Method for processing fructus aurantii medicinal slices

A processing method and technology of Citrus aurantium, applied in the processing field of Citrus Citrus decoction pieces, can solve the problems of no objective quantifiable index, change of active ingredient structure, loss of pharmacological activity, etc., to ensure drug safety, increase coronary flow, The effect of reducing myocardial oxygen consumption

Active Publication Date: 2018-01-19
TIANSHENG PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 2015 edition of "Chinese Pharmacopoeia" stipulates that the processing method of Citrus aurantium decoction pieces is: remove impurities, wash, moisten thoroughly, cut into thin slices, dry and sieve to remove the broken pulp core, stir-fry Citrus aurantii with bran to take Citrus aurantii slices, and stir-fry according to the method of bran frying (General Rule 0213) Stir-fry until the color becomes darker, with occasional scorched spots; there are no objective and quantifiable indicators in each link of the processing process, and the operation in the processing process has a certain degree of blindness. With the development of processing machinery for decoction pieces, most of the decoction pieces are currently The factory adopts automatic or semi-automatic mechanized production, which reduces human errors to a certain extent. However, due to the inconsistent control of processing parameters by different manufacturers, most of the parameter settings are based on experience and there is no uniform standard. The quality of the products also varies greatly
Since hesperidin, neohesperidin, naringin, rutin and other ingredients contain a large number of hydroxyl groups, conventional processing methods can easily cause loss of ingredients or changes in chemical structure. In the presence of glycine, etc.), oxidation-reduction reactions are prone to occur, resulting in changes in the structure of active ingredients, thereby losing pharmacological activity and even increasing toxicity

Method used

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  • Method for processing fructus aurantii medicinal slices
  • Method for processing fructus aurantii medicinal slices

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The contents of rutin naringin, naringin, hesperidin and neohesperidin in Fructus Aurantii were determined by HPLC.

[0023] Establishment of analytical methods

[0024] Chromatographic conditions: Column: Welch C18 (250×4.6mm, 5μm), the mobile phase is acetonitrile (A): 0.1% phosphoric acid (B) = 16:84 isocratic elution, the volume flow rate is 1.0mL / min, the detection wavelength is 283nm, and the injection volume is 10μL , column temperature 25°C.

[0025] Choice of mobile phase: acetonitrile (A): 0.1% phosphoric acid (B)

[0026] Preparation of the test solution: Weigh 0.5g of Fructus Fructus decoction powder (passed through No. 2 sieve), weigh it accurately, put it in a 100mL round bottom flask, add 50mL of methanol precisely, weigh it, heat and reflux for 1.5h (75°C) , let it cool, weighed, made up for the lost weight with methanol, shaken well, filtered into a 50mL volumetric flask, filtered through a 0.22μm filter membrane, and took the subsequent filtrate to...

Embodiment 2

[0032] The medicinal material of Fructus Aurantii is hard and needs to be moistened in order to facilitate cutting. Take 5kg of washed Fructus Fructus Fructus, put them in the medicine moistening machine respectively, vacuumize for 6 minutes, and moisten at 30°C, 45°C, 50°C, 60°C for 20 minutes, cut into thin slices (2mm), and blow dry at 55°C for 2 At the same time, sieve to remove the broken pulp core, and then get the decoction pieces moistened at different temperatures. The analysis method of Example 1 was used to measure the contents of rutin naringin, naringin, hesperidin and neohesperidin in each sample respectively, and the results are shown in Table 1 below.

[0033] Table 1 Comparison of the main components of Fructus Fructus decoction pieces at different infiltration temperatures (mg.g -1 )

[0034] Infiltration temperature

[0035] It can be seen from the above table 1 that when soaked at 30°C for 20 minutes, the medicinal material of Citrus aurantii is r...

Embodiment 3

[0037] Take 5kg of washed Fructus Fructus Fructus, put it in a moistening machine at 45°C for 20 minutes, cut into 1mm, 1.5mm, and 2mm thick slices, and dry it with air at 55°C for 2 hours. The contents of main components rutin naringin, naringin, hesperidin and neohesperidin in each sample were determined, and the results are shown in Table 2 below.

[0038] Table 2 Comparison of main component contents in different slice thicknesses (mg.g -1 )

[0039] slice thickness

[0040] It can be seen from the above table 2 that when the slice thickness is 2mm, the content of each main active ingredient is relatively high.

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Abstract

The invention provides a method for processing fructus aurantii medicinal slices. The method comprises the following steps: washing fructus aurantii, adding into a herbal medicine infiltrating machine, vacuumizing, and controlling a series of parameters such as infiltrating temperature and time, slice thickness, drying temperature and time and the like, thereby realizing preparation of the fructusaurantii medicinal slices. The content of active ingredients of the fructus aurantii medicinal slices, such as hesperidin, neohesperidin, naringin, narirutin and the like is high, and the curative effect of the drug is effectively ensured. The preparation method disclosed by the invention is simple and suitable for industrialized production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine Fructus aurantii, in particular to a processing method for decoction pieces of Fructus aurantii. technical background [0002] Citrus aurantium is a herbal medicine included in the "Chinese Pharmacopoeia". It is bitter, pungent, sour, and warm in nature. The medicinal source is the dry immature fruit of the Rutaceae plant lime and its cultivars. Studies have shown that Fructus Aurantii is rich in hesperidin, neohesperidin, naringin, rutin and other components. Hesperidin enhances venous tone by prolonging norepinephrine-induced venous constriction time (it still has this effect in the state of fever and acidosis), and can reduce the adhesion and migration of leukocytes and vascular endothelial cells, and reduce the post-disintegration The release of inflammatory substances (such as histamine, bradykinin, complement, leukotrienes, prostaglandins, excessive free radicals, etc.), thereby reducing th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752
Inventor 刘群谈宗华杨荣平吴统选周文杰胡华东
Owner TIANSHENG PHARMA GROUP
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