5 results about "Bdellovibrio" patented technology

The present application provides a composite sonosensitizer and its bacterial target delivery system BPT-ICG@Bd capable of treating pseudomonas aeruginosa biofilm related infection, wherein the composite sonosensitizer (BPT-ICG) is composed of inorganic sonosensitizer (BPT) and organic sonosensitizer (ICG), Bd is natural gram-negative bacteria predator Bdellovibrio, the composite sonosensitizer (BPT-ICG) is modified to the surface of Bdellovibrio (Bd) by polydopamine to form BPT-ICG@Bd. The high-speed movement characteristics of Bdellovibrio predator gram-negative bacteria are used to destroy the biofilm structure, invade bacteria, and at the same time, the composite sonosensitizer is triggered to produce a large amount of active oxygen by applying ultrasound, so as to quickly remove the biofilm and bacteria, and be used for biofilm related lung infection and bone infection.

The application discloses a Bdellovibrio strain, named sp.HCB242, which is preserved in the China Center for Type Culture Collection and has a preservation number of CCTCC NO:M 20232314. Bdellovibrio The HCB242 strain is a new species of the Bdellovibrio genus, has the excellent characteristics of a wide predation spectrum and a strong adaptability to a soil environment, can stably maintain growth in the natural environment of the soil, and thus can maintain the phagocytosis ability. The strain has a very high predation capacity on Pseudomonas solanacearum, and has the potential for preventing and controlling crop diseases such as tomato bacterial wilt.

This invention discloses a *Bdellovibrio* strain and its application in the treatment of *Salmonella lysate*, belonging to the field of microbial technology. The strain, with accession number CCTCC NO:M 20232311, has been identified as a new species of the genus *Bdellovibrio* through multiphasic classification, including 16S rRNA gene analysis, average nucleotide similarity, digital DNA-DNA hybridization, and trapping diet. This invention also discloses a biocontrol agent containing this *Bdellovibrio* and its application in the treatment of *Salmonella lysate*. The *Bdellovibrio* strain HCB006 provided by this invention exhibits high lysis efficiency and strong environmental adaptability, and can be used as an antibiotic alternative for the biocontrol of *Salmonella* in food processing, aquaculture environments, and medical fields. It is of great significance for preventing the spread of dangerous pathogens and improving food health.

The invention relates to the field of microbial technology and biological prevention and control of aquaculture diseases, in particular to halophilic bdellovibrio and application thereof.A preservation number of the halophilic bdellovibrio is GDMCC No.67013. The strain has a typical bdellovibrio form, the optimum growth salinity is 20-30% o, the growth temperature range is 4-40 DEG C, and the halophilic bdellovibrio can be used for preparing the halophilic bdellovibrio. The invention further discloses a high-density fermentation method of the strain, a microbial agent prepared from the strain and application of the strain or the microbial agent to prevention and control of bacterial diseases caused by the two types of pathogenic bacteria in mariculture. The invention has the outstanding advantages of double effect, broad spectrum and high adaptability, provides a brand new and efficient biological solution for green prevention and control of mariculture diseases, and has wide application prospects.