92 results about "Pulmonary infection" patented technology

The invention discloses a pulmonary infectious disease prediction system based on multi-modal data fusion, and aims to improve the accuracy and reliability of disease prediction through comprehensive analysis of multi-dimensional data. The system comprises a data acquisition module, a feature extraction module, a dynamic fusion module and a prediction modeling module. The data acquisition module is used for acquiring clinical and medical images and environmental factor data of a patient in real time; the feature extraction module extracts feature vectors of all data sources; the dynamic fusion module performs adaptive weight distribution on the multi-modal features and fuses the multi-modal features into multi-modal feature representation; the prediction modeling module is used for carrying out dynamic change trend modeling on the multi-modal feature representation through time sequence analysis so as to generate a probability prediction value of suffering from pulmonary infectious diseases and a disease trend prediction result of the patient; the invention provides a comprehensive and efficient disease prediction method by utilizing the collaborative advantage of multi-modal data and combining an attention mechanism and time sequence analysis, and can be widely applied to the fields of medical diagnosis and public health management.

Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and / or NTM culture conversion to negative during or after the administration period.

Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and / or NTM culture conversion to negative during or after the administration period.

The invention relates to the technical field of health management systems, in particular to a swallowing dysfunction risk management system, which comprises a swallowing training magnetoelectric stimulator for generating magnetoelectric stimulation signals; the electroencephalogram signal acquisition instrument is used for acquiring electroencephalogram signals generated by the brain of the patient aiming at the magnetoelectric stimulation signals; the main control box is connected with the swallowing training magneto-electric stimulator and the electroencephalogram signal acquisition instrument and comprises a processing module which is used for generating a stimulation effect picture based on the electroencephalogram signals, determining a swallowing dysfunction risk assessment result based on the stimulation effect picture and generating a magneto-electric stimulation scheme based on the swallowing dysfunction risk assessment result; the control module is used for controlling parameters of the magnetoelectric stimulation signals based on the magnetoelectric stimulation scheme; and the risk early warning module is used for formulating corresponding intervention measures and plans based on the swallowing dysfunction risk assessment result, and reasonably preventing and reducing pulmonary infection and other complications caused by the swallowing dysfunction of the patient through risk management and control.

The invention relates to the technical field of medical data mining, in particular to a postoperative pulmonary infection prediction method and system.The postoperative pulmonary infection prediction method comprises the following steps that a continuous data set is formed by collecting breathing parameters and conducting alignment completion, tidal volume and blood oxygen response delay characteristics are extracted through sliding analysis, and a functional abnormal pulmonary segment is located through local anomaly recognition; and fusing physiological and anatomical features to establish a spatial probability map, extracting a respiratory variation coefficient and a risk feature regression analysis confidence index, and outputting an infection risk early warning list with anatomical positioning. According to the method, data faults are eliminated through timestamp alignment to improve the reliability of time sequence association, the breathing compensation capability is quantified through multi-scale window analysis dynamic coupling, lesion avoidance feature masking is accurately positioned through local anomaly detection, and the result interpretability is enhanced through combination of multi-modal feature fusion and space mapping. The three-stage progressive mechanism improves the prediction precision and timeliness, and provides a decision basis with both time sensitivity and anatomical orientation for clinic.

The present invention discloses a lung infectious disease prediction system based on multimodal data fusion, aiming to improve the accuracy and reliability of disease prediction through comprehensive analysis of multidimensional data; the system comprises a data acquisition module, a feature extraction module, a dynamic fusion module and a prediction modeling module; the data acquisition module acquires the patient's clinical, digital medical imaging and environmental factor data in real time; the feature extraction module extracts the feature vectors of each data source; the dynamic fusion module adaptively weights the multimodal features and fuses them into a multimodal feature representation; the prediction modeling module performs dynamic change trend modeling on the multimodal feature representation through time series analysis to generate a probability prediction value of the patient suffering from a lung infectious disease and a disease trend prediction result; the present invention utilizes the synergistic advantages of multimodal data, combines the attention mechanism and time series analysis, and provides a comprehensive and efficient disease prediction method, which can be widely used in the fields of medical diagnosis and public health management.

