18 results about "Thyroid parathyroid glands" patented technology

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

The invention discloses a parathyroid gland identification method and device based on AI assistance. The parathyroid gland identification method comprises the following steps: S1, constructing a training data set of an important anatomical structure; s2, preprocessing the training data set of the important anatomical structure; s3, processing a plurality of segmentation models based on the preprocessed important anatomical structure training data set, and outputting a pixel probability graph of each segmentation model; s4, pixel values in each pixel probability graph are multiplied by corresponding weights, and a summation result is calculated; and S5, based on the addition result, performing post-processing and generating a parathyroid gland segmentation map. According to the method, a comprehensive probability graph containing advantages of different models is obtained based on processing of a plurality of segmentation models and weighted fusion processing. Compared with a traditional detection method, the accuracy and flexibility of recognition are remarkably improved. The method model is integrated into the device, and real-time positioning and recognition of important anatomical structures in an operation are achieved.

The invention belongs to the field of biological medicine, and provides circular RNA for treating multiple endocrine tumor type I and application of the circular RNA. According to the invention, after different optimization and design are carried out on the circular RNA for coding Menin, the circular RNA with relatively good expression level and long half-life period is finally obtained, and the anti-tumor effect is mainly achieved by supplementing cell-deficient Menin. Compared with the prior art, the circular RNA for expressing the Menin protein provided by the invention is more stable in intracellular expression and longer in half-life period. In an immortalized parathyroid gland cell model, the Menin protein can be expressed by transfecting the circular RNA for 6 hours, and the circular RNA has good treatment potential for multiple endocrine tumor type I.

The invention discloses a parathyroid gland identification and positioning method and system based on hyperspectrum, and relates to the field of parathyroid gland identification, and the method comprises the steps: employing a hyperspectral imaging device, and carrying out the hyperspectral information collection of a panoramic operation field where a parathyroid gland is exposed in a thyroid operation, so as to obtain a parathyroid gland hyperspectral image; after wave band selection is carried out on the parathyroid gland hyperspectral image, the parathyroid gland hyperspectral image is input into a parathyroid gland recognition and positioning model to be recognized and positioned, and parathyroid gland information is obtained; the parathyroid gland information comprises parathyroid gland pixel sites and parathyroid gland categories corresponding to the pixel sites; the parathyroid gland type is parathyroid gland negative or parathyroid gland positive; the parathyroid gland recognition and positioning model is obtained by training a deep learning classification framework by adopting a parathyroid gland sample set. The parathyroid gland recognition precision can be improved, and real-time high-precision positioning can be achieved.

This invention discloses an endoscopic device for thyroid surgery based on fluorescence lifetime and Raman spectroscopy imaging, comprising: a light source assembly, an endoscope probe, a fluorescence lifetime image signal acquisition module, a Raman spectroscopy signal acquisition module, and a color image acquisition module; a host unit, including a control unit and an image processing unit; and a display for displaying an image fused with the Raman spectroscopy signal, the fluorescence lifetime image signal of cancerous tissue, and the color image, as well as an image fused with the Raman spectroscopy signal and the color image. This invention utilizes Raman spectroscopy to visualize the autofluorescence of the parathyroid glands, enabling precise localization of the parathyroid glands. Raman spectroscopy can also locate regional lymph nodes and adipose tissue in the central thyroid region, and combined with fluorescence lifetime imaging, it can provide the conformational state of fluorophores in the neck tissues, marking cancerous tissues and providing real-time optical auxiliary localization for differentiating various anatomical tissues during thyroid endoscopic surgery.

The disposable grinding injection device comprises a cylinder, the rear end of the cylinder is open, and the front end of the cylinder is sequentially provided with a Luer taper and a needle head; according to the double-layer plane grinding net, the mesh diameter of a first grinding net sheet is 1.0-1.5 mm, and the mesh diameter of a second grinding net sheet is 0.5-0.8 mm; the two layers of grinding meshes keep a vertical distance of 2-3mm, and mesh patterns of the two layers of grinding meshes are rotationally staggered at an angle of 30-45 degrees; the cylindrical push rod is hermetically and loosely matched with the inner cavity of the barrel body and is arranged in the barrel body and at the rear end of the double-layer plane grinding net; the push rod pushes the tissue to move towards the mesh when being pushed, negative pressure is generated when the push rod is pulled back, and liquid suction is achieved. Standardized control over the size of tissue particles is achieved; the operation time is shortened to 2-3 minutes; tissue exposure links are reduced, and pollution risks are reduced; a grinding mechanism based on shearing force is adopted, so that the cell survival rate is improved; grinding and injection are integrated, and an intermediate transfer link is eliminated.

