Application of breast milk fat globule cuticle growth factor 8 to preparation of drugs for preventing/treating serious acute pancreatitis

A technology of epidermal growth factor and acute pancreatitis, which is applied in the field of medicine to achieve the effects of inhibiting severe disease, protecting local organs, and preventing multiple organ failure syndrome

Active Publication Date: 2019-03-29
崇好科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Currently, there is no report on the application of milk fat globule epidermal growth factor 8 in severe acute pancreatitis

Method used

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  • Application of breast milk fat globule cuticle growth factor 8 to preparation of drugs for preventing/treating serious acute pancreatitis
  • Application of breast milk fat globule cuticle growth factor 8 to preparation of drugs for preventing/treating serious acute pancreatitis
  • Application of breast milk fat globule cuticle growth factor 8 to preparation of drugs for preventing/treating serious acute pancreatitis

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Example 1: Dissolving milk fat globule epidermal growth factor 8 with physiological saline, and preparing an injection.

[0018] Take this injection as an example to study the effect of milk fat globule epidermal growth factor 8 on severe acute pancreatitis.

experiment example 2

[0019] Experimental example 2: animal experiments.

[0020] one. Experimental animals: 20-25g male C57BL / 6J mice were randomly divided into 3 groups, 6 in each group:

[0021] Normal control group (Sham);

[0022] Severe acute pancreatitis control group: mice were intraperitoneally injected with 8% L-arginine 4g / kg twice with an interval of one hour (Vehicle);

[0023] Severe acute pancreatitis milk fat globule epidermal growth factor 8 treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg twice with an interval of one hour, and 50 μg / kg milk fat globule epidermal growth factor 8 was given 1 hour later.

[0024] Two: Severe acute pancreatitis model production: Vehicle mice were intraperitoneally injected with 8% L-arginine 4g / kg to create a severe acute pancreatitis SAP model. The sham group was intraperitoneally injected with the same volume of normal saline; the mice in the severe acute pancreatitis milk fat globule epidermal growth factor 8 treat...

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Abstract

The invention provides a new medicine application of a breast milk fat globule cuticle growth factor 8 (MFG-E8), namely an application of the breast milk fat globule cuticle growth factor 8 to preparation of drugs for preventing/treating serious acute pancreatitis. During treatment of serious acute pancreatitis of mice, through intravenous injection of exogenous breast milk fat globule cuticle growth factor 8, the function of pancreases can be notably improved, the apoptosis of the pancreases can be alleviated, the damage of pancreatic tissue and cell death are reduced, the release of mediators of inflammation and inflammatory cell soaking are improved, and the mortality rate of the mice suffering from serious acute pancreatitis is reduced. Results prove that the breast milk fat globule cuticle growth factor 8 can notably improve the serious acute pancreatitis and can be used as a new medicine or medicine target for preventing /treating the serious acute pancreatitis for development.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to the application of human milk fat globule epidermal growth factor 8 (MFG-E8) in the preparation of drugs for preventing / treating severe acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is a common acute abdomen in clinical practice, and 20%-25% of patients are clinically severe, and may have local or systemic complications, multiple organ failure, or even life-threatening. Severe acute pancreatitis (Severe Acute Pancreatitis, SAP). The etiology of SAP is complex, and its pathogenesis has not yet been fully clarified. According to the World Health Organization, SAP will become the number one cause of death in pancreatic diseases by 2020. After nearly 30 years of research, the treatment effect of severe acute pancreatitis in my country has been significantly improved, and the treatment viewpoint has also reached a consensus in principle, that i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61P1/18
CPCA61K38/1808A61P1/18
Inventor 吴荣谦任一凡吕毅
Owner 崇好科技有限公司
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