5 results about "Wedelolactone" patented technology

The present invention relates to a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, a feed composition for improving brain cognitive function, and a method for preparing same and, specifically, to: a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredients, extracts of Atractylodes lancea, Eclipta prostrata, and Magnolia officinalis, and a method for preparing same; and a pharmaceutical composition for preventing, ameliorating or treating diseases associated with brain cognitive function, a food composition for improving brain cognitive function, and a feed composition for improving brain cognitive function, each comprising, as active ingredient(s), atractylodin, wedelolactone, and / or honokiol, and a method for preparing same.

The application belongs to the technical field of biological medicine, and particularly relates to a medium-chain fatty acid composition for improving immunity of calves and a preparation method thereof. The medium-chain fatty acid composition for improving immunity of calves according to the application comprises, in terms of weight fractions, 20-30 parts of lactose, 5-10 parts of medium-chain fatty acid, 1-3 parts of mangiferin derivative, 0.5-2 parts of wedelolactone and 0.2-1 part of vitamin C. The mangiferin derivative according to the application can relieve local inflammatory reaction of the intestinal tract, repair the intestinal mucosal barrier damaged by stress, and enhance the non-specific immune capacity of the body. The wedelolactone according to the application forms a double synergy with the lactose and the medium-chain fatty acid, greatly improves the utilization efficiency of energy and nutrients, and thus promotes the growth and development of the calf. In addition, the wedelolactone can also synergize with the mangiferin derivative, maintains the intestinal health of the calf in the early weaning period, and significantly weakens the weaning stress impact.

The invention discloses a biodegradable composite high-molecular three-dimensional scaffold and a preparation method thereof, the three-dimensional scaffold comprises a matrix material and an active substance loaded on the matrix material, and the matrix material is selected from biodegradable high-molecular polymers with biocompatibility; the active substance is wedelolactone lipidosome, or the wedelolactone lipidosome and beta-tricalcium phosphate nano particles. The degradable biofilm based on the single wedelolactone liposome has a good promotion effect in the aspect of tissue repair; the scaffold is combined with wedelolactone lipidosome and beta-tricalcium phosphate nano-particles, so that bionic design of natural bone tissues can be realized, functional complementation of nano-materials is realized, good cell compatibility is realized, osteogenesis performance is effectively promoted, and the scaffold has a good application prospect. Meanwhile, the biodegradable high polymer material based on the wedelolactone lipidosome has a good prospect in the field of tissue regeneration and repair.

The invention relates to the technical field of quality detection of traditional Chinese medicines, in particular to a quality control method of a wild-imitated dendrobium officinale medicinal material. The method comprises the following steps: S1, preparing a test solution, namely crushing a dendrobium officinale medicinal material, extracting with a solvent A, filtering and concentrating; s2, preparing a reference substance solution, namely dissolving a New Zealand vitexin 2 reference substance, a schaftoside reference substance, a rutin reference substance, a quercetin reference substance and a naringenin reference substance into a solvent A; s3, high performance liquid chromatography detection: respectively determining the test solution and the reference solution in a gradient elution mode to obtain a fingerprint spectrum; s4, similarity evaluation: importing the fingerprint into a traditional Chinese medicine chromatographic fingerprint similarity evaluation system, and analyzing to obtain the fingerprint of the dendrobium officinale medicinal material. According to the method, the fingerprint spectrum of the wild-imitated dendrobium officinale is established for the first time, whether the dendrobium officinale is cultivated in a wild-imitated mode or not can be well distinguished, and the method has important significance on guaranteeing the quality of the dendrobium officinale medicinal material. The method is simple and easy to implement, good in reproducibility and suitable for quality control in large-scale production.

The invention belongs to the technical field of traditional Chinese medicine plant chemistry, and particularly relates to a total synthetic preparation method of wedelolactone or norwedelolactone. Raw materials (6-hydroxybenzo[2,1-d][1,3]dioxolan-5-yl) methyl acetate and 2,4,6-trimethoxybenzoic acid are used for synthesis to obtain an intermediate compound, and wedelolactone and norwedelolactone are synthesized respectively through the intermediate compound. The preparation method of the invention avoids the use of a metal catalyst (palladium catalyst, copper catalyst, etc.), reduces costs, has a simple reaction, and a short route, thus facilitating subsequent further efficacy research on wedelolactone and norwedelolactone.