54 results about "Econazole Nitrate" patented technology

The nanometer antifungal econazole nitrate emulsion medicine consists of econazole nitrate, surfactant, oil and distilled water. Its preparation process includes the following steps: weighing the materials; mixing the surfactant and oil and dissolving econazole nitrate in dimethyl sulphoxide; mixing the solution of econazole nitrate with the surfactant and oil; and final adding distilled water slowly while stirring to form stable homogeneous transparent nanometer antifungal econazole nitrate emulsion medicine. The medicine is used in treating candidal tinea corporis, tinea cruris and tinea pedis, aural mycosis, seborrheic dermatitis, etc. The medicine is absorbed through skin to enter into blood circulation, and this avoids the first pass effect of liver, prolongs the medicine release and prevents stimulation to gastrointestinal tract. The preparation process is simple and low in power consumption.

The invention discloses a triamcinolone acetonide and econazole nitrate cream which contains econazole nitrate and triamcinolone acetonide. The invention is characterized in that the cream also contains octodecyl alcohol or hexadecanol. The triamcinolone acetonide and econazole nitrate cream is more subtle and even, is easy to be daubed and washed on and away from the skin and is harmless to skin, has no odor. No greasiness is to be felt when the cream is daubed on the skin, and the quality is more stable.

The nanometer antifungal econazole nitrate emulsion medicine consists of econazole nitrate, surfactant, oil and distilled water. Its preparation process includes the following steps: weighing the materials; mixing the surfactant and oil and dissolving econazole nitrate in dimethyl sulphoxide; mixing the solution of econazole nitrate with the surfactant and oil; and final adding distilled water slowly while stirring to form stable homogeneous transparent nanometer antifungal econazole nitrate emulsion medicine. The medicine is used in treating candidal tinea corporis, tinea cruris and tinea pedis, aural mycosis, seborrheic dermatitis, etc. The medicine is absorbed through skin to enter into blood circulation, and this avoids the first pass effect of liver, prolongs the medicine release and prevents stimulation to gastrointestinal tract. The preparation process is simple and low in power consumption.

The invention discloses a compound dimetridazole premix for preventing and treating the poultry enterovirus syndrome. The premix is prepared by uniformly mixing the following components in percentage by weight: 10 to 30 percent of dimetridazole, 4 to 10 percent of neomycin sulfate, 2 to 8 percent of decoquinate econazole nitrate, 10 to 30 percent of lysozyme, 0.5 to 5 percent of etamsylate, 3 to 10 percent of lactic acid TMP and the balance of pharmaceutically applicable auxiliary material. According to the invention, the novel high-efficiency anticoccidial drug decoquinate econazole nitrate, the dimetridazole and the neomycin sulfate which have a special curative effect on intestinal infection, the lysozyme with effects of resisting to bacteria, resisting to viruses, diminishing inflammation, relieving pain and repairing intestinal mucosa, the high-efficiency hemostatics etamsylate and the drug synergist are compounded into a compound preparation; and the compound dimetridazole premix has a high-efficiency treatment effect on the poultry enterovirus syndrome. The compound dimetridazole premix has a reasonable and scientific formula, is simple to prepare, has wide application and can be used as a priority drug for preventing and treating the poultry enterovirus syndrome.

A compound zedoary oil ointment for treating vaginitis, tinear manuum, tinear pedis, ringworm of body and skin infection is prepared through mixing zedoary oil, monoglyceride stearate, stearic acid and vaseline, heating, filtering to obtain liquid, adding econazole nitrate, borneol, sodium laurylsulfate and hydroxyethylester to the mixture of glycerine and water, heating, filtering to obtain liquid, mixing two kinds of liquid together and stirring.

