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31 results about "Syringaresinol" patented technology
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Syringaresinol is a lignan found in Castela emoryi, in Prunus mume or in Magnolia thailandica. This compound inhibits Helicobacter pylori motility in vitro.
Eleutherosides as adjuncts for vaccines and immune modulation
InactiveUS20030175777A1Reduce the amount requiredBiocideBacterial antigen ingredientsChlorogenic acidAdjuvant
Vaccines containing adjuvant comprising eleutherosides and related compounds are shown to be useful for the prevention of viral infections, bacterial infections and parasitic infections. The adjuvant compounds have been shown to modulate the expression of a wide variety or proteins involved in the immune response and inflammatory response. Exemplary eleutherosides and related compounds include eleutheroside A, eleutheroside B, eleutheroside C, eleutheroside D, eleutheroside E, eleutheroside F, and eleutheroside G, coniferylaldehyde, caffeic acid ethyl ester, chlorogenic acid, sinapinalcohol, isofraxidin, syringaresinol and 6,8-dimethoxy-7-hydroxycoumarin.
Owner:BONAGURA VINCENT R +3
Application of lignan compound
ActiveCN105030802AGood treatment effectLower levelOrganic active ingredientsMetabolism disorderUse medicationTriterpene
The invention belongs to the field of biological medicine, and specifically relates to an application of a lignan compound in the preparation of drugs for reducing blood fat. The disclosed triterpene lignan compound is (-)-syringaresinol-4-O-glucoside, and the structural formula of the lignan compound is represented by the formula (I). The provided compound can prominently inhibit lipid accumulation in-vitro, is capable of obviously reducing the cholesterol and triglyceride in the animal blood of a hyperglycemia model, and has a prominent effect on reducing blood fat. The lignan compound can be used as a novel drug for reducing blood fat, and can be used to treat hyperglycemia, and the drug is user-friendly.
Owner:HAINAN MEDICAL COLLEGE
Lymphatic vessel stabilizer
Provided is a lymphatic vessel stabilizer composed of Tie2 activator. The Tie2 activator is preferably at least one type selected from the group consisting of angiopoietin 1 (Ang-1), extract of Cinnamomum species plants, extract of Siberian Ginseng and syringaresinol.
Owner:SHISEIDO CO LTD
Application of Chinese prickly ash extract to preparation of medicament for regulating cholesterol metabolism
Belonging to the field of pharmacy, the invention relates to application of a Chinese prickly ash extract to preparation of medicaments for regulating cholesterol metabolism. In particular, the invention relates to regulation of cholesterol metabolism by a petroleum ether extract, an ethyl acetate extract and an n-butanol extract in high cholesterol and inflammation states. In vitro experiments show that in high cholesterol condition, the extracts can reduce the content of total cholesterol and secretion of an apolipoprotein B, inhibit the expression of related genes and proteins in a cholesterol biosynthesis pathway in cells, increase the expression of related genes or proteins in a reverse cholesterol transport process in cells. In vivo experiments prove that the ethyl acetate extract and n-butanol extract have anti-inflammatory activity, and improve the accumulation of inflammation-induced cholesterol in the liver by affecting expression of a liver X receptor-alpha and an ATP-binding cassette transporter gene 1. The invention further provides monomer (-)-syringaresinol-4-O-beta-D-glucoside isolated from the n-butanol extract and application thereof to regulation of cholesterol metabolism.
Owner:FUDAN UNIV
Composition for inhibiting vascular aging comprising syringaresinol
ActiveUS9192597B2Excellent effect of preventingPreventing or improving cardiovascular diseasesBiocideDispersion deliveryMedicineVascular ageing
Owner:AMOREPACIFIC CORP
Preparation method of Suaeda salsa used as agricultural pesticide and application
ActiveCN103315008AGood control effectGood insecticidal active ingredientBiocideAnimal repellantsAgricultural pesticidesTamarixetin
The invention relates to a plant pesticide and its preparation method. The pesticide is prepared by extraction processing of herb of Suaeda salsa. Main active components of the plant pesticide comprise: by weight, 15-20% of tamarixetin-3-O-rutinoside, 5-10% of genkwanin-4'-O-beta-D-rutinoside, 5-10% of syringaresinol-4-O-beta-D-glucoside, 5-60% of other phenolic acids, water and a surfactant. The above components are made into an emulsion in water, and the emulsion in water is diluted to be used for killing insects. The preparation method provided by the invention has advantages as follows: the raw materials are easily available; the technology is simple; and costs are low. The plant pesticide prepared by the preparation method has a very good effect of controlling aphid, armyworm, spider mite, rice stem borer and a plurality of noctuidae insects, has rapid speed of killing insects, is safe to crops, causes no pollution to the environment, and is a biopesticide preparation suitable for nuisanceless agricultural product production requirements of our country.
