572 results about "Antiinflammatory Effect" patented technology

The invention provides glabridin nano-vesicles based on glycyrrhizic acid wrapping, a preparation method of the glabridin nano-vesicles and application of the glabridin nano-vesicles in preparation of whitening and skin care cosmetics, and relates to the technical field of cosmetics. According to the glabridin nano-vesicle based on glycyrrhizic acid wrapping, glabridin is carried by glycyrrhizic acid, glycyrrhizic acid serves as a carrier, the solubility of glabridin can be improved, the skin transmittance of glabridin can be increased, the anti-inflammatory effect of glabridin can be achieved, then the effect of one stone for three birds is achieved, the characteristic and advantage of integration of medicine and auxiliary materials are achieved, and the glabridin nano-vesicle based on glycyrrhizic acid wrapping has good application prospects. The tyrosinase inhibition activity of the glabridin is greatly improved. Meanwhile, the glabridin nano-vesicles wrapped based on glycyrrhizic acid have the advantages of high encapsulation efficiency, large drug loading capacity, good stability and high safety, can effectively promote the whitening factor glabridin to penetrate through the skin cuticle to enter the skin deep tissue, can stay in the skin at a high concentration for a long time, and can continuously play a whitening role.

The present invention belongs to the technical field of cosmetic raw materials, and specifically relates to a kind of oxidized hyaluronic acid-PDRN-peptide nanoemulsion and its preparation method. The nanoemulsion comprises oxidized hyaluronic acid, PDRN and polypeptide, and the nanoemulsion is formed by oxidized hyaluronic acid, PDRN and polypeptide through layer-by-layer self-assembly technology. Specifically: positively charged polypeptide is used to wrap negatively charged PDRN to form positively charged composite particles, or negatively charged PDRN is used to wrap positively charged polypeptide to form electrostatic composite particles, and then, the positively charged composite particles or the electrostatic composite particles are further wrapped with oxidized hyaluronic acid as a packaging material, and finally oxidized hyaluronic acid-PDRN-peptide nanoemulsion is formed. The nanoemulsion of the present invention can improve the stability of polypeptides, improve the problems that polypeptide molecules are difficult to penetrate the skin and have low bioavailability, and effectively improve the transdermal rate and stability of PDRN, give play to the tissue repair function of PDRN, further amplify the anti-inflammatory effects of the two, and improve the bioavailability of active ingredients.

The invention relates to the technical field of functional microorganism screening and application, and particularly provides a strain of lactobacillus plantarum and an application of the lactobacillus plantarum in improvement of intestinal inflammation and repair of intestinal mucosa injury. The plant lactobacillus is preserved in the China General Microbiological Culture Collection Center (CGMCC for short) on August 1, 2024, the address is No.3, No.1 Yard, Beichen West Road, Chaoyang District, Beijing, and the preservation number of the plant lactobacillus is CGMCC No.31521. The strain has remarkable antioxidant, bacteriostatic and anti-inflammatory effects, can repair intestinal barrier injury of mice with colitis, promote renewal of intestinal stem cells, promote growth of intestinal beneficial bacteria and inhibit proliferation of harmful bacteria, can be widely applied to prevention and treatment of enteritis, and has a wide market prospect.

The invention discloses pulsatilla saponin B4-oleanolic acid self-assembled nanoparticles as well as preparation and application thereof, and relates to the technical field of pharmaceutical preparations. Inspired by compatibility and solubilization of traditional Chinese medicines, the pulsatilla saponin B4-oleanolic acid self-assembled nanoparticles (AB4-OA NPs) are prepared by taking natural active components, namely micromolecular pulsatilla saponin B4 and oleanolic acid, as raw materials; the oleanolic acid has the effects of promoting dissolution and resisting inflammation, the water solubility of the oleanolic acid is improved, the bioavailability is improved, and the anti-inflammatory effect of the oleanolic acid is enhanced. Experimental results show that the AB4-OA NPs can effectively improve the dissolution rate of the oleanolic acid, so that the bioavailability of the oleanolic acid is effectively improved, meanwhile, the AB4-OA NPs has a better anti-inflammatory effect, and the effect is better than that of a single drug with the same dosage. In addition, the synthetic preparation method is simple and convenient, has the advantages of nano-scale drugs, realizes auxiliary-material-free pure drug self-delivery, and improves the delivery efficiency.