The invention relates to an econazole nitrate microemulsion aerosol and a method for preparing the same. The aerosol is prepared by the materials mainly comprising econazole nitrate, polyethylene glycol 400, polysorbate 80, octane pheno1 polyoxyethylene 10, imidazoline, sodium lauryl sulfate, coconutt diethanol amide, sodium laureth sulfate, dioctyl sulfosuccinate sodium salt, polyoxyethylenated castor oil, purified water, and propane and butane. The method for preparing the aerosol comprises the following steps: dissolving the materials under different conditions; uniformly stirring the solution obtained after dissolution to obtain a primary emulsion; passing the primary emulsion first through a 0.80 mu m of filter membrane, then a nanomachine, and finally a 0.22 mu m of filter membrane; and filling, filling propane-butane projectile and sealing to obtain the finished product of econazole nitrate nanometer microemulsion aerosol.

The invention provides a water-soluble cyclodextrin derivative clathrate of econazole nitrate, a vaginal contraception thermosensitive gelata containing the clathrate and a preparation method of the gelata. According to the invention, water-indissoluble econazole nitrate is clathrated by a water-soluble cyclodextrin derivative to improve the solubility of econazole nitrate in water, so the vaginal thermosensitive gelata is prepared by treating econazole nitrate as a sperm killing active component for an external contraceptive, and the vaginal thermosensitive gelata which is a novel external contraception preparation comprises the water-soluble cyclodextrin derivative clathrate of econazole nitrate, a thermosensitive gel skeletal material and an acidic buffer. The contraception thermosensitive gelata which is a liquid when it is at the outside of a body can be rapidly and uniformly coated on vaginal surfaces, and becomes a semisolid gel when it is in the body to immobilizedly capture sperms until the sperms are killed. The contraception thermosensitive gelata of econazole nitrate has the advantages of use convenience, rapid action, reliability, and good safety. The gelata which is a novel dosage form and has the characteristics of easy preparation and low material cost is in favor of the family planning work in such a world's most populous country China.

The invention belongs to the field of external-use medicine, and provides a spray for treating cutaneous moniliasis. The spray is prepared from econazole nitrate, polysorbate-80, propylene glycol, ethanol, purified water and rose essence. The spray for treating the cutaneous moniliasis has the advantages that the stability of the econazole nitrate as a pharmaceutical active ingredient, as well asthe stability of the pharmaceutical preparation are improved through interaction of the components; the transdermal absorption is fast, and the antibacterial effect is good; the spray is convenient toprepare and use, and low in cost, thereby being an effective fungicide.

The invention discloses a method for synthesizing econazole nitrate by using a one-pot method, and belongs to the technical field of synthesis methods of econazole nitrate. The method comprises: carrying out an N-alkylation reaction under the actions of K2CO3 / KOH / Al2O3 and PEG-200 by using 1-(2,4-dichlorophenyl)-2-chloro-ethanol and imidazole as raw materials to obtain toluene-containing imidazoleethanol; and carrying out an O-alkylation reaction on the toluene-containing imidazole ethanol and p-chlorobenzyl chloride under the actions of K2CO3 / KOH / Al2O3 and PEG-200 to obtain econazole nitrate. According to the method of the invention, the intermediate imidazole ethanol is directly subjected to the O-alkylation reaction without water washing to achieve nearly neutral state, re-crystallization and drying, so that the environmental pollution caused by drying is reduced, the imidazole ethanol dissolving process is shortened, the reaction efficiency is improved, and the solvent recovery frequency is reduced; and after the O-alkylation reaction is finished, the impurity removal is performed before the acidification, so that the high product viscosity caused by many impurities is greatlyreduced, the solid-liquid separation is easy to realize, the one-pot production is realized, the cost is low, the operation is simple and convenient, and the method is suitable for industrial popularization.

