The invention relates to dual-targeting
ursolic acid (UA) / siRNA loaded fluorescent
mesoporous silica dioxide-
hyaluronic acid and application. The technical scheme of the invention lies in that 1, fluorescently-labeled
mesoporous silica dioxide nano particles are synthesized through the template method; 2, the surface of FMSN is subjected to amino modification through 3-aminopropyltriethoxysilane; 3,
ursolic acid (UA) and siRNA are jointly loaded into porous channels of the nano particles; 4,
hyaluronic acid is loaded into the outer surfaces of the nano material in a wrapping manner through electrostatic absorption, so as to obtain the dual-targeting
ursolic acid (UA) / siRNA loaded fluorescent
mesoporous silica dioxide-
hyaluronic acid nano particles. According to the dual-targeting ursolic acid (UA) / siRNA loaded fluorescent mesoporous silica dioxide-hyaluronic acid and application, the prepared nano material is uniform in
particle size distribution, and good in dispersibility, the stability of siRNA can be improved, and besides, siRNA can further specifically target tumor
cell surface adhesion molecules like ICAM and CD44, therefore the anti-tumor effect of drugs can be greatly improved, and the toxic and
side effect of the drugs can be further reduced.