32 results about "Antiinflammatory Effect" patented technology

To provide a skin cosmetic composition that exhibits excellent anti-inflammatory effects on the skin by increasing the production of IL-1ra, which prevents inflammatory signaling to cells. [Solution] (A) Curcumin and, (B) Contains baicalin, The skin cosmetic composition is characterized in that the mass ratio of the content of component (B) to the content of component (A) [(B) / (A)] is 0.05 or more and 5 or less.

The present invention relates to: a water-soluble substituent-based novel compound having high solubility and a method for preparing same. The novel compound having high solubility of the present invention has repeating units represented by chemical formula 1, and has an excellent anti-inflammatory effect and an excellent effect on diseases caused by oxidative stress and neuroinflammatory diseases, and thus is useful as a health food or a pharmaceutical composition. [Chemical formula 1]

The application belongs to the technical field of cell biology, and particularly relates to a solution rich in Sargassum fusiforme nano-vesicles and a preparation method and application thereof. The solution rich in Sargassum fusiforme nano-vesicles is prepared by a differential centrifugation combined with hollow fiber membrane concentration, and the obtained solution rich in Sargassum fusiforme nano-vesicles can play an anti-inflammatory role, inhibit high-fat diet induced fatty liver and osteoporosis, and can also be used for preparing a mask with soothing, moisturizing and anti-wrinkle effects.

This invention discloses the application of chestnut total burr ethanol extract in the preparation of anti-colitis drugs. In this invention, the chestnut total burr ethanol extract with anti-colitis properties is obtained by extracting chestnut total burrs with 70% ethanol. This chestnut total burr ethanol extract inhibits the production of LPS-induced pro-inflammatory mediators (NO) and pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) without cytotoxicity; it has a significant inhibitory effect on dextran sulfate sodium-induced colitis in mice, including slowing down weight loss, reducing mouse DAI scores, alleviating colonic tissue damage, downregulating the levels of IL-6, IL-1β, TNF-α, and MDA in mouse colonic tissue and serum, and enhancing the activities of CAT and SOD in mouse colonic tissue and serum. Therefore, the chestnut total burr ethanol extract has significant anti-inflammatory effects both in vivo and in vitro, and can be used to treat colitis.

This invention relates to the field of biomedical technology, and in particular to a method for preparing and applying a nanomedicine for treating deep endometriosis. The method involves mixing ferrous ammonium sulfate, trisodium citrate, and polyethyleneimine, then adding thioacetamide and triethanolamine via a solvothermal reaction to obtain two-dimensional iron sulfide nanosheets. Dopamine hydrochloride is then added and stirred at room temperature in anhydrous ethanol to obtain polydopamine-coated iron sulfide (FP). FP is then mixed with larotrectinib and anhydrous ethanol to obtain the nanomedicine FPL for treating deep endometriosis. The synthesis method of this invention is simple and highly operable; the product is stable and reproducible; FPL exhibits good biocompatibility and biodegradability. After entering the microenvironment of deep endometriosis lesions, it can responsively release larotrectinib, effectively inhibiting the Trk signaling pathway and significantly reducing the degree of nerve infiltration; simultaneously, the anti-inflammatory effect of the FP carrier alleviates the local inflammatory response, jointly inhibiting lesion progression.

The present application provides a kind of composition for protecting gastric mucosa and its preparation method and application, the composition includes the following weight parts of component: L-glutamine 60-110 weight parts, sodium hyaluronate 0.5-3 weight parts, oligoisomaltose 0.5-5 weight parts, tricholoma matsutake extract 10-30 weight parts, Pleurotus eryngii extract water extract 10-30 weight parts, turmeric 0.5~3 weight parts.The composition not only has protective effect on gastric mucosa, but also can repair damaged gastric mucosa cell, in addition, the composition also has significant anti-inflammatory effect, can inhibit the release of inflammatory factors, effectively anti-inflammatory, especially suitable for the daily protection of gastric mucosa and the early prevention of injury.

