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Triamcinolone acetonide and miconazole emulsion type gel

A technology of deeconazole emulsion and triamcinolone acetonide, which is applied in the field of medicine, can solve the problems of difficulty of econazole nitrate and triamcinolone acetonide, poor patient compliance, and high viscosity of propylene glycol, and achieves good transparency and drug penetration. Small amount of skin, the effect of promoting absorption

Active Publication Date: 2013-06-12
TAIJI GRP SICHUAN TIANCHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Combining econazole nitrate and triamcinolone acetonide can synergistically improve the curative effect, but econazole nitrate and triamcinolone acetonide are difficult to dissolve. Glue, by adding 80% propylene glycol, but propylene glycol itself is relatively viscous and has certain irritation to the skin, and the addition of a large amount of propylene glycol makes the patient's compliance poor; the publication number is the triamcinolone acetonide econazole emulsifiable cream disclosed in CN101239066A, By adding 8%-12% of liquid paraffin and 18%-22% of emulsifier, its oil content is high, and it feels greasy after being applied to the skin, and the above products all have the problem of poor appearance

Method used

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  • Triamcinolone acetonide and miconazole emulsion type gel
  • Triamcinolone acetonide and miconazole emulsion type gel
  • Triamcinolone acetonide and miconazole emulsion type gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Triamcinolone acetonide econazole emulsion gel, 100g contains the following components: 1g econazole nitrate, 0.1g triamcinolone acetonide, 2g liquid paraffin, 4g polyethylene glycol-7-stearate, caprylic capric acid Polyethylene glycol glyceride 6g, propylene glycol 10g, ethanol 10g, sodium carboxymethylcellulose 2g, tert-butyl p-hydroxyanisole 0.005g, disodium edetate 0.01g, benzoic acid 0.25g, the balance is distilled water.

[0028] The preparation method of triamcinolone acetonide econazole emulsion type gel, concrete steps are as follows:

[0029] (1) Take the prescribed amount of sodium carboxymethyl cellulose, add the prescribed amount of distilled water, stir to form a paste, soak overnight to fully swell, and obtain a hydrophilic gel matrix, which is set aside;

[0030] (2) Dissolve the prescribed amount of polyethylene glycol-7-stearate, macrogol caprylate caprylate and tert-butyl p-hydroxyanisole in liquid paraffin, heat to 65°C, and record as mixing Liquid...

Embodiment 2

[0034] Triamcinolone acetonide econazole emulsion gel, 100g includes the following components: 1g econazole nitrate, 0.1g triamcinolone acetonide, 6.5g liquid paraffin, 5g caprylic capric macrogol glyceride, Tween-80 3g, propylene glycol 12g, polyethylene glycol 400 12g, ethanol 16g, hypromellose 2.5g, tert-butyl-p-hydroxyanisole 0.005g, edetate disodium 0.01g, benzoic acid 0.25g, balance for distilled water.

[0035] The preparation method of triamcinolone acetonide econazole emulsion type gel, concrete steps are as follows:

[0036] (1) Take the formulated amount of hypromellose, add 24g of distilled water, stir to dissolve, soak overnight to fully swell to obtain a hydrophilic gel matrix, and set aside;

[0037] (2) Take the prescribed amount of caprylic capric acid macrogol glyceride and tert-butyl p-hydroxyanisole dissolved in liquid paraffin, heat to 70°C, record it as the mixed solution A, and set aside; the formulated amount of polysorbate Dissolve -80 in the remaini...

Embodiment 3

[0041] Triamcinolone acetonide econazole emulsion gel, 100g contains the following components: econazole nitrate 1g, triamcinolone acetonide 0.1g, stearic acid 1g, lauryl alcohol 1g, caprylic / capric glyceryl 6g, polysorbate Ester-80 5g, fatty acid sorbitan-80 5g, polyethylene glycol 400 10g, ethanol 10g, carbomer 940 1g, tert-butyl p-hydroxyanisole 0.005 g, disodium edetate 0.01 g, benzoic acid 0.25 g, 0.9 g of 75% triethanolamine, and the balance is distilled water.

[0042] The preparation method of triamcinolone acetonide econazole emulsion type gel, concrete steps are as follows:

[0043] (1) Take the formulated amount of Carbomer 940 and disodium edetate, add 24g of distilled water, stir well, soak overnight to fully swell, then add the formulated amount of triethanolamine to adjust the pH to 5.2-5.6 to obtain hydrophilic sex gel base, set aside;

[0044] (2) Dissolve the formulated amount of fatty acid sorbitan-80, tert-butyl p-hydroxyanisole, stearic acid and lauryl a...

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Abstract

The invention discloses triamcinolone acetonide and miconazole emulsion type gel. The gel comprises econazole nitrate and triamcinolone with effective doses, as well as 1 to 9 weight percent of lipophilic phase and 90 to 98 weight percent of hydrophilic phase, wherein the lipophilic phase comprises a lipophilic compound and / or a lipophilic surfactant, and the hydrophilic phase comprises hydrophilic gel matrix, a hydrophilic compound and a hydrophilic surfactant. According to the triamcinolone acetonide and miconazole emulsion type gel prepared by the prescription disclosed by the invention, econazole nitrate and triamcinolone have good in stability and cannot be easily separated out, and the product has a good transparent appearance; due to the low content of lipophilic phase in the product, oily feeling does not exist after the gel is applied to skin; and the hydrophilic gel matrix is contained in the product, so that a transparent film can be formed after the gel is applied to skin, the texture is uniform and smooth, and the gel is easily applied, is not irritant and can be used for increasing the compliance of a patient.

Description

technical field [0001] The invention belongs to the field of medicine and relates to triamcinolone acetonide and econazole emulsion gel. Background technique [0002] Superficial fungal infections mostly occur on the body surface, mainly invading the skin, hair, and nails, etc., causing tinea pedis, tinea corporis, jock itch, tinea imbricate, onychomycosis, tinea capitis, and candidiasis of the skin. It has the characteristics of high morbidity, easy infection, easy recurrence or reinfection, etc., which brings harm and pain to patients no matter in terms of body or appearance. At present, triamcinolone acetonide econazole cream is a commonly used preparation and is widely used in the treatment of skin diseases. Econazole nitrate is a broad-spectrum antifungal drug, the chemical name is 1-[2,4-dichloro-β(4-chlorobenzyloxy)phenethyl]imidazole nitrate, and the molecular formula is C 18 h 15 Cl 3 N 2 O HNO 3 , with a relative molecular mass of 444.70, is white or yellowis...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61K31/4174A61K47/44A61K9/107A61P31/10A61P31/04A61P17/00A61P29/00A61P17/04A61P37/08
Inventor 黄珠成辛龙涛蒋娅肖坤全李静一吉杰标陈晓华
Owner TAIJI GRP SICHUAN TIANCHENG PHARMA
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