67 results about "Hydroxyanthraquinone" patented technology

The invention relates to hydroxy anthraquinone derivatives and their use in preparing anti-cancer medicament, test has shown that the hydroxy anthraquinone derivatives have appreciable inhibitory action for various tumor cell strains, thus can be used in preparing cancer treatment medicament. The chemical structural formula of the hydroxy anthraquinone derivatives is shown by I, wherein R1, R2,R3 are defined in the description.

The invention relates to a preparation method of 2,2'-bis(trifluoromethyl)-4,4'-diaminodiphenyl. The preparation method comprises the following steps: synthesizing 3,3'-bis(trifluoromethyl)hydrazo-benzene in an inorganic alkaline aqueous solution by adopting nitrobenzotrifluoride as a raw material, adopting a phase transfer catalyst, a co-catalyst and Pd/C as a catalytic system and adopting aromatic hydrocarbon as a solvent, and performing the re-arrangement reaction on the 3,3'-bis(trifluoromethyl)hydrazo-benzene in an inorganic acid aqueous solution, thus obtaining 2,2'-bis(trifluoromethyl)-4,4'-diaminodiphenyl, wherein the phase transfer catalyst is one or a mixture of more of sodium dodecyl benzene sulfonate, sodium dodecyl sulfate and cetyl trimethyl ammonium bromide, and the co-catalyst is one or a mixture of more of 2,3-dichloro-1,4-naphthoquinone, 2-hydroxyanthraquinone and 2,6-dioxyanthraquinone. The preparation method has the advantages of mild reaction condition, simple process, high product quality and yield, low production cost, environmental friendliness, suitability for continuous production and the like.

The invention discloses a method for preparing 1,4-dihydroxy anthraquinone by taking a boric acid dehydration compound as a catalyst. The method comprises the following steps: (1) heating boric acid at 100-250 DEG C to prepare the boric acid dehydration compound; (2) adding fuming sulphuric acid, phthalic anhydride, the boric acid dehydration compound and parachlorophenol into a condensation kettle in sequence, and carrying out condensation reaction at 100-250 DEG C; (3) adding a proper amount of water and the materials in the condensation kettle into a hydrolysis kettle, carrying out hydrolysis reaction at 50-115 DEG C, discharging a reactant, filtering the reactant by pressing, washing and drying the reactant to prepare 1,4-dihydroxy anthraquinone. According to the method, the boric acid dehydration compound is used as the catalyst, so that the addition amount of the raw materials including fuming sulphuric acid and phthalic anhydride is reduced; the resource consumption can be reduced; the cost is reduced; the waste emission is reduced; the method is relatively environmentally-friendly and economical.

The invention relates to a method for synthesizing N-[4-[(4-hydroxy anthraquinone-1-yl) amino] benzyl] acetamide. The method comprises the steps of: with hydrochloric acid as a catalyst, carrying out condensation reaction on 1,4-dihydroxy anthraquinone, a 1,4-dihydroxy anthraquinone leuco body and p-phenylenediamine for 10-16h at 95-105 DEG C in a butanol-water solution medium; after the condensation reaction is completed, sequentially carrying out water adding and distilling, filtering, heating treatment with dilute alkali liquor, water washing till reaching a neutral state and drying to obtain a condensation material; and carrying out acylation reaction on the condensation material and acetic anhydride for 2h at 110-112 DEG C in a acetic acid medium, cooling to normal temperature, filtering, washing and drying to obtain a product of N-[4-[(4-hydroxy anthraquinone-1-yl) amino] benzyl] acetamide. The N-[4-[(4-hydroxy anthraquinone-1-yl) amino] benzyl] acetamide product synthesized with the method has high purity, controllable content, fewer 1,4-dihydroxy anthraquinone residues, and low byproduct content and product ash content, and is suitable for polyester spinning and dying.

The invention provides a comprehensive treatment method for 1,4-dihydroxy anthraquinone production wastewater. The method comprises the steps of extraction, back extraction, acidification, evaporation and the like. After the pH value of the 1,4-dihydroxy anthraquinone production wastewater is regulated with alkali and filtration treatment is performed, acidic substances in the wastewater are complexly extracted, back extraction is performed with alkali liquor on a load extraction agent, the extraction agent is recycled after being regenerated, strip liquor is acidized and filtered to recycle phthalic acid, and filtrated stock returns to an extraction system; raffinate is transferred into an with alkali liquor system and processed through evaporation separating to obtain a sodium sulfate by-product, and evaporation condensate water is processed through oxidation treatment to be drained or recycled after reaching the standard. According to the method, not only is the 1,4-dihydroxy anthraquinone production wastewater treated, but also resource utilization and comprehensive treatment of the wastewater are achieved.

