36 results about "Milk fat globule" patented technology

The invention belongs to the field of functional substance research, and particularly relates to a nutritional composition for promoting absorption of fatty acid and mineral substances and application. The nutritional composition provided by the invention comprises necessary active ingredients shown as the following (I) and (II): (I) 1, 3-dioleic acid-2-palmitic acid triglyceride; (II) a milk fat globule membrane, and / or, 2 '-fucosyllactose; moreover, in the nutritional composition, the mass ratio of the necessary active component shown in (I) to the necessary active component shown in (II) is (5-10): (0.5-10). The combination of OPO and MFGM and / or 2 '-FL provided by the invention can be beneficial to promoting the absorption of the body to fatty acids and mineral substances, and especially can be beneficial to promoting the transmembrane transport capability of intestinal cells of the body to fatty acids and mineral substances, so that the absorption efficiency is improved.

This disclosure relates to dairy products, methods for producing dairy products, uses of dairy products, and dairy-based products including dairy products. This disclosure also relates to methods for improving or maintaining physical performance in subjects, and dairy products or dairy-based food products for use in improving or maintaining physical performance in subjects.

The invention discloses a pet food containing probiotic-lactoferrin pellets and a preparation method of the pet food. An immune golden triangle formula is adopted, layered wrapping is carried out, active probiotics, prebiotics, protein for enhancing immunity and antioxidant substances are used as formula raw materials, the probiotics are wrapped by the prebiotics and milk fat globule membrane protein, and then the prebiotics and the milk fat globule membrane protein are wrapped by lactoferrin and shiitake mushroom powder. And finally, coating lactoferrin with a coating solution containing antioxidant substances to prepare pellets, and applying the pellets to preparation of pet food. Functional substances such as probiotics and immune protein are delivered to the intestinal tract through multi-layer wrapping, and various functional components capable of improving immunity in the intestinal tract have a synergistic effect, so that the immunity of pets can be remarkably improved.

The invention discloses a nutritional composition for short-time internal inflammation balance after medium-high-strength resistance training and application of the nutritional composition, and belongs to the technical field of food processing. The composition comprises an inflammation control component composed of a plant inflammation control component and a milk source inflammation control component, the inflammation control component is composed of a plant source component and a milk source component and specifically comprises omega-3 unsaturated fatty acid, curcumin, iron unsaturated lactoferrin and a milk fat globule membrane according to a specific weight ratio, the weight ratio of EPA to DHA in the omega-3 unsaturated fatty acid is not lower than 1.5: 1, and the weight ratio of the curcumin to the iron unsaturated lactoferrin to the milk fat globule membrane is not lower than 1.5: 1. The iron saturation of the iron unsaturated lactoferrin is less than or equal to 30%, and the phospholipid accounts for 4-10% of the milk fat ball membrane. Experimental results show that the composition can effectively regulate and control the level of inflammatory factors within 6 hours after training, and accurate regulation and control of inflammatory response within an inflammatory regulation window period within 6 hours after training are achieved. The invention also relates to application of the composition in preparation of functional food and dairy products.

The invention relates to the technical field of nata de coco processing, in particular to a method for improving nata de coco processing technology to improve taste and quality, which comprises coconut milk, natural plant juice and coconut water, and further comprises a pretreatment process of raw materials, a fermentation link formula and regulation, a post-treatment and function strengthening process and process and finished product monitoring. According to the present invention, during the raw material pretreatment, the particle size of the coconut milk fat globules can be homogenized to less than or equal to 2 [mu] m through the 800 MPa high-pressure micro-jet homogenization, and the 254 nm ultraviolet ray is matched to cooperate with the 40 DEG C composite sterilization so as to ensure the thorough sterilization of the raw material and the uniform distribution of the fat particles so as to lay the fine and smooth taste foundation for the subsequent fermentation.

This invention provides an application of a nutritional composition for enhancing immunity. The nutritional composition of this invention comprises medium- and long-chain triglycerides (MLCT) and milk fat globule membrane (MFGM) in a mass ratio of 0.3:1 to 120:1. This nutritional composition can increase the proliferation of immune cells, and is used as a method for improving immunity.

The invention discloses an anthocyanin ingredient containing milk fat globules and a preparation method thereof.The preparation method comprises the specific steps that the milk fat globules are extracted from fresh raw milk, anthocyanin and the milk fat globules are added into deionized water to be emulsified, and the anthocyanin emulsion type ingredient containing the milk fat globules is obtained; wherein anthocyanin in the ingredients and a fat membrane of the milk fat globules form a specific structure, and the specific structure is rich in long-chain unsaturated fatty acid and medium-chain fatty acid in a specific ratio of 1: (7-10) after being digested by in-vitro simulated gastrointestinal fluid. The anthocyanin ingredient containing the milk fat globules is a novel stable emulsion taking the natural milk fat globules as an anthocyanin carrier, is particularly suitable for being used as an ingredient of nutritional and healthy food, and is wide in application range. And the preparation method adopts a probe type ultrasonic combined high-speed shearing technology, so that the obtained emulsion is better in dispersity and stability, simple, efficient, green and safe.