This invention belongs to the field of traditional Chinese medicine chemistry and natural product separation technology, specifically relating to a novel triterpenoid compound and its epimerical form from *Eleutherococcus senticosus*, along with its extraction and separation methods and applications. The new compound is named 22α-Hydroxy-19-epi-chiisanogenin, and its epimerical form is named 22α-Hydroxychiisanogenin. The extraction and separation method provided by this invention employs acid hydrolysis / ethanol reflux extraction, macroporous resin column adsorption, silica gel column chromatography, ODS column chromatography, and high-performance liquid chromatography for separation, purification, and preparation. The compound was successfully extracted and separated. This method involves only five steps, is simple and rapid, and mainly uses conventional reagents such as ethanol, dichloromethane, and methanol. The process is simple and environmentally friendly, and the purity of the compound obtained by this method is high, exceeding 90%. Furthermore, studies have shown that this compound has anti-inflammatory effects. Therefore, the compound of this invention can be used as a lead compound for the synthesis of other compounds, as well as a raw material for new drug development and pharmacological activity research, and can also be used to prepare anti-inflammatory drugs.

The application belongs to the technical field of medicine, and particularly relates to preparation and application of an anti-endometritis and probiotic regulating gel. The preparation method comprises the following steps: adding poloxamer and inulin into a solvent, and stirring and reacting to obtain a gel solution. The temperature-sensitive gel has stable gel structure and good rheological property, can be precisely delivered in the uterus, can realize slow release of the drug after loading the drug, fully plays the anti-inflammatory effect, and can regulate the flora. The application has simple preparation process, good stability, good biocompatibility, and good application prospect.

This invention provides a hydrogel for treating atopic dermatitis and its applications, relating to the field of biomedical technology. The hydrogel comprises SA, plasma water, L-G2, and / or FLA. Preliminary evaluation of the hydrogel was conducted through in vitro cytotoxicity and antibacterial performance tests, confirming its ability to inhibit Staphylococcus aureus and Escherichia coli. Simultaneously, the hydrogel exhibits low cytotoxicity, meeting the basic requirements for biomedical dressings. In animal experiments, by comparing skin lesions before and after treatment in AD mice, the hydrogel was observed to significantly improve skin lesions on the back of mice, demonstrating good anti-inflammatory effects. Pathological histological analysis showed that the hydrogel can reduce epidermal thickness, inhibit the increase in TNF-α levels induced by DNCB, and promote inflammation relief. Simultaneously, SA can provide a moist healing environment for skin wounds, helping to promote wound repair. Therefore, this hydrogel provides a new strategy for the treatment and management of AD and is expected to become a novel topical drug for AD treatment.

The application discloses a pet nutrition composition based on intestinal-brain axis regulation and application thereof, and the composition comprises 5-20% of probiotics, 10-25% of prebiotics, 2-10% of neurotransmitter precursors, 5-15% of anti-inflammatory and neurotrophic factors, 1-10% of plant extracts and the rest of carriers. The application remolds intestinal microecology by the synergy of probiotics and prebiotics, promotes the synthesis of 5-hydroxytryptamine and dopamine by neurotransmitter precursors, exerts the neuroprotective and anti-inflammatory effects by omega-3 fatty acids, vitamin B group and magnesium elements, realizes the anti-anxiety and tranquilizing effects by L-theanine, chamomile and lavender extracts, and forms a regulation link of multi-target point synergistic intervention of intestinal-brain axis. According to animal experiment verification, the application can significantly improve the anxiety behavior of pets, improve the content of fecal short-chain fatty acids, remodel the intestinal flora structure, and realize the synergistic effect of 'intestinal health-nerve regulation-behavior improvement'.

This invention discloses a 7-O-7' lignan (+) / (–)-7- epi -oryzativol, its preparation method, and its applications belong to the field of pharmaceutical chemistry technology. The 7-O-7' lignan (+) / (–)-7- epi -oryzativol has the structure shown in formula C. This class of compounds was first obtained from Artemisia bulbifera (… Laportea bulbifera The compound was isolated from (+) / (–)-7- epi -oryzativol exhibits significant inhibitory activity against cyclooxygenase-2 (COX-2), and compound (+)-7- epi -oryzativol has a high COX-2 selectivity index and exhibits significant anti-inflammatory effects, making it suitable for use in the preparation of anti-inflammatory drugs.

