4 results about "Triamcinolone acetonide" patented technology

A triamcinolone acetonide pharmaceutical composition and a preparation method therefor. The pharmaceutical composition contains the following ingredients: (i) a triamcinolone acetonide active ingredient, (ii) hyaluronic acid or a salt thereof. (iii) a buffering agent; and (iv) a tonicity adjustment agent. The pharmaceutical composition has a suitable viscosity, osmotic pressure and particle size range and is easily injected, especially administrated by means of a suprachoroidal space injection.

The invention relates to topical ophthalmic formulations of triamcinolone acetonide-loaded liposomes for the prevention of macular thickening and its associated visual outcomes following lens surgery. The liposome formulation comprises thermodynamically self-forming liposomes that are useful topically for treating diseases of the posterior segment of the eye.

The present invention relates to the technical field of organic synthesis. Disclosed is a crystal-form-controllable triamcinolone acetonide preparation method. Triamcinolone acetonide has two crystal forms, i.e. crystal form 1 and crystal form 2, respectively. The method comprises: for crystal form 1, adding ethanol to a crude product of triamcinolone acetonide for dissolution under reflux, cooling and stirring the mixture for crystallization, and performing filtering to obtain a wet product of triamcinolone acetonide; adding ethanol for dissolution under reflux, adding water to a reflux solution and controlling the temperature of the system to be 70-80ºC; and after the addition of water is complete, cooling and stirring for crystallization to obtain single crystal form 1 of triamcinolone acetonide having a low organic solvent content; and for crystal form 2, adding ethanol to a crude product of triamcinolone acetonide for dissolution under reflux, cooling and stirring the mixture for crystallization, and performing filtering to obtain a wet product of triamcinolone acetonide; adding ethanol for dissolution under reflux, cooling and stirring the mixture for crystallization to obtain single crystal form 2 of triamcinolone acetonide having a low organic solvent content. The triamcinolone acetonide preparation method of the present invention achieves crystal form controllability, high purity, and low solvent residual amount, and can prepare a product of a single crystal form according to requirements, with strong controllability, easy method production, and high process stability.

The application provides a drug-loaded substrate, which is modified with a coating layer containing chitosan and triamcinolone acetonide. The combination of triamcinolone acetonide and chitosan in the drug-loaded substrate of the application can significantly promote the healing of the epithelial mucosa of the urinary tract and digestive tract and inhibit scar formation while inhibiting bacteria, and is a good material for preparing medical devices such as catheters.