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151results about How to "The chemical composition is simple and clear" patented technology

Woodlouse small peptide drug for treating ischemic stroke

The invention discloses a pharmaceutical composition for treating angiocardiopathy, and belongs to the field of traditional Chinese medicine. The pharmaceutical composition for treating the angiocardiopathy is characterized in that traditional Chinese medicine effective parts extracted from woodlice, panax notoginseng, salviae miltiorrhizae and uncaria are matched according to a certain proportion, preparation auxiliary materials are added, and corresponding tablets or capsules are prepared through a conventional method. The pharmaceutical composition for treating the angiocardiopathy has a good effect. According to the clinical application of the drug, the drug is good in effect, low in cost, pure in traditional Chinese medicine preparation and controllable in quality and has a better market prospect.
Owner:ANHUI BIOLOGICAL PEPTIDE IND RES INST

Extract of an traditional Chinese medicine containing isopsoralen, preparation method and use thereof

The invention has provided Chinese traditional medicine extract which contains 10%-24% of angelicin, 8-19% part of psoralen, 4-12% of neobavaisoflavone and 2-9% of corylin. The preparing procedure of the invention includes the following steps: soaking the psoraleae medicine into pure water; heating and backstreaming to remove volatile oil; putting the gruffs into alcohol, heating and extracting the medicine; condensing the eluted solution into extractum; separating the extractum with ODS-C18 column using asgradient methanol from low density to high density; drying the eluted solution to get the extract which has definite structures and high content. The medical experiment shows that the extract can substantially inhibit sensitive tumor cell and multidrug resistance tumor cell so that it has obvious anti-tumor function. The invention has proper design and simple preparing method which can be used in preparing medicine that can inhibit sensitive tumor cell and multidrug resistance tumor cell.
Owner:ZHEJIANG UNIV

Effective component of Rabdosia amethystoides and preparation and use thereof

The present invention relates to an effective component of rabdosia and the preparation method and usage. For the effective component of rabdosia of the present invention, the preparation process includes the following steps: step 1: the mixture of ethyl acetate and ethanol is used as a solvent to extract rabdosia; step 2: the extract goes through column chromatography to obtain the eluent; step 3: the mobile phase of the eluent obtained from the preparation of liquid chromatogram gradient elution is water and acetonitrile, the eluent is collected for 20.0 to 24.0min or 24.0 to 28.0min so as to obtain the effective component.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of vietnamese sophora root and preparation and use thereof

The present invention relates to an effective component of root of subprostrate sophora and the preparation method and usage. For the effective component of root of subprostrate sophora of the present invention, the preparation process includes the following steps: step 1: the mixture of ethyl acetate and ethanol is used as a solvent to extract the root of subprostrate sophora; step 2: the extract goes through column chromatography to obtain the eluent; step 3: the mobile phase of the eluent obtained from the preparation of liquid chromatogram gradient elution is water and acetonitrile, the eluent is collected for 36.0 to 40.0min so as to obtain the effective component.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of artemisia leaves and preparation method thereof

The invention relates to an effective component of artemisia leaves as well as a preparation method and an application thereof. The preparation process of the effective component of the artemisia leaves comprises the following steps: (1) a mixture of ethyl acetate and ethanol is used as a solvent to extract the artemisia leaves; (2) dregs of a decoction are extracted with the ethanol so as to obtain an extracting solution; (3) the extracting solution is processed by chromatography through a chromatographic column to obtain an eluent; (4) the eluent is eluted by prepared liquid chromatogram gradient and is collected for 28.0-32.0 minutes, 36.0-40.0 minutes, 48.0-52.0 minutes, 52.0-56.0 minutes and 52.0-60.0 minutes to obtain the effective component by taking water and acetonitrile as flow phases.
Owner:TIANJIN TASLY PHARMA CO LTD

