A PEG-modified two-dimensional nanosheet light-to-heat conversion material and its application

A two-dimensional nano- and thermal conversion technology, which is applied in the fields of wave energy or particle radiation treatment materials, medical preparations without active ingredients, and medical preparations containing active ingredients. Stabilize the problems of tumor photothermal therapy, severe photobleaching, etc., to achieve good photothermal conversion efficiency and photothermal stability, large cross-sectional area, and good application prospects.

A two-dimensional nano- and thermal conversion technology, which is applied in the fields of wave energy or particle radiation treatment materials, medical preparations without active ingredients, and medical preparations containing active ingredients. Stabilize the problems of tumor photothermal therapy, severe photobleaching, etc., to achieve good photothermal conversion efficiency and photothermal stability, large cross-sectional area, and good application prospects.

CN107625962BActive Publication Date: 2020-07-03MENGCHAO HEPATOBILIARY HOSPITAL OF FUJIAN MEDICAL UNIV
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  • A PEG-modified two-dimensional nanosheet light-to-heat conversion material and its application
  • A PEG-modified two-dimensional nanosheet light-to-heat conversion material and its application
  • A PEG-modified two-dimensional nanosheet light-to-heat conversion material and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Use an electronic balance to weigh 1 mg of tetrahydroxyanthraquinone powder and dissolve it in 40 μL of tetrahydrofuran solution, then add 950 μL of deionized water, mix well, and add 10 mg / mL CuCl 2 (pH 7.4, adjust pH with NaOH) 10 μL and stir for 1 h. Centrifuge at 13000rpm / min, after obtaining the precipitate, add neutral PBS solution to wash, centrifuge at 13000rpm / min, repeat 3 times, and then disperse in PBS buffer for later use.

[0030] The obtained two-dimensional nanosheets: bisamino-polyethylene glycol mixture (PEG-(NH 2 ) 2 ) were mixed overnight at a mass ratio of 1:10, washed with neutral PBS, centrifuged, and resuspended three times to obtain PEG-modified two-dimensional nanosheets.

Embodiment 2

[0032] Example 1 The two-dimensional nanosheets are prepared with a size of about 500-800nm×500-800nm, which has a relatively high absorption coefficient, photothermal stability, and photothermal conversion capability. It can be used for photothermal therapy of tumors.

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Abstract

The invention relates to a PEG-modified two-dimensional nanosheet photothermal conversion material. The material is formed through coordination self-assembling of tetrahydroxyanthraquinone and bivalent copper ions and modification with PEG, and the diameter of the above nanosheet is 500-800 nm, wherein a molar ratio of the tetrahydroxyanthraquinone to the bivalent copper ions is (1.5-2):1. The two-dimensional nanosheet has a high light absorption coefficient in the near-infrared region, high photothermal conversion ability under the irradiation of near-infrared laser, expands existing photothermal conversion materials, and can be used in the photothermal therapy of tumors.

Description

[0001] (1) Technical field [0002] The invention relates to a novel two-dimensional nanosheet photothermal conversion material and its application. [0003] (2) Background technology [0004] In recent years, tumor photothermal therapy based on photothermal conversion nanomaterials has become an emerging hotspot in cancer treatment. The principle is that photothermal conversion materials can absorb near-infrared light energy and convert light energy into superheated energy, which is used to heat kill tumors. cells for the purpose of tumor therapy. The near-infrared light it absorbs can effectively penetrate the human skin and reach the deep tumor tissue, which is the skylight of the lesion. At the same time, the irradiation wavelength is adjustable, the irradiation range is controllable, and the damage to the human body is small. Many biomaterials scientists are committed to synthesizing this new material, which has become a research hotspot in biological applications. [00...

Claims

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Application Information

Patent Timeline
03 Jul 2020
Publication
CN107625962B
IPC
A61K41/00; A61K47/60; A61P35/00; C08G65/337
Inventors
张达; 刘景丰