The antibody disclosed by the invention can specifically target high-virulence klebsiella pneumoniae of different serotypes, and specifically targets klebsiella pneumoniae of K1 and K2 serotypes. The antibody disclosed by the invention can be combined with high-toxicity klebsiella pneumoniae extracellular capsular polysaccharide with high affinity, has very strong neutralizing activity on klebsiella pneumoniae, and can mediate complement and mature neutrophil to neutralize and kill bacteria in an in-vitro killing experiment, so that the bacterial density is reduced, and the killing effect is improved. The traditional Chinese medicine composition can effectively prevent and treat high-toxicity klebsiella pneumoniae clinical infection and effectively improve pulmonary infection, provides a way for solving the problems of klebsiella pneumoniae infection and multiple drug resistance, has remarkable significance in preventing, diagnosing and treating klebsiella pneumoniae infection, and has important value in development of a new generation of klebsiella pneumoniae medicine.

Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle. The method comprises administering to the lungs of the patient a pharmaceutical composition comprising a liposomal complexed aminoglycoside comprising a lipid component comprising electrically neutral lipids and an aminoglycoside. Administration comprises aerosolizing the pharmaceutical composition to provide an aerosolized pharmaceutical composition comprising a mixture of free aminoglycoside and liposomal complexed aminoglycoside, and administering the aerosolized pharmaceutical composition via a nebulizer to the lungs of the patient. The methods provided herein result in a change from baseline on the semi-quantitative scale for mycobacterial culture for a treated patient, and / or NTM culture conversion to negative during or after the administration period.

The invention discloses a pulmonary infection risk probability prediction method and device, equipment, a medium and a product, and relates to the field of pulmonary infection risk probability prediction.The method comprises the steps that a training data set is acquired; based on the training data set, judging whether a pulmonary infection risk prediction probability value of a pulmonary infection risk probability prediction model and an actual risk probability value are in a set error range or not; if yes, predicting a pulmonary infection risk probability value of the postoperative patient according to the pulmonary infection risk probability prediction model; if not, correcting the pulmonary infection risk probability prediction model; and predicting the pulmonary infection risk probability value of the postoperative patient according to the corrected pulmonary infection risk probability prediction model. According to the application, the accuracy of predicting the pulmonary infection risk probability is improved.

The invention discloses application of a TIMM10 gene as a target spot in resisting influenza A virus, and belongs to the technical field of biological medicine. Specifically, TIMM10 gene knock-down is carried out on A549 cells, and it is found that in the cells with knocked-down TIMM10, expression of main protein hemagglutinin and nucleoprotein of influenza viruses is remarkably improved, and virus RNA and virus titer in supernate are also remarkably increased; overexpression of TIMM10 in A549 cells inhibits replication and infectivity of IAV in the cells. A further in-vivo experiment is carried out through a TIMM10 whole body knockout heterozygote mouse, and a result shows that the lung of the TIMM10 heterozygote mouse shows more serious pulmonary infection, including pulmonary hemorrhage and increased inflammatory cell infiltration. Based on the effect of TIMM10 in the influenza virus infection process, the invention provides a new therapeutic target, and provides a new thought and direction for developing a therapeutic strategy for IAV in the future.

The invention discloses an integrated nano-enzyme with multiple response mechanism synergism, and a preparation method and application thereof. A Z-type heterojunction based on boron nanosheets (B NSs) and rare earth doped iron phosphide (Nd < 0.02 > Fe < 1.98 > P) is constructed for the first time, and CTAB is used for surface modification to obtain a ternary composite nano-enzyme (BFC); according to the present invention, the material is endowed with the multi-response ability (POD / GSHOx enzyme activity synergistic activation) on the bacterial infection microenvironment (low pH and high H2O2), and the nano-enzyme has excellent acoustic-magnetic responsiveness, can break through the depth limitation, and can achieve the precise and controllable generation of the reactive oxygen species (ROS). Under the acidic microenvironment of pulmonary infection, the activity of peroxidase (POD) and glutathione oxidase (GSHOx) is activated, so that efficient and controllable synergistic killing is performed on bacteria.

