37 results about "Bone Infection" patented technology

Cationic steroidal antimicrobials (“CSAs” or “ceragenins”) and methods of making and using the same. Particularly advantageous uses include treating infections in patient and sub-patient populations, especially those having a bone disease, a broken bone, a bone infection, or a bone implant.

A method for local therapies using heat generating implants comprising magnetic or magnetizable features or objects distributed in a solidified moldable matrix to treat bone infection or loosening of implants by the mechanism of hyperthermia or thermoablation.

The present invention relates to a bioactive glass having the composition of SiO2 44-65 wt-% of the final total weight, Na2O 5-26 wt-% of the final total weight, CaO 10-25 wt-% of the final total weight, K2O 0-1 5 wt-% of the final total weight, MgO 0-6 wt-% of the final total weight, B2O3 0-4 wt-% of the final total weight, and P2O5 0-7 wt-% of the final total weight, for use in the long- and short-term prevention and / or treatment of conditions relating to or caused by bone infections, provided that the total amount of Na2O and K2O is 10-30 wt-% of the final total weight, and that any source of oxygen capable of releasing oxygen in the form of molecular oxygen or reactive oxygen species, is absent.

Poly(ester-anhydrides) or polyesters formed from ricinoleic acid and natural fatty diacids and their method of preparation and its use for delivering bioactive agents including small drug molecules, peptides and proteins, DNA and DNA complexes with cationic lipids or polymers or nano and microparticles loaded with bioactive agents are disclosed herein. The drug delivery compositions are administered to a patient in a liquid form, increase in viscosity in vivo to form a drug depot or implant, and are able to release the incorporated bioactive agent for weeks. In the preferred embodiment, the drug delivery formulations are administered by injection. In one embodiment, the compositions are suitable for local or regional delivery of drugs to diseased sites, such as treating solid tumors and bone infections. In a preferred embodiment, the drug delivery compositions are suitable for site-specific chemotherapy for the treatment of solid tumors including: squamous cell carcinoma (SCC) of the head and neck, prostate cancer, and sarcomas for intratumoral injection or insertion.

The invention discloses a 3D printed Ti-PDA-PLGA microsphere bone defect repair stent. A 3D printed Ti stent is prepared by a laser sintering technology. Then, under certain conditions, dopamine is self-polymerized on the fiber surface of the 3D printed Ti stent to form a PDA coating, thereby preparing a 3D printed Ti-PDA stent; then PLGA microspheres carrying VEGF are prepared by a double emulsion-solvent evaporation method, and finally, BMP-2 and PLGA microspheres carrying VEGF are adsorbed and immobilized on the surface of the stent by an adsorption method, and finally the 3D printed Ti-PDA-PLGA microsphere bone defect repair stent is formed. The bone defect repair tissue engineering stent disclosed by the invention has the advantages of reliable mechanical property, high biological activity and safety, convenient implantation, small trauma and low cost, and can be used for the repair treatment of bone defect after bone traumas, bone tumors and bone infection.

The invention relates to a construction method of medical titanium alloy implant surface antibiotics slow release system. At first, titanium beads or titanium is mixed with an additive, and then the mixture is coated on the surface of prosthesis and titanium beads are sintered together by sintering, and at the same time, the titanium beads are sintered with the prosthesis; after being washed by ultrasound, the matter is immerged into the hydrogen peroxide solution, and then after being washed by the acetone solution, the matter is put into the carbonyldiimidazole acetone solution, and then after being washed by acetone solution, the matter is put into the sodium bicarbonate solution with dissolved RGD, then is washed by PBS after being taken out. Drugs curing and preventing bone infection and gelatin are combined into drug-loaded microspheres, then the drug-loaded microspheres are combined with the micro-porous layer on the surface of the prosthesis by protein cross-linker, thus obtaining the medical titanium alloy implant surface antibiotics slow release system. The medical titanium alloy implant surface antibiotics slow release system of the invention improves the physical absorption on metal surface and the chemical bond binding capacity, and stable combination strength between the low release microspheres and the implant can be obtained along with the function of the protein cross-linker.

