The invention discloses a warning and intervention system for drunk driving of drivers and an operation and control method of the drunk driving detecting, warning and intervening system. The system comprises a system enable detection unit, a driver alcohol detection unit, a driver response ability detection unit and an execution unit, the system enable detection unit consists of a WISDD (warning and intervention system for drunk driving) controller (20), a vehicle door opening sensor (11) and a driver seat pressure sensor (12), the driver alcohol detection unit comprises a primary alcohol detection unit and a secondary blowing type alcohol detection unit (6), the driver response ability detection unit comprises four signal lamps and four switches, structures of the four signal lamps are identical, structures of the four switches are identical, and the execution unit mainly consists of a voice prompting loudspeaker (3), a speed limiting prompting lamp (4), a double-flash warning relay (13), a double-flash warning lamp (15) and a system fault lamp (17). The system enable detection unit, the driver alcohol detection unit, the driver response ability detection unit and the execution unit are respectively connected with the WISDD controller (20) by electric wires. The invention further provides the operation and control method of the warning and intervention system for drunk driving of drivers.