method for separating and culturing pituitary gland cells of a rat. The method comprises steps as follows: (1), an 8d male SD rat is selected and subjected to anesthesia execution; (2), the anesthetized rat is fixed on a board with the ventral side facing upwards, the pituitary gland of the rat is taken out under the sterile condition, put in a pre-cooled PBS (poly(butylene succinate)) liquid and washed repeatedly, bloodstain is removed, and pituitary gland envelope is removed; (3), the pituitary gland is cut into 1 mm*1 mm fragments by ophthalmic scissors in the pre-cooled PBS liquid under the sterile condition; (4), pre-heated III type collagenase is combined with neutral enzyme for mixed digestion; (5), the digestion is stopped, filtering is performed, a filtrate is collected and centrifuged, a supernatant is abandoned, a culture medium is added for resuspension, and the operation is repeated three times; (6), a 24-hole culture plate is inoculated with cells for culture; (7), the cells cultured for 7d are subjected to trypsin digestion and then are purified by a screen again, a supernatant is abandoned after centrifugation, the cells are resuspended, and the treated culture plate is inoculated with the cells; (8), the cells are subjected to cell immunofluorescence identification. The method for separating and culturing the pituitary gland cells of the rat is simple to operate, the obtained pituitary gland cells are high in survival rate and good in activity, can be used for establishing a cell experimental model in vitro and meet the requirement of pituitary gland cell experiments.

The present invention describes a newly discovered human G-protein coupled receptor and its encoding polynucleotide. Also described are expression vectors, host cells, agonists, antagonists, antisense molecules, and antibodies associated with the polynucleotide and / or polypeptide of the present invention. In addition, methods for treating, diagnosing, preventing, and screening for disorders associated with aberrant cell growth, endocrine conditions, neurological conditions, and diseases or disorders related to the pituitary gland, colon, breast, lungs, and prostate are illustrated.

A Chinese sturgeon brain tissue sample sampling bench comprises a main body. The main body is hollow inside; the upper edge of the main body is provided with an embedding groove; the lower part edge of a fixing box is embedded into the embedding groove; a chute is formed in the fixing box; fixing plates are arranged on the chute; and the fixing plate can slide in the chute. By the use of the sampling bench, a problem of difficulty in fixation of Chinese sturgeon head part during the brain tissue sampling work can be overcome, so scientific researchers can conveniently acquire pituitary gland and hypothalamus samples.

The present invention relates to a system, its catheter and its method for providing electrical pulses and / or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal. The catheter, containing an electrode or a microcannula or both, is moved through an endovascular route of a patient to his / her sinus cavernosus and then the distal end of the electrode or microcannula is moved through an opening in the distal end of the catheter and then through a perforation in the medial wall of the sinus cavernosus, to the pituitary gland.

Disclosed is a meditation cinnamon steam eye mask, comprising an outer main body of an eye mask, ear hangers connected with both ends of the outer main body of the eye mask through hot rolling, and two heating bags arranged inside the outer main body of the eye mask, wherein the heating bags are composed of a temperature control film bag and a heat sheet sealed inside the eye mask, and the outer main body of the eye mask is sprayed with Chinese medicinal essential oil. The invention provides a meditative cinnamon steam eye patch, which is simple and reasonable in structure design, convenient in use and convenient in packaging. Essential oil of antioxidant traditional Chinese medicine (warming and tonifying antioxidant cinnamon extract) is added into the eye mask, which acts on the pituitary gland through nasal inhalation, promotes dopamine secretion, relaxes people, enhances happiness, transdermal absorption, accelerates blood circulation, exerts antioxidant effect, relieves eye fatigue, and removes dark circles.

The invention discloses a raising method for increasing the duck egg laying rate. Through reasonable material changing and adding and adding of algae powder in feed, the iodine content of duck eggs can be increased, the egg yolk color is darkened, the content of amino acids in added broccoli stem and leaf powder and citrus peel powder, high-quality protein resources are provided for laying ducks,colored matters including lutein and carotenoid of the duck yolk in the feed are improved, and the color and luster of the egg yolk are improved; in addition, a mildew inhibitor is added, the oxidization deterioration of the feed is prevented, and the color of the egg yolk is further kept; by increasing the illumination, the temperature of a duck shed is improved and meanwhile kept, it is avoidedthat the laying rate of the laying ducks is decreased due to the uneven temperature, the sex hormone secretion of pituitary glands of the laying ducks can be promoted, ovulation is accelerated, the egg producing period is prolonged, and the laying rate of the laying ducks is increased.

A method of modulating glandular secretions by administering acoustic shock waves to a gland, includes the steps of activating acoustic shock waves of an acoustic shock wave generator to emit acoustic shock waves and subjecting the gland to acoustic shock waves stimulating the gland to have a modulated response. The modulated response is one of an adjustment in hormonal release which increases low level output, decreases high level output or stabilizes erratic output. The emitted acoustic shock waves are focused or unfocused low energy acoustic shock waves. The gland underlies the patient's skin. The shock wave generator is acoustically coupled to the patient's skin using a coupling gel or liquid. The gland is one of a testicle, ovary, pituitary gland, adrenal gland, thyroid gland, thymus, pineal gland, parathyroid, or hypothalamus. The method can be repeated one or more times.