A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment of bone infection occurring after operations for total arthroplasty and / or bone fracture. (1) A medical composition for treatment of bone infection comprising an antibiotic and a polysaccharide.

A biodegradable composition containing an antibiotic or a physiologically active substance for use in surgical treatment of infection. A highly safe and biocompatible composition showing appropriately sustained release of an antibiotic or physiologically active substance which produces excellent antibiotic and bone regenerating effects. A composition having excellent effects in treatment of bone infection occurring after operations for total arthroplasty and / or bone fracture. (1) A medical composition for treatment of bone infection comprising an antibiotic and a polysaccharide.

The invention especially relates to a kidney-tonifying bone-invigorating traditional Chinese medicine extract-antibiotic-calcium sulfate sustained-release system and a preparation method and application thereof, which belongs to the technical field of an implantable sustained-release administration system. The sustained-release system comprises, by mass, 0.1 to 1.0 part of a kidney-tonifying bone-invigorating traditional Chinese medicine extract, 0.1 to 2.0 parts of an antibiotic and 5 to 20 parts of a calcium sulfate carrier. The invention has the following beneficial effects: a drug effect lasts for a long time; effect-enhancing and toxicity-reducing functions are achieved through combination of Chinese traditional and Western medicine; healing of bone infection diseases is effectively promoted, complications are reduced, and a cure rate is improved.

The present invention provides a bone infection preventing and treating composite bone cement, which comprises, by mass, 0.5-70 wt% of magnesium-based metal particles, 10-95 wt% of a calcium phosphate bone cement matrix, and 1-60 wt% of a curing liquid. According to the bone infection preventing and treating composite bone cement of the present invention, the calcium phosphate bone cement matrix of the composite magnesium-based metal particles is adopted to replace the commonly used antibiotic-loaded calcium phosphate bone cement matrix so as to be used for bone defect filling and infection prevention, chronic osteomyelitis treatment and osteoporosis vertebral body enhancing, and the antibacterial capability is far higher than the antibacterial capability of the traditional bone cement and achieves the antibacterial capability similar to the antibacterial capability of the antibiotic bone cement while the generation of the antibiotic resistance is avoided; the bone infection preventing and treating composite bone cement can be used for patients with antibiotic resistance so as to provide great clinical application values; and after the magnesium-based metal in the composite bone cement of the present invention is degraded, the degradation product can promote the bone density of the surrounding bone to be increased.

A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and / or mineralized bone matrix (MBM) and optionally comprising bone morphogenetic protein / s (BMP) and / or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint and / or a cranio-facial maxillary bone, for restoring and / or enhancing the formation of a new hyaline cartilage and subchondral bone structure. The composition of the invention and method of treatment employing the same may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, malignant bone or cartilage disorders, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease. The composition and method may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including artificial implants. The method of the invention may further be used for treating damaged joints or degenerative arthropathy associated with malformation and / or dysfunction of cartilage and / or subchondral bone. A kit is provided for performing transplantation into a joint or a cranio-facial-maxillary bone of a mammal of the composition of the invention.

The present invention provides a bone infection preventing and treating composite bone cement, which comprises, by mass, 0.5-70 wt% of magnesium-based metal particles, 10-95 wt% of a calcium phosphate bone cement matrix, and 1-60 wt% of a curing liquid. According to the bone infection preventing and treating composite bone cement of the present invention, the calcium phosphate bone cement matrix of the composite magnesium-based metal particles is adopted to replace the commonly used antibiotic-loaded calcium phosphate bone cement matrix so as to be used for bone defect filling and infection prevention, chronic osteomyelitis treatment and osteoporosis vertebral body enhancing, and the antibacterial capability is far higher than the antibacterial capability of the traditional bone cement and achieves the antibacterial capability similar to the antibacterial capability of the antibiotic bone cement while the generation of the antibiotic resistance is avoided; the bone infection preventing and treating composite bone cement can be used for patients with antibiotic resistance so as to provide great clinical application values; and after the magnesium-based metal in the composite bone cement of the present invention is degraded, the degradation product can promote the bone density of the surrounding bone to be increased.