The present invention discloses a combined prediction method for the risk of pulmonary infection after kidney transplantation, comprising the following steps: S1, quantifying a clinical data set; S2, designing a feature extraction network for preoperative static data and extracting features of the preoperative static data; S3, designing a feature extraction network for postoperative dynamic data sequences and extracting features of the postoperative dynamic data sequences; S4, fusing the features obtained in step S3 and the features obtained in step S4; S5, performing binary classification calculation on the fused features obtained in step S5 using a linear classifier, and inversely obtaining an intelligent prediction result of whether there is an infection from the classification result. The present invention can be applied to predicting in advance the occurrence of the risk of pulmonary infection at each time node after kidney transplantation for patients, and providing clinical auxiliary decision-making support for the diagnosis and treatment plan after kidney transplantation.

The invention discloses aztreonam microspheres as well as a preparation method and application thereof. The microsphere is an inhalation preparation and can be effectively deposited in the lung, so that the slow release of the medicine is realized. According to the aztreonam microspheres, aztreonam and cinnamyl aldehyde are synthesized into a small molecule drug, and the small molecule drug is self-assembled into the microspheres. The preparation method comprises the following steps: (1) placing aztreonam AZT and cinnamyl aldehyde CA in a glass bottle according to a molar ratio of 3: 2, adding dimethyl sulfoxide DMSO, stirring and dissolving, and stirring and reacting at room temperature for 5-7 hours; (2) dialyzing the reacted solution in a dialysis bag, removing DMSO and unreacted small molecules, and obtaining dialysate after 48 hours; (3) performing freeze drying to obtain yellow powder of cinnamyl aldehyde-aztreonam CAT; and (4) weighing the CAT powder, dissolving the CAT powder in deionized water, and shaking to dissolve the CAT powder to obtain the aztreonam microspheres. The microspheres are suitable for treatment of pulmonary infections, in particular for local drug delivery and sustained release control.

The invention provides a chest tumor patient postoperative pulmonary infection prediction method and system based on deep learning, a logic regression model established based on patient data is used as a risk factor for pulmonary infection judgment, and the risk factor is further explained and evaluated by establishing a hybrid expert model. By comprehensively reflecting indexes of the overall evaluation performance, a verification result shows that the accuracy of the hybrid expert model is better than that of a single model, the hybrid expert model is not influenced by distribution of discrete feature and continuous feature data in a training set and a test set, and the hybrid expert model has good generalization ability.

The invention discloses a severe pulmonary infection sputum sample sampling device, and relates to the technical field of medical sampling instruments.The severe pulmonary infection sputum sample sampling device comprises a sampling tank and a negative pressure pipe, a mounting cabin is fixedly installed on the sampling tank, a filtering module used for filtering sputum sample particles is further arranged outside the sampling tank, and a detection module used for detecting a sputum sample is further arranged on the sampling tank; the sampling tank is connected with the detection module through a transfer pipe, the filtering module comprises a filtering box installed on the mounting cabin in a sealed mode, a sampling pipe used for sucking a sputum sample is arranged on the filtering box, a sputum suction head is fixedly installed at the end, extending out of the filtering box, of the sampling pipe, and filtering holes distributed in an arrayed mode are formed in the side, close to the sputum suction head, of the filtering box. The filter holes are formed in the filter box, and the filter membrane is arranged at the joint of the sampling tank and the mounting cabin, so that secondary filtration of a sputum sample is realized, large particles and fine impurities in the sputum sample can be effectively removed, and a pure sample can be obtained without additional filtration steps.

