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Effective component of airpotato yam as well as preparation method and use thereof

An effective component, the technology of xanthate, is applied in the field of traditional Chinese medicine extracts for the treatment of tumor diseases, and can solve problems such as side effects and involvement of normal cells

Inactive Publication Date: 2009-01-21
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the treatment of malignant tumors in the industry is mainly based on surgery, radiotherapy, and chemotherapy, but many chemical anticancer drugs often involve normal cells when they act on target cells, causing serious side effects

Method used

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  • Effective component of airpotato yam as well as preparation method and use thereof
  • Effective component of airpotato yam as well as preparation method and use thereof
  • Effective component of airpotato yam as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] The preparation of embodiment 1 xanthophyll effective component

[0094] The xanthophyll seeds are pulverized, passed through a 20-mesh sieve, added 8 times the amount of ethyl acetate: ethanol = 1: 1, heated and refluxed for 1 hour, extracted 2 times, added 8 times the amount of 70% ethanol to the dregs, heated and refluxed for 1 hour, extracted 2 times Once, the filtrate was combined to obtain the extract, after the extract was concentrated, the sample was dissolved with 5% methanol, and the ODS-C18 column was crossed. At first, 1250ml of 5% methanol was used as the mobile phase, and then 1250ml of 60% methanol was replaced as the mobile phase to obtain Eluent, continue to separate eluent by preparative liquid chromatography, separation conditions: chromatographic column is Agilent preparative column (ZorbaxSB-C18; 21.2mm×250mm), mobile phase is water A and acetonitrile B, gradient elution procedure is as follows

[0095]

[0096] The flow rate is 10ml / min, and the...

Embodiment 2

[0097] The analysis of the effective component of embodiment 2 xanthate

[0098] Chromatographic conditionsChromatographic column Agilent Zorbax SB-C18 column (4.6mm × 150mm, 5 μm); using gradient elution, mobile phase A is 0.2% glacial acetic acid aqueous solution, mobile phase B is acetonitrile solution containing 0.2% glacial acetic acid; gradient elution The procedure is as follows: at 0 minutes, mobile phase A is 90% 0.2% glacial acetic acid aqueous solution, mobile phase B is 10% 0.2% glacial acetic acid in acetonitrile solution; at 10 minutes, mobile phase A is 50% 0.2% glacial acetic acid Aqueous solution, mobile phase B is 50% 0.2% glacial acetic acid acetonitrile solution; 30 minutes, mobile phase A is 5% 0.2% glacial acetic acid aqueous solution, mobile phase B is 95% 0.2% glacial acetic acid acetonitrile solution; 35 In minutes, the mobile phase A was 5% 0.2% glacial acetic acid in water, and the mobile phase B was 95% 0.2% glacial acetic acid in acetonitrile. S...

Embodiment 3

[0101] Embodiment 3 xanthophyll active ingredient preparation

[0102] Take the effective component of xanthophylla in Example 1, mix 0.5g with 10.5g polyethylene glycol-6000 evenly, heat and melt, move the material to drip irrigation, drop the drug solution into liquid paraffin at 6-8°C, remove Oil, made 400 drop pills.

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PUM

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Abstract

The invention relates to effective components of an airpotato yam rhizome, a preparation method and the application thereof. The process for preparing the effective components of an airpotato yam rhizome comprises the following steps: step 1, the airpotato yam rhizome is extracted by the mixture of ethyl acetate and ethanol, which is used as a solvent; step 2, medicine residues are extracted by ethanol to obtain extracting solution; step 3, extracting solution is treated with column chromatography to obtain elution solution; step 4, the eluate obtained by elution in the preparation of liquid phase chromatographic gradient is adopted; the mobile phase is water and acetonitrile, and the eluate of 10.8-13.8 min is collected to obtain the effective components.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract for treating tumor diseases, in particular to an effective component extracted from xanthophylla chinensis, a preparation and a preparation method and use thereof. Background technique [0002] Tumor is a common and frequently-occurring disease, among which malignant tumor is the most serious disease that endangers human health. At present, the treatment of malignant tumors in the industry is mainly based on surgery, radiotherapy, and chemotherapy. However, many chemical anticancer drugs often involve normal cells when they act on target cells, causing serious side effects. The genotoxicity of botanical medicine is not obvious, and Chinese herbal medicine has unique advantages and broad application prospects in anti-cancer and anti-mutation, and Chinese medicine also plays a role that cannot be ignored in the adjuvant treatment of tumors. Paclitaxel is a typical natural compound obtained ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61P35/00C07D311/04A61K125/00
Inventor 贺庆刘雳史强程翼宇水文波葛志伟窦静霍阳
Owner TIANJIN TASLY PHARMA CO LTD
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