The invention discloses a laser heat thermal induction reduction reaction type discharge printing agent as well as a preparation method and application thereof. The laser heat thermal induction reduction reaction type discharge printing agent is composed of an active component and a catalytic component, wherein the active component comprises sodium oxalate, ammonium oxalate, glucose, sodium benzene sulfinate, sodium methanesulphinate, thiourea dioxide, citric acid, sodium citrate, ammonium citrate and de-ionized water; the catalytic component comprises hydroxyanthraquinone, zinc sulfate, a discharging-resisting fluorescent whitening agent, glycerin, polyethylene glycol and de-ionized water. According to the laser heat thermal induction reduction reaction type discharge printing agent, respective technical advantages of traditional chemical-method discharge printing and modern laser etching printing and graphic image digital control are combined together to create a new discharge printing technology which is different from the traditional chemical-method discharge printing, is also different from the present new laser etching printing, and has the characteristics of good white discharge effect, less damages on fabric fibers, less drop of fabric strength, short technical flow, convenience in operation, flexibility, energy conservation, environmental friendliness and the like.

A positive resist composition is provided comprising a polymer comprising recurring units having a carboxyl or phenolic hydroxyl group substituted with an acid labile group and recurring units of hydroxyanthraquinone or hydroxy-2,3-dihydro-1,4-anthracenedione methacrylate, and having a Mw of 1,000-500,000. The resist composition has a satisfactory effect of suppressing acid diffusion and a high resolution, and forms a pattern of good profile and minimal edge roughness after exposure.

The invention discloses a key material of a modified straw flocculant and a technical method for same. The key material includes, by weight part ratio: ozonized ultrapure water, straw powder, phenyl succinic acid, nonyl phenol sulfosuccinic monoester disodium salt, N-(2-methphenyl)trichloroacetamide, 1-amino-2-bromo-4-[(4-methphenyl)amino]-9,10-anthracenedione, 1-amino-4-bromoanthraquinone, 3,5-dimethoxybromobenzene, berkelium nano particles, 1-amino-2-bromo-4-hydroxyanthraquinone, 2-[(4-chloro-2-nitrophenyl)azo]-N-(2,3-dihydro-2-oxy-1H-benzoimidazole-5-yl)-3-oxo-butanamide, and 2-[[4-cyclohexylamino-9,10-dihydro-9,10-dioxy-1-anthryl]amino]-5-ethoxybenzenesulfonic sodium salt. The key material herein achieves synchronization of an organic flocculant during production and avoids complex steps of producing and purifying a bio-flocculant and compounding the bio-flocculant with the organic flocculant to complete the production of the compound flocculant, thereby reducing synthesize process and reducing cost.

The invention discloses a preparation method and application of a desulfurized fly ash energy-saving environmental-friendly building material adhesive. The desulfurized fly ash energy-saving environmental-friendly building material adhesive consists of the following components in parts by weight: cation water, fatty alcohol polyethylene oxide ether sodium sulfate salt, succinic anhydride, N-cyclohexyl para toluene sulfonamide, N,N-dimethyl-p-nitrosoaniline, 1-amino-5-hydroxyl-4-[(1-methyl propyl] amino]-8-nitro-9,10-anthraquinone, 1-phenylamino-4-hydroxyanthraquinone, p-Methylthiobenzyl alcohol, gold nanoparticles, 4,4'-diamido-triphenylmethane, succinic anhydride, 4,4'-(3,3'-dichlorobiphenyl-4,4'-dinitrogen)di(4,5-dihydro-5-oxo-1-phenylpyrazole-3-formic acid) diethyl ester, benzotriazole-1-tri(trimethylamino)-trifluorophosphate, N-(2-benzimidazolyl) methyl carbamate and alpha-bromonaphthalene. The preparation method has the advantages that the adhesive is prevented from saponification, the surface tension of mixtures is reduced, and the mixtures can be relatively solidly adhered to one another; the adhesive has the advantages of stable chemical properties, wide application and high surface cleanliness ratios of molded structures.

The invention relates to an improved condensation process of disperse red 146. 1-amino-anthraquinone is taken as raw material, 1-amino-2-bromo-4-hydroxyanthraquinone is obtained by bromination and hydrolysis in sulfuric acid solution; the 1-amino-2-bromo-4-hydroxyanthraquinone is condensed with phydroxy phenol in mixed solvent medium, with the existing of acid binding agent and catalyst, and the temperature reduces to 75-80 DEG C after reaching the end point and methanol is dripped with controlling the temperature, and the segregation is done, the temperature is reduced under 50 DEG C after the segregation; the disperse red 146 is produced after standing, filtering and then the filter cake is cleaned by methanol and hot water. The invention is characterized in that: the 1-amino-2-bromo-4-hydroxyanthraquinone used in the condensation is wet cake added with the mixed solvent medium as well as the catalyst. By applying 1-amino-2-bromo-4-hydroxyanthraquinone wet cake directly, drying process is saved and operation is simplified, thereby reducing equipment investment and improving operation environment and reducing labor intensity; besides, the method also improves reaction yield and product quality and the economic benefit is very obvious.