Owner:INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
Sirt 1 activator including syringaresinol
ActiveUS20140371307A1High expressionHigh activityBiocideSenses disorderMedicineBULK ACTIVE INGREDIENT
The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.
Owner:AMOREPACIFIC CORP
Compound nanometer preparation for treating diabetes mellitus type 2 and preparation method thereof
InactiveCN105641674AInsulation absorptionPromote absorptionMetabolism disorderTripeptide ingredientsSide effectAdditive ingredient
The invention discloses a compound nanometer preparation for treating the diabetes mellitus type 2 and a preparation method thereof. The compound nanometer preparation for treating the diabetes mellitus type 2 is mainly prepared from, by weight, 8-15 parts of aloe acetylation gulcomannan, 3-6 parts of Cicletanine, 1-2 parts of decanoyl acetaldehyde, 4-8 parts of syringaresinol monoglucoside, 5-20 parts of banana leaf powder, 3-7 parts of grapefruit seed extract, 1-4 parts of sodium ethylene diamine tetracetate, 0.8-2.0 parts of myristic acid, 0.1-0.5 part of syringic acid, 0.1-0.3 part of gentisic acid, 3-10 parts of lysine, 1-3 parts of carotenoid and 0.03-0.1 part of antioxidant. According to the compound nanometer preparation, blood glucose rising is controlled through interaction of various ingredients, the blood pressure and blood fat of a patient suffering from the diabetes mellitus type 2 are adjusted, sufficient nutritional ingredients can be provided for the patient suffering from the diabetes mellitus type 2, the immunity of the patient is improved, diabetes mellitus and arteriosclerosis are relieved, the effect of treating the diabetes mellitus type 2 is remarkable, and the side effect is small.
Owner:李华红
Composition containing pinoresinol diglucoside and preparation method and application of composition
InactiveCN113413395APrevention and treatment of osteoporosisPromote circulationSkeletal disorderPharmaceutical non-active ingredientsSyringaresinolPharmaceutical Substances
The invention belongs to the technical field of medicine preparation, and particularly relates to a composition containing pinoresinol diglucoside and a preparation method and application of the composition. The composition containing the pinoresinol diglucoside is prepared from the following components: the pinoresinol diglucoside, syringaresinol, agaric polysaccharide, gamma-aminobutyric acid, manninotriose and fingered citron lactone. The composition has a good effect of treating osteoporosis, the preparation method is simple, the toxic and side effects are small, and the cost is low.
Owner:JIANGXI POZIN PHARMA
Composition for preventing or treating heart disease
ActiveUS20150283110A1Good effectPreventing or improving heart diseaseBiocideHydroxy compound active ingredientsCardiac muscleBULK ACTIVE INGREDIENT
The present invention relates to a composition for preventing or treating heart disease, and more particularly, to a composition for preventing or treating heart disease, comprising (+)-syringaresinol. Specifically, (+)-syringaresinol as an active ingredient may exhibit excellent effect of preventing or improving heart disease by promoting SIRT1 expression and suppressing death of cardiomyocytes induced by reactive oxygen species. Accordingly, the composition according to the present disclosure may be used to prevent, improve or treat heart diseases including cardiovascular diseases.
Owner:AMOREPACIFIC CORP
Composition comprising syringaresinol for improving the skin
InactiveCN103889413AEasy to removeInhibits tyrosinase activityCosmetic preparationsToilet preparationsMedicineBULK ACTIVE INGREDIENT
The present invention relates to a composition for improving the skin, which comprises the compound of chemical formula 1, the derivatives thereof, or the pharmaceutically acceptable salts thereof as active ingredients.
