36results about How to "Inhibition of reabsorption" patented technology

The present invention provides novel type IIc Na / Pi cotransporters. These cotransporters are important Pi transporters that are highly expressed during the growth period from the weaning stage to the adult stage. Furthermore, the present invention provides FGF23 and mutants thereof as factors that regulate the expression of type II Na / Pi cotransporters. FGF23 suppresses Pi reabsorption through suppression of type II Na / Pi cotransporter expression in kidneys. Therefore, FGF23 can be used as a target substance for regulating Pi reabsorption in kidneys. The present invention provides important factors for the development of preventive and therapeutic agents for hyperphosphatemia or hypophosphatemia.

The invention discloses an optical-fiber laser device which includes pump devices, fiber bragg gratings, a gain optical fiber and a pump feedback device. Pump light sent by the pump devices is injected into the gain optical fiber through pump couplers. The fiber bragg gratings are used as endoscopes of the laser device and fusion welded at the two ends of the gain optical fiber. The gain optical fiber is shorter in length than an optical fiber needed for completely absorption of the injected pump light so as to ensure 10%-50% of residual pump light. The pump feedback device feeds back the residual pump light at the tail end of the gain optical fiber into a pump injection end and then the pump light is injected into the gain optical fiber again. The optical-fiber laser device uses a shorter gain optical fiber to reserve specific residual pump light so that re-absorption of signal light by the gain optical fiber in the laser device is inhibited effectively and generation of a nonlinear effect is inhibited effectively and under the same output power, the laser device has a larger nonlinear effect threshold than a conventional laser device so that the laser device is applicable to laser devices of a plurality of kinds of wavelengths and amplifiers.

The invention provides a feed for improving the immunity of laying hens. The feed comprises the following components: corn, carrot, egg shell, wheat bran, traditional Chinese herbal mixture, limestone, fish meal, aminophylline, choline chloride, lysine, methionine, multi-vitamin, copper sulphate, ferrous sulphate, zinc sulfate, manganese sulfate, sodium selenite, and L-lactic acid, wherein the traditional Chinese herbal mixture comprises the following components: licorice, raw rehmannia root, radix astragali, fructus forsythia, radix bupleuri, clerodendroa cyrtophyllum, almond, dried orange peel, balloonflower root, and radix codonopsis. The feed can fully provides the required nutrients for laying hens, has an antiseptic and anti-inflammation function, can improve the immunity of the laying hens, effectively prevents diseases from happening in chicken groups, and controls the death rate of laying hens; furthermore the feed has the advantages of no residual drug and no pollution, can increase the economic profits for farmers, and satisfies the needs of consumers.

The present invention generally relates to the novel pharmaceutical use of fungal immunoregulatory proteins. More specifically, the present invention relates to the use of fungal immunoregulatory proteins and compositions containing fungal immunoregulatory proteins to inhibit osteoblast neovascularization, inhibit bone resorption, and prevent and treat disorders associated with bone loss.

The present invention provides an application of angelica peony powder in preparation of drugs for treating cirrhosis ascites. With the angelica peony powder of the present invention, indicators of TBIL, ALT and AST of cirrhosis ascites rats can be significantly reduced, ALB can be increased, A / G ratio inversion is improved, liver cell metabolism is improved, liver function is improved, and liver protection is achieved; and a liver fibrosis pathological state is improved, and pseudolobule formation is slowed so as to prevent cirrhosis formation. With combination of the angelica peony powder and V2 receptors of distal convoluted tubules and collecting ducts of kidney, water reabsorption of kidney collecting ducts is inhibited. In addition, with the angelica peony powder of the present invention, AQP4 expression in liver tissues is unregulated, ascites transportation is prompted, and cirrhosis ascites generation is reduced so as to provide treatment effects for cirrhosis ascites.

The invention relates to a dicyclic derivative of glucoside as well as a preparation method and the application of the dicyclic derivative. Specifically, the invention relates to a compound as shown in Formula I, a stereisomer or pharmaceutically acceptable salt or ester of the compound, a pharmaceutical composition of the compound, and application of the compound in preparation of drugs for treating diabetes or relevant diseases.

