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Application of angelica peony powder in preparation of drugs for treating cirrhosis ascites

A technology of Angelica shaoyao powder and liver cirrhosis ascites, which can be applied in the directions of drug combination, digestive system, medical formula, etc., can solve the problems of patient injury and high cost of liver transplantation

Inactive Publication Date: 2012-10-17
ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above-mentioned treatment methods and techniques are effective, there are many disadvantages due to the new damage to the patient and the high cost of liver transplantation.

Method used

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  • Application of angelica peony powder in preparation of drugs for treating cirrhosis ascites
  • Application of angelica peony powder in preparation of drugs for treating cirrhosis ascites
  • Application of angelica peony powder in preparation of drugs for treating cirrhosis ascites

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1 prepares medical material extract

[0031]According to 2 parts by weight of angelica, 18 parts by weight of peony, 6 parts by weight of Rhizoma Chuanxiong, 5 parts by weight of Atractylodes macrocephala, 3 parts by weight of Poria cocos, 10 parts by weight of Alisma and pharmaceutically allowed auxiliary materials, add 10 times the 50 parts of the total weight of the medicinal materials. % ethanol, soak for 60min, reflux in a water bath for 1.5h, collect the filtrate after cooling; add 50% ethanol which is 8 times the total weight of the medicinal materials, reflux in a water bath for 1.5h, and collect the filtrate after cooling. Combine the two filtrates, filter, recover ethanol until there is no alcohol smell, concentrate in a water bath to an extract, and dry in a vacuum to obtain Danggui Shaoyao Powder.

Embodiment 2

[0032] Embodiment 2 prepares medical material extract

[0033] According to 3 parts by weight of Angelica sinensis, 16 parts by weight of peony, 8 parts by weight of Rhizoma Chuanxiong, 4 parts by weight of Atractylodes macrocephala, 4 parts by weight of Poria cocos, 8 parts by weight of Alisma and pharmaceutically allowed auxiliary materials, add 10 times to 50 parts of the total weight of the medicinal materials. % ethanol, soak for 60min, reflux in a water bath for 1.5h, collect the filtrate after cooling; add 50% ethanol which is 8 times the total weight of the medicinal materials, reflux in a water bath for 1.5h, and collect the filtrate after cooling. Combine the two filtrates, filter, recover ethanol until there is no alcohol smell, concentrate in a water bath to an extract, and dry in a vacuum to obtain Danggui Shaoyao Powder.

Embodiment 3

[0034] Embodiment 3 prepares medical material extract

[0035] According to 4 parts by weight of Angelica sinensis, 14 parts by weight of peony, 10 parts by weight of Rhizoma Chuanxiong, 3 parts by weight of Atractylodes macrocephala, 5 parts by weight of Poria cocos, 6 parts by weight of Alisma and pharmaceutically allowed auxiliary materials, add 10 times to 50 parts of the total weight of the medicinal materials. % ethanol, soak for 60min, reflux in a water bath for 1.5h, collect the filtrate after cooling; add 50% ethanol which is 8 times the total weight of the medicinal materials, reflux in a water bath for 1.5h, and collect the filtrate after cooling. Combine the two filtrates, filter, recover ethanol until there is no alcohol smell, concentrate in a water bath to an extract, and dry in a vacuum to obtain Danggui Shaoyao Powder.

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Abstract

The present invention provides an application of angelica peony powder in preparation of drugs for treating cirrhosis ascites. With the angelica peony powder of the present invention, indicators of TBIL, ALT and AST of cirrhosis ascites rats can be significantly reduced, ALB can be increased, A / G ratio inversion is improved, liver cell metabolism is improved, liver function is improved, and liver protection is achieved; and a liver fibrosis pathological state is improved, and pseudolobule formation is slowed so as to prevent cirrhosis formation. With combination of the angelica peony powder and V2 receptors of distal convoluted tubules and collecting ducts of kidney, water reabsorption of kidney collecting ducts is inhibited. In addition, with the angelica peony powder of the present invention, AQP4 expression in liver tissues is unregulated, ascites transportation is prompted, and cirrhosis ascites generation is reduced so as to provide treatment effects for cirrhosis ascites.

Description

technical field [0001] The invention relates to a medicine for treating liver cirrhosis ascites, in particular to the application of Danggui Shaoyao powder in the preparation of medicine for treating liver cirrhosis ascites. Background technique [0002] Liver cirrhosis is the late stage of the development of various chronic liver diseases. It is chronic, progressive, and diffuse damage to the liver caused by one or more causes acting on the liver for a long time. Tissue hyperplasia and fibrosis lead to destruction of normal liver structure and formation of pseudolobules, leading to liver function damage and portal hypertension. The liver is in a compensatory state in the early stage of liver cirrhosis. If there is no intervention, it will enter the decompensation period, and the quality of life and survival rate of patients will be greatly affected. About 75% of patients with decompensated liver cirrhosis are accompanied by ascites, of which about 15% of patients die withi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P1/16A61P7/10
Inventor 许钒彭代银陶春蕾
Owner ANHUI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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