72 results about "Collagen secretion" patented technology

Provided is a method for enhancing collagen secretion and preventing cutaneous aging using Chenopodium formosanum extract. The Chenopodium formosanum extract includes active ingredients that are able to effectively enhance the ability of collagen secretion of dermal fibroblasts as well as prevent the glycation of collagen and resist the damage of ultraviolet light exposure. The preparation of the Chenopodium formosanum extract is environmental friendly and is able to promote the economic value of Chenopodium formosanum; thus, the present invention is suitable for applications in the development of food products, especially beverages, skin care and cosmetic products.

The invention relates to an anti-aging skin care product, and in particular discloses a stem cell essence and a preparation method thereof. The stem cell essence is prepared by mixing the following raw materials in percentage by weight: 28-32% of a stem cell extract, 3-7% of glycerol, 0.2-0.8% of lactic acid, 0.7-1.3% of trehalose, 0.2-0.5% of vitamin A acetate, 0.1-0.3% of vitamin E acetate, 0.1-0.3% of 4',6,7-trihydroxyisoflavone, 0.5-0.7% of titanium dioxide, 0.01-0.02% of xanthan gum, 0.02-0.03% of triethanolamine, 2-4% of isopropyl myristate, 0.8-1% of propylene glycol, 0.02-0.07% of sodium hyaluronate, 0.8-1.2% of an antiseptic and the balance of de-ionized water, wherein the stem cell extract is an extract of sheep umbilical cord blood stem cells. The stem cell essence provided by the invention, after being absorbed by the epidermis, can penetrate to the corium layer and the subcutaneous tissue, so as to comprehensively activate the differentiation of stem cells in skin and rapidly replace old cells, so that collagen secretion is enhanced and skin elasticity is improved; the stem cell essence can be used for promoting the synthesis activation of protein and enhancing the softness of the skin; and the stem cell essence can be also used for stimulating the muscular layer to generate fibroblast and skin protein so as to enhance skin toughness and elasticity.

The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.

The invention relates to microneedle paster for replenishing water and dispelling wrinkles and a preparation method of the microneedle paster, and relates to the field of skin-care products. The microneedle paster comprises a base and a microneedle, wherein a plurality of needles are uniformly distributed on the base; the base and the needles are made from main body support components, and functional components are dispersed in the main body support components; and the main body support components are hyaluronic acid, and the functional components are bioactive peptide P-WH. The microneedle paster disclosed by the invention can effectively penetrate through stratum corneum to dissolve by tissue liquid of a cuticular layer and epidermis, P-WH is released to cuticle and dermal tissue to diffuse so as to stimulate secretion of skin cell collagen, and the effects of preventing and repairing skin ageing and rough skin, replenishing water and resisting ageing can be achieved.

The invention belongs to the field of biology, and particularly relates to a skincare stem cell activin and a preparation method and application thereof. The preparation method of the skincare stem cell activin includes the steps of S1, culturing stem cells in vitro; S2, collecting the stem cells, performing cell lysis to obtain cell lysate, subjecting the cell lysate to low-speed centrifuging, removing cell debris, and freezing to preserve supernate to obtain the stem cell activin. Compared with general chemical skincare products, the skincare stem-cell activin has the advantages that under action of the cell signal regulation mechanism and the synergistic effect of various growth factors, nutrition metabolism of epithelial cells can be improved, skin protection can be achieved, skin injury caused by various reasons can be prevented and cured, skin collagenocyte growth can be accelerated, collagen secretion of skin can be accelerated, and further, wrinkle resistance and ageing resistance can be achieved. Therefore, the skincare stem cell activin has good application prospect in fields of medicines, healthcare and beautifying.

The invention discloses applications of pseudolaric acid B in preparation of anti-pulmonary-fibrosis medicines. The structure of the pseudolaric acid B is shown as a formula (I). Experiments prove that the pseudolaric acid B (PLAB) obviously relieves the degree of alveolar catarrh and pulmonary fibrosis of mice in a pulmonary fibrosis model built by utilizing bleomycin, and inhibits collagen secretion and deposition in fibrotic lung tissues, thus preventing and treating pulmonary fibrosis.

The invention discloses a truncated growth differentiation factor 11 (GDF11) with biological activity and a preparation method thereof and belongs to the technical field of biological medicines. The truncated growth differentiation factor 11 comprises 95 amino acids, wherein the amino acid sequence is as shown in SEQ ID NO.1 The biological activity of the obtained truncated growth differentiation factor 11 is researched, and the result shows that the truncated GDF11 is capable of stimulating collagen secretion of fibroblasts and has the activity of promoting phosphorylation of cardiac fibroblasts Smad2 / 3 and activating a passage of the cardiac fibroblasts Smad2 / 3. Therefore, the truncated growth differentiation factor 11 has a wide application prospect in treatment or prevention of irreversible senile diseases such as a diastolic heart failure and alzheimer disease.

The invention provides collagen secretion promotion ultrashort peptides and application thereof, and belongs to the technical field of biomedicine. The two kinds of collagen secretion promotion ultrashort peptides Magin-FL and Purin-WH3 have the capability of promoting the collagen synthesis; in addition, the characteristics of ultra-high oxidization resistance, aging-resistant activity, no cell toxicity, no hemolysis activity, simple preparation method and the like are realized, so that the collagen secretion promotion ultrashort peptides are used for preparing medicine for treating injured skin restoration and regeneration such as medicine for treating burnt injury, scald injury and skin ulceration, and can replace EGF to be used in the fields of anti-aging and anti-oxidization beatification skin care product new raw materials for skin restoration and skin collagen proliferation simulation and the like. In addition, the effects are possibly not limited to the field. The ultrashort peptides Magin-FL and Purin-WH3 have small molecular weight and simple structure; the used chemical synthesis method has very low cost; the ultrashort peptides Magin-FL and Purin-WH3 have the obvious beneficial characteristics through being compared with EFG with the sale price being nearly 2 million U.S dollars per gram.

The invention relates to the technical field of biology, in particular to a preparation method of a biological preparation for skin damage repair. The preparation method comprises the steps that P3 substituted adipose derived stem cells are taken to be recovered and added into a DMEM (dulbecco's modified eagle medium) high glucose complete medium containing 10-12% of FBS (fetal bovine serum) to becultured till the cell confluence rate is as high as 80-90%, and supernatant is collected; the P3 substituted adipose derived stem cells are washed and added into a DMEM / F12 basal culture medium to be cultured for 24 hours, and supernatant is collected; the cell culture after the supernatant is collected is taken, the culture medium is replaced, culture is conducted continuously, the culture liquid is collected, and the steps are repeated for 1-2 times; the supernatants are combined, and the biological preparation is obtained. The biological preparation prepared by adopting the preparation method provided by the invention can outstandingly promote skin fibroblast proliferation and collagen secretion, and has the good effect of promoting skin damage repair.