This disclosure relates to antibodies that specifically bind to parathyroid hormone-related protein (PTHrP). Immunoconjugates, nucleic acids, vectors, cells, and compositions comprising said antibodies are also provided. The antibodies, immunoconjugates, nucleic acids, vectors, cells, and compositions can be used for the diagnosis and treatment of diseases, particularly cancer and / or hypercalcemia.

This application relates to a method for constructing and applying an acute anxiety model for experimental animals. By injecting exogenous parathyroid hormone-related proteins into the experimental animals, the animals develop anxiety symptoms within a short period of time, thereby obtaining an acute experimental animal model with anxiety symptoms. The acute anxiety model for experimental animals obtained in this application has the advantages of rapid effectiveness, short modeling time, and a distinct anxiety phenotype. This method overcomes the problems of traditional animal acute anxiety models, such as the tendency to incur additional injuries during the modeling process, poor ventilation of experimental animals, differences in restraint pressure, and additional dizziness in experimental animals. This method facilitates the study of the mechanisms of anxiety disorders and drug development.

The application provides a multimodal fluorescence imaging method and system applied to thyroid surgery, and the method comprises the following steps: collecting image data by using a multi-wavelength endoscope system, and generating an image set; performing Fourier transform on the image set, performing fine enhancement processing on a target region based on a local contrast adjustment enhancement technology, and obtaining an enhanced image; monitoring the blood flow state of parathyroid glands in real time, constructing a parathyroid gland function protection and blood flow change evaluation model to evaluate the function risk of parathyroid glands in real time; comparing the real-time blood flow change with the existing standard model of electrical impedance change, and when the monitoring data exceeds the set threshold, an alarm is triggered to remind the operation team of the possible damage risk of the parathyroid gland region, and meanwhile, the protection measures are automatically activated according to the parathyroid gland function risk evaluation model. Through spectral navigation, the tumor positioning in the operation process and the protection of important surrounding tissues are effectively guaranteed, and the problems of incomplete cutting and accidental injury are avoided.

The present application provides a complex for protecting a cell and / or tissue graft. The complex comprises a cell mixture and a cell / tissue transplant. The cell mixture is used to protect the cell / tissue graft. The transplantation body is at least one of hepatocytes, islet cells, hematopoietic stem cells, adrenal medullary cells, testicular interstitial cells, follicle cells, gland pituitary cells, thyroid tissue blocks, parathyroid gland tissue blocks and thymus tissue blocks. The cell mixture comprises at least one of mesenchymal stem cells, primary hepatocytes, primary fibroblasts, dendritic cells, primary hepatocytes and fibroblasts. The complex not only can solve the problems of oxygen deficit and lack of nutritional factors in the transplantation process of the transplantation body, but also can reduce the immunological rejection reaction of a receptor to an allosome or xenograft after the transplantation of the transplantation body. The invention further provides a preparation method and application of the complex. By utilizing the product, cells or tissues can be transplanted into the spleen, the abdominal cavity or the position below the greater omentum, so that the application range of the transplant is expanded.

This invention relates to the fields of medical surgical navigation and artificial intelligence, and discloses a multimodal real-time fusion AI navigation system and method for laparoscopic thyroid surgery. The system includes: a multimodal data acquisition module for simultaneously acquiring near-infrared fluorescence image data and visible light video data of the laparoscopic surgical area and outputting a dual-channel data stream; an AI intelligent processing module for receiving the dual-channel data stream and performing preprocessing; an image fusion and segmentation using a multimodal AI segmentation network based on an edge-guided fusion mechanism, outputting four types of key structure segmentation masks; a visualization fusion module for overlaying and fusing the key structure segmentation masks in a highlighted form into the visible light video data to generate an augmented reality surgical field of view; and a surgical guidance module for generating dynamic guidance markers in the augmented reality surgical field of view based on the key structure segmentation masks and a preset surgical planning path. This invention can accurately identify key anatomical structures such as the parathyroid gland and recurrent laryngeal nerve.

The invention relates to the technical field of optical detection, provides a multi-mode parathyroid gland in-situ detection device and method, and discloses a multi-mode parathyroid gland in-situ detection device which is characterized in that an excitation electric signal receiving end is electrically connected with an excitation electric signal transmitting end; the exciting light signal transmitting end transmits an exciting light signal to a to-be-detected target object through the transmitting optical fiber, the feedback light signal receiving end receives a feedback light signal from the to-be-detected target object through the receiving optical fiber, and the feedback module is used for separating the feedback light signal and converting the feedback light signal into a backscattering light electric signal and an autofluorescence electric signal; the scattered light electric signal transmitting end is electrically connected with the scattered light electric signal receiving end, and the fluorescent light electric signal transmitting end is electrically connected with the fluorescent light electric signal receiving end; the invention further discloses a multi-mode parathyroid gland in-situ detection method executed by the main control module. According to the invention, comprehensive analysis and judgment on the characteristics of thyroid gland, parathyroid gland, brown fat and the like are realized, the identification specificity is improved, and multi-mode detection is realized at the same time.

