12 results about "Thyroid Gland Tissue" patented technology

The invention discloses an optical positioning method and system for papillary thyroid cancer cells of a terahertz near-field system, and relates to the field of terahertz near-field imaging, and the method comprises the following steps: carrying out the imaging observation of a thyroid tissue section under a first magnification factor through a microscope, carrying out low-magnification imaging partitioning on an area where imaging observation is located according to the morphological characteristics of the cells to form partitioned images; selecting an area of suspected papillary thyroid cancer cells, performing observation and comparison under a second magnification, comparing the observed morphology with the known optical characteristics of the papillary thyroid cancer cells, and selecting an area near the area with the suspected characteristics as an optical positioning point and performing marking; and carrying out positioning according to the optical positioning point, and carrying out scanning imaging by using a terahertz near-field system. The problems that a terahertz near-field system is long in time consumption and difficult to locate when finding papillary cancer cells in multiple cells of thyroid tissue slices are mainly solved.

The invention discloses a 3D printing-based thyroid puncture model manufacturing method capable of being trained under the guidance of B-type ultrasound, and relates to the field of medical teaching model manufacturing. The core of the method is that a 3D printing technology and a traditional casting technology are fused, and firstly, a split thyroid shaping mold capable of being customized in a personalized mode is printed through digital design; then, a polyvinyl alcohol-graphite powder composite material with a specific ratio is adopted to simulate thyroid tissues and nodules respectively, so that the high simulation degree of the model on acupuncture handfeel and B-type ultrasonic images is ensured; and then through innovative two-stage casting and a special nodule fixing structure, the precise positioning problem of the suspended nodule in the model is solved. And finally, performing freeze-thaw cycle treatment to obtain a finished product. The high-simulation thyroid model manufacturing method suitable for ultrasonic guided puncture training has the advantages of being low in cost, high in simulation degree and high in individuation.

The invention relates to the technical field of medical image and artificial intelligence technology crossing, in particular to an intelligent auxiliary diagnosis method and system for a frozen section in a thyroid cancer operation. According to the technical scheme, the method comprises the following steps that a thyroid tissue intraoperative frozen section to be diagnosed is prepared, and the frozen section does not need to be dyed or subjected to section sealing treatment; and scanning the frozen section by using a terahertz near-field imaging system to obtain terahertz near-field image data of the frozen section. According to the method, the terahertz near-field imaging technology is adopted, the situation that cell nucleus morphology is difficult to observe due to ice crystal artifacts in a traditional frozen section is avoided, cancer cells are automatically recognized in combination with an AI model trained based on large-scale labeling data, and the objectivity and consistency of diagnosis are remarkably improved; meanwhile, the steps of dyeing and mounting are omitted, and rapid imaging and analysis are realized, so that the intraoperative diagnosis time is greatly shortened, and a generated visual contour report also provides visual decision support for pathologists.

The invention relates to the technical field of near-field imaging, in particular to a papillary thyroid carcinoma identification method based on terahertz imaging. According to the technical scheme, the method comprises the following steps that two sets of sections at the same position of the thyroid tissue of a patient are obtained, one set is stained sections, and the other set is unstained sections; and comparing the two groups of slices through an optical microscope, observing the position corresponding relation of the two groups of slices, and selecting an observation area based on cell morphological characteristics. According to the invention, synchronous acquisition of tissue apparent morphology and internal structure under nanoscale resolution is realized through the terahertz near-field imaging system, automatic analysis of an undyed thyroid section can be completed within 30 minutes by combining multi-modal feature fusion and a target detection algorithm, objective positioning and diagnosis scores of a cancerous region are directly output, and the accuracy and accuracy of diagnosis of the cancerous region are improved. And rapid, lossless and quantitative papillary thyroid carcinoma identification is realized.

The application relates to the field of thyroid tissue sampling technology and discloses a thyroid tissue sampling needle with a negative pressure adsorption function, which comprises a guide stab needle and a hollow needle tube, a mounting block is arranged on the hollow needle tube, a communication hole in communication with the hollow needle tube is arranged on the mounting block, a communication pipe is arranged on the side wall of the mounting block, the communication pipe is in communication with the communication hole and an external negative pressure device, a fixing block is arranged on the top of the mounting block, a fixed magnetic ring is arranged in the fixing block, a fixed magnetic block and a positioning magnetic block are embeddedly arranged on the guide stab needle; when the fixed magnetic block is attracted to the fixed magnetic ring, the guide stab needle is arranged in a posture that the needle tip part penetrates through the needle tip part of the hollow needle tube; when the positioning magnetic block is attracted to the fixed magnetic ring, the guide stab needle is arranged in a posture that the needle tip part moves into the communication hole, so that the communication pipe is in communication with the hollow needle tube through the communication hole; the application has the advantages of coherent operation, guaranteed sample quality, avoided sample pollution and loss.