The invention discloses a bionic nano-composite, a preparation method thereof and application of the bionic nano-composite in preparation of a product for treating atherosclerosis, and belongs to the technical field of medicine preparation. The bionic nano compound is a metal nano enzyme Ir-TiO2 coated by an M2 macrophage cell membrane. According to the invention, the surfaces of Ir-TiO2 nanoparticles are coated with M2 macrophage membranes, so that the nanocomposite with a bionic structure is prepared. After intravenous injection, the formed bionic nanocomposite can actively target endothelial cells in atherosclerotic lesions, and release Ir-TiO2 antagonism to endothelial cells in plaques and cytoplasm of inflammatory macrophages. After the Ir-TiO2 reaches the diseased region, the Ir-TiO2 can play an enzyme role to achieve an anti-inflammatory effect, and can promote inflammatory cells such as macrophages and smooth muscle cells at the diseased region to discharge cholesterol, reduce lipid deposition in the cells, reduce the generation of foam cells and promote the growth of plaques. The nanotherapy can effectively prevent the progress of atherosclerosis lesion inflammation and relieve atherosclerosis.

The invention discloses a honeysuckle leaf-derived exosome-like nano-vesicle functional miRNA (micro Ribonucleic Acid) and application thereof, the honeysuckle leaf-derived exosome-like nano-vesicle functional miRNA is miR-novel1 or ath-miR396b-5p, the nucleotide sequence of the miR-novel1 is as shown in SEQ ID NO.1, and the nucleotide sequence of the ath-miR396b-5p is as shown in SEQ ID NO.2. The invention further discloses a preparation method of the honeysuckle leaf-derived exosome-like nano-vesicle functional miRNA and application of the honeysuckle leaf-derived exosome-like nano-vesicle functional miRNA. The invention also specifically discloses an application of the functional miRNA in preparation of anti-inflammatory drugs. The functional miRNA in the honeysuckle leaf exosome-like nano-particles obviously inhibits transcription of pro-inflammatory cytokine genes and expression of protein for synthesizing pro-inflammatory mediator enzymes (iNOS and COX-2) by inhibiting an STAT3 signal channel under the condition of no cytotoxic effect, so that the anti-inflammatory effect is achieved, and the honeysuckle leaf exosome-like nano-particles can be used as a new choice for preparing anti-inflammatory drugs and other anti-inflammatory products.

The invention discloses a nano-antibacterial agent for treating biofilm infection through Prussian blue and a preparation method and application thereof.According to the nano-antibacterial agent, hollow Prussian blue (HPB) serves as a carrier to load a substance with anti-inflammatory and anti-oxidation effects, a metal polyphenol network structure is formed through chelating of tannic acid (TA) modified by hyaluronic acid (HA) and high-valence metal ions, and the nano-antibacterial agent is used for treating biofilm infection through Prussian blue. And the MPNs are packaged to obtain the product. All the components of the nano antibacterial agent have a synergistic effect, MPNs formed by chelating TA modified by hyaluronic acid and high-valence metal ions in the antibacterial agent have good photo-thermal performance, and light energy can be converted into heat energy for photo-thermal therapy. According to the invention, the nanoparticles for photo-thermal antisepsis and anti-inflammation are constructed, so that comprehensive treatment of anti-biofilm and anti-inflammatory effect is realized, and healing of infected parts is promoted. And the antibacterial agent has good biocompatibility and high biological safety, and is very suitable for replacing antibiotics to treat biological membrane infection.