Owner:AMOREPACIFIC CORP
Application of syringaresinol in preparation of medicine for preventing and treating liver ischemia-reperfusion injury
PendingCN111067888ASmall toxicityGreat social significanceDigestive systemHeterocyclic compound active ingredientsSide effectLiver ischemia
The invention discloses application of syringaresinol in preparation of a medicine for preventing and treating liver ischemia-reperfusion injury, and belongs to the technical field of syringaresinol application. According to the present invention, the drug experiment research results show that the syringaresinol is the natural traditional Chinese medicine monomer, has the low toxic-side effect, can be used for preparing the liver ischemia-reperfusion injury prevention and treatment drug, opens up the new liver ischemia-reperfusion injury prevention and treatment drug, and opens up the new useof the syringaresinol so as to provide the broad market prospects. And great social significance and economic benefits are achieved.
Owner:AFFILIATED HOSPITAL OF GUILIN MEDICAL UNIV
Compositions of eleutherosides capable of modulating protein expresion
InactiveUS20070134711A1Reduce the amount requiredMicrobiological testing/measurementAntibody medical ingredientsChlorogenic acidAdjuvant
Vaccines containing adjuvant comprising eleutherosides and related compounds are shown to be useful for the prevention of viral infections, bacterial infections and parasitic infections. The adjuvant compounds have been shown to modulate the expression of a wide variety or proteins involved in the immune response and inflammatory response. Exemplary eleutherosides and related compounds include eleutheroside A, eleutheroside B, eleutheroside C, eleutheroside D, eleutheroside E, eleutheroside F, and eleutheroside G, coniferylaldehyde, caffeic acid ethyl ester, chlorogenic acid, sinapinalcohol, isofraxidin, syringaresinol and 6,8-dimethoxy-7-hydroxycoumarin.
Owner:BONAGURA VINCENT R +3
Lymphatic vessel stabilizer
Provided is a lymphatic vessel stabilizer composed of Tie2 activator. The Tie2 activator is preferably at least one type selected from the group consisting of angiopoietin 1 (Ang-1), extract of Cinnamomum species plants, extract of Siberian Ginseng and syringaresinol.
Owner:SHISEIDO CO LTD
Chinese medicine effective part for treating depressive disorder and insomnia, preparation method and application thereof
InactiveCN108721397AIncreased terpenoid contentGood lookingOrganic active ingredientsNervous disorderDiseaseDaucosterol
The invention discloses a Chinese medicine compound effective part for treating depressive disorder and insomnia, a preparation method and application of the Chinese medicine compound active part. Chinese herbal compound suanzaoren hehuan formula is extracted by ethanol, concentrated, purified by macroporous resin, and eluted with aqueous slkali to collect 50%-80% ethanol solution elution part, sothat total terpene effective part can be obtained. The obtained effective part mainly comprises albiforin,(-)-syringaresinol-4-0-Beta-D-apiofuranosy-(1 arrow 2)-Beta-D- glucopyranoside, betulinic acid, botulin and daucosterol. Experiment results shows that the effective part provided by the invention has remarkable effects of anti-depression and sedative-hypnotic activity, can be applied to prevent and treat depressive disorder and insomnia at the same time, and has very good economic benefits and application prospects.
Owner:TIANJIN MEDICAL UNIV
Sirt 1 activator including syringaresinol
Owner:AMOREPACIFIC CORP
Composition for preventing or treating heart disease
ActiveUS9795583B2Good effectPreventing or improving heart diseaseHydroxy compound active ingredientsCardiovascular disorderCardiac muscleBULK ACTIVE INGREDIENT
The present invention relates to a composition for preventing or treating heart disease, and more particularly, to a composition for preventing or treating heart disease, comprising (+)-syringaresinol. Specifically, (+)-syringaresinol as an active ingredient may exhibit excellent effect of preventing or improving heart disease by promoting SIRT1 expression and suppressing death of cardiomyocytes induced by reactive oxygen species. Accordingly, the composition according to the present disclosure may be used to prevent, improve or treat heart diseases including cardiovascular diseases.