The invention discloses application of melatonin in anti-inflammatory intervention of bilirubin encephalopathy, and the melatonin relieves neuroinflammation of the bilirubin encephalopathy by inhibiting activation of NLRP3 inflammasome, reducing GSDMD splitting decomposition and reducing the levels of proinflammatory factors TNF-alpha, IL-6 and IL-1beta and depending on a PI3K / AKT signal channel; the administration dosage of the melatonin is 10-20 mg / kg of body weight; the medicine is administrated through intraperitoneal injection; the melatonin plays an anti-inflammatory role by inhibiting the activation of NLRP3 inflammasome; the melatonin plays an anti-inflammatory role by reducing splitting decomposition of the GSDMD; the medicine further comprises a pharmaceutically acceptable carrier. The invention provides a new anti-inflammatory treatment strategy except for reducing bilirubin for the bilirubin encephalopathy.

The application belongs to the technical field of dressings and relates to a dressing for promoting healing of a wound of a diabetic foot and a preparation method thereof.The preparation method comprises the following steps: dissolving methacrylated gelatin and a photoinitiator in PBS to obtain solution A; dispersing sodium alginate in anhydrous ethanol, adding deionized water and sodium periodate, and reacting to obtain aldehyde-modified sodium alginate; dissolving the aldehyde-modified sodium alginate in PBS to obtain solution B; adding a tannin acid derivative to solution B, and then adding solution A and stirring; and curing under light to obtain the dressing.The dressing has precise microenvironment response characteristics, can realize on-demand release of H2S according to physiological indexes specific to a wound of a diabetic foot, has a high-efficiency anti-inflammatory effect, can improve local microcirculation and promote blood vessel and tissue neogenesis, and can accelerate healing of a wound of a diabetic foot.

A novel humectant eye drop composition is disclosed. The composition comprises a synergistic combination of nicotinamide and adenosine in concentrations at which neither component is effective individually. In preferred embodiments of the invention, the composition comprises 0.025% (w / v) and 0.05% (w / v) nicotinamide. Within 2 - 3 weeks of commencement of application, the composition improves the Tear Film Breakup Time, improves tear production as measured by the Schirmer Test, reduces the severity of the Dry Eye Syndrome as measured by Lissamine Green staining, and shows anti-inflammatory effects.

Compositions and methods for protecting against a wide spectrum of viral and bacterial infections, including Covid-19, and for treating established infection and infectious inflammation are described. The composition includes a novel combination of vitamins, minerals, nutraceuticals, and phytochemicals, which may be compounded as a pill, tablet, powder, capsule or liquid to be taken orally or via other administration routs one or more times per day, to serve as immune boosters, antibacterial agents, and antiviral agents along with providing anti-inflammatory effects in humans and animals.

This invention relates to topical pharmaceutical preparations containing nanosystems based on Lippia sidoides Cham. (rosemary-pepper) essential oil or thymol, indicated for the treatment of inflammatory diseases. The present invention relates to topical pharmaceutical preparations containing nanosystems such as polymeric nanoparticles or nanoemulsions, based on Lippia sidoides Cham. essential oil, or the isolated compound thymol, carried in pharmaceutical preparations in liquid or semi-solid forms, indicated for the treatment of inflammatory diseases. This invention also contemplates the standardization of the essential oil used as an active ingredient in these preparations, as well as the method of preparing the nanosystems consisting of polymeric nanoparticles or nanoemulsions, as well as their compositions and their potential in the treatment of inflammatory diseases.