The invention discloses a preparation method of four new skeleton alkaloid compounds with anti-inflammatory effect in the root of Anachymin and the use of the anti-inflammatory activity thereof. The four new skeleton alkaloid compounds are extracted from the root (root of Anachymin) of Roman pyrethrum (Anacyclus pyrethrum (L.) DC.) by using an organic solvent, and then separated by two or three methods of normal phase silica gel column chromatography, reverse phase silica gel column chromatography and semi-preparative high performance liquid chromatography to obtain eight new skeleton alkaloid monomer compounds, and the structures thereof are identified by high-resolution mass spectrometry, nuclear magnetic resonance spectroscopy and X-ray single crystal diffraction. The invention also provides the NO inhibition effect of these compounds.

The invention provides an application of a cross-linked decellularized bovine amniotic membrane (CAM) and manganese carbon dots (Mn CDs) combined in preparation of an ophthalmic medical material for alkali burn cornea repair. The invention further provides a compound for repairing the alkali burn cornea. Cell and animal experiments show that the compound CDs (at) CAM has good biocompatibility and strong antioxidant and anti-inflammatory effects, can significantly promote corneal epithelium regeneration and inhibit corneal neovascularization and scar generation, and provides a new strategy for treatment of alkali burn cornea and various corneal epithelium injuries and diseases.

The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and / or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-α and anti-TGF-β1 action for the treatment of hepatic fibrosis.

The invention discloses a synbiotics composition with bacteriostatic and anti-inflammatory effects, which comprises probiotics and prebiotics in parts by weight, the probiotics comprise the following components in parts by weight: 0.05 to 0.15 part of freeze-dried powder of lactobacillus rhamnosus PB-LR76, 0.05 to 0.15 part of freeze-dried powder of lactobacillus acidophilus HH-LA26, 0.05 to 0.15 part of freeze-dried powder of lactobacillus bulgaricus HH-LB57, 0.05 to 0.15 part of freeze-dried powder of bifidobacterium lactis HH-BA68, 0.05 to 0.15 part of freeze-dried powder of lactobacillus reuteri PB-LR09, and 0.05 to 0.15 part of freeze-dried powder of lactobacillus plantarum HH-LP56; the prebiotics are fructo-oligosaccharide or a rhizoma polygonati extract. Compared with the single use of probiotics or prebiotics, the synbiotics composition disclosed by the invention has stronger antibacterial and anti-inflammatory effects. The invention further discloses application of the synbiotics composition in preparation of a medicine for treating enteritis.

The invention relates to the technical field of medicines, in particular to application of an active ingredient xanthohumol (XAN) derived from a traditional Chinese medicine humulus lupulus in preparation of medicines for reducing uric acid and resisting gout, and the xanthohumol (XAN) can be prepared into various oral preparations, injection preparations and external preparations with the assistance of pharmaceutically acceptable auxiliary materials and has good development and application prospects. The inventor finds that the xanthohumol has relatively strong effects of reducing blood uric acid, resisting inflammation, resisting bone damage and the like, and the mechanism of the effect of reducing the blood uric acid is that the activity of xanthine oxidase is inhibited so as to reduce the generation of uric acid, and the renal function of an organism is improved so as to enhance uric acid excretion; according to the anti-inflammatory effect, the inflammatory reaction is relieved mainly by down-regulating the levels of inflammatory factors such as IL-1beta, IL-6, TNF alpha and PEG2; the mechanism for resisting gout bone damage is realized through the fact that RANKL / OPG / RANK signal pathway participates in bone metabolism regulation.

The invention relates to an anti-inflammatory and repair-promoting hydrogel for a uterine cavity as well as a preparation method and application of the anti-inflammatory and repair-promoting hydrogel, and relates to the technical field of biological medicines. The uterine cavity anti-inflammatory and repair-promoting hydrogel is prepared from the following raw materials: an anti-inflammatory component, a biomacromolecule with active ester and an amino high-molecular polymer. The hydrogel for resisting inflammation and promoting repair of the uterine cavity, which is prepared by the invention, has good biological safety, injectability and adhesiveness with tissues; in intrauterine adhesion prevention treatment, a three-dimensional network structure formed by crosslinking of the biomacromolecules with the active ester and the amino high-molecular polymer plays a physical isolation role, the anti-inflammatory component plays an anti-inflammatory role by inhibiting expression of an inflammation signal channel, and the biomacromolecules with the active ester and the amino high-molecular polymer achieve a synergistic treatment effect.