The invention belongs to the technical field of biological medicine, and particularly relates to probiotics capable of improving hypothyroidism and application of the probiotics. The probiotics are lactobacillus casei N1115, the strain of the lactobacillus casei N1115 is preserved in the China General Microbiological Culture Collection Center, and the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.4691. The invention relates to application of lactobacillus casei N1115 in preparation of drugs for improving hypothyroidism. The probiotic combined medicine can improve functional indexes of hypothyroidism, decrease of TSH, increase of T3 and T4 and remarkably improve decrease of physiological indexes and dyslipidemia in serum caused by hypothyroidism, thyroid tissue damage can be improved to a certain degree through probiotic intervention, and the synergistic medicine treatment effect is more remarkable. The behavioral performance of the rats is remarkably improved through intervention, the autonomous activity and the exploring behavior ability of the rats are improved, and the anxiety state caused by hypothyroidism is relieved.

The invention relates to the technical field of image analysis, in particular to a rat thyroid classification method based on a multi-modal image. The method comprises the following steps: acquiring a digital pathological image of SD rat thyroid tissue, and preprocessing the digital pathological image to obtain preprocessed image data; training a multi-task deep learning model by using an image database including annotation information, the multi-task deep learning model being used for processing the preprocessed image data to output image analysis information including an image region classification result and quantitative morphological features; and inputting a to-be-analyzed digital pathological image of the thyroid tissue of the SD rat into the trained multi-task deep learning model, and executing model reasoning to obtain a preliminary analysis result. According to the method, the complex tissue image of the thyroid gland of the rat can be automatically analyzed with high precision.

The application provides a system for determining whether a thyroid tissue lesion is a benign lesion or a malignant lesion and application thereof, the system is used for simultaneously detecting expression levels of MET gene, TIMP1 gene, TGFA gene, CITED1 gene and FN1 gene in thyroid tissue, and a model is constructed based on detection results of the five genes to determine whether the thyroid tissue lesion is a benign lesion or a malignant lesion. The application firstly constructs an arithmetic model for calculating mRNA expression of five genes based on high expression of 15 genes in thyroid cancer tissue, and obtains a final scoring model for distinguishing thyroid malignant canceration and benign lesion, and the scoring value can be more accurate than cytology and gene mutation methods.

The invention provides application of C. sporogenes or supernate thereof in preparation of a medicine for preventing and / or treating Graves disease, and belongs to the technical field of biological medicine. The research finds that after intervention of C.sporogenes and supernate thereof, thyroid hormones FT4 and TRAb of a mouse suffering from Graves disease are obviously reduced, TSH is increased, serum inflammation anti-inflammatory factors are increased, proinflammatory factors are reduced, body weight is increased, and food intake is reduced; the colon tissue structure is complete, columnar epithelial cells of the epithelial layer are arranged in order, cup-shaped cells are evenly distributed and moderate in number, colon villus is complete, a small amount of panesian cells can be seen in crypts, thyroid tissue follicles are normal in structure and are oval or round, the follicles are different in size, the epithelial cells are in a single-layer flat shape and are arranged in order, and the follicles contain rich colloid. The Graves disease can be effectively treated.

The invention discloses a thyroid normal cell terahertz near-field imaging and comparison method, and relates to the technical field of terahertz near-field system imaging. The method comprises the following steps: on the basis of continuous sections of thyroid tissue, firstly carrying out pathological staining imaging on one section, directly fixing the other section, then obtaining a cell optical image, a near-field imaging surface image and a near-field imaging internal image, and then by taking a macrostructure as a mark, aligning a pathological imaging image and the cell optical image to lock a first to-be-detected area; terahertz imaging characteristics and optical characteristics are summarized in combination with cell nucleus positions in a pathological imaging picture, a second to-be-detected area is selected from other areas for verification, accurate positioning, clear identification and reliable verification of thyroid normal cell terahertz near-field imaging are finally achieved, operability and accuracy are both achieved, and the method is suitable for large-scale popularization and application. Accurate imaging is achieved through a coherent process of double-slice parallel processing, multi-image correlation comparison and feature induction verification, and the problem that the thyroid normal cell terahertz near-field imaging position is difficult to find and imaging is difficult to distinguish is solved.

The utility model provides a nail-shaped lingual cyst positioning device and a nail-shaped lingual cyst positioning assembly. The nail-shaped lingual cyst positioning device comprises a tailorable hose and a developing agent injection part, wherein the developing agent injection part and the tailorable hose are of a detachable structure; two end parts of the developer injection part are provided with limiting bulge structures; the diameter of the limiting protrusion structure is larger than that of the tailorable hose. The developer injection member is also provided with a developer injection part. The device is simple in structure, deformable, convenient to use and capable of being effectively applied to relation identification of lumps and thyroid tissues.

The present application relates to the technical field of diagnosis and risk assessment of thyroid papillary carcinoma, and particularly relates to a composition, application and system for preoperative diagnosis and / or risk assessment of thyroid papillary carcinoma. The composition for preoperative diagnosis and / or risk assessment of thyroid papillary carcinoma comprises reagents for measuring the expression level of CLDN16 protein and / or the mRNA expression level of the gene encoding CLDN16 protein. Through the composition, the mRNA expression level of CLDN16 in thyroid tissue can be detected preoperatively, which is used for accurate diagnosis of the primary lesion and metastatic lesion of thyroid papillary carcinoma, and simultaneously, the disease risk of thyroid papillary carcinoma is accurately predicted to guide clinical decision-making.