The invention discloses a gallium-contained polycaprolactone / bioglass porous bone repair 3D printing support and the application thereof in infectious bone defect repair. Gallium has the good antibacterial property, and can inhibit bone damage differentiation as well, so that gallium can effectively inhibit osteolysis which might exist in bone infection. Bioglass has the capability of promoting osteogenic differentiation, and mesoporous bioglass particles have pore channel structures, and thereby being capable of being loaded with ingredients and releasing the ingredients slowly. According tothe gallium-contained polycaprolactone / bioglass porous bone repair 3D printing support and the application thereof in infectious bone defect repair, the antibacterial property and the bone damage inhibition effect of gallium, and the bone differentiation promotion effect of bioglass are combined, a local infection focus is directly removed, and the balance between osteogenesis and bone damage in the bone repair process can be further adjusted; and the functional bone repair support is built by applying the 3D printing technology and utilizing the good biocompatibility and the dynamic supporting action of polycaprolactone, the structure of the support can be flexibly designed according to the features of a damaged part, the size of the support is controllable, and the support has the significant application prospect in bone defect repair.

The invention discloses a 3D printed PCL-PDA-lithium ion bone repair tissue engineering scaffold and a preparation method thereof. The preparation method comprises: preparing a 3D printed PCL scaffoldthrough a melt extrusion molding 3D printing technology so that the dopamine is self-polymerized on the fiber surface of the 3D printed PCL scaffold to form a PDA coating, and loading lithium chloride to the fiber surface of the 3D printed PCL-PDA scaffold through an in-situ reduction method. The scaffold has the advantages of the existing bone repair material, and fully exerts the performances of the 3D printing technology and the scaffold material, so that the scaffold has the advantages of simple and reliable structure, controllable shape and microstructure, reliable mechanical property, controllable ion release performance, convenient implant, small trauma and low cost and can be used for the repair of bone defects after bone trauma, bone tumor and bone infection.

The invention relates to the technical field of medical supply manufacturing tools, and relates to an antibiotic bone cement prefabricated mesh plate, an antibiotic bone cement steel plate and a manufacturing frame of the steel plate. The antibiotic bone cement prefabricated mesh plate comprises a mesh plate body, the mesh plate body is in a strip shape, and the mesh plate body comprises a plurality of mesh layers which are stacked and distributed from top to bottom. The antibiotic bone cement steel plate comprises an antibiotic bone cement plate body and the antibiotic bone cement prefabricated mesh plate. The manufacturing frame comprises a base, a pressing plate, a gasket, a limiting screw, a suspension cross beam, a connecting plate and a lifting rod; the base comprises a left verticalplate, a lower transverse plate and a right vertical plate, and the left end and the right end of the lower transverse plate are fixed together with the lower ends of the left and right vertical plates respectively. The antibiotic bone cement steel plate can be manufactured more conveniently, the antibiotic bone cement steel plate can reduce the frequency of debridement of infected bones and softtissue treatment, the length of stay and time in bed can be shortened for patients, and the situation that due to local bone infection and bone ununion, operations are needed again and accordingly extra medical cost is increased for the patients is avoided.

The present invention relates to an anti-infection ultrasonic responsive bone repair material, a production method thereof and use of a sound-sensitive material in production of the anti-infection ultrasonic responsive bone repair material to prevent infection. The ultrasonic responsive bone repair material is a bone repair material containing the sound-sensitive material, the surface of the bone repair material is covered with the sound-sensitive material, or the sound-sensitive material is added in the process of the production of the bone repair material, so that the sound-sensitive material is contained in the bone repair material, under the effect of ultrasonic wave, the sound-sensitive material on the surface of the bone repair material or in the bone repair material is activated into reactive oxygen species to kill microorganisms and prevent bone infection, the ultrasonic responsive bone repair material can be applied to all clinical bone defect repairs to prevent infection after implantation of the bone repair material, and the effect of bone repair materials in the prior art cannot match the effect of the ultrasonic responsive bone repair material.