The invention relates to streptococcus thermophilus CT-02 with an immune regulation effect and application of the streptococcus thermophilus CT-02, the classification name of the streptococcus thermophilus CT-02 with the immune regulation effect is Streptococcus thermophilus, the preservation number of the streptococcus thermophilus CT-02 is GDMCC No: 64474, and the preservation date of the streptococcus thermophilus CT-02 is March 29, 2024. The strain has an excellent immune regulation effect which is specifically shown as follows: by moderately activating macrophages, not only can the excessive activation of TNF-alpha, IL-1beta, IL-6 and IL-12 be avoided, but also the activation level of IL-10 can be improved, that is, the levels of various inflammatory factors secreted by the macrophages are comprehensively regulated, and the strain has a potential anti-inflammatory effect while activating immunity. The strain has a prospect for preparing a product with an immune regulation effect or a product with an inflammatory factor regulation effect.

The invention relates to an amphiphilic polypeptide assembly as well as a preparation method and application thereof. The amphiphilic polypeptide assembly is obtained by assembling palmitoyl tripeptide-1, palmitoyl tetrapeptide-7 and palmitoyl hexapeptide-12 in water. The amphiphilic polypeptide assembly provided by the invention synergistically improves the slow release ability of the three polypeptides, contributes to long-acting exertion of the tightening, anti-wrinkle and anti-inflammatory effects of the three polypeptides on the skin, and has a wide application prospect in the field of cosmetic preparation. The invention further provides a co-assembly containing the amphiphilic polypeptide, a surfactant is additionally added on the basis of the three polypeptides, and the ability of the original polypeptide penetrating through the skin cuticle is further improved.

The invention discloses a grape seed source anti-inflammatory peptide, and belongs to the technical field of biological medicine. The amino acid sequence of the anti-inflammatory peptide is selected from any one of WGF, SHFGF, EGPFF, WAPR, SFYRAF, HFAFL, PGRF or FDSF. A BPS-induced RAW 264.7 mouse mononuclear macrophage inflammation model is established, and the eight synthetic peptides are found to significantly reduce the content level of NO in inflammatory cells and have an inhibition effect on secretion of inflammatory factors TNF-alpha and IL-6. A qRT-PCR (quantitative reverse transcription-polymerase chain reaction) experiment shows that the synthetic peptide can inhibit expression of mRNA (messenger Ribonucleic Acid) of p65, Tnf alpha, Il6, Il1b and Nos2, and can play an anti-inflammatory role by regulating and controlling an NF-kappa B signal channel. According to the method, the high-activity anti-inflammatory peptide is screened from the wine brewing byproduct grape seeds for the first time, and green and high-value utilization of the grape processing byproduct is realized.

The invention discloses an itching-relieving and hair-loss-preventing micro-capsule composition containing a golden camellia extract and a preparation method of the itching-relieving and hair-loss-preventing micro-capsule composition, and relates to the technical field of daily chemical products. The microcapsule mainly comprises a surfactant, palmitoyl tripeptide, ossein amino acid, betaine salicylate, a nano zinc oxide chelate, a plant extract, vegetable oil and a microcapsule component formed by a microcapsule wall material prepared from gelatin and sodium alginate. The plant extract, the plant oil-containing microcapsules, palmitoyl tripeptide, ossein amino acid, betaine salicylic acid, nano-zinc oxide chelate and the like have synergistic interaction, and the plant extract has antioxidant, antibacterial and anti-inflammatory effects and is matched with other components, so that lasting antibacterial effect is enhanced, dandruff can be effectively cleaned and removed, scalp can be repaired, microcirculation of the scalp can be effectively improved, and the scalp care effect can be improved. The scalp itching is reduced, and the alopecia problem is improved.

