58 results about "Pancreatic function" patented technology

The subject invention a method for converting liver stem / progenitor cells to a pancreatic functional cell by transfecting said liver cells with a pancreatic development gene and / or by culturing with pancreatic differentiation factors. The resulting cells produce and secrete insulin protein in response to glucose stimulation.

The present invention relates to compositions for the treatment of conditions, including pancreatic insufficiency. The compositions of the present invention comprise lipase, protease and amylase in a particular ratio that provides beneficial results in patients, such as those afflicted with pancreatic insufficiency. This invention also relates to methods using such compositions for the treatment of pancreatic insufficiency. The compositions specifically comprise crosslinked Burkholderia cepacia lipase crystals, Aspergillus melleus protease crystals and amorphous Aspergillus oryzae amylase in a ratio of about 1:1:0.15 USP units.

Compositions of the present invention, comprising the combination of enterically coated and uncoated pancreatic enzyme-containing beads are useful for treating or preventing pancreatitis pain, and optionally disorders associated with digestive enzyme deficiencies.

Disclosed herein are methods, compounds and compositions for preventing or treating a pancreatic disorder, including diabetes mellitus (e.g. type 1 and / or type 2 diabetes). The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3-propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for improving or at least stabilizing pancreatic function(s) and for the prevention and / or treatment of metabolic syndrome and its components. The invention further relates to methods, compounds and compositions for the prevention and / or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in patients in need thereof, including diabetic patients.

Proliferating pancreatic islet cells obtained by the method of isolating a population of cells that preferably includes predominantly islet precursor cells that express one or more marker associated with an islet precursor cell and providing the precursor cells with one or more a pancreatic differentiation agent so that a population of cells is obtained that has a high proportion of cells with phenotypic characteristics of functional pancreatic islet β-cells. Optionally, the precursor cells are pretreated by providing them with one or more cell expansion agent to increase the number of cells in the population prior to differentiation. The pancreatic differentiation agent composition comprises a gastrin / CCK receptor ligand, e.g., a gastrin, in an amount sufficient to effect differentiation of pancreatic islet precursor cells to mature insulin-secreting cells. The cell expansion agent composition comprises one or more epidermal growth factor (EGF) receptor ligand in an amount sufficient to stimulate proliferation of the precursor cells. The methods of treatment include transplanting either undifferentiated precursor cells and providing the pancreatic differentiation agent either alone or in combination with the cell expansion agent in situ, or transplanting the functional pancreatic islet β-cells into the patient. The pancreatic islet β-cells can be used for drug screening, and replenishing pancreatic function in the context of clinical treatment.

The invention discloses bifidobacterium capable of enhancing the pancreatic function and application of the bifidobacterium. The invention discloses application of animal bifidobacterium in preparation of a product for preventing and / or treating diabetes. By research on the apparent characteristics of the bifidobacterium to type II diabetes and development of the state of the illness, the bifidobacterium has a delaying effect and other good biological effects, and a certain theoretical basis is supplied to relevant experimental researches on the diabetes.

Agents for protecting or ameliorating pancreatic cells and tissues which contains as the active ingredient a neurotrophic factor such as BDNF. By using these drugs, degenerative dropout of pancreatic cells and pancreatic hypofunction caused by diabetes, acute / chronic pancreatitis, etc. can be efficaciously prevented and treated.

The present invention relates to the ligand polypeptide for the human pituitary- and mouse pancreas-derived G protein-coupled receptor proteins. The ligand polypeptide or the DNA which codes for the ligand polypeptide can be used for (1) development of medicines such as pituitary function modulators, central nervous system function modulators, and pancreatic function modulators, and (2) development of recombinant receptor proteins and screening of pharmaceutical candidate compounds. In particular, by the receptor binding assay systems utilizing the expression of recombinant G protein-coupled receptor proteins in accordance with the invention, agonists and antagonists of G protein-coupled receptors which are specific to human and other warm-blooded animals can be screened and the agonists or antagonists obtained can be used as therapeutic and prophylactic agents for various diseases.

Compounds such as 4-methylcholest-7-en-3-ol, 4-methylergost-7-en-3-ol and 4-methylstigmast-7-en-3-ol which have an activity for improving pancreatic function are used as an active ingredient of a pancreas function improving drug and food or drink.

Compositions of the present invention, comprising the combination of enterically coated and uncoated pancreatic enzyme-containing beads are useful for treating or preventing pancreatitis pain, and optionally disorders associated with digestive enzyme deficiencies.

