21 results about "OI - Osteogenesis imperfecta" patented technology

A telescopic intramedullary nail for the treatment of fractures or deformations of long bones, such as for example in the case of osteogenesis imperfecta or pseudoarthrosis may include a hollow stem and a rod telescopically coupled inside said hollow stem. The hollow stem may include, at a free distal end, an anchor tip configured to be internally fixed inside a distal portion of a long bone of a patient, without protruding from said long bone. The rod may include a free proximal end arranged to be fixed to a proximal site of said long bone.

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

The invention is directed to a method of treating pediatric osteogenesis imperfecta comprising administering an anti-sclerostin antibody to the subject in an amount ranging from 1 mg / kg to 10 mg / kg.

The present invention addresses the problem of providing an osteogenesis promoting agent and a pharmaceutical composition for preventing or treating a disease or a symptom involving bone defect, osteogenesis imperfecta, osteogenesis disorder, and / or bone hyperresorption.　The problem is solved by: a compound represented by general formula (I), a salt thereof, or a prodrug thereof; and a composition and a pharmaceutical composition containing the same.

The present invention provides usage of boric acid in a method of brittle bone disease treatment. In the present invention, moreover, there is a new brittle bone disease (osteogenesis imperfecta) in-vitro model for observing the effect of boric acid on brittle bone disease.

Telescopic nail for the treatment of fractures or deformations of long bones, as for example in the case of osteogenesis imperfecta or pseudo arthrosis. Comprising of a hollow stem; a rod telescopically inserted into said hollow stem; a first fastening element coupled to an end of said hollow stem for fixing to a first long bone end; a second fastening element coupled to an end of said rod for fixing to a second long bone end. Advantageously, one end of said hollow stem is provided with coupling means for coupling to an end of a tool which can be inserted into a cavity formed in the bone for insertion of the nail.

The invention discloses a novel extensible long intramedullary rod and a matched tool, and relates to the technical field of medical instruments, the novel extensible long intramedullary rod comprises a female rod and a male rod, one end of the female rod is provided with a fixed tip, the other end of the female rod is provided with a blind hole, the male rod is sleeved with the blind hole, the fixed tip is used for being connected with the epiphysis of the far end of a long bone, and the end of the male rod is flush with an implantation opening. And the length of the male rod sleeved into the female rod is at least 1 / 2 of the length of the female rod. The extensible long intramedullary rod can effectively fix a long bone, prevent fracture of the long bone and maintain the shape of the long bone, can gradually achieve the purpose of extension along with the growth of the bone, can better maintain the mechanical axis of the bone, has a stronger protection effect on the fracture end, is particularly suitable for being applied to special patients in the department of orthopedics of children, and has a wide application prospect. And intraoperative and postoperative protection of lower limb long bone malformation and fracture caused by osteogenesis insufficiency and congenital long bone artificial joints can be realized.

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions containing said polypeptides and methods of using the polypeptides to treat diseases and conditions including neuromuscular diseases, osteogenesis imperfecta, myelofibrosis, thrombocytopenia, neutropenia, and metabolic disease.

A telescopic intramedullary nail (1) for the treatment of fractures or deformations of long bones, such as for example in the case of osteogenesis imperfecta or pseudoarthrosis, extended along a longitudinal axis, comprising: a hollow stem (2); a rod (3) telescopically coupled inside said hollow stem (2); means for constraining said hollow stem (2) and said rod (3) in rotation about said longitudinal axis (x) during the insertion and / or during the removal of said telescopic intramedullary nail (1).

Disclosed herein are compounds and methods for treating Osteogenesis Imperfecta in an individual. In some embodiments, the compounds include a bone anabolic agent, a linker, and a bone targeting ligand. In some embodiments, the methods include reducing the incidences of or likelihood of bone fracture, increasing bone density or strength of a bone, and providing compounds to low density and weakened bone sites in an individual with Osteogenesis Imperfecta.

The invention relates to a telescopic plate (8) designed to prevent or stabilize fractures and correct long (femur) bone deformities in children older than 18 months with osteogenesis imperfecta (glass bone).