The invention discloses a gallium-containing polycaprolactone / bioglass porous bone repair 3D printing scaffold and its application in the repair of infectious bone defects. Gallium has good antibacterial properties, and can also inhibit osteoclast differentiation, effectively inhibiting possible osteolysis in bone infection. Bioglass has the ability to promote osteogenic differentiation, and mesoporous bioglass particles have a pore structure that can load components and release them slowly. The invention combines the antibacterial and osteocracking effects of gallium and the osteogenic differentiation promoting effect of bioglass, directly removes local infection foci and further regulates the balance of osteogenesis and osteoclastion in the process of bone repair. The invention applies 3D printing technology and utilizes the good biocompatibility and mechanical support of polycaprolactone to construct a functional bone repair scaffold whose structure can be flexibly designed according to the characteristics of the defect site and whose size is controllable. has important application prospects.

The invention relates to application of recombinant IFN-lambda1 protein in preparation of a medicine for preventing and treating inflammation-induced bone loss, thereby solving a problem of bone metabolism imbalance caused by overactive osteoclasts triggered by release of a large number of inflammatory factors in a serious inflammatory bone loss state caused by bone infection. The applicant findsthat the recombinant IFN-lambda 1 protein can regulate and control the osteoclast differentiation and fusion process and reduce inflammatory factor release in the osteoclast differentiation process through experimental exploration, thereby solving a problem that osteoclasts are excessively activated in an inflammatory state and thus realizing the effect of protecting inflammatory bone loss.

The invention discloses a drug carrier with bone targeting. The drug carrier comprises beta-cyclodextrin serving as an entrapment drug main body and aspartic acid hexapeptide serving as a target and with bone targeting, wherein the aspartic acid hexapeptide is connected with the beta-cyclodextrin through a flexible chain. The preparation method comprises the following steps: 1) dissolving beta-CDin PBS, performing argon deoxygenation protection for 30 min, dropwise adding the flexible chain into a beta-CD solution, stirring the materials at room temperature for 1 h, dropwise adding a D6 solution into the solution, stirring at room temperature overnight, collecting a product, dialyzing the material for 3 days, and freeze-drying to obtain solid powder. The drug carrier can be used for loading hydrophobic antibacterial small molecular drugs which are difficult to encapsulate, has bone targeting performance, and can be prepared into a bone targeting drug, the drug can increase the hydrophilicity of a hydrophobic antibacterial small molecule drug, the antibacterial property of the hydrophobic antibacterial small molecule drug can be completely provided, and bone diseases such as bone infection and the like can be efficiently and accurately treated.

The invention discloses a bone filling material with a long-acting antibacterial function as well as an application and a preparation method thereof, the bone filling material is composed of degradable porous biological ceramic, polylysine salt and polyaspartate, and the polylysine salt and the polyaspartate are loaded in the porous biological ceramic. According to the invention, degradable polylysine salt and polyaspartate with good biocompatibility and broad-spectrum antibacterial performance are loaded into the degradable porous biological ceramic in an opposite charge solution soaking manner, so that the continuous release of the polylysine salt is realized, and a long-acting antibacterial effect is achieved. Meanwhile, the bone filling material disclosed by the invention has a porousstructure, and lysine, aspartic acid, calcium ions and phosphate ions are controllably degraded and released, so that the bone filling material has very high osteogenesis activity, and can be appliedto fracture or bone defect filling for preventing or preventing postoperative bone infection and bone defect filling caused by bone infection fracture or bone infection.

The invention relates to the technical field of medical treatment, in particular to a one-time surgical implantation bone scaffold for treating bone infection, which comprises a 3D biological ceramic bone scaffold and an antibacterial microsphere layer loaded with rifampicin / moxifloxacin duplex antibiotics and attached to the surface of the 3D biological ceramic bone scaffold through nanoscale corn starch, the antibacterial microsphere layer adopts a composite carrier formed by compounding a nanometer carrier derived from yolk lipid and mesoporous silica, and the particle size of the composite carrier is 100-1000 nanometers. According to the scheme, the bone scaffold which is excellent in mechanical property, capable of inducing bone repair, controllable in degradation and capable of slowly releasing antibiotics to treat infection is constructed, a new method and a new material are provided for clinical treatment of infectious bone defects, the disease course is shortened, and the curative effect is improved.