Owner:AMOREPACIFIC CORP
Sirt 1 activator including syringaresinol
ActiveUS20160263079A1High expressionHigh activitySenses disorderAntipyreticMedicineBULK ACTIVE INGREDIENT
Owner:AMOREPACIFIC CORP
Application of syringaresinol in preparation of medicines for treating depression
InactiveCN110179784ANervous disorderHeterocyclic compound active ingredientsSodium GlutamateClinical research
The present invention discloses an application of syringaresinol in preparation of medicines for treating depression. When concentration of activity-screened syringaresinol is 12.5 [mu]M, the syringaresinol has an obvious protection activity against SH-SY5Y cell injury induced by sodium glutamate, facilitates further pharmacological and clinical research, and creates conditions for developing themedicines for treating depression.
Owner:THE KEY LAB OF CHEM FOR NATURAL PROD OF GUIZHOU PROVINCE & CHINESE ACADEMY OF SCI
Method for constructing characteristic chromatogram of caulis sinomenii
ActiveCN114858938AFully reflectEfficient methodComponent separationAgainst vector-borne diseasesMedicinal herbsFormulary
The invention discloses a method for constructing a characteristic chromatogram of caulis sinomenii, which is characterized in that sinomenine, magnoflorine and clove resinol diglucoside are taken as characteristic components, common peaks of different original caulis sinomenii samples are confirmed by an efficient detection method, and the characteristic chromatogram is constructed. According to the method, samples with different basic sources can be distinguished, and alkaloid and lignan contained in the caulis sinomenii are taken as representative components, so that the product quality can be relatively comprehensively reflected; the method is suitable for rapid and comprehensive quality control of caulis sinomenii medicinal materials, decoction pieces, extracts, standard decoction, formula granules and standard samples, preparation intermediate products and finished products of classic famous prescriptions containing caulis sinomenii, and is efficient, convenient to operate and suitable for quality monitoring of continuous production.
Owner:JIANGYIN TIANJIANG PHARMA
Sirt 1 activator including syringaresinol
ActiveUS20160263077A1High expressionHigh activitySenses disorderAntipyreticMedicineBULK ACTIVE INGREDIENT
Owner:AMOREPACIFIC CORP
Composition for preventing or treating neurological and mental disorders, containing syringaresinol
ActiveUS11000501B2Reduce transmissionReduced activityNervous disorderAntineoplastic agentsDiseaseNervous system
Owner:SEOUL NAT UNIV R&DB FOUND
Application of a lignan compound
ActiveCN105030802BGood treatment effectLower levelOrganic active ingredientsMetabolism disorderTriterpeneEfficacy
The invention belongs to the field of biological medicine, and specifically relates to an application of a lignan compound in the preparation of drugs for reducing blood fat. The disclosed triterpene lignan compound is (-)-syringaresinol-4-O-glucoside, and the structural formula of the lignan compound is represented by the formula (I). The provided compound can prominently inhibit lipid accumulation in-vitro, is capable of obviously reducing the cholesterol and triglyceride in the animal blood of a hyperglycemia model, and has a prominent effect on reducing blood fat. The lignan compound can be used as a novel drug for reducing blood fat, and can be used to treat hyperglycemia, and the drug is user-friendly.
Owner:HAINAN MEDICAL COLLEGE
Pharmaceutical composition for preventing or treating parkinsonism and preparation method thereof
ActiveCN101537011BThe chemical composition is simple and clearImprove quality controlOrganic active ingredientsNervous disorderDaucosterolDose level
The invention discloses a pharmaceutical composition for preventing or treating parkinsonism and a preparation method thereof. The pharmaceutical composition consists of eleutheroside B, eleutheroside D, syringaresinol-di-glucoside and daucosterol. The invention determines the optimal dose level range of the four components and on the base, adopts an orthogonal test for screening out the optimal compatibility proportion of the four active components. Proved by experiment results, the pharmaceutical composition which is prepared by the compatibility of the eleutheroside B, the eleutheroside D,the syringaresinol-di-glucoside and the daucosterol according to a weight ratio of 1:2:8:8, can obviously improve PC12 cell survival rate and has obvious protective effects on dopaminergic neuron injuries. The active ingredients of the acanthopanax have simple and clear chemical compositions and quality control is easy to be conducted in production. The pharmaceutical composition can be used for preparing medicaments with good therapeutic effects for preventing and treating parkinsonism safely and reliably.
