Econazole nitrate vagina soft capsule and preparation method thereof

A technology of econazole nitrate and soft capsules is applied in the directions of capsule delivery, pharmaceutical formulations, and non-active ingredients medical preparations, etc., which can solve the problems of large temperature influence, drug storage, and ensure the quality of drugs, inconvenience in use, easy discoloration, etc. problems, to ensure stability, prevent product changes, and facilitate storage.

Inactive Publication Date: 2016-10-05
SHENZHEN JIATAI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is to provide a kind of econazole nitrate vaginal soft capsule and its preparation method, which is used to solve the problem that the econazole nitrate vaginal preparation is greatly affected by temperature in the prior art, and it is easy to change color when exposed to light, which makes the patient's storage of the medicine difficult. As well as the inconvenient problem of ensuring the quality and use of medicines

Method used

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  • Econazole nitrate vagina soft capsule and preparation method thereof
  • Econazole nitrate vagina soft capsule and preparation method thereof
  • Econazole nitrate vagina soft capsule and preparation method thereof

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Embodiment Construction

[0018] The present invention will be further elaborated below with reference to the accompanying drawings.

[0019] The invention provides econazole nitrate vaginal soft capsule, which comprises a soft capsule skin and contents filled in the soft capsule skin.

[0020] The contents include by weight parts: 50 parts of econazole nitrate, 250-350 parts of white petrolatum, 25 parts of beeswax and 325-425 parts of light liquid paraffin. Wherein, econazole nitrate is the main active ingredient of the econazole nitrate vaginal soft capsules, and white petrolatum, beeswax and light liquid paraffin are the dispersants of the econazole nitrate vaginal soft capsules.

[0021] The selection preliminary test result of table 1 dispersant

[0022]

[0023] Table 1 is the selection preliminary test result of the dispersant of econazole nitrate vaginal soft capsule, as shown in table 1, test result has shown the proterties (degree of dispersion), color and consistency of dispersant under...

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Abstract

The invention relates to an econazole nitrate vaginal soft capsule and a preparation method thereof, wherein the econazole nitrate vaginal soft capsule comprises a soft capsule skin and contents filled in the soft capsule skin, wherein the contents are as follows: Parts by weight include: 50 parts of econazole nitrate, 250-350 parts of white vaseline, 25 parts of beeswax and 325-425 parts of light liquid paraffin; the soft capsule skin includes by weight parts: 1 part of gelatin, 0.6 1 part glycerin, 1 part water and 0.008 part opacifier. The econazole nitrate vaginal soft capsule of the present invention can be stored and transported at room temperature, which is convenient for patients to store the drug and ensure the quality and use of the drug, and the soft capsule skin contains a sunscreen, which effectively prevents econazole nitrate Econazole nitrate is stable due to product changes due to exposure to light during storage and transportation.

Description

technical field [0001] The invention relates to the field of gynecological external preparations, in particular to econazole nitrate vaginal soft capsules and a preparation method thereof. Background technique [0002] Candidal vulvovaginitis (VVC) is a common and multiple vulvovaginal inflammatory disease, which has been increasing year by year in recent years. Candida vaginitis is caused by Candida albicans infection. The most suitable pH value for Candida reproduction is 5.5-6.5. When the glycogen in the vagina increases and the acidity increases, it will multiply rapidly and cause inflammation, so it is more common in pregnant women and diabetes Patients and those who receive a large amount of estrogen, such as long-term use of antibiotics, change the mutual inhibition relationship between microorganisms in the vagina, and it is also easy for Candida to reproduce and cause infection. Candida can exist in the human oral cavity, intestinal tract and vaginal mucosa without...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/4174A61K47/46A61K47/44A61P15/02A61P31/10
Inventor 李冠霖张小勇农达舒李欢欢
Owner SHENZHEN JIATAI PHARMA
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