The invention provides a nutritional type collagen peptide and sea cucumber polypeptide chewable tablet for adjusting endocrine and a preparation method thereof. The chewable tablet comprises the following ingredients: marine fish oligopeptide, collagen peptide, sea cucumber polypeptide, soybean peptide, soy protein powder, concentrated whey protein, vitamin C, fruit and vegetable powder, lactose,resistant dextrin, xylooligosaccharide, erythritol, sorbitol, citric acid and magnesium stearate. The fruit and vegetable powder includes the following ingredients: kiwi fruit powder, tomato powder,blackberry powder, pumpkin powder, carrot powder, mushroom powder and the balance strawberry powder. The chewable tablet provided by the invention can maintain the activity of various active peptides,and directly acts on endocrine glands including the hypothalamus, the pituitary, the thyroid, the parathyroid, the adrenal, the gonad and pancreas after reaching intestinal tracts and being absorbedby small peptide transporters in the intestinal tracts, then, the endocrine imbalance of women is fundamentally regulated, and then the technical effects of resisting aging, beautifying skin and maintaining skin elasticity from the inside out are achieved.