A balsam pear buccal tablet takes balsam pear powder as the major ingredient and American ginseng saponin and mannite as accessories; wherein the weight percent of the ingredients is: 50-55 percent of balsam pear powder, 25-30 percent of American ginseng saponin and residual amount of mannite. The preparation comprises the following steps: 1) selecting high-quality fresh balsam pear as the raw material, dehydrating the fresh balsam pear by low temperature technology and preparing into balsam pear powder; 2) uniformly mixing the powder material based on the weight percent of the ingredients; 3) pressing the powder into tablets by the conventional method, packing or filling hermetically. The balsam pear buccal tablet has the advantage that, in the balsam pear buccal tablet prepared by the method, the hypoglycemic peptide in the main raw material--balsam pear, has the efficacy of reducing blood sugar safely and stably, improving the function of pancreas, increasing the activity of insulin cells of human body, improving the capability of regulating blood sugar, regulating blood fat and lowering blood pressure. Furthermore, the bitter principle in the balsam pear can stimulate the secretion of salivary gland to increase, better relive the symptoms of dry mouth and thirst of diabetics. The balsam pear buccal tablet is easy to eat, which is a pure natural healthcare product.

The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and conditions. Such diseases and conditions can include impaired pancreatic function, treating a metabolic disease, for example, diabetes, both type 1 and type 2 diabetes, islets induction, expansion and proliferation for trans plantation, promoting neuroprotection or nerve regeneration, promoting liver regeneration or inhibiting inflammation.

Compounds having a cyclolanostane skeleton such as 9,19-cyclolanostan-3-ol and 24-methylene-9,19-cyclolanostan-3-ol are used as an active ingredient of a drug and food or drink for improving pancreatic functions.

The invention belongs to the technical field of tissue engineering and regenerative medicines, aims to solve the technical problems that in the prior art pancreas functions are hard to recover and pancreas tissue injury caused by acute necrotizing pancreatitis is hard to recover, and provides a preparation method and application of pancreas substrate hydrogel for repairing pancreatic tissue. The preparation method comprises the following steps: B, preparing pancreas substrate hydrogel, namely performing freeze-drying on decellularized pancreatic tissue, powdering, mixing with a hydrochloric acid-stomach protease solution according to a ratio, and adjusting the pH value to a physiological status, thereby obtaining the pancreas substrate hydrogel. The pancreas substrate hydrogel provided by the invention not only has the advantages of temperature sensitivity, low immunogenicity and capability of providing extracellular microenvironments and the like, but also is simple in operation process, gentle in implementation condition and capable of providing a hydrogel material to pancreas tissue engineering. The material is applicable to growth of pancreas cells, anti-inflammatory M2 type polarization of macrophage can be regulated and controlled, and endogenous repairing of severe pancreatitis pancreatic tissue is promoted.

The invention belongs to the technical field of strain preparation, and discloses a bifidobacterium animalis and a preparation method thereof. The preservation number of the bifidobacterium animalis is CGMCC No:12944. The bifidobacterium animalis NMC disclosed by the invention is separated from the intestinal tract of a healthy 100-year-old person, the strain has extremely high acid resistance, capable of resisting gastric acid to successfully arrive at the intestinal tract, and an intestinal tract experiment proves that the strain has the probiotic functions of significantly alleviating constipation, improving intestinal flora, alleviating ulcerative colitis, enhancing the pancreatic islet function and fat metabolism of animals with type II diabetes, decreasing the triglyceride and cholesterol level in blood and the like, so the strain is an excellent probiotic strain; and the bifidobacterium animalis can treat constipation, prevent and treat tumors, protect the liver, treat cardiovascular disease, improve lactose digestion and delay senescence.

The invention discloses a preparation method of traditional Chinese medicinal pills for treating diabetes. The preparation method sequentially comprises the following steps: preparing materials, extracting, condensing, collecting a paste, coarsely grinding, sterilizing, mixing paste powder, drying the paste powder, grinding the dry paste, totally mixing, preparing a soft material, refining, preparing pills, flattening, drying plain pills, screening pills, coating and polishing, drying the coated pills and selecting the pills. The traditional Chinese medicinal pills are prepared from the following raw materials in parts by weight: 17-23 parts of rehmannia, 12-18 parts of radix ophiopogonis, 4-6 parts of fruit of Chinese magnoliavine, 19-23 parts of pachyrhizua angulatus, 15-19 parts of root of Chinese trichosanthes and 5-7 parts of liquorice. The preparation method disclosed by the invention is convenient to operate, and is capable of reducing labor intensity of operators and increasing yield; the preparation method is convenient for continuous and mass production; the traditional Chinese medicinal pills prepared by the method have the functions of nourishing yin, promoting fluid, quenching thirst, relieving restlessness, and benefiting and strengthening qi, and are applicable to treating material and carbohydrate metabolic disorders caused by pancreatic function decrease, diabetes caused by increase in blood sugar, deficiency in lung, stomach, kidney and yin, and later period of fever.

