77 results about "Neogenesis" patented technology

Compositions and methods are provided for islet neogenesis therapy comprising a member of a group of factors that complement a gastrin / CCK receptor ligand, with formulations, devices and methods for sustained release delivery and for local delivery to target organs.

Scaffolds made of composite materials and uses thereof in the field of biomedical engineering are disclosed, wherein the composite materials comprise bioactive microparticles that could induce the human bone tissue to regenerate. The scaffolds uses the combination of silicon, calcium, and phosphorus microparticles as bioactive substance that could actively induce the human osteoblasts to proliferate and differentiate, promote the formation and calcification of new bone. Furthermore, the scaffolds employs organic polymer as carrier, takes a three-dimensional structure and external anatomical shape, and exhibits several characteristics compatible with the regeneration of bones and the neogenesis of blood vessels, thereby it could be used safely, economically and effectively for repairing the defect of bone tissue as well as in orthopedic operation of human bone. The present invention also discloses the methods for preparing the scaffolds.

Cellophane wrapping (CW) of hamster pancreas induces proliferation of duct epithelial cells followed by endocrine cell differentiation and islet neogenesis. Using the mRNA differential display technique a cDNA clone expressed in cellophane wrapped but not in control pancreata was identified. Using this cDNA as a probe, a cDNA library was screened and a gene not previously described was identified and named INGAP.

The invention discloses a tissue engineered bone compound which comprises porous perforated between aperture artificial bone bracket and mesenchymal stem cells implanted in hole and transfected with vascular endothelial growth factor gene. The invention also discloses the application of the tissue engineered bone compound as material for bone defect repair. The inventive tissue engineered bone compound can make seed cell exert osteogenesis, express and secrete VEGF, thereby promoting vasal formation and growth, providing material basis for new bone formation, in favor of neogenesis of vascularized tissue engineered bone tissue, improving effect for repairing bone defect.

The present invention relates to a method to stimulate reversal of a diabetic state in a patient; a method to prevent autoimmune destruction of new insulin-producing cells (pancreatic beta-cells) in a patient; a method to promote survival of the newly regenerated insulin-producing cells (pancreatic beta-cells); and an in vivo method for the induction of islet cell neogenesis and new islet formation and the prevention of autoimmune destruction of said new cells.

The invention relates to a skin-whitening and freckle-dispelling essence and a preparation method thereof. The skin-whitening and freckle-dispelling essence contains the following active ingredients which are selected in the aspects of eight factors according to the latest skin-whitening and freckle-dispelling mechanism: nano-wrapped supercritical bee glue, sunscreen algae (helionori), a lytic keratinase complex (protease complex), multiex bsasm, skin-whitening polypeptide (melanostatine DM), skin neogenesis energy algae (AOAINE), epidermal growth factor bionic peptide (CG IDP-5) and a brazzil tourmaline extracting solution (tourmalina). Compared with the prior art, the skin-whitening and freckle-dispelling essence is clear in mechanism, natural and efficient in sorting, and has the advantages of inhibiting melanin, screening sun, promoting metabolism, diminishing inflammation, reducing genuine melanin, accelerating the metabolism of the melanin, improving obscuration caused by wrinkle spots and the like; after skin-whitening and freckle-dispelling essence is used, skin is the fair and tender and white lucent; and the preparation method is scientific.

The gene clone and expression of Japonese lampreyí»s oral gland model proteins RGD with antineoplastic action are disclosed. Three cDNA sequences with said model proteins RGD and their clones, the protein sequence and its expression in engineered bacteria, and the action of proteins RGD in closing the signal transfer channel to suppress the vascular neogenesis and tumor cell reproduction for antineoplastic purpose are also disclosed.

The invention discloses an inorganic bioactive material and a method for a polymer porous composite material. The method comprises the following steps of: selecting a pore-forming agent with required particle size; mixing the inorganic bioactive material, polymer, an organic solvent and the pore-forming agent; placing an obtained mixture into a die and carrying out curing; and removing the pore-forming agent to obtain the porous composite material. According to the invention, a die plate and the pore-forming agent can be synthesized and formed in one step by pressurization and polymerization; the process is simple; the uniformity and the continuity of pores are ensured; and a good environment can be provided for subsequent cell growth and tissue neogenesis. Moreover, the prepared material has certain elasticity and has good ductility.