The invention discloses a preparation method of a cross-linked antibiotic specific demineralized extracellular matrix scaffold, and belongs to the technical field of bone infection treatment. The invention discloses a method for preparing a specific demineralized extracellular matrix scaffold of cross-linked antibiotics. The specific demineralized and decellularized cancellous bone extracellular matrix scaffold (SDECM) is used as a substrate, and the specific demineralized and decellularized cancellous bone extracellular matrix scaffold (SDECM) is used as a substrate, and the antibiotic is electrostatically adsorbed and chemically adsorbed. Cross-linking two forms of composite drug loading, releasing antibiotics through rapid pH response and accompanying material degradation in an acidic environment, anti-infection through antibiotics and promoting repair through SDECM, so as to achieve pH-sensitive drug release in an acidic environment in the early stage of infection Rapid sterilization, sustained sterilization by slow release of drugs in the mid-late physiological environment, and permanent sterilization ability to prevent infection recurrence in the absence of infection provide new ideas and tools for the antibacterial and repairing treatment of bone infections.

Provided herein is a novel method for creating fixed, non-antagonistic molar ratios of drugs in and around the bone environment for desired periods of time. This method enables treating bone and bone-related disease by administering a pharmaceutical composition comprising a bone-targeted therapeutic agent able to release a drug payload from the bone surface, in addition to a second therapeutic agent. Such methods are useful in the treatment of bone and bone-related diseases, such as cancer-induced bone disease, osteomyelitis and bone infection, bone pain and inflammatory bone disease, metabolic disease, as well as others.

The invention discloses a bone substitute material, which comprises the following components in parts by weight: 1 part of ginsenoside sodium alginate microspheres and 90-110 parts of strontium-doped calcium sulfate hemihydrate loaded with silver nanoparticles; the ginsenoside alginate In the sodium microspheres, the mass ratio of ginsenoside to sodium alginate is: ginsenoside: sodium alginate = 1:4000-12000. The invention loads ginsenosides into the natural polymer alginic acid microspheres, which can promote the proliferation, migration and osteogenic differentiation of human bone marrow stromal cells. At the same time, sodium alginate microspheres are introduced into calcium sulfate hemihydrate containing strontium, which improves The strontium calcium sulfate hemihydrate material has the problems of high brittleness and sudden release. The prepared bone substitute material is a composite artificial bone material with certain mechanical properties and drug sustained release; nano-silver is added to the bone repair material, which can reduce the Risk of inflammation due to bone infection from surgery or trauma.

The invention discloses a pure natural extracting solution for eliminating lymphadenopathy caused by skin pustule sore bone, and belongs to the field of traditional Chinese medicine. The invention provides a method for relieving pain in inflammatory part and for eliminating lymphadenopathy, in order to solve the problems that patients suffer great pain from lymphadenopathy caused by skin pustule sore bone, and the patients bear unnecessary pain caused by intravenous drip, medication and like methods which are difficult to cure, long in duration and slow to take effect in treating the skin pustule sore bone; the method comprises the following steps: picking fresh peach leaves; cleaning, sterilizing & disinfecting, chopping, grinding and soaking the peach leaves; then, mixing the processed peach leaves with natural maple pulp; filtering, separating, extracting, disinfecting & sterilizing, etc. so as to obtain the extracting solution. The pure natural extracting solution disclosed by the invention has the beneficial effects that the extracting solution is capable of promoting the absorption of lymph skin surface to medicines and accelerating blood circulation inside lymph, and the extracting solution has the characteristics of short treatment course, obvious curative effect, high cure rate and the like; and the extracting solution, which is made from pure natural medicines, is free from side effect.