Owner:HAERBIN SHENGYUAN BIOENG
Stabilizer for lymph vessel
ActiveCN102056630AImprove edemaImprove and/or prevent edemaPeptide/protein ingredientsAldehyde active ingredientsLymphatic vesselCinnamomum
Owner:SHISEIDO CO LTD
Preparation method of Suaeda salsa used as agricultural pesticide and application
ActiveCN103315008BGood control effectGood insecticidal active ingredientBiocideAnimal repellantsAgricultural pesticidesTamarixetin
Owner:INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
Composition for inhibiting vascular aging comprising syringaresinol
ActiveUS20140248381A1Excellent effect of preventing vascular agingHigh expressionBiocideDispersion deliveryMedicineAdditive ingredient
The present invention discloses a composition for inhibiting vascular aging comprising a compound of Chemical formula 1, a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient.
Owner:AMOREPACIFIC CORP
A kind of effective part of Dendrobium melon and its preparation method and application
ActiveCN110354205BImprove antioxidant capacityQuality is easy to controlOrganic active ingredientsNervous disorderDiseaseSecondary metabolite
The invention relates to the technical field of traditional Chinese medicines, and specifically discloses an effective fraction of Dendrobium melon, a preparation method and application thereof. The main secondary metabolite compound type of the effective part of Dendrobium melon is glycoside compound. The main glycoside components of the effective part of Dendrobium officinalis are pimarane-type monoglycoside, flickinflimoside B, diglycoside fliflidioside A, (+)-syringaresin-O-β-D-glucopyranoside and the like. In vitro activity studies show that the effective fraction of Dendrobium melonii of the present invention has good DPPH free radical and OH free radical scavenging activity, α-glucosidase inhibitory activity, and inhibitory activity of glutamate-induced HT22 cell damage. The effective part of Dendrobium candidum can be developed into an auxiliary drug or health care product for treating Alzheimer's disease, liver protection, type II diabetes and other diseases.
Owner:SUN YAT SEN UNIV
Pinellia tomentosa extract and method for separating clove resinol from Pinellia tomentosa extract
PendingCN114652786ARich material baseHas the effect of promoting blood circulation and removing blood stasisOrganic chemistryAntinoxious agentsDiseasePinellia
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a toadflower toadflower herb extract and a method for separating clove resinol from the toadflower toadflower herb extract. The invention provides an extract with effects of resisting oxidation and relaxing blood vessels. Through a column chromatography separation method, the active pharmaceutical ingredient clove resinol can be further separated from the extract. Due to the antioxidant effect and the vasodilatation effect, the extract and the syringaresinol have the potential of serving as drugs for treating or preventing hypertension, hyperlipidemia, lung cancer and related cancers, vascular dementia, diabetic erectile dysfunction, acute hyperuricemia or thrombotic diseases. The invention provides a new thought for research and development of the new drug, enriches the material basis of the tripterygium wilfordii, contributes to scientific and efficient utilization of the traditional Chinese medicinal material tripterygium wilfordii, and has higher application potential.
Owner:SHAANXI UNIV OF CHINESE MEDICINE
Application of syringaresinol in preparation of drugs for resisting rheumatoid arthritis
InactiveCN109925306AInhibit apoptosisHigh clinical application valueAntipyreticAnalgesicsMedicineApoptosis
The invention discloses an application of syringaresinol in preparation of drugs for resisting rheumatoid arthritis. Syringaresinol is a ditetrahydrofuran lignan, and it is found for the first time that the syringaresinol can obviously inhibit the proliferation of rheumatoid arthritis synoviocytes and induce the apoptosis of rheumatoid arthritis synoviocytes. Therefore, the compound can be used for preparing the drugs for preventing and / or treating rheumatoid arthritis, and has higher clinical application value and development prospect.
Owner:NINGXIA MEDICAL UNIV
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