The application discloses a postoperative auxiliary comprehensive treatment system with spatiotemporal response and a preparation method and application thereof, and relates to the fields of biology and medicine and the technical field of pharmaceutical preparations. The system comprises a temperature-sensitive hydrogel matrix, an anti-inflammatory drug dispersed in the hydrogel matrix, and nanoparticles loaded with an immunomodulator and dispersed in the hydrogel matrix. In an embodiment of the application, a postoperative auxiliary treatment comprehensive system is successfully constructed, and curcumin and MPDA encapsulating R848 are simultaneously loaded in the gel support. The small molecule curcumin is preferentially released from the gel to play an anti-inflammatory role, and R848 needs to be gradually released from the mesopore of the MPDA and the gel, so that the immune microenvironment can be improved after the anti-inflammatory curcumin promotes wound healing.

The present invention relates to the technical field of medicine, in particular to a chondroitin sulfate polysaccharide, and a semi-synthetic preparation method therefor and the use thereof. A metal salt of the chondroitin sulfate polysaccharide provided by the present invention has an anti-inflammatory effect, and can be used for preparing a drug against inflammatory diseases. In particular, the metal salt of the chondroitin sulfate polysaccharide provided by the present invention has anti-inflammatory and bone-protecting effects, and can be used for preparing a drug against rheumatoid arthritis and for preparing a drug against osteoarthritis. The present invention provides a method for preparing the metal salt of the chondroitin sulfate polysaccharide, and the metal salt of the chondroitin sulfate polysaccharide with different degrees of sulfation can be obtained by semi-synthetic means in the present invention. The method is simple to operate and suitable for large-scale production.

The invention relates principally to an active ingredient intended to confer an at least non-therapeutic cosmetic effect, said ingredient comprising an extract consisting of a non-volatile fraction of exudate of Canarium, preferably of Canarium schweinfurthii. The invention also relates to the uses of an active ingredient derived from a non-volatile fraction of Canarium exudate as a cosmetic agent for use by topical application conferring a repairing and / or anti-inflammatory effect, but also for combating acne, excess sebum and blackheads.

This invention provides a topical traditional Chinese medicine preparation for pain relief and its preparation method, relating to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from *Saussurea involucrata*, *Eclipta prostrata*, *Eclipta prostrata*, *Rehmannia glutinosa*, *Ipomoea quamoclit*, *Kaempferia galanga*, *Phyllanthus emblica*, *Terminalia chebula*, *Gentiana macrophylla*, *Angelica sinensis*, *Paeonia suffruticosa*, *Lonicera japonica*, and *Codonopsis pilosula*. This preparation exhibits significant anti-inflammatory and analgesic effects, inhibiting the excessive secretion of LPS-induced pro-inflammatory factors TNF-α, IL-1β, and IL-6, and effectively reducing the abnormal release of NO under inflammatory conditions. Simultaneously, this preparation significantly inhibits carrageenan-induced rat paw edema and significantly reduces the content of TNF-α, IL-1β, and PGE2 in local tissues, effectively blocking the inflammatory cascade and exerting rapid swelling reduction and anti-inflammatory effects. This preparation possesses both good safety and multi-target, multi-pathway synergistic anti-inflammatory properties, inhibiting excessive secretion of inflammatory factors and effectively relieving acute inflammatory symptoms such as local redness, swelling, heat, and pain.

This invention proposes a compound plant composition for inhibiting intestinal inflammatory response in pigs, its preparation method, and its application, relating to the field of veterinary technology. The compound plant composition contains the following active ingredients in parts by weight: 50-70 parts carvacrol, 10-20 parts thymol, 30-50 parts cinnamaldehyde, 5-10 parts baicalein, 5-10 parts apigenin, and 3-8 parts chlorogenic acid. The preparation method involves mixing the active ingredients in proportion, adding water and Tween-80, and stirring until homogeneous. This invention can significantly reduce the levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in the serum and small intestinal tissue of pigs infected with enterotoxigenic Escherichia coli, and increase the level of the anti-inflammatory cytokine IL-10. It also exerts its anti-inflammatory effect by inhibiting the activation of the TLR4-MyD88-NF-κB signaling pathway. This invention uses a compound of natural plant extracts, eliminating the risk of antibiotic resistance and veterinary drug residues, and is simple to prepare.

