36results about How to "Inhibition of reabsorption" patented technology

The present invention provides novel type IIc Na/Pi cotransporters. These cotransporters are important Pi transporters that are highly expressed during the growth period from the weaning stage to the adult stage. Furthermore, the present invention provides FGF23 and mutants thereof as factors that regulate the expression of type II Na/Pi cotransporters. FGF23 suppresses Pi reabsorption through suppression of type II Na/Pi cotransporter expression in kidneys. Therefore, FGF23 can be used as a target substance for regulating Pi reabsorption in kidneys. The present invention provides important factors for the development of preventive and therapeutic agents for hyperphosphatemia or hypophosphatemia.

The invention provides a phloridzin derivative with a general structure formula (1), which has a function of inhibiting SGLT2. The preparation method of the compound is easy, and the Phloridzin derivative can be used for treating metabolic diabetes, complication thereof and the like.

The invention discloses an optical-fiber laser device which includes pump devices, fiber bragg gratings, a gain optical fiber and a pump feedback device. Pump light sent by the pump devices is injected into the gain optical fiber through pump couplers. The fiber bragg gratings are used as endoscopes of the laser device and fusion welded at the two ends of the gain optical fiber. The gain optical fiber is shorter in length than an optical fiber needed for completely absorption of the injected pump light so as to ensure 10%-50% of residual pump light. The pump feedback device feeds back the residual pump light at the tail end of the gain optical fiber into a pump injection end and then the pump light is injected into the gain optical fiber again. The optical-fiber laser device uses a shorter gain optical fiber to reserve specific residual pump light so that re-absorption of signal light by the gain optical fiber in the laser device is inhibited effectively and generation of a nonlinear effect is inhibited effectively and under the same output power, the laser device has a larger nonlinear effect threshold than a conventional laser device so that the laser device is applicable to laser devices of a plurality of kinds of wavelengths and amplifiers.

The invention provides a feed for improving the immunity of laying hens. The feed comprises the following components: corn, carrot, egg shell, wheat bran, traditional Chinese herbal mixture, limestone, fish meal, aminophylline, choline chloride, lysine, methionine, multi-vitamin, copper sulphate, ferrous sulphate, zinc sulfate, manganese sulfate, sodium selenite, and L-lactic acid, wherein the traditional Chinese herbal mixture comprises the following components: licorice, raw rehmannia root, radix astragali, fructus forsythia, radix bupleuri, clerodendroa cyrtophyllum, almond, dried orange peel, balloonflower root, and radix codonopsis. The feed can fully provides the required nutrients for laying hens, has an antiseptic and anti-inflammation function, can improve the immunity of the laying hens, effectively prevents diseases from happening in chicken groups, and controls the death rate of laying hens; furthermore the feed has the advantages of no residual drug and no pollution, can increase the economic profits for farmers, and satisfies the needs of consumers.

The present invention generally relates to the novel pharmaceutical use of fungal immunoregulatory proteins. More specifically, the present invention relates to the use of fungal immunoregulatory proteins and compositions containing fungal immunoregulatory proteins to inhibit osteoblast neovascularization, inhibit bone resorption, and prevent and treat disorders associated with bone loss.

The present invention provides an application of angelica peony powder in preparation of drugs for treating cirrhosis ascites. With the angelica peony powder of the present invention, indicators of TBIL, ALT and AST of cirrhosis ascites rats can be significantly reduced, ALB can be increased, A/G ratio inversion is improved, liver cell metabolism is improved, liver function is improved, and liver protection is achieved; and a liver fibrosis pathological state is improved, and pseudolobule formation is slowed so as to prevent cirrhosis formation. With combination of the angelica peony powder and V2 receptors of distal convoluted tubules and collecting ducts of kidney, water reabsorption of kidney collecting ducts is inhibited. In addition, with the angelica peony powder of the present invention, AQP4 expression in liver tissues is unregulated, ascites transportation is prompted, and cirrhosis ascites generation is reduced so as to provide treatment effects for cirrhosis ascites.

The invention belongs to the technical field of biology, and specifically relates to a combined drug for treating diabetes mellitus and complications and a pharmaceutical composition of the combined drug. The invention discloses combined use of components (i): a compound represented by a general formula (I), pharmaceutical salt of the compound and isomers of the compound and the pharmaceutical salt and a component (ii): an SGLT2 inhibitor in preparation of drugs for preventing and/or treating the diabetes mellitus and/or the complications of the diabetes mellitus, and further discloses the pharmaceutical composition containing the components (i) and the component (ii). The combined drug is capable of synergetically reducing blood sugar of db/db diabetic mice, generating an unexpected synergetic effect, improving blood lipid indexes, particularly improving content of triglyceride in serum and further generating a combined effect in aspects of control of body weight and protection of blood lipid, blood pressure, livers and kidneys, so that more benefits are brought to prevention and/or treatment of the diabetes mellitus and the complications including cardiovascular and cerebrovascular diseases, kidney diseases and hepatic diseases.

The invention discloses a 2H-benzo [b][1,4] oxazine-3(4H)-ketone compound as shown in a formula (I) or salts, hydrates, solvents, and stereoisomerides, which are pharmaceutically acceptable, a preparation method of the 2H-benzo [b][1,4] oxazine-3(4H)-ketone compound, a preparation containing the compound, and an application of the 2H-benzo [b][1,4] oxazine-3(4H)- ketone compound in the aspects of treating diabetes and complications thereof.