The invention relates to a novel tumor VEGFR-3 molecular photographic developer, which comprises polypeptide with a structural formula 68Ga-DOTA-GGG-Cyclic (CGLARGRGC), wherein DOTA is 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracarboxylic acid; the novel tumor VEGFR-3 molecular photographic developer is connected with the targeted VEGFR-3 molecular polypeptide under the chelation action of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetracarboxylic acid, and is labeled with a radionuclide tracer 68Ga. The novel molecular diagnostic agent 68Ga-DOTA-TMVP1 minute for PET inspection fills the blank of a neogenesis lymphatic polypeptide photographic developer for inspecting tumors by PET, so that great assistance in clinical VEGFR-3 molecular diagnosis in the future and instruction of the individuation of a tumor patient is realized.

Compositions and methods are provided for achieving in vivo islet cell regeneration in subjects with preexisting diabetes. The methods comprise short term treatment with a composition having a gastrin / cholecystokinin receptor ligand and an EGF receptor ligand. Treatment with such a composition for a short term resulted in a prolonged period of increased insulin release, decreased fasting blood glucose, and improved glucose tolerance, the prolonged efficacy, the period being considered from the time of cessation of treatment.

The invention relates to a cell regeneration and restoration essence. The essence comprises, by mass, 2-5% of Hamamelis mollis extract, 1-3% of aloe extract, 1.5-3% of nicotinamide, 15-30% of a humectant, 0.03-0.5% of a thickener, 0.05-1% of an antiseptic, 0.01-5% of a pH adjusting agent, 0.02-0.3% of a solubilizer, 0.01-0.5% of a perfume, and the balance of water. The Hamamelis mollis extract, the aloe extract and nicotinamide are reasonably combined to synergistically realize anti-inflammation, bacteriostasis, grease secretion adjustment, thorough pore cleaning and dirt, residue and oil removal effects as a skin restoration agent, and are helpful for removing blackheads, whiteheads and acnes to promote cell neogenesis and restore and reconstruct tissues in order to realize the curing purpose.

A liver textoblastic factor and its use are disclosed. It can be used to improve in vitro hepatic cell proliferation and in vivo liver neogenesis and tumor cell apoptosis, and inhibit tumor cell growth.

The invention belongs to the technical field of medical apparatus and instruments, and specially relates to the technical field capable of performing damage endothelium repair on a device implantationposition. The invention provides an application of anti-adhesion polypeptide in preparation of an implanted medical instrument. The implanted medical device is loaded with a cell trapping substance and the anti-adhesion polypeptide. A preparation method of the implanted medical instrument includes the following steps: loading the cell trapping substance on a surface of the cell trapping substancethat the implanted medical device plan to load, and loading the anti-adhesion polypeptide into a hole or a groove of the implanted medical device. According to the technical scheme, from the perspective of anti-cell adhesion, a mechanism of combining the anti-adhesion peptide with an adhesion molecule on a cell membrane is adopted, and the adhesion of other types of cells except captured specialcells to the surface of the implanted medical device is blocked, and therefore, the purity of the captured cells can be greatly improved, the efficiency of endothelial repair is improved, thereby achieving the purpose of promoting endothelial neogenesis, inhibiting intimal hyperplasia, and inhibiting an inflammatory reaction.

The invention provides a beautification method for resisting human skin aging by using a monopolar radio frequency. The method mainly uses the heat energy generated by the monopolar radio frequency and conducts the heat energy to a deep layer of the human skin to stimulate positive and negative ions in deep layer cells of the human skin to perform friction motions and generate heat energy to ensure that a collagen tissue of a dermis layer of the human skin is heated to accelerate the blood circulation of a dermis and a subcutaneous tissue and stimulate neogenesis and re-establishment of collagen so as to achieve effects of firming the skin and removing wrinkles. The beautification method is matched with the permeability of pure oxygen and other correlative auxiliary products to ensure that the skin is fuller, more compact and more lenitive so as to fulfill the aim of resisting aging; besides, by strictly controlling steps and the time of operation, the method can effectively reduce wrinkles of a human body and promote the neogenesis of the skin, and can effectively solve the skin problems of skin aging, languor, hydropenia, pimples, sensitivity and the like.

The invention belongs to the biological medicine field, and in particular, relates to a polypeptide for inhibition of blood vessel neogenesis or growth, a coding sequence, a vector containing the coding sequence, host cells, pharmaceutical compositions and a pharmaceutical use of the polypeptide. The polypeptide has the advantages of small molecular weight, good water solubility, high safety and good stability, and can be prepared by a solid phase synthesis method; and the purity is high, the yield is high and the cost is low.

The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for trans plantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.

This invention provides compositions in the form of skin substitutes comprising epithelial cells and mesenchymal cells, wherein the mesenchymal cells are not isolated from the occipital or nape region of the scalp, as well as methods for using the same.