The invention discloses a liniment for treating deep bedsores combined with a bone infection and a preparation method of the liniment, and belongs to the field of traditional Chinese medicines. The liniment is prepared from 1-50% of clear paste, 1-25% of polyvinyl alcohol (17-88), 1-10% of methylcellulose, 1-30% of hydroxypropyl methyl cellulose, 0.1-3% of phthalic acid dibutyl ester, 1-10% of chitosan, 1-10% of glycerin, 1-10% of laurocapram and the balance water. The clear paste is prepared from leaves of purpleflower holly, astragalus membranaceus, sweetgum roots, creeping mallotus root leaves, cinnamon, garden balsam stems, ligusticum wallichii, pteris dispar, maguey, serissa japonica, drymaria cordata, rhizoma decumbentis and liquorice. According to the liniment, beginning from multiple target spots, the regeneration instinct of a body is sufficiently maintained and mobilized, the tissue regeneration environment is improved, the body immunity is improved, and the effect of treating deep bedsores combined with the bone infection is remarkable.

The invention belongs to the technical field of medicaments and particularly relates to a biological enzyme-carrying calcium phosphate bone cement with a controlled release effect and a preparation method thereof. The preparation disclosed by the invention comprises the following components in percentage by weight: 25 to 90 percent of calcium phosphate bone cement substrate, 0.001 to 50 percent of biological enzyme composite and 5 to 50 percent of curing liquid. When the biological enzyme-carrying calcium phosphate bone cement preparation is implanted, the biological enzyme with an antibacterial effect is released suddenly and then is stably released, so the biological enzyme-carrying calcium phosphate bone cement has the effect of filling and repairing bone defect as well as the effects of preventing and treating bacterial infection, and can be used for treating chronic osteomyelitis, preventing implanted part infection and preventing relapse after a bone tumor is removed.

The invention relates to the application of recombinant IFN-λ1 protein in the preparation of medicines for preventing and treating inflammatory bone loss. In order to solve the problem of bone metabolism imbalance caused by excessive activation of osteoclasts triggered by the release of a large number of inflammatory factors in the state of severe inflammatory bone loss caused by bone infection, the applicant found through experiments that recombinant IFN‑λ1 protein can regulate The process of osteoclast differentiation and fusion reduces the release of inflammatory factors in the process of osteoclast differentiation to solve the problem of excessive activation of osteoclasts in an inflammatory state and achieve the effect of protecting inflammatory bone loss.

The invention discloses a staphylococcus aureus New Zealand white rabbit bone infection animal model construction method. The method comprises the following steps: a, selecting a New Zealand white rabbit; b, selecting a titanium alloy screw, and pretreating the titanium alloy screw; c, a longitudinal incision with the length of 1 cm is formed in the position, 2 cm away from the inner side below the left knee joint, of the New Zealand white rabbit, and bone cortex is cut open layer by layer; d, a drill bit with the diameter being 2 mm is selected, a hole is formed in the bone cortex, the titanium alloy screw polluted by the staphylococcus aureus is implanted into the bone tunnel, incisions are sutured layer by layer, and sterile binding is conducted; e, CT iconography data are obtained, and the conditions of bone destruction, soft tissue swelling and the like around the titanium alloy screw are observed; and f, taking out the screw, carrying out scanning electron microscope detection, and carrying out histopathologic staining. The method is simple, effective, convenient to operate and short in modeling time, can serve as a perfect and feasible bone infection biological model, and can provide an experimental basis for exploration of clinical bone infection pathogenesis, bone infection treatment ways and evaluation of the effect and safety of new drug development.

Provided herein is a novel method for creating fixed, non-antagonistic molar ratios of drugs in and around the bone environment for desired periods of time. This method enables treating bone and bone-related disease by administering a pharmaceutical composition comprising a bone-targeted therapeutic agent able to release a drug payload from the bone surface, in addition to a second therapeutic agent. Such methods are useful in the treatment of bone and bone-related diseases, such as cancer-induced bone disease, osteomyelitis and bone infection, bone pain and inflammatory bone disease, metabolic disease, as well as others.