Stellera chamaejasme L extract and anti-tumor action thereof

The invention relates to a Stellera chamaejasme L extract and an anti-tumor action thereof. The Stellera chamaejasme L extract of the invention is extracted by absolute ethyl alcohol to obtain a primary extract; the primary extract is further treated by macroporous resin column chromatography or polyamide column chromatography and then eluted by water and ethyl alcohol to obtain a secondary extract; and in the secondary extract, the secondary extract separated by a macroporous resin column is further treated by polyamide column chromatography and then eluted by water and ethyl alcohol to obtain a tertiary extract.
Owner:INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI

Effective component of chebula fruit as well as preparation method and use thereof

The invention relates to an effective component of myrobalam. The preparation process for the effective component comprises the following: step one, using a mixture of ethyl acetate and ethanol as solvent to extract the myrobalam; step two, using the ethanol to extract medicine dregs to obtain extract; step three, obtaining eluent through chromatography of the extract; and step four, using prepared liquid-phase chromatographic gradient to elute the eluent, and collecting the eluent for 48.0 to 52.0 minutes to obtain the effective component, wherein a mobile phase comprises water and methyl cyanide. The invention also discloses a preparation method for the effective component, a pharmaceutically acceptable preparation, and application thereof to preparing anti-tumor medicament.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of cynanchum atratum and preparation method thereof

The invention relates to an effective component of cynanchum atratum as well as a preparation method and an application thereof. The effective component of the cynanchum atratum is prepared according to the following steps: (1) a mixture of ethyl acetate and ethanol is used as a solvent to extract the cynanchum atratum; (2) dregs of a decoction are extracted with the ethanol so as to obtain an extracting solution; (3)the extracting solution is processed by chromatography through a chromatographic column to obtain an eluent; and (4) the eluent is eluted by prepared liquid chromatogram gradient and collected for 40.0-44.0 minutes, 44.0-48.0 minutes, 48.0-52.0 minutes, 52.0-56.0 minutes, 56.0-60.0 minutes and 60.0-64.0 minutes to obtain the effective component by using water and acetonitrile as flow phases.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective components of Cacumen Platycladi and preparation method thereof

The invention relates to effective components of Cacumen Platycladi as well as a preparation method and a purpose thereof. The preparation process comprises the following steps: 1. the mixer of ethyl acetate and ethanol is used as a solvent for extracting Cacumen Platycladi; 2. eluent is obtained from an extracting solution through chromatographic column chromatography; 3. with the moving phase ofwater and acetonitrile, the eluent obtained by the phase color chromatographic gradient elution of a preparation solution is collected for 36.0-40.0 minutes, and the effective components are obtained from the eluent after 44.0-48.0 minutes.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of artemisia leaves and preparation method thereof

The invention relates to an effective component of artemisia leaves as well as a preparation method and an application thereof. The preparation process of the effective component comprises the following steps: (1 )a mixture of ethyl acetate and ethanol is used as a solvent to extract the artemisia leaves; (2) an extracting solution is processed by chromatography through a chromatographic column to obtain an eluent; (3) the eluent is eluted by prepared liquid chromatogram gradient and is collected for 4.0-8.0 minutes, 8.0-10.0 minutes, 16.0-20.0 minutes, 20.0-24.0 minutes, 24.0-28.0 minutes, 28.0-32.0 minutes and 36.0-40.0 minutes to obtain the effective component by taking water and acetonitrile as flow phases.
Owner:TIANJIN TASLY PHARMA CO LTD

Pharmaceutical composition for preventing or treating parkinsonism and preparation method thereof

The invention discloses a pharmaceutical composition for preventing or treating parkinsonism and a preparation method thereof. The pharmaceutical composition consists of eleutheroside B, eleutheroside D, syringaresinol-di-glucoside and daucosterol. The invention determines the optimal dose level range of the four components and on the base, adopts an orthogonal test for screening out the optimal compatibility proportion of the four active components. Proved by experiment results, the pharmaceutical composition which is prepared by the compatibility of the eleutheroside B, the eleutheroside D, the syringaresinol-di-glucoside and the daucosterol according to a weight ratio of 1:2:8:8, can obviously improve PC12 cell survival rate and has obvious protective effects on dopaminergic neuron injuries. The active ingredients of the acanthopanax have simple and clear chemical compositions and quality control is easy to be conducted in production. The pharmaceutical composition can be used for preparing medicaments with good therapeutic effects for preventing and treating parkinsonism safely and reliably.
Owner:HAERBIN SHENGYUAN BIOENG

