32 results about "Secondary hyperparathyroidism" patented technology

The invention relates generally to compounds which are allosteric modulators (e.g., negative and positive allosteric modulators, allosteric agonists, and ago-allosteric modulators) of the G protein coupled receptor PTHR1, also known as parathyroid hormone/parathyroid hormone related protein receptor. The PTHR1 compounds are derived from the intracellular loops and domains of the PTHR1 receptor. The invention also relates to the use of these PTHR1 receptor compounds and pharmaceutical compositions comprising the PTHR1 receptor compounds in the treatment of diseases and conditions associated with PTHR1 receptor modulation, such as osteoporosis; humoral hypercalcemia of malignancy; osteolytic and osteoblastic metastasis to bone; primary and secondary hyperparathyroidism associated increase in bone absorption; vascular calcification; psychiatric disorders and cognitive disorders associated with hyperparathyroidism; dermatological disorders; and excess hair growth.

A method of treating and preventing secondary hyperparathyroidism in CKD by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin Din a patient by administering 25-hydroxyvitamin D₃ with or without 25-hydroxyvitamin D₂ and, as necessary, 1,25-dihydroxyvitamin D₂ as a Vitamin D hormone replacement therapy.

A computer-implemented method for determining at least one secondary hyperparathyroidism risk factor (“SHPT”) for a patient is implemented using a risk evaluation computer system in communication with a memory. The method includes receiving a plurality of demographic data associated with a patient from a mobile computing device, receiving a concentration of a renal filtration marker associated with the patient from the mobile computing device, and determining at least one SHPT risk factor for the patient based on the plurality of demographic data and the concentration of the renal filtration marker using at least one estimating equation, the SHPT risk factor indicating a likelihood that the patient has SHPT.

The present invention provides a dihydropyridazine-3,5-dione derivative or a salt thereof, or a solvate of the compound or the salt, a pharmaceutical drug, a pharmaceutical composition, a sodium-dependent phosphate transporter inhibitor, and a preventive and/or therapeutic agent for hyperphosphatemia, secondary hyperparathyroidism, chronic renal failure, chronic kidney disease, and arteriosclerosis associated with vascular calcification comprising the compound as an active ingredient, and a method for prevention and/or treatment.

The invention relates to novel medicinal application of medical carbon, in particular to the application of the medicinal carbon in the preparation of medicaments for curing hyperphosphatemia. In the invention, clinical tests prove that the medicinal carbon, when taken orally, can reduce the serium inorganic phosphorus level and the product of calcium and phosphorus of patients who have received hemodialysis and peritoneal dialysis but do not have the hyperphosphatemia controlled after receiving the treatment by the calcium-containing phosphate binder, and provides a voltage detection (VD) therapy opportunity for patients with secondary hyperparathyroidism which cannot be treated by the VD therapy because of over-high product of calcium and phosphorus. The medical carbon is favorable for reducing and preventing angiocardiopathy development death, caused by chronic kidney disease-mineral and bone disorder (CKD-MBD), of the dialysis patients. Thus, the medicinal carbon can be used as novel medicaments for curing the hyperphosphatemia of patients with dialysis.

A subject with symptoms of chronic kidney disease (CKD), who does not have end-stage renal disease (ESRD), can be treated by orally administering a pharmaceutical composition as an active ingredient a therapeutically effective amount of a non-toxic lanthanum compound. Administration of a lanthanum compound can prevent the progression of CKD, treat soft tissue calcification, and treat secondary hyperparathyroidism.

The invention provides for methods of using 20-methyl Gemini vitamin D₃ compounds to treat osteoporosis and secondary hyperparathyroidism.

Methods, compositions, and kits for adjunctive therapy using 25-hydroxyvitamin D are disclosed. The 25-hydroxyvitamin D may be administered with an agent that increases the risk of hypocalcemia and/or an anticancer agent. The adjunctive therapy is effective to treat and prevent iatrogenic hypocalcemia and/or secondary hyperparathyroidism, as well as delay cancer progression and the time to a post-treatment skeletal related event.

The present invention includes an oral pharmaceutical capsule comprising a shell, lanthanum carbonate or lanthanum carbonate hydrate, and a lubricant such as talc, wherein the shell encapsulates the lanthanum carbonate or lanthanum hydrate and the lubricant. Capsule shells comprise, for example, gelatin. The capsules of the present invention dissolve at a similar rate before and after storage. The oral pharmaceutical capsules of the present invention can be administered to treat a patient at risk for or suffering from hyperphosphatemia, at risk for or suffering from chronic kidney disease (CKD), at risk for or suffering from soft tissue calcification associated with CKD, or at risk for or suffering from secondary hyperparathyroidism.

