Application of wedelolactone in preparing anti-candida albicans medicines

Abstract

The invention discloses an application of wedelolactone in preparing anti-candida albicans medicines. According to the invention, candida albicans is taken as a test object by the inventor so as to screen out a compound which is efficient, low in toxicity and can avoid easy generation of drug resistance, discovering that the wedelolactone can take an excellent inhibitory effect on adhesion, a mycelium formation rate, bio-film formation and pathogenicity of candida albicans. Moreover, the compound, which is relatively low in toxicity, can avoid influence to growth of human cells, and meanwhile,the compound can avoid influence to normal growth of the candida albicans, showing that the compound, instead of killing the candida albicans, can take effects on the candida albicans strains by inhibiting the adhesion, mycelium formation, bio-film formation and pathogenicity of the candida albicans, therefore, drug resistance can be prevented from causing easily. The wedelolactone has a good application prospect in the development of novel anti-fungal medicines, and in particular in the aspect of developing anti-candida albicans infection medicines.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of wedelolide in the preparation of anti-candida albicans drugs. Background technique [0002] Candida albicans (Candida albicans) is a fungal disease widely spread in humans. It is an important opportunistic pathogenic fungus, usually causing acute, subacute or chronic infections, and it is also one of the most important pathogens of hospital-acquired infections. . On healthy human mucosal surfaces, such as the oral cavity and intestinal tract, Candida albicans usually does not cause disease, but in patients with compromised or suppressed immune systems, such as chemotherapy patients, organ transplant patients or AIDS patients, it can cause serious systemic damage. Sexual infection, the fatality rate is as high as 40%. [0003] At present, there are limited types of antifungal drugs clinically, among which azole drugs (fluconazole) are widely us...

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Problems solved by technology

[0003] At present, there are limited types of antifungal drugs in clinical practice, among which azole drugs (fluconazole) are widely used, and fluconazole acts as a bacteriostasis by inhibiting fungal replication effect, but with the abuse of antibiotics, the phenomenon of drug resistance is becoming more and more serious

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