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Compound econazole nitrate zedoary turmeric oil emulsion type foam aerosol and its preparation method

A technology of econazole nitrate curcuma and foam aerosol, which is applied in the field of medicine and health, can solve the problems of backward dosage forms, limited wide application, and low bioavailability, and achieve the goals of reducing pollution, improving therapeutic effect, and improving bioavailability Effect

Inactive Publication Date: 2006-10-11
王晓黎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, several preparation methods disclosed above generally have backward dosage forms, low drug loading, low bioavailability, and inconvenient use, which limit the wide application of this compound preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The present invention contains the following mass numbers in every 1000mL emulsion: econazole nitrate 2g, turmeric oil 2g, Tween-805g, sodium benzoate 0.1g, isobutane 50g, and the balance is solvent water and propylene glycol, the batching of water and propylene glycol The ratio is 1:1.

[0019] Preparation method: Dissolve 5g Tween-80 in 2g zedoary oil as oil phase; dissolve 2g econazole nitrate and 0.1g sodium benzoate in solvent as water phase. Stir the two phases separately and heat them to about 60°C, slowly add the water phase into the oil phase dropwise, stir while adding, continue to stir for 15 minutes after the addition, and then disperse and emulsify in a tissue masher to obtain the initial phase milk. The colostrum is homogenized three times with a homogenizer under high pressure to obtain the final milk. The final milk is passed through a 0.45 μm microporous membrane, then 50 g of isobutane is added, filled, sealed, and sterilized to obtain the product. ...

Embodiment 2

[0021] The present invention contains the following mass numbers in every 1000mL emulsion: 98g of econazole nitrate, 198g of zedoary oil, 125g of soybean lecithin, 10g of hydroxybenzoate, 250g of n-butane, and the rest are solvent water and PEG400. The batching ratio of water and PEG400 is 1:1.

[0022] Preparation method: 98g of econazole nitrate and part of the solvent are dissolved in 198g of zedoary oil as the oil phase; 125g of soybean lecithin and 10g of paraben are dissolved in the remaining part of the solvent as the water phase. Stir the two phases separately and heat them to about 80°C. Slowly add the oil phase to the water phase, and stir while adding. After the addition, continue to stir for 40 minutes, and then disperse and emulsify in a tissue masher to obtain the initial phase. milk. The colostrum is homogenized three times with a homogenizer under high pressure to obtain the final milk. The final milk is passed through a 0.45 μm microporous membrane, then 250...

Embodiment 3

[0024] The present invention contains the following mass numbers in every 1000mL emulsion: 99g of econazole nitrate, 150g of zedoary oil, 125g of poloxamer, 10g of ethyl p-hydroxybenzoate, 250g of propane, and the rest are solvent water and ethanol. The proportioning ratio of water and ethanol is 1:1.

[0025] Preparation method: heat 25g of poloxamer with 95% ethanol in an appropriate amount to dissolve it, add 99g of econazole nitrate and 150g of zedoary oil as the oil phase: 100g of poloxamer and 10g of ethyl p-hydroxybenzoate are dissolved in the solvent as the aqueous phase. Stir the two phases separately and raise the temperature to about 25°C. Slowly add the oil phase to the water phase, stirring while adding, and continue stirring for 80 minutes after the addition, and then disperse and emulsify in a tissue masher to prepare Get colostrum. Colostrum is homogenized five times with a homogenizer under high pressure to obtain end milk. The final milk is passed through ...

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PUM

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Abstract

The invention relates to a compound aromatic turmeric oil emulsion type foam aerosol of Econazole nitrate and its preparing process, wherein each 1000mL of the aerosol contains the following constituents (by mass ratio): Econazole nitrate 1-100g, aromatic turmeric oil 1-200g, emulsifying agent 5-250g, preservative agent 0.1-20g, projection agent 50-500g, and balancing dissolvent. The aerosol can be used for treating vaginitis, cervical erosion and uterine neck disease.

Description

(1) Technical field [0001] The invention relates to the technical field of medicine and hygiene, in particular to a compound econazole nitrate zedoary oil emulsion type foam aerosol and a preparation method thereof. (2) Background technology [0002] Econazole Nitrate (EconazoleNitrate) is a synthetic broad-spectrum antifungal drug, which has a good effect on the treatment of diseases caused by skin filamentous fungus, Candida, yeast, black filamentous fungus, Aspergillus, Penicillium and actinomycetes infection. Efficacy. It has a broad antibacterial spectrum and good tolerance, and its main metabolites also have high antifungal activity. Curcuma oil is extracted by steam distillation from the dried rhizomes of Curcuma phaeocaulis Val., Curcuma kwangsiensis S.G.Lee et C.F.Liang or Curcumawenyujin Y.H.Chen et C.Ling. Active ingredients. It has the effects of promoting qi and blood circulation, eliminating accumulation and relieving pain, promoting blood circulation and re...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K31/4164A61K9/12A61P31/10
Inventor 王晓黎佟宝光杨永刚
Owner 王晓黎
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