The invention relates to a spawning induction method of highland oxygymnocypris stewartii. The method comprises the following steps: selecting adult parent fishes; selecting type and dose of drugs for spawning induction; processing the drugs; determining the drug application method; performing artificial fertilization. According to the spawning induction method, the use of carp pituitary gland is reduced and even removed from the spawning induction drugs under the condition that the carp pituitary gland is difficult to obtain at Tibet region, the compatibility of proper spawning induction agents suitable for spawning induction of oxygymnocypris stewartii is developed, and batch artificial propagation of oxygymnocypris stewartii is successfully performed at high-altitude and alpine region in Tibet.

Compositions and methods that use the body's natural secretory immune system in a new way against steroid hormone responsive tumors of the breast and prostate, as well as other glandular / mucus epithelial tissues such as colon, ovary, endometrium, kidney, bladder, stomach, pancreas and secretory pituitary gland are provided. Also provided are new ways of identifying carcinogenic, or potentially carcinogenic, bacteria in a tissue or body fluid to provide better anti-cancer therapies and preventatives than have been available previously.

The invention relates to the field of beluga culture, particularly discloses a beluga artificial propagation method and application of a carp pituitary gland, and relates to a beluga artificial propagation method. The method comprises the steps that 1, nutrient enrichment culture is performed on a beluga milter parent and a beluga raun parent; 2, the beluga milter parent and the beluga raun parent obtained after nutrient enrichment culture are subjected to low temperature stimulation; 3, the water temperature is increased to the pre-spawning induction temperature, and spawning induction medicine administration is performed on the beluga milter parent and the beluga raun parent so as to be subjected to spawning induction; 4, free eggs and seminal fluid are collected to be subjected to artificial fertilization and incubation, wherein the spawning induction medicine is the carp pituitary gland. The invention further relates to application of the carp pituitary gland for beluga artificial propagation, and application of the carp pituitary gland for preparing medicine for artificial propagation of beluga. The beluga spawning induction medicine is easy to obtain and prepare, the spawning induction rate of spawning induction propagation performed by adopting the beluga spawning induction medicine is high, the fertilization incubation effect is good, and the postpartum parent fish survival condition is good.

A method of modulating glandular secretions by administering acoustic shock waves to a gland, includes the steps of activating acoustic shock waves of an acoustic shock wave generator to emit acoustic shock waves and subjecting the gland to acoustic shock waves stimulating the gland to have a modulated response. The modulated response is one of an adjustment in hormonal release which increases low level output, decreases high level output or stabilizes erratic output. The emitted acoustic shock waves are focused or unfocused low energy acoustic shock waves. The gland underlies the patient's skin. The shock wave generator is acoustically coupled to the patient's skin using a coupling gel or liquid. The gland is one of a testicle, ovary, pituitary gland, adrenal gland, thyroid gland, thymus, pineal gland, parathyroid, or hypothalamus. The method can be repeated one or more times.

Lotus seed, walnut kernel and lotus root powder is prepared from lotus root starch, walnut kernel powder, lotus seed starch, white granulated sugar and edible flavor. Lotus root contains mucin and dietary fiber, which can reduce absorption of fats. The lotus root further contains tannins which have certain effects of tonifying spleen to cure diarrhea, whetting appetite and promoting digestion. Lotus seeds have the effects of clearing away the heart fire, clearing heat, improving eyesight, stopping bleeding, soothing nerves, quenching thirst and the like. Trace elements such as zinc and manganese in the walnut kernel are important constituents of pituitary gland and have the effect of nourishing the brain to improve intelligence. The lotus seed, walnut kernel and lotus root powder has the functions of calming and nourishing brain and is rich in nutrition.

The present invention relates to decapeptide derivatives with LHRH receptor antagonistic activity, the function of inhibiting pituitary gland secretion of gonadotropin and gonadal secretion of steroid hormones, their preparation method, their pharmaceutical composition and their role in the treatment of prostate cancer and Use for sex hormone dependence-related diseases related to reproduction.

The invention discloses a fat composition for reducing the immunological stress of pigs and application of the fat composition. The fat composition is composed of fish oil and caprylic capric triglycerride with the weight ratio of (2.5-5):1. A use method is that the addition amount of the fat composition is 2-4% of the total weight of the pig feed. The fat composition provided by the invention has the following outstanding advantages: compared with the conventional grease (such as corn oil), the fat composition not only can serve as a raw material for preparing high-energy feed, but also can effectively alleviate the allergic reaction and increased body temperature caused by vaccine (such as hog cholera vaccine) or lipopolysaccharide (LPS) of coli bacillus, as well as the content rise of hormones, related to the stress of hypothalamus-pituitary gland-hypothalamic pituit-aryadvenal axis, in blood, and improve the productivity of the pigs.