Application of Heterophyllin B to anti-candida-albicans drug preparing

Abstract

The invention discloses application of Heterophyllin B to anti-candida-albicans drug preparing. Candida albicans serves as a test object, an efficient and low-toxic compound which is not prone to drugresistance generation is screened, and it is discovered that the Heterophyllin B has good inhibiting effect on adhesion and pathogenicity of the candida albicans. The toxicity of the Heterophyllin Bis small, and growth of human cells is not influenced; meanwhile, normal growth of the candida albicans is not influenced, it is indicated that the effect of the Heterophyllin B on candida albicans strains does not mainly depend on killing candida albicans, and depends on inhibiting the adhesion and the pathogenicity of the candida albicans, and therefore the drug resistance is not prone to generation. The Heterophyllin B has good application prospects in development of novel antifungal drugs, particularly, has good application prospects in the development aspect of anti-candida-albicans infection drugs.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of heterophyllin cyclic peptide B in the preparation of anti-candida albicans drugs. Background technique [0002] Candida albicans (Candida albicans) is a fungal disease widely spread in humans. It is an important opportunistic pathogenic fungus, usually causing acute, subacute or chronic infections, and it is also one of the most important pathogens of hospital-acquired infections. . On healthy human mucosal surfaces, such as the oral cavity and intestinal tract, Candida albicans usually does not cause disease, but in patients with compromised or suppressed immune systems, such as chemotherapy patients, organ transplant patients or AIDS patients, it can cause serious systemic damage. Sexual infection, the fatality rate is as high as 40%. [0003] At present, there are limited types of antifungal drugs clinically, among which azole drugs (flucon...

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Problems solved by technology

[0003] At present, there are limited types of antifungal drugs in clinical practice, among which azole drugs (fluconazole) are widely used, and fluconazole acts as a bacteriostasis by inhibiting fungal replication effect, but with the abuse of antibiotics, the phenomenon of drug resistance is becoming more and more serious

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