The invention relates to a hydroxyanthraquinone chlormethine derivative having antitumor activity, and a preparation method thereof, and belongs to an antitumor drug derivative and a preparation method thereof, wherein the hydroxyanthraquinone chlormethine derivative is a 2-(1-substituted-bis(2-chloroethylamino)methyl)-1,4-dihydroxy-9,10-anthraquinone derivative. The preparation method comprises that 1,4-dihydroxyanthraquinone is adopted as a raw material, hydroxyalkyl is introduced into the site 2 of the 1,4-dihydroxyanthraquinone through hydroxyalkylation to obtain 2-(1-substituted-1-hydroxymethyl)-1,4-dihydroxy-9,10-anthraquinone, the 2-(1-substituted-1-hydroxymethyl)-1,4-dihydroxy-9,10-anthraquinone reacts with thionyl chloride to chlorinate the hydroxyalkyl so as to obtain 2-(1-substituted-1-chloromethyl)-1,4-dihydroxy-9,10-anthraquinone, the 2-(1-substituted-1-chloromethyl)-1,4-dihydroxy-9,10-anthraquinone reacts with diethanolamine at a room temperature, and finally the produced 2-(1-substituted-bis(2-hydroxyethylamino)methyl)-1,4-dihydroxy-9,10-anthraquinone reacts with thionyl chloride to obtain the 2-(1-substituted-bis(2-chloroethylamino)methyl)-1,4-dihydroxy-9,10-anthraquinone derivative. The compounds of the present invention have good antitumor activity.

The invention discloses a 1,8-dihydroxyl-9,10-anthraquinone derivative and a preparation method and application thereof and provides application of a 1,8-dihydroxyl-9,10-anthraquinone derivative shownin a formula I or a pharmaceutically acceptable salt of the 1,8-dihydroxyl-9,10-anthraquinone derivative to preparation of medicines for treatment and/or prevention of hepatitis C. The formula I is as shown in the specification, wherein R refers to C1-C6 alkoxy carbonyl, R<1> substituted or non-substituted benzenesulfonyl, or R<2> substituted or non-substituted benzyl, and R<1> and R<2> are C1-C4alkyl or C1-C4 alkoxy independently. The 1,8-dihydroxyl-9,10-anthraquinone derivative is high in anti-HCV activity.

The invention discloses a functional material for fixing phorate degrading bacteria based on polycarbonate modification. Polycarbonate is cleaned and is then prepared into a substance B through being modified by a mixed solution prepared from 2,5-furandicarboxylic acid, ethyl alcohol, 3-chloro-4-methylpyridazine, 2-hydroxyanthraquinone, 3-flavonol and N-2-naphthyl-3-hydroxyl-2-naphthanilide; the substance B is modified by a mixed solution prepared from acetone phenylhydrazone, ethyl alcohol, quinoline-8-carboxaldehyde, 4-benzopyrone-2-carboxylic acid and 4-chloro-3-nitropyridine; and an obtained substance is the functional material for fixing the phorate degrading bacteria based on polycarbonate modification.

The invention discloses a production method of 2,2'-dimethyl[1,1'-biphenyl]-4,4'-diamine. According to the production method of the 2,2'-dimethyl[1,1'-biphenyl]-4,4'-diamine, with 3-nitrotoluene as aninitial raw material, reduction is conducted at first to obtain 3,3'-dimethylhydrazo-benzene, and then rearrangement is conducted to obtain the 2,2'-dimethyl[1,1'-biphenyl]-4,4'-diamine; reduction isconducted with Pd/C as a main catalyst and an anthraquinone compound plus sodium di(2-ethyl-hexyl)sulfosuccinate as cocatalysts; and the anthraquinone compound is one or two of 1,4-dihydroxyanthraquinone, 2-hydroxyanthraquinone and 2,6-dihydroxyanthraquinone. According to the production method of the 2,2'-dimethyl[1,1'-biphenyl]-4,4'-diamine, through a large number of experiments, it is found that by combining the sodium di(2-ethyl-hexyl)sulfosuccinate and the anthraquinone compound as the cocatalysts, the reaction selectivity of production of the 3,3'-dimethylhydrazo-benzene through reduction of the 3-nitrotoluene can be greatly improved, and the reaction yield which is 70% or above can be obtained finally, so that conditions are created for mass application of the 2,2'-dimethyl[1,1'-biphenyl]-4,4'-diamine on the aspect of production of special materials.