The invention discloses an intelligent crusher with a feeding port dustproof function, relates to the technical field of crushing equipment, and aims to solve the technical problems that fine particles and dust can be generated when ore is impacted and ground at a high speed, and pulmonary infection can be caused when people inhale the fine particles and dust. The intelligent crusher comprises a machine base, and a crushing box is fixedly connected to the top of the machine base. According to the ore crushing device, by arranging the atomizing nozzles, during ore crushing, water flow passes through the atomizing nozzles to be atomized, powder particles generated by ore crushing are settled, meanwhile, part of atomized water can cool the surface of ore, settled mixed liquid flows downwards through the inner wall of the water collecting frame and flows into the water tank from the second pipeline to be settled, and the ore crushing efficiency is improved. According to the device, the functions of dust falling at the feeding port and ore surface cooling can be achieved, meanwhile, water circulation can be achieved through the sedimentation box, water resource consumption is reduced, and the reliability of the device can be improved.

The utility model relates to the technical field of medical accessories, in particular to a breathing machine pipeline fixing device which comprises two J-shaped supporting arms, the bent ends of the supporting arms are used for being connected with the external environment, the straight ends of the supporting arms are provided with containing cups, the containing cups are used for containing water collecting cups, and the supporting arms are provided with a plurality of pipe clamps. The pipe clamp is used for clamping a breathing machine pipeline; by means of the respirator pipeline fixator, the respirator pipeline and the water collecting cup are fixed, the respirator pipeline is kept in a downward inclined state, meanwhile, the water collecting cup is also kept in a downward state, condensate water is prevented from being gathered in the pipeline, backflow of the condensate water is prevented, the risk of pulmonary infection of a patient is reduced, and the respirator pipeline fixator is suitable for popularization and application. The treatment on a patient is facilitated.

The application discloses a sputum suction device for patients with lung infection and relates to the technical field of sputum suction devices.The sputum suction device comprises a sputum suction machine body, a sputum storage tank is connected to the sputum suction machine body through an adapter hose, a sputum main pipe is connected to an input end of the sputum storage tank, a cleaning ring pipe is fixedly arranged at an upper end in the sputum storage tank, a plug-in pipe is connected to one end of the sputum main pipe, a cleaning mechanism is arranged in an installation box, and a disinfection mechanism is arranged in the installation box.The plug-in pipe and the cleaning ring pipe are arranged to clean the inside of the sputum storage tank and the sputum main pipe.An ozone generating part is arranged to facilitate the disinfection of the inside of the sputum storage tank and the sputum main pipe.Silica gel hoses are arranged in a wastewater tank, so that the used ozone can further disinfect the waste liquid in the wastewater tank, thereby reducing the spread of bacteria and viruses.

The present invention provides a composition comprising a caveolin-1 (Cav-1) peptide. Also provided are methods of using the Cav-1 peptide to treat pulmonary infections or acute or chronic lung injury, particularly pulmonary fibrosis.

The present application provides a composite sonosensitizer and its bacterial target delivery system BPT-ICG@Bd capable of treating pseudomonas aeruginosa biofilm related infection, wherein the composite sonosensitizer (BPT-ICG) is composed of inorganic sonosensitizer (BPT) and organic sonosensitizer (ICG), Bd is natural gram-negative bacteria predator Bdellovibrio, the composite sonosensitizer (BPT-ICG) is modified to the surface of Bdellovibrio (Bd) by polydopamine to form BPT-ICG@Bd. The high-speed movement characteristics of Bdellovibrio predator gram-negative bacteria are used to destroy the biofilm structure, invade bacteria, and at the same time, the composite sonosensitizer is triggered to produce a large amount of active oxygen by applying ultrasound, so as to quickly remove the biofilm and bacteria, and be used for biofilm related lung infection and bone infection.

