The invention discloses 3,5-diaryl
pyrazole or 3,4-diaryl
pyrazole derivative and application thereof. The 3,5-diaryl
pyrazole or 3,4-diaryl
pyrazole derivative is prepared from compound which is shown in a formula (I), a formula (II), a formula (III) or a formula (IV) or pharmaceutical-acceptable salt of the compound. A formula of the 3,5-diaryl pyrazole or 3,4-diaryl
pyrazole derivative is shownin a following image, wherein R1, R2, R3, R4 and R5 are respectively and independently chosen from
hydrogen atom, hydroxy, nitro, amino, alkoxy or ester group with a C1 to C10
alkyl substituent group;
alkyl in the alkoxy is a C1 to C10
alkyl; R is independently chosen from
hydrogen atom, 2-ethoxy, acetyl, phenyl, benzoyl, p-methoxyphenyl, 4-trifluoromethoxy, 2-cyanoethyl or C1 to C10 alkyl. The 3,5-diaryl
pyrazole derivative or the 3,4-diaryl pyrazole derivative can be applied to preventing and treating fungal infection; especially, application in treating
candida albicans infection and reversing
fluconazole drug resistance has good development value.