The invention belongs to the technical field of medicines, and discloses application of baicalein in drugs related to the treatment effect of S protein and LPS induced acute lung injury. Specifically, the invention discloses an application of baicalein in preparation of drugs playing a protective role in treating pulmonary edema, inflammatory cell infiltration and cytokine storm caused by acute lung injury induced by S protein combined with LPS. Pharmacological experiments prove that baicalein has an anti-inflammatory effect in treatment of acute lung injury induced by S protein combined with LPS, and can improve pulmonary edema and promote lesion lung tissue repair.

The invention discloses a preparation method and antipyretic and anti-inflammatory application of a novel carrier-free metal-organic small molecule supramolecular hydrogel derived from Maxing Shigan Decoction. The hydrogel drug raw materials of the invention include pseudoephedrine hydrochloride in Ephedra sinica in the prescription of Maxing Shigan Decoction, amygdalin in Armeniaca vulgaris, magnesium ions in Gypsum fibrosum, and glycyrrhizic acid in Glycyrrhiza uralensis Fisch. The preparation method of the quaternary magnesium hydrogel drug is simple, green, has good stability and high biocompatibility. In a rat fever model induced by lipopolysaccharide at different doses, the antipyretic effect of the hydrogel drug can last up to 12 hours, and the antipyretic effect is significantly better than that of other metal ions such as quaternary calcium hydrogel, quaternary zinc hydrogel, and quaternary copper hydrogel groups. At the same time, it has a more persistent antipyretic effect than the whole prescription of Maxing Shigan Decoction; the hydrogel drug does not require the addition of excipients, has no toxic and side effects, and has a high drug utilization rate.

The invention discloses a glucose responsive composite material as well as a preparation method and application thereof. The composite material sequentially comprises porous metal, a polydopamine layer and a mesoporous silicon dioxide coating from inside to outside, the porous metal is coated with the polydopamine layer, the polydopamine layer is coated with the mesoporous silicon dioxide coating, and preparation raw materials of the mesoporous silicon dioxide coating comprise aminated mesoporous silicon dioxide, aspirin, 4-carboxyphenylboronic acid and sodium alginate. The composite material disclosed by the invention has blood sugar concentration dual-mode response capability, aspirin is suddenly released in a hyperglycemia environment, up-regulation expression of anti-inflammatory factors is remarkably promoted, and an anti-inflammatory effect is dominated; in a normal blood glucose environment, aspirin is slowly released, and the expression of osteogenic factors is remarkably up-regulated, so that osteogenic differentiation is promoted as a leading effect; the dual-mode response realizes accurate regulation and control of ASP dosage, organically combines bone formation promotion and anti-inflammatory functions, and provides a brand new solution for patients with bone defects, especially patients with bone defects caused by diabetes mellitus.

The invention relates to a streptococcus thermophilus CT-01 and application of the streptococcus thermophilus CT-01 in preparation of an immunomodulatory preparation, the classification name of the streptococcus thermophilus CT-01 is Streptococcus thermophilus, the preservation number of the streptococcus thermophilus CT-01 is GDMCC No: 64473, and the preservation date of the streptococcus thermophilus CT-01 is March 29, 2024. The bacterium has an excellent immune regulation effect which is specifically shown as follows: comprehensive regulation is performed on the behavior of secreting inflammatory factors by macrophages, excessive activation of TNF-alpha, IL-1beta and IL-6 can be avoided, the level of IL-10 can be improved, and the bacterium has a potential anti-inflammatory effect while regulating immunity. The strain has a prospect for preparing a product with an immune regulation effect or a product with an inflammatory factor regulation effect.