Composition of effective parts of ground beetle small peptides for treating cardiovascular diseases

The invention discloses a composition of effective parts of ground beetle small peptides for treating cardiovascular diseases and belongs to the field of traditional Chinese medicine. The composition is characterized by being prepared into a corresponding dosage form by extracting effective parts from ground beetle, pseudo-ginseng, radix salviae miltiorrhizae and ramulus uncariae cum uncis and adding pharmaceutical adjuncts according to a specific ratio and conventional methods. The composition as a pure traditional Chinese medicine preparation is capable of treating hypertension, hyperviscosity, coronary disease and angina pectoris effectively and is low in raw material cost and exact in treatment effect, thereby being promising in application prospect.
Owner:山东禹泽药康产业技术研究院有限公司

Effective component of airpotato yam as well as preparation method and use thereof

The invention relates to effective components of an airpotato yam rhizome, a preparation method and the application thereof. The process for preparing the effective components of an airpotato yam rhizome comprises the following steps: step 1, the airpotato yam rhizome is extracted by the mixture of ethyl acetate and ethanol, which is used as a solvent; step 2, medicine residues are extracted by ethanol to obtain extracting solution; step 3, extracting solution is treated with column chromatography to obtain elution solution; step 4, the eluate obtained by elution in the preparation of liquid phase chromatographic gradient is adopted; the mobile phase is water and acetonitrile, and the eluate of 10.8-13.8 min is collected to obtain the effective components.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of schisandra chinensis, preparation method and use thereof

The invention provides an active component of schisandra fruit. The active component of the schisandra fruit is prepared as follows: step 1, the mixture of ethyl acetate and ethanol is taken as the solvent for extracting the schisandra fruit; step 2, the eluent is obtained from an extracting solution through chromatographic column chromatography; and step 3, the eluent is prepared by liquid chromatography gradient elution, the mobile phase comprises water and acetonitrile, and the active component is obtained after the eluent is collected for 48.0-52.0 min. The active component of the schisandra fruit and the pharmaceutical composition prepared by the component are applied to the anti-tumor aspect.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of hedyotis diffusa and method of preparing the same and application

The invention provides the effective constituents of oldenlandia, which mainly contain two compounds of 2-methoxyl-3-hydroxyanthraquinone (A) and 2-methyl-3-hydroxyanthraquinone (B), wherein the content of A is 55-75%, the content of B is 15-25%. The constituents are obtained through steps of heating, extracting, concentrating, separating with silica gel column, eluting, concentrating and drying the eluent, continuously conducting liquid phase chromatographic separation, collecting the solution, concentrating and drying the solution. The effective constituents can be used for treating and preventing tumors.
Owner:ZHEJIANG UNIV

Effective component of cortex dictamni, preparation method and use thereof

The invention relates to an active component of cortex dictamni radicis, and a preparation method and the application thereof. The preparation process comprises the following steps: step 1, the mixture of ethyl acetate and ethanol is taken as a solvent for extracting the cortex dictamni radicis; step 2, the eluent is obtained from an extracting solution through chromatographic column chromatography; and step 3, the eluent is prepared by liquid chromatography gradient elution, the mobile phase includes water and acetonitrile, and the active component is obtained after the eluent is collected for 24.0-28.0 min, 28.0-32.0 min, 32.0-36.0 min, 48.0-52.0 min, 52.0-56.0 min and 60.0-64.0 min.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of Spatholobus stem and preparation and use thereof

