The invention discloses a composition for intestinal dialysis of pet dogs and cats and a preparation method thereof, belonging to the pet medical field. The dialysis composition comprises the following components: 10-20g of raw rhubarb, 10-20g of chitosan, 10-20g of calcium butyrate, 50-100g of modified zeolite, and 200-300ml of acetic acid with a volume fraction of 4%. During preparation, fully dissolve raw rhubarb, chitosan and calcium butyrate in acetic acid, then add modified zeolite to make a paste, make it fully infiltrated, granulate with a granulator, and dry at 60°C for 4 hours. Finished products with a particle size of 0.8‑1.2mm. The components of the intestinal dialysis composition for pet dogs and cats provided by the present invention cooperate with each other, and can absorb uremic toxins such as urea in the intestinal tract and their decomposition products such as ammonia, phosphate, creatinine, etc., and promote blood circulation. Small molecular substances such as uremic toxins such as urea are excreted into the intestinal cavity, thereby reducing the concentration in the blood, relieving hypernitremia and hyperphosphatemia caused by renal failure, and benefiting the recovery of renal failure. Economical and easy to operate.