33 results about "Thyroid parathyroid glands" patented technology

Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.

This invention relates to pyrimidine compounds of formula (I), formula (I′), and formula (I″):and pharmaceutically acceptable salts, solvates, clathrates, and prodrugs thereof, wherein R1, R2, R3, R4, R5, U, V, W, X, Y, Z, and n are defined herein. This invention also relates to compositions comprising these compounds and methods for using them. The compounds and compositions of this invention are useful to treat or prevent disorders associated with excessive bone loss, including, without limitation periodontal disease, non-malignant bone disorders (such as osteoporosis, Pagers-disease of bone, osteogenesis imperfecta, fibrous dysplasia, and primary hyperparathyroidism) estrogen deficiency, inflammatory bone loss, bone malignancy, arthritis, osteopetrosis, and certain cancer-related disorders (such as hypercalcemia of malignancy (HCM), osteolytic bone lesions of multiple myeloma and osteolytic bone metastases of breast cancer and other metastatic cancers).

Systems and methods are disclosed for locating the parathyroid. In one aspect, temporal variation among a plurality of images is evaluated and at least one image is enhanced according to the temporal variation. The image may be enhanced to one or both of reduce conspicuity of the thyroid gland and enhance conspicuity of the parathyroid gland. Some of the plurality of images may be adjusted in order to align representations of a target portions. Adjustments may be based locations of one or more organs or one or more artificial markers affixed to a living body in the plurality of images. A local positioning system (LPS), GPS, or other locating system may be used to position a living body, align the plurality of images, or to guide the positioning of objects relative to the living body. An elastomeric gel marker for imaging applications is also disclosed.

The present invention provides a device for identifying a tumor site in a subject, the device spectroscopically detecting fluorescence of protoporphyrins present in the tumor site,the protoporphyrins being protoporphyrin IX (PpIX) and photo-protoporphyrin (PPp), andthe device comprising:a light irradiation unit that converts part of PpIX into PPp;a spectroscopy unit that separates PpIX fluorescence and PPp fluorescence:a spectroscopy detection unit that detects the relative fluorescence intensity of the PpIX fluorescence and the PPp fluorescence; anda tumor discrimination unit that discriminates between the tumor site and a non-tumor site based on the relative fluorescence intensity of PpIX and PPp.

The invention relates to PTH variants and uses thereof in the detection, diagnosis, and treatment of various disease states.

Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1-34) fragment are disclosed that combine the N-terminal signaling domain (residues 1-9) and the C-terminal binding domain (residues 15-31) via a linker. Nucleic acid molecules and peptides for PTH(1-9)-(Gly)5-PTH(15-31) (PG5) and PTH(1-9)-(Gly)7-PTH(15-31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.

A method for orally administering a parathyroid hormone, PTH, comprising orally co-administering to a patient in need of PTH an effective amount of a PTH and an effective amount of calcitonin. The method according to the invention allows for the oral administration of PTH without the hypercalcemia, hypercalcuria and nephrolithiasis side effects.

The invention discloses a three-dimensional tissue-like body of composite cells. By grafting small molecule compounds containing double bonds onto gelatin molecules with excellent biocompatibility tobuild gelatin DB-Gel modified by groups containing double bonds, a gelatin DB-Gel aqueous solution of a certain concentration is mixed with living cell (such as parathyroid gland cells) suspension, and through ultraviolet light curing, the three-dimensional tissue-like body of the composite cells is obtained. In the process of building the tissue-like body, DB-Gel is fully utilized as photo-polymerized hydrogel and has good bioactivity; by directly mixing the gelatin DB-Gel and the cells in a liquid state, the cells can be completely and uniformly dispersed in space, a three-dimensional growing environment closer to the internal environment is built for the cells, the efficiency of interaction between the cells and the external environment is improved in a three-dimensional cell culturingprocess, and compared with cells cultured in two dimensions, maintenance of cell forms and activity are both improved. A preparation method of the three-dimensional tissue-like body of the composite cells is simple, rapid and low in both equipment requirement and cost, and has great potential in internal and external research.

The present disclosure provides a medical training simulation apparatus for training medical professionals, emergency medical support personnel, military personnel, parents or families of persons who have or will be undergoing neck or airway surgery, or any other persons requiring a simulator for learning the anatomy or practicing procedures or surgery of the neck and / or airway. The apparatus may include a simulated base that may be free standing or may rest on a mannequin and may have a hole for accessing the simulated airway, simulated skin, simulated fat, simulated lymph nodes, simulated neck musculature, simulated arteries and veins with simulated blood therein, simulated thyroid gland, simulated parathyroid glands, simulated laryngeal and tracheal cartilage including the hyoid bone, thyroid cartilage, cricoid cartilage, tracheal rings, epiglottis and arytenoid cartilages, mucosa, recurrent laryngeal nerves, trachealis muscle, esophagus and prevertebral fascia. The apparatus may include alteration or addition of one or more anatomical parts to simulate congenital or acquired anomalies. One or more parts of the simulation apparatus may be disposable or replaceable.

