Tissue repair filler based on adipose-derived stem cells as well as preparation method and application thereof

By combining autologous fat with cerium dioxide nanozymes to arm adipose-derived stem cells, and combining hyaluronic acid microspheres loaded with zinc and magnesium ions with a sodium carboxymethyl cellulose hydrogel matrix, the problems of autologous tissue defects and poor biocompatibility in existing soft tissue repair methods are solved, achieving efficient and safe facial soft tissue repair results.

CN122163911APending Publication Date: 2026-06-09SHANGHAI LUYI CELL BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202610514151.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-17
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing soft tissue repair methods suffer from problems such as autologous tissue defects, poor biocompatibility, unsatisfactory transplantation results, and insufficient long-term stability. In particular, in the repair of facial soft tissue defects, existing fillers have problems such as low compressive strength, rapid absorption, poor shaping properties, and insufficient safety.

Method used

A tissue repair filler based on adipose-derived stem cells was prepared by combining autologous fat with cerium dioxide nanozymes to arm adipose-derived stem cells, and mixing hyaluronic acid microspheres loaded with zinc and magnesium ions with a sodium carboxymethyl cellulose hydrogel matrix. By controlling the microsphere particle size and material combination, the anti-inflammatory, antioxidant and mechanical properties of the filler were improved.

Benefits of technology

It improves the survival rate of fat particles, reduces infection complications, provides good biocompatibility and mechanical properties, ensures long-term stable filling effect, and reduces inflammatory response and tissue absorption. It has good adaptability and high safety.

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Abstract

The invention provides a tissue repair filler based on adipose-derived stem cells as well as a preparation method and application thereof, and belongs to the technical field of tissue repair. Uniformly mixing the autologous adipose tissue with the cerium dioxide nano-enzyme armed adipose-derived stem cells to obtain a mixed stem cell / adipose system; the hyaluronic acid microspheres loaded with the zinc ions and the magnesium ions are added into a sodium carboxymethyl cellulose hydrogel matrix, the mixed stem cell / fat system is added, uniform mixing and standing defoaming are conducted, and the tissue repair filler based on the adipose-derived stem cells is prepared and has the good anti-inflammatory, anti-oxidation and microenvironment improving effects, the rejection reaction is small, the self-adaptability is good, and the tissue repair filler can be used for repairing the adipose-derived stem cells. The safety is high, and the proper mechanical property is achieved.
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