The invention discloses a method for constructing a model for performing treatment outcome grouping on AIDS (acquired immune deficiency syndrome) and phthisis patients and application of the method. The invention provides a method for constructing a model for performing anti-tuberculosis treatment outcome grouping on AIDS (Acquired Immune Deficiency Syndrome) and pulmonary tuberculosis patients, which comprises the following steps of: taking five specific index data of known AIDS and pulmonary tuberculosis patient groups with different anti-tuberculosis treatment outcomes as training samples; training a model for performing anti-tuberculosis treatment outcome grouping on the AIDS and pulmonary tuberculosis patients; the five specific indexes are CAR, extrapulmonary tuberculosis, other pulmonary infections, lung cavities and CD4 + T lymphocyte count. According to the method, clinical doctors can quickly identify AIDS and tuberculosis patients with high treatment failure risk, personalized management is carried out on the AIDS and tuberculosis patients, the method is of great importance to reduction of the occurrence rate of retreatment and drug-resistant tuberculosis, and a new strategy is provided for precise treatment.

The invention discloses a sputum suction connecting tube, and relates to the technical field of medical instruments, in particular to a sputum suction connecting tube which comprises an inner tube, the sputum suction end of the inner tube is slidably sleeved with an outer tube, the front end of the inner tube is wrapped with a buffer layer, and an air cavity is formed between the buffer layer and the inner tube. A negative pressure moving ring capable of moving inwards through negative pressure is arranged on the inner wall of the sputum suction end of the inner tube, and an air bag capable of inflating the air cavity is arranged on the inner side, close to the negative pressure moving ring, of the inner wall of the sputum suction end of the inner tube. The covering cylinder at the end part of the outer tube is flexibly propped against the buffer layer at the front end of the inner tube, so that when the outer tube carries the covering cylinder to enter the upper respiratory tract in advance and is fixed at a preset position, the inner tube can be independently pushed forwards to go deep into the lower respiratory tract, and colonized florae in the upper respiratory tract are effectively prevented from invading the lower respiratory tract along with the sputum suction tube by utilizing the physical isolation effect of the outer tube; the iatrogenic pulmonary infection risk is reduced.

The invention relates to a polymyxin B sulfate dry powder inhalation and application thereof, which can effectively solve the problem of medication for treating pneumonia and pulmonary infection caused by multi-drug-resistant gram-negative bacteria, the polymyxin B sulfate dry powder inhalation is prepared from polymyxin B sulfate, leucine and mannitol, and the preparation method comprises the following steps: dissolving polymyxin B sulfate, leucine and mannitol in ultrapure water according to a mass ratio, carrying out ultrasonic treatment to obtain a uniformly mixed medicine solution, and carrying out freeze drying to obtain the polymyxin B sulfate dry powder inhalation. The composition is simple, scientific and reasonable, the raw materials are rich, the preparation method is easy to operate, the product quality is good, the composition is administrated through aerosol inhalation, the composition is effectively used for treating pneumonia and pulmonary infection caused by multi-drug-resistant gram-negative bacteria, the composition is fast to absorb, the pulmonary drug concentration is high, the stability is good, and the composition is suitable for clinical application. The medicine is a great innovation in treatment of pneumonia and pulmonary infection caused by the multi-drug-resistant gram-negative bacteria, and has remarkable economic and social benefits.

The invention discloses an augmented reality chest surgery grading nursing intervention management method, and relates to the technical field of chest surgery nursing, and the technical scheme is characterized in that the method comprises the following steps: obtaining personalized health record data of a chest surgery patient and operation track data in an AR nursing scene, and obtaining multi-modal time sequence nursing data; judging the real-time fluctuation characteristics of the nursing demand of the patient based on the multi-modal time sequence nursing data to generate a nursing demand fluctuation characteristic data set; constructing an effectiveness evaluation dimension system of thoracic surgery nursing intervention, establishing a corresponding relation set of effectiveness evaluation and nursing grading, and extracting coupling influence coefficients of effectiveness evaluation indexes under different nursing grading standards to obtain a nursing effectiveness coupling coefficient set; the method has the effects of accurately positioning abnormal requirements by combining a fluctuation feature recognition technology, reducing traditional experience judgment nursing deviation, and greatly reducing the risk of complications such as pulmonary infection and poor incision healing.