The invention discloses a parathyroid gland function imaging method and system, and an endoscope. The method comprises the following steps: outputting visible light and laser through the endoscope to irradiate parathyroid glands, generating near-infrared fluorescence, and reflecting the near-infrared fluorescence together with the visible light and the laser into an endoscope probe; separating the visible light, the near-infrared fluorescence and the laser input by the endoscope probe; acquiring and obtaining a parathyroid gland color image, a near-infrared fluorescence image and laser speckles; performing decorrelation processing to obtain a decorrelated speckle pattern; and acquiring an image which is fused by the near-infrared fluorescence image and the color image and an image which is fused by the decorrelated speckle image and the color image in virtue of a fusion registration technology. According to the invention, near-infrared fluorescence is applied in the endoscope to position the parathyroid glands, laser speckles are used for detecting blood supply of the parathyroid glands, a decorrelation algorithm is used for processing the laser speckles, and the fusion registration technology is combined for use, so a decorrelated speckle fusion image of the parathyroid glands is displayed to guide parathyroid gland function diagnosis in thyroid surgery.

The invention discloses a parathyroid gland recognition device and system, and belongs to the technical field of biological tissue detection and identification. The parathyroid gland recognition device comprises an autofluorescence excitation device and an autofluorescence collecting and processing device; the autofluorescence excitation device is used for generating 650-810 nm excitation light toirradiate human tissues to enable parathyroid gland to generate autofluorescence; the autofluorescence collecting and processing device is used for collecting autofluorescence of the parathyroid gland and processing the autofluorescence into recognizable information. The parathyroid gland recognition device is characterized by further comprising a light filtering device; the transmission wavelength of the light filtering device is 810 nm, interference light of a light source cannot penetrate through the light filtering device, and parathyroid gland recognition is prevented from being interfered. Through cooperation of multiple recognition devices, the parathyroid gland recognition device is applied to all links of an operation, the recognition range is large, the speed is high, the accuracy is achieved, and the occurrence rate of permanent parathyroid gland hypofunction is reduced to the maximum extent. The parathyroid gland needs to be excised for a secondary hyperthyroidism patient,and the secondary hyperthyroidism which is difficult to find by a doctor can be identified and excised.

Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1-34) fragment are disclosed that combine the N-terminal signaling domain (residues 1-9) and the C-terminal binding domain (residues 15-31) via a linker. Nucleic acid molecules and peptides for PTH(1-9)-(Gly)5-PTH(15-31) (PG5) and PTH(1-9)-(Gly)7-PTH(15-31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.

An intraoperative real-time parathyroid gland recognition system based on near-infrared autofluorescence is characterized by comprising a probe (1) composed of at least one emission optical fiber (1-1) and at least one detection optical fiber (1-2), wherein the emission optical fiber and the detection optical fiber are connected with a corresponding emitter (3-2) and a corresponding detector (3-4) respectively; a detection host (3), wherein the emitter and the detector both belong to a part of the detection host, the detection host further comprises a controller (3-1) and a man-machine interaction interface (3-3), and the controller and the man-machine interaction interface are connected with the emitter and the detector. The controller is configured to initiate operation of the at least one transmitter and the at least one detector; the human-computer interaction interface is configured to provide feedback about operation of the tissue detection system to an operator. According to the invention, the occurrence of medical negligence in the thyroid surgery can be greatly reduced or even completely eradicated.

A method of modulating glandular secretions by administering acoustic shock waves to a gland, includes the steps of activating acoustic shock waves of an acoustic shock wave generator to emit acoustic shock waves and subjecting the gland to acoustic shock waves stimulating the gland to have a modulated response. The modulated response is one of an adjustment in hormonal release which increases low level output, decreases high level output or stabilizes erratic output. The emitted acoustic shock waves are focused or unfocused low energy acoustic shock waves. The gland underlies the patient's skin. The shock wave generator is acoustically coupled to the patient's skin using a coupling gel or liquid. The gland is one of a testicle, ovary, pituitary gland, adrenal gland, thyroid gland, thymus, pineal gland, parathyroid, or hypothalamus. The method can be repeated one or more times.