The invention discloses a rat dermal mesenchymal stem cell culture method. The method comprises the steps of digesting skin tissue and keeping the skin tissue for a whole night; separating epidermis and dermis of the skin tissue; sticking a dermis tissue block in a cell culture dish and adhering in an inverted incubator at 37 DEG C for half an hour, and cultivating the tissue block through low-sugar DMEM and 10% of FBS; implementing conventional pancreatin digestion subculture when the dish is full of cells cultivated from the dermis tissue block to obtain dermal mesenchymal stem cells. The method disclosed by the invention is a novel method combining a skin tissue block adherent method and an enzyme digestion method, not only effectively avoids epidermal keratinocyte pollution caused by the skin tissue block adherent method but also avoids influence of a long-time pancreatic function on a cell growth state in the enzyme digestion method. The culture method disclosed by the invention provides possibility for further research on effects of mesenchymal stem cells in the skin tissue on skin development, growth and damage repair.

The invention provides a new medicine application of a breast milk fat globule cuticle growth factor 8 (MFG-E8), namely an application of the breast milk fat globule cuticle growth factor 8 to preparation of drugs for preventing / treating serious acute pancreatitis. During treatment of serious acute pancreatitis of mice, through intravenous injection of exogenous breast milk fat globule cuticle growth factor 8, the function of pancreases can be notably improved, the apoptosis of the pancreases can be alleviated, the damage of pancreatic tissue and cell death are reduced, the release of mediators of inflammation and inflammatory cell soaking are improved, and the mortality rate of the mice suffering from serious acute pancreatitis is reduced. Results prove that the breast milk fat globule cuticle growth factor 8 can notably improve the serious acute pancreatitis and can be used as a new medicine or medicine target for preventing / treating the serious acute pancreatitis for development.

3-O-β-D-Glucopyranosyl-4-methyl-ergost-7-en-3-ol or a composition containing 0.001 to 10% by dry mass of the aforementioned compound, which is an extract of a plant of the family Liliaceae or a fraction thereof containing the compound, is used as an active ingredient of a drug for improving pancreatic functions.

The invention discloses a traditional Chinese medicine composition for treating diabetes. The traditional Chinese medicine composition is composed of sixteen traditional Chinese medicines such as radix curcumae, lumbricus, dragon's blood, myrrh, fingered citron, radix bupleuri, rhizoma corydalis, common macrocarpium fruit, mantis egg-case, the root of kudzu vine, radix cyathulae, raw white atractylodes rhizome, radix pseudostellariae, coptis root, herba lycopi and fructus gardenia. The traditional Chinese medicine composition can soothe liver and tonify kidney, promote blood circulation to remove blood stasis, mediate meridians and collaterals, regulate activities of qi, tonify spleen and qi, discharge fire and remove toxicity and support the healthy energy. By combining the above medicines, the traditional Chinese medicine composition can play the role of soothing the liver and tonifying the kidney, promoting blood circulation to remove blood stasis and supporting the healthy energy, so that the functions of pancreas can be recovered.

The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1+ cells and / or progeny cells thereof and / or soluble factors derived therefrom. The method of the invention is useful for treating and / or preventing and / or delaying the onset or progression of a disorder resulting from or associated with pancreatic dysfunction, e.g., resulting from abnormal endocrine or exocrine function of the pancreas.

The invention discloses a composition for curing II-type diabetes mellitus, comprising the following components in parts by weight (in dry weight): 3-6 parts of balsam pear or roots and stems of the balsam pear, 3-6 parts of animal pancreas, 3-6 parts of lotus root starch, 10-20 parts of pumpkin powder and 3-5 parts of ginseng. The invention also discloses a preparation method of the composition. The composition makes the pancreas functions of patients return to normal by adopting the combination of pure plants and animal pancreas with a scientific and standard application method to fundamentally cure the II-type diabetes mellitus. The fasting blood-glucose values of the patients can be reduced to the normal level in general after the composition is taken 5-10 months, fasting urine glucose is in light blue, which is a negative and no-urine glucose standard, and no recidivation condition exists after drug withdrawal. The preparation method of the composition has the advantages of simple operation and easy enforcement.