This application provides an intelligent parathyroid gland identification and localization system based on ultrasound imaging, comprising: an image recognition module configured to acquire real-time ultrasound image sequences and output at least one suspicious target region and its corresponding preliminary identification result; a knowledge base module storing a parathyroid gland identification rule base constructed based on medical prior knowledge; an interaction module receiving the suspicious target region and its corresponding preliminary identification result; extracting image context features of the suspicious target region and matching them with verification rules in the knowledge base module; when a target verification rule conflicting with the preliminary identification result is matched, generating an interactive verification task to guide the user to confirm specific image features; receiving user feedback information on the interactive verification task through a user interface; and a result correction and output module connected to the interaction module for dynamically correcting the identification result of the suspicious target region.

The parathyroid gland autotransplantation device comprises an injection sleeve, a mounting plate is fixedly arranged on the upper portion of the injection sleeve, a nut sleeve is fixedly arranged on the mounting plate, a screw matched with the nut sleeve is arranged in the nut sleeve, and a screw rod is arranged in the screw rod. A knob for driving the screw rod to rotate is fixedly arranged at the upper end of the screw rod; a piston is arranged in the injection sleeve in a sealed and sliding manner; the lower end of the screw rod penetrates through a through hole formed in the middle of the piston, and a crushing disc is fixedly arranged at the lower end of the screw rod; the upper portion of the crushing disc is attached to the bottom of the piston, and a plurality of crushing pin teeth are evenly arranged at the bottom of the crushing disc. A connecting structure used for being rotationally connected with the piston is arranged on the portion, located on the upper portion of the piston, of the screw. The parathyroid gland transplanter can rapidly crush parathyroid glands, is convenient and rapid to operate on the premise of ensuring a normal injection function, and can effectively reduce the use cost of the transplanter.

The present invention relates to a dual-laser excitation system for parathyroid gland identification. The system comprises: a microprocessor for outputting a modulation signal within a frequency range of 1 kHz to 100 kHz; the microprocessor is connected to a near-infrared laser and a visible light laser and is used to control the near-infrared laser and the visible light laser to output laser light corresponding to the modulation signal; the near-infrared laser and the visible light laser are respectively connected to a first dichroic mirror; the output end of the first dichroic mirror is coupled to a beam of light in an optical fiber through a coupling lens; the optical fiber is connected to a probe, and the bottom of the probe is aligned with a tissue to be detected; the other beam of light in the probe is coupled to a collimating lens; a photoelectric measuring device is connected to the rear of the collimating lens; the photoelectric measuring device is a dual-path laser simultaneous detection photoelectric measuring device or a dual-path laser time-sharing detection photoelectric measuring device; the photoelectric measuring device is connected to an audible and visual alarm display device.

The invention discloses a thyroid separator for the general surgery department, and belongs to the technical field of medical instruments, the thyroid separator for the general surgery department comprises an end part, a handle and a hollow tubular rod body, the handle and the hollow tubular rod body are fixedly connected to the lower part and the right side of the end part respectively, and the outer side of the hollow tubular rod body is sleeved with a first mounting sleeve; an extension pipe is arranged on one side of the hollow tubular rod body, a flat nozzle is installed on one side of the extension pipe, and a second installation sleeve is arranged on the digging-out portion of the flat nozzle in a sleeving mode; the miniature camera and the symmetrical LED lamps are integrated at the position of the flat mouth, so that real-time high-definition visual illumination of an operation field is realized, an operator can clearly identify key anatomical structures such as recurrent laryngeal nerves, parathyroid glands and vascular branches, and the risk of accidental injury is remarkably reduced; the flexible flat cable is arranged to penetrate through the hollow tubular rod body, it is guaranteed that signals are stably transmitted without affecting the flexibility of the instrument, the accurate operation mode of separating while watching is truly achieved, and the operation safety and efficiency are improved.

The present disclosure concerns systems and methods related to an adjustable surgical dilation device for the mechanical dilation of an anatomical opening, including, but not limited to, an endoscopic or robotic port. In certain embodiments, this device may create and expand an anatomical opening with novel petal-like mechanism. In certain embodiments, this device may be utilized in laparoscopic procedures including, but not limited to, thyroid or parathyroid removal.

The disclosure pertains to antibodies that specifically bind to Parathyroid Hormone Related Protein (PTHrP). Also provided are immunoconjugates, nucleic acids, vectors, cells and compositions comprising the antibodies. The antibodies, immunoconjugates, nucleic acids, vectors, cells and compositions can be used in the diagnosis and treatment of disease, particularly cancer and / or hypercalcemia.