The invention belongs to the technical field of medical bioengineering and discloses a human parathyrine PTH (1-34) fusion protein and its use in preparation of a pharmaceutical composition. A human IgG-derived Fc zone is connected to a C end of PTH (1-34) so that a circulating half life of the PTH (1-34) is effectively prolonged and / or biological activity of the PTH (1-34) is improved and the existing PTH (1-34) degradation problems are solved. The human parathyrine PTH (1-34) fusion protein has long-acting biological activity, has a high expression level and can be used for industrial large-scale production.

The invention discloses parathyroid gland detection equipment. The parathyroid gland detection equipment comprises an equipment box, a detection grab handle and a box cover and further comprises a grab handle controller, an operation controller and a monitoring unit, the top of the equipment box is covered with the box cover, an equipment bin is formed in the top of the interior of the equipment box, and the grab handle controller, the operation controller and the monitoring unit are sequentially assembled in the equipment bin; the monitoring unit is a fluorescence detector, a detection grab handle is further arranged in the equipment bin, and a guide-out light guide fiber and a guide-in light guide fiber are assembled at the end of a detection handle rod of the detection grab handle in an inserted and embedded mode. According to the parathyroid gland detection equipment, the fluorescence wave crest with the wavelength nanometer of 807 + / -1.5% is fed back to be in contact with parathyroid gland interested tissue of a patient, so that a thyroid gland tissue area needing surgical treatment is positioned through the fed-back light source wavelength, the operation is simple, the carrying is convenient, and the parathyroid gland treatment efficiency and the success probability are greatly improved.

The invention relates to an electric picking and tracting hook for separating small blood vessels under a microscope, which can be used for safely separating and reserving parathyroid glands blood vessels during a surgery, and is provided with a metal hook rod (1). In the invention, an insulation sleeve body (2) is covered on the hook rod; a hook arm (3) is integrally connected to the front end of the hook rod in a bending way; an uncovered joint section (11), which can be connected to a handle of an electrocoagulation scalpel in an insertion way, is arranged on the rear end part of the hook rod; an uncovered transition section (12) is arranged on the front end part of the hook rod; a rotation-stop structure section (21), which is matched with the handle of the electrocoagulation scalpel, is arranged on the rear end part of the insulation sleeve body; the length of the hook rod is 110mm-160mm; the hook arm is in a straight form and has 2.5mm-5.0mm long; a break angle alpha between the hook rod and the hook arm is 115 degrees-135 degrees; the radial dimension of a transition zone from the hook rod to the hook arm is in a gradual change form; and the front end of the hook arm is a blunt circular arc end. The electric picking and tracting hook for separating the small blood vessels under the microscope, provided by the invention, is used for separating and reserving the parathyroid glands blood vessels during the thyroid surgery.

The invention relates to a method for curing senile wintercough by soaking feet in traditional Chinese medical liquid which is prepared from the following traditional Chinese medicines: 18g of cortex mori radicis, 20g of tuber pinellia, 13g of bare almonds, 50g of morning glory seeds, 13g of steamed stemona, 13g of ophiopogon roots, 20g of loquat leaves, 16g of fritillaria thunbergii, 50g of affine cudweed, 30g of honey-fried licorice roots, 15g of brassica alba seeds, 50g of broiled ephedra and 50g of asarum. The preparation method of the traditional Chinese medical liquid comprises the following steps: taking and combining all the 13 traditional Chinese medicines together and pouring in a large basin; soaking in 5000 ml of warm water for 15 minutes; then, decocting to boil up for several times; removing slag and taking liquid when 3500 ml of medical liquid is remained; and pouring the medical liquid in a wood footbath. The medical liquid is firstly used for fumigating both feet and soaking the feet when the temperature is lowered to 42 DEG C or suitable; meanwhile, the crus san li point and the fenglong point at the calf part are kneaded, hit and massaged for 100 times by suitable force for a person to feel sore and ache; then, the medical liquid is wiped off from the feet after the feed are soaked for 50-60 minutes; and the san yin chiao point, the foot bronchus point, the foot parathyroid gland point, the foot lung point, the sole center point and the foot spleen point are respectively and alternately hit by the hand for 100-200 times.