The invention belongs to the technical field of health-care foods and particularly relates to a gugua polypeptide composition. The gugua polypeptide composition comprises melon seed peptide and bone marrow peptide. The invention also provides application of the gugua polypeptide composition in preparing medicines and health-care foods which have the efficacy of improving immunity, promoting woundhealing as well as preventing and treating diseases caused by free radical damage. The gugua polypeptide composition provided by the invention has the effects of effectively promoting the wound healing, improving the immunity, eliminating excess free radicals in the body, realizing an anti-aging effect, promoting calcium absorption and collagen secretion, reducing morning stiffness, increasing joint flexibility, reducing joint pain and swelling, improving diseases such as osteoporosis, fracture, rheumatism, rheumatoid, scapulohumeral periarthritis and lumbar disc herniation, improving the digestive system, promoting gastrointestinal peristalsis and digestive enzyme secretion, treating chronic gastrointestinal disease, improving pancreatic function, promoting automatic insulin secretion ofthe body and reducing insulin resistance, thereby achieving the aims of decreasing blood sugar and preventing complications.

The invention discloses a traditional Chinese medicine composition for treating diabetes and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw medicinal materials in parts by weight: 30-90 parts of radix pseudostellariae, 20-60 parts of Chinese yam, 20-60 parts of pollen, 15-45 parts of poria cocos, 20-60 parts of the root of kudzu vine, 20-60 parts of astragalus, 20-60 parts of rhizome of rehmannia, 15-45 parts of endothelium corneum gigeriae galli, 20-60 parts of roasted rhizoma atractylodis macrocephalae, 20-60 parts of fructus corni, 10-30 parts of coptis chinensis, 15-45 parts of houttuynia cordata and 10-60 parts of pig pancreas. The traditional Chinese medicine composition for treating diabetes disclosed by the invention can achieve the effects of obviously improving symptoms such as polydipsia, dieresis, polyphagia, emaciation, fatigue and lack of strength and hypopsia caused by diabetes and reducing blood sugar and is fast in effectiveness; and due to long-term administration, the diabetes and complications thereof can be completely treated, and pancreatic function is restored.

The invention discloses a chitosan composition for preventing and treating diabetes and a preparation method of the chitosan composition. The preparation method comprises the following steps: extracting puerarin, radix rehmanniae recen, bitter gourd, astragalus membranaceus, polygonatum odoratum and ganoderma lucidum to prepare dry paste powder, mixing the dry paste powder with sieved chitosan and starch, granulating, filling capsules, polishing and packaging to prepare the chitosan composition for preventing and treating diabetes. In the formula of the chitosan composition disclosed by the invention, the chitosan can promote internal secretion by regulating organ functions to regulate the pancreatic function, improve the activity of islet cells, so as to promote increased insulin secretion; such traditional Chinese medicinal materials in the formula as the puerarin, the radix rehmanniae recen, the bitter gourd, the astragalus membranaceus and the ganoderma lucidum are dialectically used to ensure functions of nourishing yin, engendering liquid and allaying thirst, moistening dryness and tonifying qi, and cooperatively condition human body organ functions with the chitosan so as to effectively prevent and treat diabetes and complication.

The invention belongs to the field of medicine, and particularly discloses application of irisin in a drug for preventing and treating severe acute pancreatitis. In the mice severe acute pancreatitis,by virtue of the intravenous injection of exogenous irisin, the pancreas function can be significantly improved, the endoplasmic reticulum stress of the pancreas cell can be alleviated, and the pancreas tissue injury and cell death can be reduced, which proves that the irisin can significantly improve the severe accurate pancreatitis; and the irisin is applied to the drug development, when the acute pancreatitis is diagnosed in emergency treatment, the irisin drug is used for intravenous injection, and the local inflammation reaction of pancreatitis is prevented from being developed to the whole-body inflammation reaction syndrome or the whole-body inflammation reaction syndrome chain-type expansion can be inhibited and prevented, so that the worsening of the pancreatitis can be inhibited, and an effect for protecting local internal organs and preventing the multiple organ dysfunction syndrome can be achieved; and by adopting the application of the irisin, a brand new choice and concept can be provided for preventing and treating the severe acute pancreatitis at present.

The invention discloses a Chinese medicinal preparation for lowering blood sugar, wherein the formula comprises ginseng 10-15 parts, astragalus root 50-80 parts, dried rehmannia root 15-20 parts, radix scrophulariae 15-20 parts, root of Chinese trichosannthes 15-25 parts, wolfberry fruit 20-30 parts, and curculigo rhizome 15-25. The invention also discloses its preparing process.

Methods and compositions comprising a bone morphogenetic protein (BMP) are described for stimulating uptake of serum glucose by peripheral cells and tissues, for treating type 1 or type 2 diabetes, for controlling exocrine pancreatic function, and for treating pancreatitis by an insulin-independent pathway.

Provided is a drug for improving pancreatic function and / or liver function having been worsened by usual life habits. A liver function improving agent and / or a pancreatic function improving agent, said agents comprising a liver hydrolysate as an active ingredient, for people with high-fat diet and alcohol intake.