The invention discloses a compound zedoary-turmeric-oil foam agent and the preparation method. The invention is characterized in that econazole nitrate, zedoary-turmeric oil and so on which serve as raw material and excipient are poured together into a container, then a foam-emulsion pump (or called foam pump or manual foam-generating device) is covered in a twisted way to generate foam by manually pressing the emulsion pump. The preparation method includes the following steps: first take econazole nitrate and zedoary-turmeric oil to mix evenly with polysorbate-80; add propanediol, water of proper amount for dissolution; then add polysorbate-80, lauryl sodium sulfate, propanediol, glycerin and so on, and mix evenly; add distilled water to total amount and mix evenly to adjust pH value; pour into the container and cover with the foam-emulsion pump (or called foam pump or manual foam-generating device) in a twisted way. Then the foam can be generated by manually pressing the emulsion pump. Generating foam by using medicine, emulsifier and a foam-emulsion pump and by pressing the foam-emulsion pump manually can save the cost, eliminate the environmental pollution caused by adding propellant and reduce the explosion probability of pressure vessels, so that the foam-generating process is safer. The invention is a novel foam agent of simple preparation, low cost, security and environmental protection. The compound zedoary-turmeric-oil foam agent can have the medicine distributed evenly in the vaginal canal and the surface of the skin and coated extensively, so at to filter into the vagina mucosa plica rapidly and effectively. The invention which is a good medicine for treating gynecologic diseases has the advantages of sufficient and rapid exertion of the curative effect, good curative effect, safe, sanitary and convenient usage.

The invention relates to a daily product, in particular to a cleanser essence containing anti-allergy components. The cleanser essence is prepared from, by weight, 18-24 parts of an anionic surfactant, 11-16% of a nonionic surfactant, 0.02-0.03% of econazole nitrate, 0.002-0.003% of triamcinolone acetonide, 0.2-0.4% of polyoxyethylene olein, 0.2-0.4% of ethylenediaminetetraacetic acid disodium salt, 0.1-0.5% of vitamin E, 0.02-0.05% of butylated hydroxyanisole, 0.05-0.13% of citric acid, 0.05-0.5% of edible essence, 0.05-0.2% of carbon phthalein trichloroaniline and the balance deionized water. The cleanser essence contains anti-allergy components, and therefore the skin irritation of chemical components in the cleanser essence can be relieved.

The invention discloses a compound preparation for treatment of psoriasis; the compound preparation includes econazole nitrate, triamcinolone acetonide acetate, ketoconazole and a plurality of accessories. With use of the formula of the compound preparation for preparing a drug, the charges for medicines can be reduced, the curative effect is improved, and effective treatment of psoriasis is achieved.

The invention relates to the application of compound oil of zedoary turmeric bolt in manufacturing medicament to cure desquamation colpitis. Every ten thousand application units contain 1.05-6.30L oil of zedoary turmetric, 0.25-1.50KG nitric acid econazole, 0.015-0.09KG ice slabs, and the bolt agent includes tween-80, dimethyl sulphoxide, stearic acid poly hydrocarbon(40) ester, polyethylene glycol-1500, polyethylene glycol-6000, etc. The compound oil of zedoary turmetric bolt has the function of promoting flow of qi and blood circulation, clearing away the heat-evil and expelling superficial evils and enhancing organism immunizing ability; ice slabs could remove putrefaction, relieve inflammation, alleviate pain and promote wound surface cicatrizing. It has good effect in curing desquamation colpitis.

The invention discloses a compound dimetridazole premix for preventing and treating the poultry enterovirus syndrome. The premix is prepared by uniformly mixing the following components in percentage by weight: 10 to 30 percent of dimetridazole, 4 to 10 percent of neomycin sulfate, 2 to 8 percent of decoquinate econazole nitrate, 10 to 30 percent of lysozyme, 0.5 to 5 percent of etamsylate, 3 to 10 percent of lactic acid TMP and the balance of pharmaceutically applicable auxiliary material. According to the invention, the novel high-efficiency anticoccidial drug decoquinate econazole nitrate, the dimetridazole and the neomycin sulfate which have a special curative effect on intestinal infection, the lysozyme with effects of resisting to bacteria, resisting to viruses, diminishing inflammation, relieving pain and repairing intestinal mucosa, the high-efficiency hemostatics etamsylate and the drug synergist are compounded into a compound preparation; and the compound dimetridazole premix has a high-efficiency treatment effect on the poultry enterovirus syndrome. The compound dimetridazole premix has a reasonable and scientific formula, is simple to prepare, has wide application and can be used as a priority drug for preventing and treating the poultry enterovirus syndrome.