The invention provides a nutritional type collagen peptide and sea cucumber polypeptide chewable tablet for adjusting endocrine and a preparation method thereof. The chewable tablet comprises the following ingredients: marine fish oligopeptide, collagen peptide, sea cucumber polypeptide, soybean peptide, soy protein powder, concentrated whey protein, vitamin C, fruit and vegetable powder, lactose,resistant dextrin, xylooligosaccharide, erythritol, sorbitol, citric acid and magnesium stearate. The fruit and vegetable powder includes the following ingredients: kiwi fruit powder, tomato powder,blackberry powder, pumpkin powder, carrot powder, mushroom powder and the balance strawberry powder. The chewable tablet provided by the invention can maintain the activity of various active peptides,and directly acts on endocrine glands including the hypothalamus, the pituitary, the thyroid, the parathyroid, the adrenal, the gonad and pancreas after reaching intestinal tracts and being absorbedby small peptide transporters in the intestinal tracts, then, the endocrine imbalance of women is fundamentally regulated, and then the technical effects of resisting aging, beautifying skin and maintaining skin elasticity from the inside out are achieved.

The invention relates to a method for treating chronic trachitis among middle-aged population by soaking feet in Chinese medicament solution. The method adopts 16 g of loquat leaf, 18 g of thunberg fritillary bulb, 15 g of cordate houttuynia, 15 g of perillaseed, 15 g of Hongguang, 15 g of radix stemona, 13 g of white mustard seed, 10 g of snakegourd fruit, 12 g of honey-fried licorice root, 30 g of honey-fried herba ephedrae, 30 g of tuber pinellia and 50 g of monkshood, and comprises the following steps: taking the 12 Chinese herbal medicaments according to the proportion and combining all herbal medicaments together; pouring the herbal medicaments in a big basin and adding 5,000 ml warm water to soak the herbal medicaments for 15 minutes; boiling the soaked herbal medicaments; removing the dregs and taking the decoction when the decoction is left about 3,500 ml; pouring the decoction in a wood basin to fumigate both feet firstly; when the temperature dropping to 42 DEG C or being comfortable, dipping both feet in the decoction, and kneading and pressing crural zusanli point and rich and prosperous point 100 times at the same time by moderate force which is advisable to ensure that a patient feels slight ache and pain; and after soaking the feet for 50 to 60 minutes, wiping water off by a foot towel and alternately pressing each of the sanyinjiao point, plantar bronchia point, plantar parathyroid gland point, plantar lung point, plantar heart point and plantar spleen point for 100 to 200 times by hand.

The invention relates to the technical field of animal specimen models, in particular to an endoscope thyroid resection training model and a manufacturing method thereof. The manufacturing method of the endoscopic thyroid resection training model comprises the following steps that animal stomach tissue and intestinal canal tissue are used for manufacturing a chest front wall subcutaneous space andthyroid and parathyroid glands, then the animal stomach tissue and the intestinal canal tissue are combined, laryngeal recurrent nerves are set, an operation channel is established, and finally cleaning and storing are conducted to obtain the endoscopic thyroid resection training model. According to the manufacturing method, the animal organ combination with the adjacent organ environment is provided for doctors, the actual situation can be simulated more truly, repeated use can be achieved, the doctors can obtain real skill training, and the surgical skill is improved.

The invention relates to a portable thyroid hormone tester, which comprises a shell, wherein a detection device is arranged in the shell; an acupuncture suction device is arranged at one end of the shell and communicates with the detection device in the shell; the detection device comprises a sample pad, a chromatographic film, a detection band, a quality control band and a colloidal gold bonding pad; and the sample pad, the colloidal gold bonding pad, the detection band, the chromatographic film and the quality control band are sequentially arranged far away from the acupuncture suction device. The portable thyroid hormone tester is capable of quickly and simply detecting PTH, and identifying parathyroid glands in situ, thus avoiding an intraoperative injury.

The invention relates to a test strip for detecting human parathyroid hormone, the test strip comprises a bottom plate, and a sample pad, a colloidal gold combination pad, a nitrocellulose membrane and a water absorption pad which are arranged on the bottom plate and connected in sequence, and a detection line is arranged on the nitrocellulose membrane; the colloidal gold combination pad contains colloidal gold particles labeled by a binding antibody; a capture antibody is anchored in the detection line, both the binding antibody and the capture antibody can specifically recognize and bind parathyroid hormone, and binding sites of the binding antibody and the capture antibody and the parathyroid hormone do not interfere with each other. The colloidal gold test strip disclosed by the invention is convenient and rapid to use, and the detection time is greatly shortened, so that a doctor is helped to judge whether the parathyroid gland is cut by mistake or not in a short time, the activity of the parathyroid gland is greatly ensured, and the incidence rate of parathyroid gland hypofunction after the thyroid surgery is greatly reduced. In addition, the colloidal gold can also be used for detecting a whole blood sample, and can be used for diagnosing parathyroid carcinoma.