The present invention relates to an effective component of leatherleaf millettia and the preparation method and usage. For the effective component of leatherleaf millettia of the present invention, the preparation process includes the following steps: step 1: the mixture of ethyl acetate and ethanol is used as a solvent to extract leatherleaf millettia; step 2: the extract goes through column chromatography to obtain the eluent; step 3: the mobile phase of the eluent obtained from the preparation of liquid chromatogram gradient elution is water and acetonitrile, the eluent is collected for 32.6 to 40.8min so as to obtain the effective component.
Owner:TIANJIN TASLY PHARMA CO LTD

Red ginseng extract as well as preparation method and application thereof

The invention discloses a red ginseng extract. The extract is characterized by containing ginsenoside Rg1, ginsenoside Re, ginsenoside Rf, notoginsenoside R2 and ginsenoside Ro. A preparation method of the extract comprises the following steps: cutting red ginseng serving as a medicinal material into pieces, adding water in an amount which is 3-10 times that of the red ginseng, soaking for 0.5-2 hours, heating and performing reflux extraction for 1-2 hours, extracting for 1-3 times, combining extraction solutions, filtering and concentrating; separating and purifying a concentrated solution with a reverse phase silica gel column; eluting with 30-40 percent methanol-water by 4-10L, and discarding; and eluting with 50-70 percent methanol-water by 4-6L, collecting an eluent and concentrating to obtain active ingredients.
Owner:SHAN DONG DONG E E JIAO

Effective component of cogongrass rhizome and preparation method thereof

The invention relates to an effective component of cogongrass rhizome as well as a preparation method and an application thereof. The preparation process of the effective component comprises the following steps: (1) a mixture of ethyl acetate and ethanol is used as a solvent to extract the cogongrass rhizome; (2) an extracting solution is processed by chromatography through a chromatographic column to obtain an eluent; (3) the eluent is eluted by prepared liquid chromatogram gradient and is collected for 56.0-60.0 minutes to obtain the effective component by taking water and acetonitrile as flow phases.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of gamene and preparation and use thereof

The invention relates to an effective component of madder root, a preparation method and the application thereof; the preparation process of the effective component of madder root in the invention includes the following steps: step 1, the mixture of ethyl acetate and ethanol is used as solvent for extracting madder root; step 2, herb residue is extracted by ethanol to obtain extract; step 3, the extract is processed with chromatographic column chromatography to obtain eluate; step4, the eluate obtained by elution in the preparation of liquid phase chromatographic gradient is adopted; the mobile phase is water and acetonitrile, and the eluate of 48.0-52.0 min is collected to obtain the effective component.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of Schisandra chinensis as well as preparation method and use thereof

The invention relates to an effective composition of fructus schizandrae. The preparation process comprises the following: step one: a mixture of acetic ether and ethanol is used as a solvent and carries out extraction on the fructus schizandrae; step two: an extraction solution is subjected to column chromatography to obtain an eluant; and step three: the eluant prepared through liquid phase chromatographic gradient elution uses water and acetonitrile as a mobile phase; and the eluant is collected for 44.0 to 48.0 minutes to obtain the effective composition. The invention also provides a method for preparing the effective composition and application thereof. The effective composition is first obtained through the method and is first applied to the drug effect screening of various tumor cell strains; and as the effective composition is precise and has definite content, a convenient preparation process and good activity, the effective composition is suitable to be developed into a novel antitumor Chinese medicine.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of chebula fruit, preparation method and use thereof

The invention relates to an active component of a myrobalan fruit, and a preparation method and the application thereof. The preparation process comprises the following steps: firstly, a mixture of ethyl acetate and ethanol is taken as a solvent for extracting the myrobalan fruit; secondly, the eluent is obtained from an extracting solution through chromatographic column chromatography; and thirdly, the eluent is prepared by liquid chromatography gradient elution, the mobile phase includes water and acetonitrile, and the active component is obtained after the eluent is collected for 24.0-28.0min, 28.0-32.0min, 32.0-36.0min, 48.0-52.0min, 52.0-56.0min and 60.0-64.0min.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of creat and preparation and use thereof