The present invention relates to a composition for treating atopic dermatitis, the composition comprising stichopus japonicus-derived extracellular vesicles. Treating LPS-induced inflammation macrophages and mouse models with stichopus japonicus-derived extracellular vesicles was found to activate anti-inflammatory effects. Accordingly, the composition comprising stichopus japonicus-derived extracellular vesicles has an excellent therapeutic effect on atopic dermatitis and can be utilized in the field of researching better therapeutic effects, and thus can be used in useful businesses related to atopic dermatitis.

The invention relates to the technical field of biological medicine, and particularly discloses application of Si-Ikzf1 in preparation of products for inflammation treatment and neuroprotection, the Si-Ikzf1 provided in the scheme of the invention reduces formation of cell eschar by promoting microglial cell MResident subtype to be generated into MPtn subtype instead of MIkzf1, and improves post-ICH neurological functions by regulating Ikzf1-SIRT1 and downstream signal pathways thereof. The scheme of the invention reveals high expression of inflammatory bodies and scorch symptom related proteins in MIkzf1 subtype microglial cells, and Si-Ikzf1 can promote the conversion of MResident in ICH rats to MPtn instead of MIkzf1, and the MPtn represents an anti-inflammatory effect of promoting nerve remodeling, and the Si-Ikzf1 is capable of promoting the conversion of MResident in ICH rats to MPtn in ICH rats to MPtn in ICH rats to MPtn in ICH rats to MPtn in ICH rats. It is revealed that Si-Ikzf1 hinders MIkzf1 inflammation, scorch symptom and cell apoptosis, so that cognitive behavior and demyelination injury are improved; moreover, the scheme of the invention proves that the Si-Ikzf1 can reverse the reduction of SIRT1 expression in BV-2 cells and ICH rat brains after inflammation stimulation, and promote the up-regulation of Ptn in MPtn.

The invention relates to an andrographolide nanocrystal suspension, preparation thereof and application of the andrographolide nanocrystal suspension in preparation of an andrographolide nanocrystal dry powder inhaler with an anti-inflammatory effect. The andrographolide nanocrystal suspension contains a) an active component andrographolide nanocrystal; b) a stabilizer; wherein the content of andrographolide in the suspension is 0.1%-30%, and the content of the stabilizer is 0.1%-5%. According to the andrographolide nanocrystal dry powder inhalant and the preparation method thereof, andrographolide nanocrystals are prepared into micro powder by adopting a spray drying technology, and auxiliary material addition and a preparation process are optimized, so that the andrographolide nanocrystal dry powder inhalant with good inhalation performance is successfully prepared and directly acts on the respiratory tract through a pulmonary drug delivery system, the administration dosage is reduced, and the inhalation effect is improved. Higher lung local concentration is obtained, the first-pass effect of the liver is avoided, meanwhile, the efflux effect of p-glycoprotein is avoided as much as possible, and then the bioavailability is improved; the technical problem that the bioavailability is poor due to the fact that andrographolide is excreted through p-glycoprotein and rapidly absorbed and metabolized in the intestinal tract is solved.

The application relates to the field of biotechnology, in particular to a Faecalibacterium prausnitzii microbial anti-inflammatory molecule and a screening method and application thereof. The amino acid sequence of the Faecalibacterium prausnitzii microbial anti-inflammatory molecule is shown in (a) or (b); (a) the amino acid sequence is shown in SEQ ID NO. 1; (b) a protein derived from (a) with anti-inflammatory activity obtained by substituting, deleting or adding one or more amino acids in the amino acid sequence in (a). Compared with the microbial anti-inflammatory molecule protein of a representative strain A2-165 of the Faecalibacterium genus, the inhibiting effects of the Faecalibacterium prausnitzii microbial anti-inflammatory molecule on the NF-kappa B signal pathway and the inflammatory factor TNF alpha are 50% and 56% respectively, and the anti-inflammatory effect (inhibiting the NF-kappa B signal pathway) of the Faecalibacterium prausnitzii microbial anti-inflammatory molecule screened in the application can reach more than 90%, and the Faecalibacterium prausnitzii microbial anti-inflammatory molecule has the advantages of small use dosage and strong anti-inflammatory effect.

