The present application provides the application of
Rabdosia serra extract in the preparation of drugs for treating
atrophic gastritis and precancerous lesions of gastric
cancer, wherein the
Rabdosia serra extract includes
Rabdosia serra aerial part extract, Rabdosia serra underground part extract, Rabdosia serra total part extract and eluate thereof, etc. The present application also provides the application of compounds in Rabdosia serra in the preparation of drugs for treating
atrophic gastritis and precancerous lesions of gastric
cancer, wherein the compounds in Rabdosia serra are selected from oridonin, rabdosin C,
norcantharidin, raxofelone and rabdosiin A. The present application proves that Rabdosia serra extract and the compounds in Rabdosia serra have good activity of reversing precancerous lesions of gastric
cancer by constructing a
cell model (MC
cell model) of
atrophic gastritis and precancerous lesions of gastric cancer by stimulating GES-1 cells with MNNG.