The invention relates to application of a compound in preparation of a drug for treating gout. The compound has a structure as shown in formula I. Through experiments, it shows that the compound can inhibit URAT1, reabsorption of uric acid is stopped, discharge of the uric acid of rats can be promoted, the serum urate levels is reduced, sodium urate induced THP-1 CELL IL-1 beta and TNF-alpha secretion can further be inhibited obviously, the degree of rat ankle swelling caused by sodium urate is reduced, inflammatory response is reduced, and arthralgia is relieved. It shows that the compound has effect of treating hyperuricemia and/or gout and has high application value.

The invention relates to a formula and production technology of a health-care food consisting of levulose and a tea extract and capable of neutralizing effect of alcoholic drinks and protecting liver.When massive wine is drunk for a long term, alcoholic liver injury, liver cirrhosis and the like can be caused, and drunk driving is also an important reason for causing traffic accidents. The health-care food consisting of levulose and a tea extract and capable of neutralizing effect of alcoholic drinks and protecting liver disclosed by the invention can solve the problems of in daily life, drunkenness caused by massive wine drinking, the liver and kidney damage, central nervous system damage and the like. The levulose tea for neutralizing effect of alcoholic drinks has the characteristics that in the formula, crystal levulose is high in proportion of 85-95%, and the tea extract is 3-15%; the levulose can accelerate the metabolism of alcohol in bodies, and promote the alcohol to be drained rapidly through the kidney; the tea extract can reinforce the activity of alcohol dehydrogenase and accelerate the alcohol metabolism and transformation, and besides, the tea extract can restrain the resorption of the alcohol by renal tubules, and can promote alcohol drainage; and therefore, the alcohol concentration in the bodies can be rapidly reduced, and the effect of quickly neutralizing effect of alcoholic drinks can be achieved. The tea extract has prevention effect on hyperuricaemia caused by the levulose, and the health-care food has favorable effects through animal experiment andapplication in human bodies.

The invention belongs to the technical field of nutritional healthcare food and methods for producing the same, and particularly relates to calcium supplementing food with probiotics and a method forproducing the calcium supplementing food. The technical scheme includes that the calcium supplementing food with the probiotics is made from raw materials including, by weight, 10-30 parts of prunus humilis bunge, 10-30 parts of fructus crataegi, 4-6 parts of raisins, 4-6 parts of dried fructus mori, 10-20 parts of apples, 4-5 parts of seedless dateplum persimmon, 4-5 parts of carrot powder, 1-2 parts of semen sesami nigrum, 8-10 parts of cooked bean flour, 3-4 parts of auricularia auricula powder, 2-10 parts of ficus carica, 5-6 parts of mushroom powder, 0.25 part of starter culture and 0.08-0.16 part of casein phosphopeptides. The method includes steps of 1) raw material pretreatment, 2) sterilization treatment, 3) sealed fermentation and 4) smashing and packaging. The calcium supplementing food and the method have the advantage that the technical problems of poor calcium supplementing effects and healthcare properties of calcium supplementing food in existing markets mainly can be solved by the aid of the calcium supplementing food and the method.

The invention relates to a bicyclic derivative of heterocyclic glucoside as well as a preparation method and application of the bicyclic derivative, in particular to a compound shown in a formula I, a stereoisomer or pharmaceutically acceptable salt or ester of the compound, a pharmaceutical composition of the compound and application of the compound to preparation of drugs for treating diabetes or related diseases of the diabetes.

The invention provides multifunctional deer-horn gelatin paste and a preparation method thereof, and relates to the technical field of health food processing. The multifunctional deer-horn gelatin paste mainly comprises the following components in parts by weight: 50-100 parts of deer-horn gelatin, 5-10 parts of wine, 2-5 parts of Chinese yam, 1-3 parts of sesame, 1-5 parts of Chinese chives, 5-8parts of poria cocos, 3-10 parts of fructus lycii and 0.5-1 part of a thickening agent. The preparation method comprises the following steps: soaking the deer-horn gelatin for 2-3 days, then cleaningthe soaked deer-horn gelatin with vinegar for 15-30 minutes, airing the cleaned deer-horn gelatin for 1-2 hours, then crushing the aired deer-horn gelatin into powder with meshes of 80-100, disinfecting the powder under ultraviolet rays of 200-300 nm for 5-10 seconds for later use, crushing the Chinese yam, the sesame, the Chinese chives, the poria cocos and the fructus lycii into powder with meshes of 80-100, adding 500-1,000 parts by weight of water, stirring the solution for 30-50 minutes to obtain first paste, mixing the first paste, the wine, the deer-horn gelatin and the thickening agent, decocting the mixture at the temperature of 20-30 DEG C for 0.5-1 hour, and carrying out stirring for 1-2 hours to obtain the multifunctional deer-horn gelatin paste.

The invention relates to processes and intermediates for preparing compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors.

The invention discloses a tea candy with refreshing and brain arousing efficacies. The tea candy is mainly prepared from the compositions: Yunnan black tea, calendula officinalis and mint leaves. Theraw material components are subjected to necessary mixing, tea steaming and pressing procedures, and then the pressed raw materials are further trimmed, aired, and packaged. The tea candy has certainrefreshing, brain arousing and breath freshening effects and can serve as a common health-care beverage in life. Meanwhile, a production method of the tea candy is simple, low in cost, convenient to process, safe and reliable.