The invention provides a method for processing fructus aurantii medicinal slices. The method comprises the following steps: washing fructus aurantii, adding into a herbal medicine infiltrating machine, vacuumizing, and controlling a series of parameters such as infiltrating temperature and time, slice thickness, drying temperature and time and the like, thereby realizing preparation of the fructusaurantii medicinal slices. The content of active ingredients of the fructus aurantii medicinal slices, such as hesperidin, neohesperidin, naringin, narirutin and the like is high, and the curative effect of the drug is effectively ensured. The preparation method disclosed by the invention is simple and suitable for industrialized production.

The invention relates to a pharmaceutical composition for treating dorking abdominal dropsy caused by high natrium, which is prepared by uniformly mixing the following components by weight: 50-400 mgof digitalis leaf ultrafine powder, 10-100 mg of triamterene and 50,000 mg of glucose. In the invention, the digitalis leaves contain digitoxin, thereby strengthening the myocardial contraction force,increasing the cardiac output and also slowing the heart rate and reducing the myocardial oxygen consumption so that heart-failure heart functions are improved; the digitalis leaf ultrafine powder isbeneficial to absorbing, thereby reducing the dosage and the side effects of medicaments and enhancing the treatment effect; the triamterene increases the discharge amount of natrium and chlorine soas to be diuretic, thereby being more suitable for heart-failure dorkings; in addition, the glucose improves the requirement of important organs of organisms for sugar in a high natrium state, therebybeing benefit to the detoxifying function of liver and kidney. The pharmaceutical composition is simple, has reasonable preparation and plays a good role in treating the dorking abdominal dropsy caused by the high natrium contained in the feeds or drinking water after being added to dorking feeds per kilogram.

The invention belongs to the technical field of biology, and specifically relates to a combined drug for treating diabetes mellitus and complications and a pharmaceutical composition of the combined drug. The invention discloses combined use of components (i): a compound represented by a general formula (I), pharmaceutical salt of the compound and isomers of the compound and the pharmaceutical salt and a component (ii): an SGLT2 inhibitor in preparation of drugs for preventing and / or treating the diabetes mellitus and / or the complications of the diabetes mellitus, and further discloses the pharmaceutical composition containing the components (i) and the component (ii). The combined drug is capable of synergetically reducing blood sugar of db / db diabetic mice, generating an unexpected synergetic effect, improving blood lipid indexes, particularly improving content of triglyceride in serum and further generating a combined effect in aspects of control of body weight and protection of blood lipid, blood pressure, livers and kidneys, so that more benefits are brought to prevention and / or treatment of the diabetes mellitus and the complications including cardiovascular and cerebrovascular diseases, kidney diseases and hepatic diseases.

The invention discloses a 2H-benzo [b][1,4] oxazine-3(4H)-ketone compound as shown in a formula (I) or salts, hydrates, solvents, and stereoisomerides, which are pharmaceutically acceptable, a preparation method of the 2H-benzo [b][1,4] oxazine-3(4H)-ketone compound, a preparation containing the compound, and an application of the 2H-benzo [b][1,4] oxazine-3(4H)- ketone compound in the aspects of treating diabetes and complications thereof.

In one aspect, the invention relates to compounds of formula (I): where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

The invention provides a Zhuang medicine composition with a treatment effect on acute gouty arthritis, Zhuang medicine particles and a preparation method of the Zhuang medicine composition and the Zhuang medicine particles, and relates to the technical field of ethnic medicines. The Zhuang medicine composition is composed of glabrous sarcandra herb, rhizoma dioscoreae hypoglaucae, plantain herb, polygonum cuspidatum, cynanchum paniculatum, garden balsam stem, honeysuckle stem and liquorice, and clinical application results prove that the Zhuang medicine composition has the effects of clearing heat toxin, removing dampness toxin, dispelling wind toxin, relieving swelling pain, adjusting water channels, dredging long channels and fire channels, and has a remarkable curative effect on gout (gout) caused by wind-damp heat toxin. The Zhuang medicine composition and the Zhuang medicine granules based on the Zhuang medicine composition have very good curative effects on arthralgia, redness and swelling, scorching heat, unfavorable flexion and extension, blood uric acid increase, tophus and the like, and particularly, the Zhuang medicine composition and the Zhuang medicine granules based on the Zhuang medicine composition can be used for treating gouty arthritis induced by MSU crystals, and have the characteristics of multiple targets and low toxicity.

