The invention discloses an integration system for health information of a regional population. The system comprises an infrastructure layer, a data resource layer, a system support layer, an application layer and a user layer, and further comprises a standard specification system, a safety guarantee system and an operation maintenance system which all perform data interaction with each layer, wherein the user layer and the application layer are arranged on a platform interaction page in the form of an operation control, respond to various operation instructions of a user, call at least one ofthe infrastructure layer, the data resource layer and the system support layer to carry out data processing and feed back a data processing result. With the integration system, data exchange among provincial, municipal and county platforms in a region can be realized, data sharing is realized among primary medical and health institutions, secondary and tertiary hospitals, disease prevention and control centers, health supervision stations, maternal and child health institutions, family planning institutions, blood stations, medical insurance, and food and medicine administration and object management institutions can be realized, and business collaboration among cross-industry institutions can be realized.