Unlock instant, AI-driven research and patent intelligence for your innovation.
Refining process of triamcinolone acetonide raw medicine
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A raw material drug and process technology, applied in the technical field of triamcinolone acetonide raw material drug refining, to achieve the effect of high content, high yield and stable quality
Active Publication Date: 2009-01-21
天津太平洋化学制药有限公司
View PDF0 Cites 5 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
It can completely solve the quality problems in the existing process and make the product fully meet the latest requirements of the Chinese Pharmacopoeia, which cannot be achieved by various previous methods
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0018] Embodiment 1: a kind of process of triamcinolone acetonidecrude drug refining, adopts mixed organic solvent recrystallization to refine, and it comprises the following steps:
[0019] 1), at 30°C, put 30kg of triamcinolone acetonide crude product into 300kg of chloroform and 300kg of methanol mixed solvent, heat to reflux at 60°C, stir and react for 1.5 hours, after the reaction is completed, cool to below 0°C, shake off and dry to obtain koji Acetonide chloroform-methanol primary refinement 28.5kg, content 95.1%;
[0020] 2), at 20°C, repeat step 1) with 28.5kg of the primary refined product, put it into 285kg of chloroform and 285kg of methanol mixed solvent, heat to 70°C and reflux, stir and react for 2 hours, after the reaction is completed, cool, filter, and dry to obtain Triamcinolone acetonide chloroform-methanol secondary refinement 27.1kg, content 96.2%;
[0021] 3), at 50°C, put 27.1kg of triamcinolone acetonide chloroform-methanol secondary refined product ...
Embodiment 2
[0022] Embodiment 2: a kind of process of triamcinolone acetonide crude drug refining, adopts mixed organic solvent recrystallization to refine, and it comprises the following steps:
[0023] 1), at 30°C, put 30kg of crude triamcinolone acetonide into 700kg of chloroform and 100kg of methanol mixed solvent, heat to reflux at 56°C, stir and react for 1.5 hours. Acetonide chloroform-methanol primary refinement 28.8kg, content 95.0%;
[0024] 2), at 20°C, repeat step 1) with 28.8kg of primary refined product, put it into 672kg of chloroform and 96kg of methanol mixed solvent, heat to 56°C and reflux, stir and react for 2 hours, after the reaction is completed, cool, filter, and dry to obtain Triamcinolone acetonide chloroform-methanol secondary refinement 27.7kg, content 96.0%;
[0025] 3), at 50°C, put 27.7kg of triamcinolone acetonide chloroform-methanol secondary refinement into 1108kg of ethanol with a content of 80%, heat to reflux at 80°C, stir and react for 2.5 hours, aft...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
The invention relates to a technology for refining a raw materialdrug of Triamcinolone. The method comprises the following steps that refining is carried out through recrystallization with a mixed organic solvent, wherein the raw Triamcinolone is added into the mixed solvent of chloroform and carbinol, heated to 50 to 70 DEG C, then a circumfluence under mixing is carried out, and the refined product undergoes the procedures until the content of Triamcinolone exceeds 96 percent, then the refined product undergoes heating circumfluence in ethanol for 2-3 hours, at a temperature of between 70 and 90 DEG C, is cooled down to a temperature below 0 DEG C, filtered by centrifuge, and then dried. The obtained final product is proved completely qualified according to China Pharmacopoeia. The invention can overcome the disadvantages of the prior refining art, and the final product produced by the method has the advantages of stable quality, high content, low impurities, and high yielding rate.
Description
technical field [0001] The invention belongs to a preparation process of medicinetriamcinolone acetonide, in particular to a process for refining triamcinolone acetonide crude drug. Background technique [0002] Triamcinolone acetonide is a glucocorticoid with anti-inflammatory, antipruritic and antiallergic effects. It is an old product that has been used for many years, but recently my country has begun to comprehensively regulate the organic solvent residues of its raw materials according to the Pharmacopoeia standards. [0003] The traditional refining method of triamcinolone acetonide crude drug is to use the crude product of triamcinolone acetonide as a raw material, and refine it with a mixed organic solvent. After the reaction is completed, the reaction solution is cooled, filtered and dried to obtain crystals. But this method can only improve the purity of the triamcinolone acetonidebulk drug, but can not reduce the corresponding organic volatile impurities, whic...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More 
