30 results about "Syringaresinol" patented technology

Vaccines containing adjuvant comprising eleutherosides and related compounds are shown to be useful for the prevention of viral infections, bacterial infections and parasitic infections. The adjuvant compounds have been shown to modulate the expression of a wide variety or proteins involved in the immune response and inflammatory response. Exemplary eleutherosides and related compounds include eleutheroside A, eleutheroside B, eleutheroside C, eleutheroside D, eleutheroside E, eleutheroside F, and eleutheroside G, coniferylaldehyde, caffeic acid ethyl ester, chlorogenic acid, sinapinalcohol, isofraxidin, syringaresinol and 6,8-dimethoxy-7-hydroxycoumarin.

Belonging to the field of pharmacy, the invention relates to application of a Chinese prickly ash extract to preparation of medicaments for regulating cholesterol metabolism. In particular, the invention relates to regulation of cholesterol metabolism by a petroleum ether extract, an ethyl acetate extract and an n-butanol extract in high cholesterol and inflammation states. In vitro experiments show that in high cholesterol condition, the extracts can reduce the content of total cholesterol and secretion of an apolipoprotein B, inhibit the expression of related genes and proteins in a cholesterol biosynthesis pathway in cells, increase the expression of related genes or proteins in a reverse cholesterol transport process in cells. In vivo experiments prove that the ethyl acetate extract and n-butanol extract have anti-inflammatory activity, and improve the accumulation of inflammation-induced cholesterol in the liver by affecting expression of a liver X receptor-alpha and an ATP-binding cassette transporter gene 1. The invention further provides monomer (-)-syringaresinol-4-O-beta-D-glucoside isolated from the n-butanol extract and application thereof to regulation of cholesterol metabolism.

The invention belongs to the technical field of medicine preparation, and particularly relates to a composition containing pinoresinol diglucoside and a preparation method and application of the composition. The composition containing the pinoresinol diglucoside is prepared from the following components: the pinoresinol diglucoside, syringaresinol, agaric polysaccharide, gamma-aminobutyric acid, manninotriose and fingered citron lactone. The composition has a good effect of treating osteoporosis, the preparation method is simple, the toxic and side effects are small, and the cost is low.

The invention discloses application of syringaresinol in preparation of a medicine for preventing and treating liver ischemia-reperfusion injury, and belongs to the technical field of syringaresinol application. According to the present invention, the drug experiment research results show that the syringaresinol is the natural traditional Chinese medicine monomer, has the low toxic-side effect, can be used for preparing the liver ischemia-reperfusion injury prevention and treatment drug, opens up the new liver ischemia-reperfusion injury prevention and treatment drug, and opens up the new useof the syringaresinol so as to provide the broad market prospects. And great social significance and economic benefits are achieved.

The invention discloses a Chinese medicine compound effective part for treating depressive disorder and insomnia, a preparation method and application of the Chinese medicine compound active part. Chinese herbal compound suanzaoren hehuan formula is extracted by ethanol, concentrated, purified by macroporous resin, and eluted with aqueous slkali to collect 50%-80% ethanol solution elution part, sothat total terpene effective part can be obtained. The obtained effective part mainly comprises albiforin,(-)-syringaresinol-4-0-Beta-D-apiofuranosy-(1 arrow 2)-Beta-D- glucopyranoside, betulinic acid, botulin and daucosterol. Experiment results shows that the effective part provided by the invention has remarkable effects of anti-depression and sedative-hypnotic activity, can be applied to prevent and treat depressive disorder and insomnia at the same time, and has very good economic benefits and application prospects.

The invention discloses a method for constructing a characteristic chromatogram of caulis sinomenii, which is characterized in that sinomenine, magnoflorine and clove resinol diglucoside are taken as characteristic components, common peaks of different original caulis sinomenii samples are confirmed by an efficient detection method, and the characteristic chromatogram is constructed. According to the method, samples with different basic sources can be distinguished, and alkaloid and lignan contained in the caulis sinomenii are taken as representative components, so that the product quality can be relatively comprehensively reflected; the method is suitable for rapid and comprehensive quality control of caulis sinomenii medicinal materials, decoction pieces, extracts, standard decoction, formula granules and standard samples, preparation intermediate products and finished products of classic famous prescriptions containing caulis sinomenii, and is efficient, convenient to operate and suitable for quality monitoring of continuous production.

The present invention discloses a composition for inhibiting vascular aging comprising a compound of Chemical formula 1, a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a toadflower toadflower herb extract and a method for separating clove resinol from the toadflower toadflower herb extract. The invention provides an extract with effects of resisting oxidation and relaxing blood vessels. Through a column chromatography separation method, the active pharmaceutical ingredient clove resinol can be further separated from the extract. Due to the antioxidant effect and the vasodilatation effect, the extract and the syringaresinol have the potential of serving as drugs for treating or preventing hypertension, hyperlipidemia, lung cancer and related cancers, vascular dementia, diabetic erectile dysfunction, acute hyperuricemia or thrombotic diseases. The invention provides a new thought for research and development of the new drug, enriches the material basis of the tripterygium wilfordii, contributes to scientific and efficient utilization of the traditional Chinese medicinal material tripterygium wilfordii, and has higher application potential.

The invention discloses an application of syringaresinol in preparation of drugs for resisting rheumatoid arthritis. Syringaresinol is a ditetrahydrofuran lignan, and it is found for the first time that the syringaresinol can obviously inhibit the proliferation of rheumatoid arthritis synoviocytes and induce the apoptosis of rheumatoid arthritis synoviocytes. Therefore, the compound can be used for preparing the drugs for preventing and/or treating rheumatoid arthritis, and has higher clinical application value and development prospect.

The invention discloses application of syringaresinol in preparation of a medicine for preventing and treating diabetic nephropathy, and belongs to the technical field of application of syringaresinol. The syringaresinol has a structural formula as follows: the administration dosage of the syringaresinol is 25mg/kg, and the syringaresinol can be prepared into any one of various forms such as injection, tablets, powder, granules, capsules, oral liquid, ointment, cream, spray, aerosol and the like. The application of syringaresinol disclosed by the invention has the beneficial effects that the syringaresinol can remarkably improve kidney injury caused by diabetes without influencing blood sugar of diabetic mice, a new thought is provided for research and development of a new drug for diabetic nephropathy, and meanwhile, the new application of the syringaresinol is also expanded.