The present application relates to the technical field of biological medicines, and in particular relates to a novel five-membered heterocycle substituted styrene derivative, and a preparation method therefor and the use thereof. The styrene derivative has a novel structure and a significant anti-inflammatory effect. A new treatment method and a new anti-inflammatory drug molecule is provided for solving the problems of a series of adverse reactions, tolerance, side effects, etc., being easily generated due to the long-term use of a large number of anti-inflammatory drugs.

This invention relates to the field of natural medicines, and particularly to a limonin compound, its preparation method, and its application. This invention provides a limonin compound having the structure shown in any of compounds 1-8. Data from the examples show that the limonin compound provided by this invention can inhibit the assembly of the NLRP3 inflammasome by inhibiting ASC oligomerization, thereby reducing the generation and release of downstream inflammatory factors and exerting an anti-inflammatory effect.

This invention discloses an immune reprogramming electrospun membrane (PA-Ce@EG) composed of EGCG and cerium-doped mesoporous bioactive glass, its preparation method, and applications. The PA-Ce@EG membrane uses polylactic acid (PLLA) as a substrate, and an extracellular matrix-mimicking nanofiber structure is constructed using electrospinning technology. Epigallocatechin gallate (EGCG) is loaded into cerium-doped mesoporous bioactive glass (Ce-MBG) and uniformly embedded in the PLLA nanofiber matrix. Rapid release of EGCG achieves early broad-spectrum antibacterial and anti-inflammatory effects; Ce... 3+ / Ce 4+ The redox cycle-mediated continuous scavenging of reactive oxygen species enables long-term antioxidant and immunomodulatory effects. This membrane possesses an extracellular matrix (ECM)-like structure, synergistically promoting antibacterial activity, immune regulation, and angiogenesis, accelerating high-quality healing of diabetic infected wounds, exhibiting good biocompatibility, and is suitable for the repair and treatment of chronic, refractory wounds.

This invention provides an application of 1-O-acetyl-Inula japonica lactone, which is used to prepare drugs for improving acute lung injury. This invention utilizes network pharmacology, molecular docking, and molecular dynamics simulations to analyze that the Keap1-Nrf2 signaling pathway is a key potential target for Inula japonica in treating acute lung injury. The characteristic component of Inula japonica, 1-O-acetyl-Inula japonica lactone, exerts antioxidant and anti-inflammatory effects by targeting Keap1 and activating the Nrf2 signaling pathway. This invention provides important evidence for the application and new drug development of 1-O-acetyl-Inula japonica lactone.

The application relates to application of a peppermint-derived exosome in preparation of a medicine for treating LPS-induced ARDS, and the peppermint-derived exosome is obtained through treatment such as soaking in a PBS solution, wall breaking, differential centrifugation, filtration, ultracentrifugation, sucrose density gradient centrifugation and the like. The peppermint-derived exosome in the application can not only reduce histological damage of lung tissue of LPS-induced ARDS mice, improve pulmonary edema, but also has an anti-inflammatory effect on the lung of the ARDS mice, so that the peppermint-derived exosome can be used for preparing a medicine for treating LPS-induced ARDS.

The present invention relates to uses of threonyl-tRNA synthetase (TARS) derived from Akkermansia muciniphila or a fragment thereof as an active ingredient for prevention, alleviation, and treatment of an inflammatory disease. The Akkermansia muciniphila TARS or a fragment thereof according to the present invention promotes the differentiation of M2 macrophages, which are anti-inflammatory macrophages, to multiply macrophages, thereby increasing the secretion of IL-10 as an anti-inflammatory cytokine, leading to the proliferation of B cells to result in an anti-inflammatory effect, and thus was verified to show alleviation effects of not only inflammatory diseases but also immune diseases, infectious diseases, and metabolic diseases accompanied by inflammation, and to have excellent effects in the prevention or treatment of an inflammatory bowel disease (IBD).