The present invention provides a method of inducing hair follicle neogenesis in the skin of a subject in need by transplanting the mixture of the skin extract or the composition with epidermal cells or fibroblasts into the subject. The skin extract of the present invention is obtained by mincing and mixing a skin tissue with phosphate buffer solution, thawing the skin tissue after freeze. The composition of the present invention includes at least lumican, galectin-1 and apolipoprotein A-I.

The invention discloses dendrobium huoshanense-containing combined essence capable of promoting skin regeneration. The dendrobium huoshanense-containing combined essence is prepared by, by weight, 15-25 parts of dendrobium huoshanense extract, 10-20 parts of Helix Aspersa Muller secretion, 3-6 parts of squalene, 5-10 parts of centella asiatica extract, 3-5 parts of usnea extract, 3-6 parts of water lotus fermentation broth, 10-15 parts of placentin, 3-7 parts of trout ovarian peptide, 5-10 parts of parsley seed extract, 2-3 parts of grape seed extract, 0.05-0.1 part of hyaluronic acid, 1.5-2.5 parts of water-soluble chitosan, 30-40 parts of deionized water, 5-10 parts of ginseng and 5-10 parts of radix astragali. The essence has evident functions of promoting cell neogenesis and repairing and rebuilding tissue and good functions of moisturizing, resisting aging and repairing.

The invention discloses a dendrobium huoshanense essence mask. The dendrobium huoshanense essence mask is prepared by the following raw materials including, by weight, 15-25 parts of dendrobium huoshanense extract, 3-6 parts of centella asiatica baking powder, 10-15 parts of placenta extract, 3-7 parts of trout ovary peptide, 5-10 parts of parsley seed extract, 2-6 parts of wall-broken spirulina extract, 0.05-0.1 part of cucumber extract liquor, 1-5-2.5 parts of trehalose, 5-10 parts of ginseng, 5-10 parts of astragalus and 5-10 parts of salicylic acid betaine. Eye cream obtained through the dendrobium huoshanense essence mask has the functions of remarkably promoting cell neogenesis and repairing and reconstructing tissue, so that the eye cream has good moisturizing, anti-aging and repairing functions. Through synergistic effects of the centella asiatica baking powder, the placenta extract, the trout ovary peptide and the homemade dendrobium huoshanense extract, cucumber extract liquor, parsley seed extract and wall-broken spirulina extract, the obtained mask has the functions of remarkably promoting cell neogenesis, repairing and reconstructing the tissue, and moisturizing.

This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1 / TSC2 function, increased mTORCI function, and / or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1 / TSC2 function, increased mTORCI function, and / or decreased mTORC2 function compared to wild type mesenchymal cells.

The invention provides compound wormwood essential oil having antioxidation and skin aging delaying effects. Component A mixed essential oil is prepared from, by volume, 40-45 parts of wormwood leaf essential oil, 12-20 parts of sweet almond oil, 10-18 parts of aloe oil, 6-15 parts of perilla oil, 1-5 parts of lucid ganoderma essential oil, 1-5 parts of rhodiola rosea essential oil, 1-5 parts of safflower seed oil and 1-5 parts of ginkgo leaf essential oil, and component B mixed essential oil is prepared from, by volume, 12-20 parts of wheat germ oil, 10-18 parts of jojoba oil, 6-15 parts of grape seed oil, 6-15 parts of rosehip oil, 1-5 parts of geranium essential of and 1-5 parts of jasmine essential oil. The compound wormwood essential oil is free of adding of artificial chemicals, thereby belonging to pure natural herbal plant essential oil and being safe and free of allergic reaction, and has effects of promoting skin cell neogenesis, restoring skin elasticity and delaying aging;preparation and usage methods of the compound wormwood essential oil are simple.

The invention discloses a method for delivery of neogenesis plants. The method adopts a sib plant two-time grafting technology. According to the method for delivery of neogenesis plants, two-time grafting is adopted, wild plants capable of resisting severe natural conditions are adopted as a male parent, a temperature altitude region improved plant is adopted as a female parent, after the male parent and the female parent are grafted, a generated younger generation is adopted as a second-time grafting female parent to be grafted to another sib wild plant resisting severe natural conditions, the younger generation and the male parent have the joint adaptability, the characteristic of resisting severe natural conditions are added for the younger generation, the younger generation is adopted as the second-time grafting female parent, and the generated younger generation further enhances the characteristic of resisting severe natural conditions. After secondary grafting, the female parent, the male parent and the younger generation are integrated and have the same characteristic of the same climatic zone, and the plants can resist cold, have the joint adaptability and can overwinter naturally.