The invention discloses anti-inflammatory polypeptide nanoparticles and a preparation method thereof, and belongs to the technical field of bioactive peptides. The anti-inflammatory polypeptide nano-particles are nano-particles obtained by coating polypeptide with an anti-inflammatory effect with chitosan and sodium tripolyphosphate, the polypeptide with the anti-inflammatory effect contains bioactive peptides of which the amino acid sequences are YAADQ, FPYTT and YVTYA. The phycocyanin anti-inflammatory peptide is natural in source, the performance of the phycocyanin anti-inflammatory peptide can be remarkably improved through the nanometer embedding technology, and compared with traditional drugs, the phycocyanin anti-inflammatory peptide has lower toxic and side effects and potential cost advantages. The polypeptide nanoparticles prepared by the invention can effectively prevent the phycocyanin anti-inflammatory peptide from being degraded in the digestive tract, have a remarkable treatment effect on mice with ulcerative colitis, and have an important application prospect in preparation of ulcerative colitis prevention and treatment products.

The invention discloses manganese-based Prussian blue-polyacrylic acid / polyvinyl alcohol hydrogel for preventing and treating allergic rhinitis. Monodisperse manganese-based Prussian blue nanoparticles synthesized by taking polyacrylic acid as a template are stably immobilized in a polyacrylic acid / polyvinyl alcohol hydrogel matrix. The obtained composite hydrogel membrane has the following prominent advantages: the composite hydrogel membrane has excellent hydrogel characteristics, including controllable membrane thickness, good tissue adhesion and air permeability; reliable biocompatibility and safety are shown; allergen permeation is effectively blocked through a physical barrier effect; prussian blue is continuously released in the slow-release degradation process, active oxygen free radicals are remarkably removed, and the powerful anti-inflammatory effect is achieved. Due to the synergistic effect of double mechanisms of protection and treatment, the material has important clinical application value and development potential in the fields of prevention and treatment of allergic rhinitis.

The invention discloses a synthesis method of helicid, and relates to the technical field of compound synthesis, glucose is taken as an initial raw material, allose is obtained through a series of reactions, pentaacetyl allose is prepared from allose through acetylation reaction, tetraacetyl alloside is prepared through selective deacetylation reaction, substitution reaction and nucleophilic substitution reaction, and the helicid is synthesized through a one-step method. And finally, carrying out a deacetylation reaction on the tetraacetyl alloside to prepare helicid. Helicid has the effects of calming, sleeping, easing pain and resisting inflammation, and can be applied to preparation of medicaments with corresponding effects. The preparation method of the helicid provided by the invention is simple to operate, can be used for large-scale industrial production, and overcomes the defect of insufficient yield of naturally extracted helicid.

The invention discloses nasal washing liquid and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The medicine formed by the nasal washing liquid is obtained through repeated optimization of clinical research and fundamental research. Experimental research and human body tests show that the nasal cavity irrigator has the effect of irrigating the nasal cavity and also has the outstanding effects that (1) the nasal cavity irrigator has a lubricating effect, and secretions are easier to discharge in the irrigating process; (2) the moisturizing effect on nasal mucosa is achieved, a peptizing layer protective film is formed on the surface layer of the mucosa after rejection, and the function of protecting cilia activity is achieved; and (3) the traditional Chinese medicine composition has the anti-inflammatory effect by inhibiting inflammatory media, reducing vascular permeability and promoting mucous membrane repair.

According to the probiotic composition and the application of the probiotic composition in preparation of products for preventing and treating vagina inflammation, the probiotic composition composed of lactobacillus gasseri B13.52 and lactobacillus mucus B14.46 screened from vaginal secretion of healthy women can effectively inhibit growth of escherichia coli, gardnerella and prevotella; the secretion of proinflammatory factors in vaginal epithelial cells can be obviously reduced, so that an anti-inflammatory effect is achieved.