The invention belongs to the technical field of medicines, and relates to an application of a 2-substituted anthraquinone derivative in treatment of candida albicans infection. Candida albicans can cause infection of the tissues and organs of a host or any part of the skin surface and can be adhered to the surfaces of various medical devices, and many diseases caused by the candida albicans are related to biofilm formation. Experiments prove that 2-ethylanthraquinone, 2-methylanthraquinone, 2-tert-butylanthraquinone and 2-hydroxyanthraquinone have an inhibiting effect on biofilm formation of the candida albicans and can reduce the metabolic activity of biofilm cells, and the 2-ethylanthraquinone also has an effect of inhibiting mycelia formation of the candida albicans. It is proved that the 2-substituted anthraquinone derivative has a good application prospect in preparation of a medicine for treatment of the candida albicans infection.

The invention relates to an anthraquinone compound, in particular to the 1- propylene oxygen group-4- hydroxyanthraquinone-9, 10- diketone and the preparation and the application. The molecular structure is shown as follows: the compound has stronger fluorescence quantum yield and good light stability. When the organic solvent contains little water, the fluorescence carrier molecule easily forms hydrogen bond compound with water so as to make the fluorescence intensity rise rapidly. The characteristics of the above fluorescence response produced by the anthraquinone derivatives in the organic solvent with water can be used to make fluorescent sensors and can realize the in-situ testing and real-time testing on the small quantities of water in organic solvent.

The invention discloses red and blue anthraquinone-contained polyphenylene sulfone copolymers and preparation methods and applications thereof, belongs to the technical field of preparation of polyether sulfone copolymers, and in particular relates to red and blue anthraquinone-contained polyphenylene sulfone copolymers and preparation methods thereof, and the applications of red and blue anthraquinone-contained polyphenylene sulfone copolymers in the dying of pure polyphenylene sulfone. According to the preparation methods, 4,4'-difluoro diphenyl sulfone, 4,4'-biphenyl diphenol and 1-aminoanthraquinone or 1,5-diamido-4,8-dihydroxy anthraquinone are employed as raw materials, a nucleophilic polycondensation method is employed to introduce anthraquinone chromophoric molecules with high thermal stability into a polyphenylene sulfone system in a covalent bond manner, thus the novel red and blue anthraquinone-contained polyphenylene sulfone copolymers with anthraquinone content of 1%-30% and thermal decomposition temperature of more than 500 DEG C can be prepared. The series of polymers have high molecular weight, good solubility and heat stability, and meanwhile have intrinsic red and blue colors and good transparency.

The invention relates to the technical field of dyes, in particular to a disperse red 60 condensation process. The process comprises the following steps: in a condensation kettle, firstly adding phenol and a 1-amino-2-bromo-4-hydroxyanthraquinone dry product, then adding sodium carbonate and a catalyst, heating to 140-160 DEG C, carrying out reactions at a constant temperature; after the reactionis finished, cooling to 90-100 DEG C, adding water within the temperature range, dropwise adding liquid caustic soda, cooling to 50-55 DEG C after dropwise adding is finished, filtering, cleaning, anddrying to obtain 1-amino-2-phenoxy-4-hydroxyanthraquinone, namely disperse red 60. According to the process, a condensed acid-binding agent (potassium carbonate) is directly substituted by sodium carbonate with a lower price, and a certain amount of a proper phase transfer catalyst is added, so that the contact probability and activity of condensation reactions are improved, the aims of improvingthe product quality and yield and reducing the production cost are fulfilled, and the cost of the disperse red 60 can be reduced by 1500 yuan/ton.

The invention discloses preparation and application of an aluminum indicator, which are characterized in that 1,2-dihydroxy anthraquinone and polyformaldehyde are added into an ethanol solution, alkali is added, the mixture is subjected to a heating reaction, and separation and purification are performed to obtain a compound QS, namely the aluminum indicator. A probe prepared by the invention is simple to synthesize, stable in property and mild in determination condition, and can be stably stored for a long time; selectivity is high, and color changes exist; the indicator is suitable for construction site rapid detection. The indicator is simple in method, convenient, rapid, high in sensitivity, resistant to interference and easy to popularize.

A method for producing 1,4-diphenylamino-5,8-dihydroxyanthraquinone provides a dye with high colour strength and excellent brilliance for colouring plastics.