Preparation method and application of a core-shell composite flexible biomaterial

By using a shell-core composite flexible biomaterial, combined with a PMMA electrospun layer and PEG hydrogel, the problems of insufficient induction of film formation and osteogenic formation in traditional bone cement have been solved, achieving better tissue repair and angiogenesis, and meeting clinical needs.

CN122297794APending Publication Date: 2026-06-30XIANGYANG CENT HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XIANGYANG CENT HOSPITAL
Filing Date
2026-04-03
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Traditional bone cement has limitations in inducing membrane formation and bone formation, and may cause problems such as thermal burns, difficulty in shaping, and pain during exercise during use.

Method used

A shell-core composite flexible biomaterial, consisting of a PMMA electrospun layer, an intermediate PTFF or PE layer, and a core PEG hydrogel, is used to form a porous structure through electrospun technology. This is combined with a mechanical wave stimulation component to modulate the in vivo immune microenvironment.

Benefits of technology

It improves the ability to induce membrane formation and osteogenic formation, reduces the risk of thermal burns, enhances the plasticity and adaptability of materials, promotes tissue repair and angiogenesis, and provides better treatment results.

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Abstract

This invention discloses a method for preparing and applying a shell-core composite flexible biomaterial. The flexible biomaterial consists of an outer PMMA electrospun layer, a middle PTFF or PE layer, and a core PEG hydrogel; both the PMMA electrospun layer and the middle layer are porous. This flexible material is soft and elastic, exhibiting good film-forming and osteogenic induction effects. Animal experiments have confirmed that, compared to traditional bone cement, the flexible composite bone cement-induced biofilm shows an increase in CD31-positive cells (representing angiogenesis) and M2 macrophages (representing tissue repair), exhibiting better film-forming properties. It is a promising composite biomaterial that can be widely applied in the treatment of soft tissue defects, bone defects, and bone infections, achieving better therapeutic effects.
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