The present invention provides a comprehensive herbicide for paddy fields, which includes component A and component B, wherein component A is mesotrione, and one or more of component A and component B Item compound, used for weeding in the field; component B is alachlor, metolachlor, propachlor, acetochlor, pretilachlor, butachlor, mefenacet, quinclorac , Cyhalofop-methyl, pendimethalin, saponin, bispyribac, saflufenacil, cyclopyrafen, pyrifluben. After the above scheme is adopted in the present invention, the composition of component A and component B has a synergistic effect, and has a good control effect on both grass weeds in paddy fields and broad-leaved and sedge weeds , and the residual effect period is short, does not affect the growth of the next crop, and is friendly to the environment.