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Compound zedoary turmeric oil gelata and its preparing method

A technology of oil gel and compound curcuma, which is applied in the field of compound curcuma oil gel and its preparation, can solve the problems of easy outflow of suppositories, inconvenience for patients, loss of curative effect, etc., achieve non-irritation, increase stability and curative effect high effect

Inactive Publication Date: 2006-07-19
THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But zedoary oil itself has the property of being volatile and smelly, so that its curative effect will be lost due to volatilization or oxidative decomposition during storage, and its unpleasant smell has also brought inconvenience to patients. Easy to flow out, produce overflow

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Every 1000 grams of compound curcuma oil gel preparation, weigh materials according to the following formula:

[0035] Econazole Nitrate 12.5g

[0036] Curcuma Oil 52.5ml

[0037] Carbopol 15g

[0038] Sodium hydroxide 3g

[0039] Propylene glycol 25g

[0040] Ethanol 50g

[0041] Polysorbate-80 25g

[0042] Sorbic acid 2g

[0043] Sodium metabisulfite 0.5g

[0044] Vitamin E 0.5g

[0045] Deionized water add to full

[0046] Prepare the compound curcuma oil gel of the present invention by weighing the raw materials according to the following steps:

[0047] 1. Take Carbopol, moisten it with propylene glycol, add an appropriate amount of distilled water to fully swell, add sodium hydroxide dissolved in an appropriate amount of distilled water, and stir evenly to obtain a colorless and transparent Carbopol matrix;

[0048] 2. Take the proportioned amount of zedoary oil, add ethanol, mix well, then add it to the polysorbate-80 solution dissolved in an appropriat...

Embodiment 2

[0053] Every 1000 grams of compound curcuma oil gel preparation, weigh materials according to the following formula:

[0054] Econazole Nitrate 12.5g

[0055] Curcuma Oil 52.5ml

[0056]CMC-Na 30g

[0057] Propylene glycol 25g

[0058] Ethanol 50g

[0059] Polysorbate-80 50g

[0060] Sorbic acid 1g

[0061] Sodium metabisulfite 1g

[0062] Vitamin E 0.5g

[0063] Deionized water add to full

[0064] Prepare the compound curcuma oil gel of the present invention by weighing the raw materials according to the following steps:

[0065] 1. Take CMC-Na, moisten it with propylene glycol, add an appropriate amount of distilled water to make it fully swell, and stir evenly to obtain a colorless and transparent sodium carboxymethyl cellulose matrix;

[0066] 2. Take the proportioned amount of zedoary oil, add ethanol, mix well, then add it to the polysorbate-80 solution dissolved in an appropriate amount of distilled water, stir to make it emulsify into a milky white O / W emulsi...

Embodiment 3

[0071] Every 1000 grams of compound curcuma oil gel preparation, weigh materials according to the following formula:

[0072] Econazole Nitrate 12.5g

[0073] Curcuma Oil 52.5ml

[0074] Sodium Alginate 20g

[0075] Propylene glycol 25g

[0076] Ethanol 50g

[0077] Polysorbate-80 20g

[0078] Sorbic acid 1.5g

[0079] Sodium metabisulfite 1.5g

[0080] Vitamin E 0.5g

[0081] Deionized water add to full

[0082] Prepare the compound curcuma oil gel of the present invention by weighing the raw materials according to the following steps:

[0083] 1. Take sodium alginate, moisten it with propylene glycol, add appropriate amount of water to fully swell, stir evenly, and obtain a colorless and transparent sodium alginate matrix;

[0084] 2. Take the proportioned amount of zedoary oil, add ethanol, mix well, then add it to the polysorbate-80 solution dissolved in an appropriate amount of distilled water, stir to make it emulsify into a milky white O / W emulsion;

[0085] 3...

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PUM

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Abstract

The invention relates to a compound aromatic turmeric oil gelling agent and its preparing process, wherein each 1000g of the preparation comprises econazole nitrate 12.5g, oil of aromatic turmeric 52.5ml, gel base material 1-30g. The constituents also include sodium hydroxide, propylene glycol, ethanol, polysorbate -80, sorbic acid, sodium metabisulfite, vitamin E and deionized water. The gel base material is the mixture of carbome, sodium carboxymethylcellulose and sodium alginate.

Description

technical field [0001] The invention relates to a compound curcuma oil gel and a preparation method thereof, which is a new drug dosage form for treating vaginitis, cervical erosion and other diseases, specifically, the compound curcuma oil suppository recorded in the original Chinese Pharmacopoeia is changed into a gel agent and its preparation method. Background technique [0002] Women's vaginitis, cervical erosion and other diseases are commonly encountered diseases and frequently-occurring diseases, which have brought a lot of misery to patients and seriously affected the health of women in general. One of the more commonly used treatment method and the medicine used at present is the compound curcuma oil suppository made with Zedoary oil. But zedoary oil itself has the property of being volatile and smelly, so that its curative effect will be lost due to volatilization or oxidative decomposition during storage, and its unpleasant smell has also brought inconvenience t...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/00A61P15/02A61P15/00
Inventor 向大雄刘韶朱运贵李新中李焕德雷鹏龚莉康勇
Owner THE SECOND XIANGYA HOSPITAL OF CENT SOUTH UNIV
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