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Medicinal composition for viganitis

A composition and drug technology, applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of bacterial flora imbalance, drug-induced diseases, increase the incidence of side effects, etc., to avoid bacteria Effects of group disorder and expansion of application range

Inactive Publication Date: 2005-12-28
毛友昌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chlorhexidine is not a targeted drug, but may lead to the occurrence of side effects such as flora imbalance or increase the incidence of side effects, and even cause drug-induced diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 50 grams of metronidazole and 50 grams of miconazole nitrate and pulverize them into fine powder for later use; dry sodium bicarbonate at 60°C for 2 hours, and dry citric acid at 105°C for 1 hour, grind them separately, and pass through a 100-mesh sieve for later use; Heat and melt polyoxyethylene stearate, dehydrate with anhydrous calcium chloride, filter off calcium chloride for later use; take polyoxyethylene stearate and heat and melt, add the above-mentioned metronidazole and nitric acid respectively under stirring Miconazole, sodium bicarbonate, citric acid fine powder, fully stirred, injection molded, cooled, stripped, packaged to obtain 1000 capsules of bizoconazole effervescent suppository.

Embodiment 2

[0023] Embodiment 2: Get 500 grams of metronidazole and 500 grams of miconazole nitrate and pulverize them into fine powder for subsequent use; get lanolin, paraffin, semi-synthetic fatty acid glyceride (38 type) and heat and melt, stir evenly, and the temperature drops to about 50° C. , add the above-mentioned fine powder, fully stir, injection molding, cooling, stripping, packaging to obtain 1000 capsules of bizoconan suppository.

Embodiment 3

[0024] Embodiment 3: Take 200 grams of metronidazole and 100 grams of miconazole nitrate and pulverize them into fine powder for later use; heat and melt polyethylene glycol 6000, filter, add polyethylene glycol 400, stir, and add the above-mentioned mixture at an appropriate temperature Fine powder, fully stirred, injection molded, cooled, stripped, packaged to obtain 1000 capsules of bizocon suppositories.

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PUM

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Abstract

A composite medicine for treating vaginitis is prepared from fossyol, econazole nitrate or miconazole nitrate, and medicinal auxiliary.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating vaginitis, in particular to a pharmaceutical composition for treating vaginitis containing bisazole compounds. Background technique [0002] Vaginitis is a common and frequently-occurring disease of women, which brings a lot of misery to patients and seriously affects the health of women in general. The nitroimidazole antimicrobial drug metronidazole has anti-anaerobe and anti-trichomonad effects, and the azole antifungal drugs econazole nitrate and miconazole nitrate have anti-fungal effects. At present, metronidazole suppositories and metronidazole gel are used for the treatment of trichomoniasis and bacterial vaginosis; there are econazole nitrate suppositories for the treatment of vaginal candidiasis, and miconazole nitrate suppositories for local treatment of vulvovaginal Double infection caused by candidiasis and Gram-positive bacteria; compound preparations such as metronidazole...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164
Inventor 毛友昌毛晓敏
Owner 毛友昌
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