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External use emulsifiable paste for treating skin diseases and with econazole nitrate as active component and preparation method

A technology of econazole nitrate and external cream, applied in the field of medicine, can solve the problems of high viscosity of propylene glycol, skin irritation and the like, and achieve the effects of increasing curative effect, controllable quality and good stability

Inactive Publication Date: 2016-03-16
吉林修正药业新药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN1813770A discloses triamcinolone acetonide econazole gel, by adding 80% propylene glycol to increase solubility, but propylene glycol is viscous and has certain irritation to the skin

Method used

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  • External use emulsifiable paste for treating skin diseases and with econazole nitrate as active component and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Econazole nitrate cream, 100g includes the following components: 10g econazole nitrate, 5.5g mono- and distearate glycerides, 15.5g stearic acid, 3.7g white petrolatum, 3.2g light liquid paraffin, glycerin 12.6g, triethanolamine 3.7g, ethyl paraben 0.15g, borax 0.24g, dimethyl sulfoxide 2.5g, distilled water 15g.

[0016] The specific steps of the preparation method of econazole nitrate cream are as follows:

[0017] (1) Preparation of the oil phase: dissolve the formulated amount of ethyl paraben with the formulated amount of dimethyl sulfoxide, and then add the formulated amount of glyceryl mono- and distearate, stearic acid, white petrolatum, light liquid, Heat to 80°C and keep stirring for 30 minutes. spare.

[0018] (2) Preparation of water phase: Dissolve the formulated amount of glycerin and triethanolamine in distilled water, heat to 60°C, then add the formulated amount of borax to mix uniformly, and pass through a 150-mesh sieve as the water phase. Continue to heat...

Embodiment 2

[0021] Econazole nitrate cream, 100g includes the following components: 10g econazole nitrate, 7g mono- and distearate glycerides, 18g stearic acid, 6g white petrolatum, 5g light liquid paraffin, 15g glycerin, triethanolamine 7g, 0.3g ethyl paraben, 0.32g borax, 4g dimethyl sulfoxide, 30g distilled water.

[0022] The specific steps of the preparation method of econazole nitrate cream are as follows:

[0023] (1) Preparation of the oil phase: dissolve the formulated amount of ethyl paraben with the formulated amount of dimethyl sulfoxide, and then add the formulated amount of glyceryl mono- and distearate, stearic acid, white petrolatum, light liquid, Heat to 80°C and keep stirring for 30 minutes. spare.

[0024] (2) Preparation of water phase: Dissolve the formulated amount of glycerin and triethanolamine in distilled water, heat to 60°C, then add the formulated amount of borax to mix uniformly, and pass through a 150-mesh sieve as the water phase. Continue to heat to 80°C, keep ...

Embodiment 3

[0027] Econazole nitrate cream, 100g includes the following components: 10g econazole nitrate, 5g glyceryl mono- and distearate, 12g stearic acid, 3.4g white petrolatum, 1.2g light liquid paraffin, 10g glycerin, Triethanolamine 3g, ethyl paraben 0.1g, borax 0.12g, dimethyl sulfoxide 1g, distilled water 50g.

[0028] The specific steps of the preparation method of econazole nitrate cream are as follows:

[0029] (1) Preparation of the oil phase: dissolve the formulated amount of ethyl paraben with the formulated amount of dimethyl sulfoxide, and then add the formulated amount of glyceryl distearate, stearic acid, white petrolatum, and light liquid paraffin. , Heat to 80℃, keep stirring for 30 minutes. spare.

[0030] (2) Preparation of water phase: Dissolve the formulated amount of glycerin and triethanolamine in distilled water, heat to 60°C, then add the formulated amount of borax to mix uniformly, and pass through a 150-mesh sieve as the water phase. Continue to heat to 80°C, ke...

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Abstract

The invention provides external use emulsifiable paste for treating skin diseases and with econazole nitrate as an active component and a preparation method. The emulsifiable paste is basically prepared from, by weight, 10 parts of econazole nitrate, 3-10 parts of glycerin monostearate and glycerol distearate, 10-20 parts of stearic acid, 1-10 parts of albolene, 0.8-7 parts of light liquid paraffin, 8-17 parts of glycerinum, 1-10 parts of triethanolamine, 0.08-0.5 part of borax and 15-75 parts of distilled water. The preparation method includes the steps of oil phase preparation, water phase preparation and finished product preparation. The emulsifiable paste has the advantages that through the synergetic action of all the components in the formula, the transcutaneous permeation function of the medicine components is improved, and the treatment effect is improved. The econazole nitrate emulsifiable paste is good in stability, and the phenomenon of layering or crystal separation does not happen. The granularity of the econazole nitrate emulsifiable paste prepared through the method is small, so that it is guaranteed that the preparation is finer, uniform in content and convenient to use, and coating and clearing of the preparation are easy.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to a medicine for treating skin diseases. . Background technique [0002] Econazole nitrate cream consists of econazole nitrate, an oil phase and an aqueous phase. Econazole nitrate is an imidazole broad-spectrum antifungal drug, which can effectively kill gram-positive bacteria and dermatophytes, candida, gypsum-like tinea, rubrum, mold and other fungi in skin infections. In recent years, dermatophytes caused by fungal infections, such as hand, foot, tinea cruris, onychomycosis, and tinea capitis, have an increasing incidence, and they are easily contagious, recurring or re-infected, which gives patients physically and mentally It caused great damage. [0003] At present, the external dosage forms for the treatment of skin tinea are creams, microemulsions, gels, etc. The stability of cream preparations is worse than other solid preparations. During daily transportation, storage, and...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/4174A61K47/44A61P31/10A61P17/00
Inventor 曹翠阎君白冰林子琦于施刘学锋
Owner 吉林修正药业新药开发有限公司
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