The invention relates to a rhythmic photostimulation pattern system and application thereof. In the rhythmic photostimulation pattern system, a cycle of photostimulation is four weeks, the frequency of photostimulation is three times per week, and the time of photostimulation at a time is 10 to 40 minutes. The rhythmic photostimulation pattern system disclosed by the invention can be used for effectively improving osteoporosis induced by secondary hyperparathyroidism, remarkably inhibiting excessive secretion of parathyroid hormones induced by the secondary hyperparathyroidism, remarkably reversing bone density and/or bone bulk density decrease induced by the secondary hyperparathyroidism, activating differentiating and aging of osteoblasts and inhibiting differentiating and aging of osteoclasts, and thus, osteogenesis can be greater than osteoclastogenesis. The rhythmic photostimulation pattern system is very convenient in operating mode, and an entire process is free of introductionof drug for intervention, so that a side effect resulting from employing the system is lower compared with that of drug therapy, and the safety is higher.

The invention discloses a fully humanized monoclonal single-domain antibody for resisting human PTH1R and an application of the fully humanized monoclonal single-domain antibody. The amino acid sequence of the antibody is shown as SEQ ID NO: 2. According to the invention, aiming at wild and mutant human PTH1R ECD proteins, antibody screening is carried out by using a phage display technology, and the anti-human PTH1R blocking type single-domain antibody with a blocking effect is screened and obtained through methods such as ELISA, FACS and the like. The antibody can be combined with human PTH1R, can block the interaction between PTH and PTH1R, and has a potential application value in human body dysfunction mediated by PTH-PTH1R, such as chronic kidney disease secondary hyperparathyroidism.

The invention discloses a cardiovascular assessment system for patients with chronic kidney diseases and secondary hyperparathyroidism, relates to the field of experimental diagnosis of heart diseases, and aims to solve the problem that in the prior art, assessment cannot be well carried out according to cardiovascular conditions of the patients and corresponding treatment cannot be carried out on the patients. According to the scheme, the system comprises a patient information query module, an illness state diagnosis module, an illness state evaluation module and a treatment analysis module. Through the arrangement of the patient information inquiry module, the disease condition diagnosis module, the disease condition evaluation module and the treatment analysis module, the disease condition of a patient can be systematically examined, evaluated and treated, and the treatment of the disease of the patient is more efficiently completed; and the steps before electrocardiogram detection can be effectively simplified, so that the examination efficiency of a patient is effectively improved, and convenience is brought to the use of medical staff.

The invention relates to the field of medicines, in particular to high-affinity shrimp shell calcium powder, a preparation method thereof and application of the high-affinity shrimp shell calcium powder in preparation of medicines for treating calcium deficiency symptoms and/or diseases. According to the calcium powder, the high-affinity shrimp shell calcium powder of which the tablet loosening rate after tabletting with a protein base material is not higher than 15%, the tablet loosening rate after tabletting with a carbohydrate base material is not higher than 15% and the tablet loosening rate after tabletting with a saccharide base material is not higher than 10% is applied to calcium deficiency symptoms and/or diseases, for example, the calcium powder has a good curative effect on treating osteoporosis, rickets, chondropathy, nutritional secondary hyperparathyroidism and postpartum convulsion.

Compounds of the formula

wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6C;

Y is of the formula

or a stereoisomer thereof,

• • wherein R¹ is substituted or unsubstituted alkyl;
  • each R² is independently H, hydroxy, alkoxy (1-6C) or lower alkyl (1-4C);
  • R³ is H, hydroxy, or alkoxy (1-6C); or

Y is of the formula

wherein each n is 1, Z is N,

K comprises a substituted or unsubstituted aromatic carbocyclic or heterocyclic ring system which may optionally be spaced from the linkage position shown in formula (7) by a linker of 1-2C, or in formula (7), Z may be spaced from the carbon bonded to X by ═CR⁶— wherein R⁶ is H or linear, branded or cyclic alkyl (1-6C),

R⁵ is H or linear, branched or cyclic alkyl, and R′ represents a cation, H or a substituted or unsubstituted alkyl group of 1-6C, promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. Also disclosed is a method to identify additional compounds which are inhibitors of enzymes in the isoprenoid scheme especially of HMG-CoA reductase which results in prenylation of proteins and in the synthesis of steroids or of inhibitors of their production which are useful in treating bone disorders.

Disclosed are methods of administering 2-methylene-19-nor-(20S)-1α,25-dihydroxyvitamin D₃ to treat primary hyperparathyroidism and/or to treat and/or prevent the symptoms of primary hyperparathyroidism in as subject having or at risk for developing primary hyperparathyroidism, preferably without inducing hypercalcemia in the patient