Anti-scar drug film and its preparing method

A drug film and scar technology, which is applied in the field of anti-scar drug film and its preparation, can solve the problems of obvious hormone side effects, uneven drug diffusion, and slight curative effect, and achieve the advantages of simple and easy preparation method, convenient use, and uniform drug dispersion Effect

Inactive Publication Date: 2006-02-08
THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, in the clinical non-surgical treatment of scars, steroid hormone drugs, especially triamcinolone acetonide acetate, are recognized as a drug with definite curative effect. They are often used for local injection of scars, but there are the following deficiencies: ① Pain; ② After local injection, the drug ③The current drug dose and usage method are not easy to control, long-term use, and the systemic side effects of hormones are obvious; ④Intra-scar injection is only suitable for small-scale injection, and the expansion of the injection area will be limited by a single dose
In clinical practice, the application of silicone gel film can also help reduce the occurrence of scars, but the effect is minimal

Method used

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  • Anti-scar drug film and its preparing method
  • Anti-scar drug film and its preparing method
  • Anti-scar drug film and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of silicone rubber film layer: according to the two-component addition type room temperature vulcanization silicone rubber raw material M component and N component amount batching listed in Example 1 of the above table, mix, and then add petroleum ether with a weight ratio of 10% to fully Stir for 20 minutes, stir and mix and exhaust with a vacuum pump for 20 minutes. The raw materials after exhaust are poured into a mold with the size listed in Example 1 to form a film, and placed for 20 minutes until the petroleum ether volatilizes completely. The obtained silicone rubber film The layer thickness is 0.5 mm;

[0028] Preparation of the silicone gel film layer: according to the amount of the original powder of triamcinolone acetonide acetate listed in Example 1 of the above table, add silicone oil ingredients with a weight ratio of 10%, stir evenly, and then add two-component addition type room temperature vulcanized silicon Gel raw material M component: N c...

Embodiment 2

[0031] Preparation of silicone rubber film layer: according to the two-component addition type room temperature vulcanization silicone rubber raw material M component and the amount of N component listed in Example 2 of the above table, mix, and then add petroleum ether with a weight ratio of 15% to fully Stir for 25 minutes, after stirring and mixing, use a vacuum pump to exhaust air for 30 minutes, pour the exhausted raw materials into a mold of the size listed in Example 2 to form a film, and place it for 30 minutes until the petroleum ether volatilizes completely. The thickness of the silicone rubber film layer is 1mm;

[0032] Preparation of the silicone gel film layer: according to the amount of triamcinolone acetonide acetate raw powder listed in Example 2 of the above table and then add the low molecular weight silicone oil ingredients with a weight ratio of 5%, stir evenly, and then add the two-component addition molding at room temperature Components M and N of the v...

Embodiment 3

[0035] Preparation of silicone rubber film layer: according to the two-component addition type room temperature vulcanization silicone rubber raw material M component and the amount of N component listed in Example 3 of the above table, mix, then add petroleum ether with a weight ratio of 20% to fully Stir for 30 minutes, after stirring and mixing, use a vacuum pump to exhaust air for 40 minutes, pour the exhausted raw materials into a mold with the dimensions listed in Example 3 to form a film, and place it for 40 minutes until the petroleum ether volatilizes completely. The thickness of the silicone rubber film layer is 1.5mm;

[0036] Preparation of silicone gel film layer: according to the amount of triamcinolone acetonide acetate raw powder listed in Example 3 of the above table, add silicone oil ingredients with a weight ratio of 20%, stir evenly, and then add two-component addition type room temperature vulcanized silicon Gel raw materials M component and N component ar...

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PUM

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Abstract

The invention provides a cicatrix-resisting membrane comprising a medicinal membrane, wherein the medicinal membrane is a silicon gel film containing medicament of triamcinolone acetonide acetate and silica oil. The invention also discloses the process for preparing the membrane.

Description

technical field [0001] The invention relates to an anti-scar drug film and a preparation method thereof. Background technique [0002] Scar is an inevitable product in the process of wound healing. Scar hyperplasia is a pathological phenomenon of excessive tissue repair after skin injury. Because the hypertrophic scar is higher than the skin surface, itching, tingling, pigmentation and contracture, it often seriously affects the appearance and function of the patient. Its prevention and treatment have always been It is an urgent problem to be solved in the medical field. [0003] In the current clinical non-surgical treatment of scars, steroid hormone drugs, especially triamcinolone acetonide acetate, are recognized as a drug with definite curative effect. They are often used for local injection of scars, but there are the following deficiencies: ① Pain; ② After local injection, the drug ③The current drug dosage and usage method are not easy to control, long-term use, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K31/80A61K9/70A61P17/02
Inventor 樊东力雷泽源
Owner THE SECOND AFFILIATED HOSPITAL ARMY MEDICAL UNIV
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