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Econazole film agent and its preparation method

A technology of econazole film and econazole, applied in the directions of antifungal agents, sheet delivery, sexual diseases, etc., can solve the problems of film products coming out, and achieve the effects of short production cycle, low investment and good quality.

Inactive Publication Date: 2005-08-10
贵阳高新瑞得科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The gynecological film is a drug dosage form that has been rapidly developed in research and application at home and abroad. However, so far, there is no film product made of econazole nitrate as the active ingredient.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1: Weigh 50g of polyvinyl alcohol, add 200ml of water, soak for 0 hours, put it in a water bath at 20°C to dissolve it, take 5g of econazole and mix it with the aqueous solution, remove air bubbles, apply it to form a film, and dry it After 0.5 hour, 1000 film products were prepared.

Embodiment 2

[0020] Example 2: Weigh 150g of sodium carboxymethylcellulose, add 400ml of water, soak for 0.5 hours, put it in a water bath at 50°C to dissolve it, take 5g of econazole and dissolve it in 50ml of methanol, then mix the two solutions and stir evenly , add 0.2 g of sodium sulfite, mix well, remove air bubbles, apply and form a film, and dry for 0.5 hour to obtain 1000 film products.

Embodiment 3

[0021] Example 3: Weigh 300g of gelatin, add 500ml of water, soak for 3 hours, put it in a water bath at 60°C to dissolve it; take 5g of econazole and dissolve it in 300ml of methanol; then mix and stir the two solutions evenly, and add bisulfite Sodium 1.5g, mix well, remove air bubbles, after coating to form a film, dry for 1.5 hours to obtain 1000 film products.

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PUM

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Abstract

An econazole film for treating vaginitis is prepared from econazole, filming material and antioxidizing agent through immersing filming material in water dissolving it in water bath, dissolving econazole in methanol, mixing it with the aqueous solution of filming material, adding antioxidizing agent, stirring removing air bubbles, filming and drying.

Description

technical field [0001] The invention belongs to pharmaceutical preparations, in particular to an econazole film for treating women's vaginal candidiasis and a preparation method thereof. Background technique [0002] Candidiasis is a common vaginal disease among women. It is usually caused by Candida bacterial infection. It often presents inflammation and brings inconvenience to patients. For candidiasis, medicine has some therapeutic means, and there are econazole nitrate suppository varieties on the market. However, suppositories use a large amount of auxiliary materials, have a foreign body sensation during use, have a large volume, and have disadvantages such as being greatly affected by environmental conditions, especially temperature and humidity. [0003] Since econazole nitrate has antibacterial effects on Candida, Chromomycetes, Coccidioides, Histoplasma, Sporothrix, etc., it also has antibacterial activity on Trichophyton. In recent yea...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/4164A61P15/02A61P31/10
Inventor 李向东卢顺林
Owner 贵阳高新瑞得科技开发有限公司
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