The invention relates to application of a compound in preparation of a drug for treating gout. The compound has a structure as shown in formula I. Through experiments, it shows that the compound can inhibit URAT1, reabsorption of uric acid is stopped, discharge of the uric acid of rats can be promoted, the serum urate levels is reduced, sodium urate induced THP-1 CELL IL-1 beta and TNF-alpha secretion can further be inhibited obviously, the degree of rat ankle swelling caused by sodium urate is reduced, inflammatory response is reduced, and arthralgia is relieved. It shows that the compound has effect of treating hyperuricemia and / or gout and has high application value.

The present invention discloses a pharmaceutical composition for treating hyperuricemia. The pharmaceutical composition is prepared from the following components in parts by weight: 500-900 parts of cortex fraxini and 400-600 parts of clematis root. The pharmaceutical composition for treating the hyperuricemia can reduce concentration of blood uric acid in human body.

The invention relates to a formula and production technology of a health-care food consisting of levulose and a tea extract and capable of neutralizing effect of alcoholic drinks and protecting liver.When massive wine is drunk for a long term, alcoholic liver injury, liver cirrhosis and the like can be caused, and drunk driving is also an important reason for causing traffic accidents. The health-care food consisting of levulose and a tea extract and capable of neutralizing effect of alcoholic drinks and protecting liver disclosed by the invention can solve the problems of in daily life, drunkenness caused by massive wine drinking, the liver and kidney damage, central nervous system damage and the like. The levulose tea for neutralizing effect of alcoholic drinks has the characteristics that in the formula, crystal levulose is high in proportion of 85-95%, and the tea extract is 3-15%; the levulose can accelerate the metabolism of alcohol in bodies, and promote the alcohol to be drained rapidly through the kidney; the tea extract can reinforce the activity of alcohol dehydrogenase and accelerate the alcohol metabolism and transformation, and besides, the tea extract can restrain the resorption of the alcohol by renal tubules, and can promote alcohol drainage; and therefore, the alcohol concentration in the bodies can be rapidly reduced, and the effect of quickly neutralizing effect of alcoholic drinks can be achieved. The tea extract has prevention effect on hyperuricaemia caused by the levulose, and the health-care food has favorable effects through animal experiment andapplication in human bodies.

The invention belongs to the technical field of nutritional healthcare food and methods for producing the same, and particularly relates to calcium supplementing food with probiotics and a method forproducing the calcium supplementing food. The technical scheme includes that the calcium supplementing food with the probiotics is made from raw materials including, by weight, 10-30 parts of prunus humilis bunge, 10-30 parts of fructus crataegi, 4-6 parts of raisins, 4-6 parts of dried fructus mori, 10-20 parts of apples, 4-5 parts of seedless dateplum persimmon, 4-5 parts of carrot powder, 1-2 parts of semen sesami nigrum, 8-10 parts of cooked bean flour, 3-4 parts of auricularia auricula powder, 2-10 parts of ficus carica, 5-6 parts of mushroom powder, 0.25 part of starter culture and 0.08-0.16 part of casein phosphopeptides. The method includes steps of 1) raw material pretreatment, 2) sterilization treatment, 3) sealed fermentation and 4) smashing and packaging. The calcium supplementing food and the method have the advantage that the technical problems of poor calcium supplementing effects and healthcare properties of calcium supplementing food in existing markets mainly can be solved by the aid of the calcium supplementing food and the method.

The invention discloses a traditional Chinese medicine composition as well as a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw material medicines: turtle shell, oyster, astragalus membranaceus, codonopsis pilosula, poria cocos, bighead atractylodes rhizome, pseudo-ginseng, curcuma zedoary, phyllanthus urinaria and raw liquorice. The traditional Chinese medicine composition provided by the invention has obvious effects of softening hardness to dissipate stagnation and replenishing qi to invigorate the spleen on patients suffering from cirrhosis, and also can be used for dispersing blood stasis, dredging collaterals, nourishing yin, promoting salivation, clearing away heat and toxic materials, promoting diuresis, removing jaundice, strengthening the body resistance, eliminating pathogenic factors and treating the liver and the spleen simultaneously. Symptoms and signs such as hypochondriac pain, tiredness and weakness, unsmooth emotion, anorexia, abdominal distension, splenomegaly and dark tongue of patients with liver cirrhosis can be obviously improved. The traditional Chinese medicine composition can improve liver function and relieve hepatic fibrosis of patients with cirrhosis, enhance body resistance, and achieve the purpose of treating original diseases, thereby treating both symptoms and root causes and improving the life quality of patients.