A system for treating or providing prophylaxus against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition, and b) an inhalation delivery device. A method for providing prophylaxis against a pulmonary infection in a patient and a method of reducing the loss of antiinfective encapsulated in a lipid-based composition upon nebulization comprising administering an aerosolized pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition is also disclosed.

The invention relates to the technical field of chronic obstructive pulmonary disease treatment, and discloses a chronic obstructive pulmonary disease patient expectoration assisting and aerosol inhalation integrated device which comprises a main machine, a first connecting pipe is connected to the top of a double-end bent pipe in a penetrating mode, a second connecting pipe is connected to one side of the top of the double-end bent pipe in a penetrating mode, and a first catheter is connected to the top of the first connecting pipe in a penetrating mode. A first catheter is connected to the top of the first connecting pipe in a penetrating mode, a second catheter is connected to the top of the second connecting pipe in a penetrating mode, a connector is connected to one end of the first catheter in a penetrating mode, and a suction nozzle is fixedly arranged at one end of the connector. The operation of expectoration assistance and atomization treatment is respectively carried out through the pipeline of the same channel, meanwhile, the airflow trend and liquid flow of the two are not interfered with each other under the treatment condition of the same channel, different treatment pipelines do not need to be frequently replaced for treatment when a chronic obstructive pulmonary disease patient is treated, the risk of pulmonary infection of the patient is reduced, and the treatment efficiency is improved. The treatment effect is improved.

In one aspect, the invention provides a method for treating, inhibiting, alleviating or preventing acute respiratory distress syndrome, pneumonia, or some other pulmonary or other manifestations of coronavirus infection, such as thrombosis, in a mammalian subject infected with a coronavirus, such as SARS-CoV-2. The method comprises the step of administering to a subject infected with a coronavirus an amount of a MASP-2 inhibitor effective to inhibit MASP-2 dependent complement activation. In one embodiment, the MASP-2 inhibitor is a MASP-2 monoclonal antibody or fragment thereof that specifically binds to a portion of SEQ ID NO: 6. In one embodiment, the MASP-2 inhibitor is a small molecule MASP-2 inhibitory compound. In one embodiment, the subject is a human subject suffering from COVID-19 induced acute respiratory distress syndrome (ARDS), and supplementation of oxygen is required prior to treatment, and the MASP-2 inhibitor is administered in an amount sufficient to discontinue the need for supplementation of oxygen.

The present invention relates to pharmaceutical compositions for inhalation comprising a therapeutically effective dose of clofazimine wherein the clofazimine is provided in the form of a suspension, and processes for their preparation. Furthermore, the present invention provides pharmaceutical combinations comprising clofazimine in the form of an aerosol for pulmonary inhalation. The combinations and compositions provided by the present invention may be used in the treatment and / or prophylaxis of pulmonary infections caused by mycobacteria and other gram-positive bacteria, and of pulmonary fungal infections.

The utility model discloses an auxiliary device for an artificial airway, which can be used for connecting the artificial airway with a connecting pipeline of external equipment, and comprises a cylinder body and a first connecting piece, a gas flow channel is formed in the cylinder body, and the first connecting piece is arranged at the gas inlet end of the gas flow channel and is used for being detachably connected with the external equipment. The second connecting piece is arranged at the gas outlet end of the gas flow channel and used for being detachably connected with the artificial airway, a heating coating is annularly arranged on the pipe wall in the circumferential direction of the pipe wall, the heating coating is provided with a power supply interface electrically connected with an external power source, and the heating coating is used for heating gas flowing through the gas flow channel. According to the auxiliary device, air in the air flow channel can be uniformly heated, so that air at the temperature suitable for the human body is discharged into the artificial airway from the second connecting piece, discomfort of a patient is avoided, the risk of pulmonary infection of the patient is reduced, the heating coating does not hinder circulation of the air in the air flow channel, and the ventilation efficiency is improved.