The present invention relates to an effective component of Common Andrographis Herb and the preparation method and usage. For the effective component of Common Andrographis Herb of the present invention, the preparation process includes the following steps: step 1: the mixture of ethyl acetate and ethanol is used as a solvent to extract Common Andrographis Herb; step 2: the extract goes through column chromatography to obtain the eluent; step 3: the mobile phase of the eluent obtained from the preparation of liquid chromatogram gradient elution is water and acetonitrile, the eluent is collected for 25.5 to 33.8min so as to obtain the effective component.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of red paeonia and preparation and use thereof

The invention relates to an effective component of red peony root, a preparation method and application thereof; the preparation process of the effective component of red peony root in the invention includes the following steps: step 1, the mixture of ethyl acetate and ethanol is used as solvent for extracting red peony root; step 2, the extract is processed with chromatographic column chromatography to obtain eluate; step3, the eluate obtained by elution in the preparation of liquid phase chromatographic gradient is adopted; the mobile phase is water and acetonitrile, and the eluate of 28.6-32.2 min is collected to obtain the effective component.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of morinda officinalis and preparation method thereof

The invention relates to an effective component of morinda officinalis as well as a preparation method and an application thereof. The preparation process of the effective component of the morinda officinalis comprises the following steps: (1)a mixture of ethyl acetate and ethanol is used as a solvent to extract the morinda officinalis; (2)dregs of a decoction are extracted with the ethanol so as to obtain an extracting solution; (3)the extracting solution is processed by chromatography through a chromatographic column to obtain an eluent; (4)the eluent is eluted by prepared liquid chromatogram gradient and collected for 28.0-32.0 minutes and 52.0-56.0 minutes to obtain the effective component by taking water and acetonitrile as flow phases.
Owner:TIANJIN TASLY PHARMA CO LTD

Salvia miltiorrhiza valid component, preparing method and application

The invention provides effective components of radix salviae miltiorrhizae, mainly comprising TrijuganoneC as A compound, 7-Hydroxy-8, 13-abietadiene-11, 12-dione as B compound and Dihydrotanshinone I as C compound with respective content of 40 to 50 percent, 30 to 40 percent and 3 to 10 percent. The effective components can be obtained through following procedures: heating extraction, condensing, silica gel column separation, elution, condensing and drying of the eluted solution, liquid chromatography separation, solution collecting and condensing and drying of the solution. The effective components can be used in the preparation of drugs for treating and preventing tumors. With reasonable design, the invention can be quickly obtained and can be more favorable for quality control of the drugs.
Owner:ZHEJIANG UNIV

Effective component of rabdosia and preparation and use thereof

The present invention relates to an effective component of rabdosia rubescens and the preparation method and usage. For the effective component of rabdosia rubescens of the present invention, the preparation process includes the following steps: step 1: the mixture of ethyl acetate and ethanol is used as a solvent to extract rabdosia rubescens ; step 2: the extract goes column chromatography to obtain the eluent; step 3: the mobile phase of the eluent obtained from the preparation of liquid chromatogram gradient elution is water and acetonitrile, the eluent is collected for 15.5 to 19.6min so as to obtain the effective component.
Owner:TIANJIN TASLY PHARMA CO LTD

Effective component of phragmites communis trin, preparation method and use thereof

The invention relates to a reed rhizome effective component, a preparation method thereof and a use, and the preparation process comprises the following steps: step 1: mixture of ethyl acetate and ethanol is taken as a solvent to extract reed rhizome; step 2: eluent is obtained by leading extract liquid to pass through a chromatographic column for chromatography; and step 3: the eluent which is obtained by using the liquid-phase chromatographic gradient elution with the mobile phase of water and acetonitrile is used for collecting the eluent at 24.0-28.0 minutes, 28.0-32.0 minutes, 32.0-36.0 minutes, 48.0-52.0 minutes, 52.0-56.0 minutes and 60.0-64.0 minutes for obtaining the effective component.
Owner:TIANJIN TASLY PHARMA CO LTD
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