The invention provides a telescopic intramedullary nail system, and belongs to the technical field of medical instruments. Comprising a front bone body, a rear bone body and a limiting mechanism, a fixing sleeve is slidably connected to the inner wall of a fixing groove, a sliding rod is slidably connected to the inner wall of the fixing sleeve, and a connecting sleeve is slidably connected to the inner wall of one end of the fixing sleeve; the device is characterized in that the inner wall of the fixing sleeve is provided with a limiting mechanism for preventing the sliding rod from moving backwards; along with the growth of the front bone body and the rear bone body, the overall length of the front bone body and the rear bone body can be changed, meanwhile, the sliding rod and the fixing sleeve slide relatively through the connecting sleeve, the overall length is increased, joint growth with the bone is achieved, and the sliding rod and the fixing sleeve placed in the front bone body and the rear bone body can form the effect of an intramedullary nail. The bone fracture stabilizer can be used for preventing or stabilizing bone fractures or correcting deformity of long bones in the growth process so that patients suffering from osteogenesis imperfecta, skeletal dysplasia and other skeletal deformity can use the bone fracture stabilizer conveniently.

The invention features polypeptides that include an extracellular ActRIIB variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRIIB variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions containing said polypeptides and methods of using the polypeptides to treat diseases and conditions including neuromuscular diseases, osteogenesis imperfecta, myelofibrosis, thrombocytopenia, neutropenia, and metabolic disease.

A telescopic intramedullary nail for the treatment of fractures or deformations of long bones, such as for example in the case of osteogenesis imperfecta or pseudoarthrosis, extended along a longitudinal axis. The telescopic intramedullary nail may include a hollow stem and a rod telescopically coupled inside said hollow stem. A structure may constrain the hollow stem and said rod in rotation about said longitudinal axis during the insertion and / or during the removal of said telescopic intramedullary nail.

The present invention discloses a hydrolyzed egg yolk powder rich in growth factor-like polypeptides, its preparation method and application. The present invention relates to the fields of biotechnology and nutritional health, specifically to a hydrolyzed egg yolk powder rich in growth factor-like polypeptides and its application as a medicament for promoting bone growth. The hydrolyzed egg yolk powder is obtained by extracting from egg yolk through a specific enzymatic hydrolysis technology and is rich in growth factor-like polypeptides with significant bone formation promoting functions. The hydrolyzed egg yolk powder and growth factor-like polypeptides in the present invention can be used as pharmaceutical ingredients to effectively promote bone growth and have significant effects on treating or preventing diseases related to bone health such as osteogenesis imperfecta, osteoporosis and osteoarthritis, etc.

The present invention discloses a method for constructing a conditional point mutation animal model of the SERPINH1 gene. The present invention for the first time provides a conditional point mutation rat model of the SERPINH1 gene, its construction method and application. The rat model constructed by the method of the present invention makes up for the deficiencies of animal models related to high fracture risk genetics, provides a reliable and effective experimental animal model for studying the new mechanism of genetic regulation of high fracture risk, provides a good animal basis for the establishment of new strategies for the prevention, diagnosis and treatment of osteogenesis imperfecta and osteoporosis, and has important application value. In addition, the present invention also has potential application value in aspects such as tumors, diabetes and autoimmune diseases.

The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a binding agent that binds to transforming growth factor beta (TGFβ).

A telescopic intramedullary nail (1) for the treatment of fractures or deformations of long bones, such as for example in the case of osteogenesis imperfecta or pseudoarthrosis, comprising: a hollow stem (2); and a rod (3) telescopically coupled inside said hollow stem (2); wherein said hollow stem (2) comprises, at a free distal end (11), an anchor tip (21) configured to be internally fixed inside a distal portion of a long bone of a patient, without protruding from said long bone; wherein said rod (3) comprises a free proximal end arranged to be fixed to a proximal site of said long bone.

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

The present invention aims to provide a safe mattress which prevents the osteogenesis imperfecta patient from pressing the arm to fracture when turning over. The safe mattress comprises a bottom plate and a top plate, a longitudinal beam in the middle of the top wall of the bottom plate in the front-rear direction, the top plate is hinged at the top end of the longitudinal beam in the middle of the bottom wall, and the top plate is turned over around the top end of the longitudinal beam when one side of the top plate is pressed to turn over downward. The patient sleeps on the safe mattress in a supine position, and if the patient turns over to the left side, the weight of the body will mainly press on the left side of the top plate, the left side of the top plate will turn over downward, the longitudinal beam will make the right side of the top plate turn up to support the right side of the back of the patient, and the right side of the top plate will share part of the weight of the body for the left arm of the patient, so that the left arm is not easy to fracture. The patient turns over to the right side, and the same principle applies, which is not described here.

The present invention provides a nutritional composition and the use of the nutritional composition. The nutritional composition comprises medium and long chain triglycerides and milk fat globule membrane in a mass ratio of 2:1 - 97:1, and the two have a synergistic effect in promoting bone development, particularly increasing bone density and / or preventing or treating osteogenesis imperfecta and / or osteoporosis.