The invention provides a hair loss preventing and hair growing composition, which is characterized by comprising following Chinese medicinal ingredients in part by weight: 3 to 8 parts of Chinese mugwort leaf, 3 to 8 parts of chrysanthemum, 3 to 8 parts of divaricate saposhnikovia root, 3 to 8 parts of mint, 3 to 8 parts of ligusticum sinense oliver, 3 to 8 parts of nardostachyos root and rhizome, 6 to 10 parts of wrinkled gianthyssop herb, 8 to 14 parts of simpleleaf shrub chastetree fruit and 8 to 14 parts of schizonepeta spike. A method for preparing the composition comprises the following steps of: cleaning the Chinese medicinal materials; adding the Chinese medicinal materials into water, and decocting for 2 hours; and filtering medicinal dregs, and loading decoction into a container for later use. A method for using the composition comprises the following steps of: A, fumigating hair by using steam generated in the decoction process for 1 to 2 times in a day while massaging; B, applying the decoction to heads for 1 to 2 times in a day while massaging; and C, repeating the steps every day for 1 month. Compared with the prior art, the hair growing composition is mild in formula and low in cost, is suitable to be used for a long time and does not have any toxic or side effect; and due to the combination of two using methods of fumigation and application, hair follicles are stimulated, epicranium cells are activated, blood circulation is enhanced, and the neogenesis is promoted, so the hair loss preventing and hair growing composition has a good using effect and does not have irritation.

A bone graft or biocomposite for treating osseous defects and neogenesis of bone which is a composite of a biodegradable polymer and granules of beta-tricalciumphosphate, further comprising as active ingredient and embedded in the biodegradable polymer a physiologically effective amount of underglycosylated recombinant human BSP as a muti-dental clathrate with a basic organic compound which simulataneously is active as a plasticizer for the biodegradable polymer. The biocomposite is moldable and shapeable, hardens rapidly in situ when placed by surgery or prosthetic dentistry and which furthers osseous repair and the healing of damage or diseased tissues and lesions.

A nerve regeneration which comprises a compound is represented by formula (I): (wherein all symbols are shown in the description), a salt thereof or a prodrug thereof. The compound of the present invention is suppresses nerve cell death as a substance for accelerating growth and / or differentiation of stem cells (nerve stem cells, embryonic stem cells, bone marrow cells, etc.), a substance for accelerating growth and / or differentiation of nerve precursor cells, a potentiator for neurotrophic factor activity, a neurotrophic factor-like substance or a neurodegenerative suppressor, and accelerates repair and regeneration of nerve tissues by neogenesis, regeneration and / or axon evolution. In addition, the compound of the present invention is useful for preparation from brain tissues, bone marrow and / or embryonic stem cells of cells for transplant (nerve stem cells, nerve precursor cells, nerve cells, etc.) and also accelerates grafting, growth, differentiation and / or function expression of cells for transplant whereupon it is useful for prevention and / or treatment of neurodegenerative diseases.

The present invention relates to an in vitro method for screening agents inducing islet cell neogenesis or duct-to-islet cell transdifferentiation, which comprises the steps of: a) expanding in vitro cells of a duct-like structure obtained by inducing cystic formation in cells in or associated with post-natal islets of Langerhans; b) treating said expanded cells of said duct-like structure with an agent screened; and c) determining potency of said agent of inducing islet cell differentiation of said duct-like structure in becoming insulin-producing cells.

The invention provides a wild kiwi fruit wolfberry healthcare wine and a preparation method thereof. The method comprises the following steps: crushing wolfberry, mixing with the raw juice of wild kiwi fruit and then fermenting for 20-30 days at low temperature. The effective constituents of wolfberry are fully dissolved in the semi-finished product of wine, so that the wine tastes more thick and strong; the wolfberry pulp participates in the cold processing process of the semi-finished product, so that the non-biological stability of the end product of wine is increased; the wolfberry pulp can enhance the healthcare effect of the wild kiwi fruit raw pulp wine and has the effects of strengthening body, tonifying Yang and improving eyesight; the wild kiwi fruit wolfberry healthcare wine has a certain inhibiting effect for the generation and diffusion of cancer cells; the guanidine-containing derivative can reduce blood glucose; the wild kiwi fruit wolfberry healthcare wine can protect liver, prevent fatty liver, restrain the deposition of fat in liver cells and promote liver cell neogenesis; the wild kiwi fruit wolfberry healthcare wine can reduce the content of serum cholesterol and triacylglycerol and can relieve and prevent arteriosclerosis.