The invention discloses a fully humanized monoclonal single-domain antibody for resisting human PTH1R and an application of the fully humanized monoclonal single-domain antibody. The amino acid sequence of the antibody is shown as SEQ ID NO: 2. According to the invention, aiming at wild and mutant human PTH1R ECD proteins, antibody screening is carried out by using a phage display technology, and the anti-human PTH1R blocking type single-domain antibody with a blocking effect is screened and obtained through methods such as ELISA, FACS and the like. The antibody can be combined with human PTH1R, can block the interaction between PTH and PTH1R, and has a potential application value in human body dysfunction mediated by PTH-PTH1R, such as chronic kidney disease secondary hyperparathyroidism.

The invention discloses a parathyroid gland identification method based on an image fusion technology, and the method comprises the following steps: obtaining depth images of a fluorescent development image and a live-action image, and achieving the three-dimensional reconstruction of a thyroid tissue image based on the depth images, thereby obtaining a three-dimensional thyroid tissue image; correcting and splicing the three-dimensional thyroid tissue image based on the position information corresponding to the fluorescence development image and the real scene image, and generating a thyroid three-dimensional real scene model and a thyroid fluorescence development model; on the basis of a DssdInceptionV3 model, identification of parathyroid gland areas loaded in the thyroid three-dimensional live-action model and the thyroid fluorescence development model is achieved; overlapping fusion operation of the thyroid three-dimensional live-action model carrying parathyroid gland area marks and the thyroid fluorescence development model is realized; recognition of an overlapped parathyroid gland area is realized, and a non-overlapped area is used as a secondary focus area. According to the invention, the parathyroid gland identification accuracy is greatly improved.

The invention discloses a parathyroid gland detection device based on an L-shaped light path, the parathyroid gland detection device is composed of a probe, a handle, an optical fiber cable and a portable host, the L-shaped light path is arranged in the portable host so that emitted laser signals and received fluorescence signals are transmitted through the same optical fiber, a probe lens is arranged at the top end of the probe, and the probe adopts a replaceable design. According to the invention, the effective utilization rate of exciting light can be improved, the laser density can be improved, and the fluorescence signal intensity can be enhanced, so that the parathyroid gland detection and recognition rate can be improved, and one-time sterile operation can be realized, which has great clinical significance.

The invention relates to an anti-osteoporosis insole which comprises a left insole body and a right insole body, and forehead sinus reflection areas are arranged on the insole bodies, arranged at theforefoot position and correspond to the front half portions of toes. The insole also comprises pituitary reflection areas which are arranged at big toe positions and located below the forehead sinus reflection areas; parathyroid reflection areas which are arranged on the inner side of the insole bodies and are located below the pituitary gland reflection areas; thyroid reflecting areas which are positioned on the outer side of the parathyroid reflecting region and below the frontal sinus reflecting areas; kidney reflection areas which are arranged in the middle of the cushion body; and a ureter reflection area which is arranged below the kidney reflection areas, wherein a plurality of acupoint stimulation convex points are arranged in the reflection areas at intervals. By adopting the above scheme, the invention provides the anti-osteoporosis insole, and the acupoint stimulation points are arranged on the insole corresponding to the foot acupoints. When a user wears the insole, the corresponding foot acupoints can be massaged by the acupoint stimulation points, so that the aim of effectively preventing or reducing the incidence rate of osteoporosis is achieved.

The current invention relates to use of oral disodium pyrophosphate for preventing and / or reducing tissue calcification, particularly soft tissue calcification, and / or diseases or disorders characterized by low plasma PPi levels, as, e.g., occurs in chronic kidney disease (CKD), end-stage renal disease (ESRD), generalized arterial calcification of infancy (GACI), Pseudoxanthoma elasticum (PXE), Arterial Calcification Due to Deficiency of CD73 (ACDC), Ehlers-Danlos syndrome, arteriosclerosis obliterans, venous calcifications, crystal deposition disorders, calcification resulting from neurological disorders, calcinosis universalis, calcinosis circumscripta, scleroderma, dermatomyositis, systemic lupus erythematosus, hyperparathyroidism, neoplasms, milk-alkali syndrome, hypervitaminosis D, tumoral calcinosis, hypophosphatemic rickets, ossification of the posterior longitudinal ligament of the spine, myocardial ischemia, joint calcification, heterotropic ossification of traumatized muscle, angioid streaks, diabetes mellitus type II, cardiovascular disorder, calciphylaxis, calciphylaxis secondary to chronic kidney disease, calcific uremic arteriolopathy or atherosclerosis.