The invention provides a sodium-glucose cotransporter 2 (SGLT2) inhibitor. The SGLT2 inhibitor is trilobatin, and the specific structure of the trilobatin is shown as the following formula (please seethe specifications for the formula); and the trilobatin and the SGLT2 interact with each other, the trilobatin is in hydrogen bond connection with ASn75 and Tyr290 sites of the SGLT2, and thus the trilobatin can significantly inhibit glucose reabsorption, lowers the overall blood glucose level of an experimental subject, and meanwhile, can further improve insulin resistance of the experimental subject effectively.

The invention relates to a bicyclic derivative of heterocyclic glucoside as well as a preparation method and application of the bicyclic derivative, in particular to a compound shown in a formula I, a stereoisomer or pharmaceutically acceptable salt or ester of the compound, a pharmaceutical composition of the compound and application of the compound to preparation of drugs for treating diabetes or related diseases of the diabetes.

The invention provides multifunctional deer-horn gelatin paste and a preparation method thereof, and relates to the technical field of health food processing. The multifunctional deer-horn gelatin paste mainly comprises the following components in parts by weight: 50-100 parts of deer-horn gelatin, 5-10 parts of wine, 2-5 parts of Chinese yam, 1-3 parts of sesame, 1-5 parts of Chinese chives, 5-8parts of poria cocos, 3-10 parts of fructus lycii and 0.5-1 part of a thickening agent. The preparation method comprises the following steps: soaking the deer-horn gelatin for 2-3 days, then cleaningthe soaked deer-horn gelatin with vinegar for 15-30 minutes, airing the cleaned deer-horn gelatin for 1-2 hours, then crushing the aired deer-horn gelatin into powder with meshes of 80-100, disinfecting the powder under ultraviolet rays of 200-300 nm for 5-10 seconds for later use, crushing the Chinese yam, the sesame, the Chinese chives, the poria cocos and the fructus lycii into powder with meshes of 80-100, adding 500-1,000 parts by weight of water, stirring the solution for 30-50 minutes to obtain first paste, mixing the first paste, the wine, the deer-horn gelatin and the thickening agent, decocting the mixture at the temperature of 20-30 DEG C for 0.5-1 hour, and carrying out stirring for 1-2 hours to obtain the multifunctional deer-horn gelatin paste.

The invention relates to processes and intermediates for preparing compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors.

The invention belongs to the field of food liquor brewing and discloses medicinal liquor with detumescence and diuresis functions and a preparation method of the medicinal liquor. The medicinal liquoris prepared from 3-5 parts of flagellaria indica flavonoid glycosides, 2-4 parts of radix stephaniae tetrandrae total alkaloids, 15-20 parts of rhizoma chuanxiong, 15-20 parts of radix astragali, 8-12 parts of radix asteris, 10-15 parts of white mulberry root-bark, 10-12 parts of plantain seeds, 8-12 parts of rhizoma atractylodis, 8-10 parts of akebia stems, 10-15 parts of radix sophorae flavescentis, 10-15 parts of corn stigma, 10-12 parts of phaseolus calcaratus, 8-12 parts of bitter herbs, 600-700 parts of 60% liquor and 250-300 parts of saccharose. According to the medicinal liquor, through compounding of traditional Chinese medicine, such as flagellaria indica flavonoid glycosides, radix stephaniae tetrandrae total alkaloids, rhizoma chuanxiong, radix astragali, radix asteris, whitemulberry root-bark, plantain seeds, rhizoma atractylodis, akebia stems, radix sophorae flavescentis, corn stigma, phaseolus calcaratus and bitter herbs, with the detumescence and diuresis functions, the medicinal liquor which can adjust the central nervous of the brain and promote urine generation and discharge, has no influence on the renal function, can effectively remove edema and has good detumescence and diuresis functions is prepared.

The invention discloses a tea candy with refreshing and brain arousing efficacies. The tea candy is mainly prepared from the compositions: Yunnan black tea, calendula officinalis and mint leaves. Theraw material components are subjected to necessary mixing, tea steaming and pressing procedures, and then the pressed raw materials are further trimmed, aired, and packaged. The tea candy has certainrefreshing, brain arousing and breath freshening effects and can serve as a common health-care beverage in life. Meanwhile, a production method of the tea candy is simple, low in cost, convenient to process, safe and reliable.