The invention relates to the technical field of milk powder, and particularly discloses infant LMNP combined formula milk powder for caesarean delivery and a preparation method of the infant LMNP combined formula milk powder for caesarean delivery, 100g of formula milk powder comprises an intestinal micro-ecological regulation composition, an immune nutrition synergistic composition, a core nutrition component and a vitamin and mineral composition. The composition has the advantages that the composition is reasonable in formula, beneficial bacteria colonization and proliferation are synergistically promoted, healthy intestinal flora is quickly established, common intestinal flora imbalance of the cesarean delivery infants is effectively improved, the risks of diarrhea, constipation and the like are reduced, and an immune nutrition synergistic system is formed through scientific compatibility of lactoferrin, milk fat globule membranes and compound nucleotide. The composition can enhance immune cell activity, promote immune system development, strengthen mucous membrane defense, make up immune shortages of caesarean section babies in a targeted manner, and reduce allergy and infection risks.

The invention discloses an application of a protein substance in preparation of a composition for inhibiting coronavirus. The coronavirus inhibition comprises the following steps: inhibiting adhesion of the coronavirus on host cells; the invasion of coronavirus to host cells is hindered; the after-cell entry process of coronavirus infection is inhibited. In-vitro verification is carried out on the antiviral effect of the coronavirus GXP2V on various nutritional ingredients (whey protein, milk fat globule membrane, lactoferrin and milk-derived osteopontin), and the result shows that the coronavirus resisting activity of the whey protein, the milk fat globule membrane, the lactoferrin and the milk-derived osteopontin (LPN, short for lactopontin). At present, it is rarely reported that protein substances are used for resisting the coronavirus, the coronavirus GXP2V is a novel coronavirus-like virus, a new thought is developed for resisting the novel coronavirus-like virus, and the application value and prospect are very good.

The application discloses application of a silk fibroin nanoparticle hydrogel in treatment of pressure sore ulcers and relates to the technical field of biochemistry.The core points of the technical solution include the following steps: S1, preparation of a silk fibroin solution;S2, preparation of nanoparticles;S3, production and preparation of milk fat globule epidermal growth factor VIII (MFG-E8) in exosomes;S4, purification of MFG-E8 protein;S5, preparation of silk fibroin nanoparticles coated with MFG-E8;S6, preparation of MFG-E8-silk fibroin nanoparticles crosslinked with NGR peptides; and S7, preparation of a collagen / silk fibroin hydrogel.The silk fibroin nanoparticle hydrogel is a non-invasive treatment method and is more easily accepted by patients in clinical application.In addition, the targeted nanoparticle treatment method for pressure sore sites can significantly improve the treatment effect of patients.

The present invention relates to a method for multidimensional evaluation of the similarity of a sample to breast milk, wherein the method is performed in the following steps: (1) establishing a local breast milk phospholipid database; (2) collecting and pretreating a sample to be evaluated; (3) determining the contents of characteristic phospholipid subclasses, the contents of characteristic phospholipid molecules in the sample to be evaluated, and obtaining a microstructural image of milk fat globules in the sample by confocal laser scanning microscopy; (4) calculating the score G for the sample to be evaluated. The present invention evaluates the similarity of samples to breast milk based on phospholipids in three aspects: the composition of characteristic phospholipid subclasses, the composition of characteristic phospholipid molecules, and the morphological similarity evaluation, so that the scheme can better evaluate the simulation quality of infant formulas and their raw and auxiliary materials to breast milk based on phospholipids.

The application provides a composition for promoting growth of Akkermansia and application thereof, and the composition comprises milk fat globule membrane, colostrum basic protein and lacto-N-neotetraose, wherein the concentration ratio of the milk fat globule membrane, the colostrum basic protein and the lacto-N-neotetraose in the composition is (0.1-2):(0.025-0.3):(0.2-0.8). The composition can fully meet the nutritional requirements of Akkermansia bacteria, especially mucinophilic Akkermansia bacteria, can effectively promote the growth of Akkermansia bacteria, can be used for culturing Akkermansia bacteria in vitro, and can promote the growth of mucinophilic Akkermansia bacteria in the human intestinal tract, increase the potential probiotic Akkermansia bacteria in the intestinal tract, and improve intestinal health.

The present invention pertains to a new method of producing butter-like products based on warm shearing of liquid, high fat concentrates of milk fat globules, which liquid concentrates contain a significant amount of micellar casein. The invention furthermore pertains to the novel butter-like products as such and uses of the novel butter-like products.

The application provides a kind of no-added foaming milk and its preparation method.The preparation method comprises the following steps: separating raw milk to obtain cream and skim milk;optionally, the cream is cooled and crystallized, stirred, filtered to remove part of milk fat globule membrane, and then treated by deacidification to obtain a feed liquid A;the skim milk is micro-filtered to obtain a feed liquid B and a feed liquid C;for UHT milk, the feed liquid A, the feed liquid B and the feed liquid C are mixed in a certain proportion to obtain a first mixed feed liquid;for pasteurized milk, the cream, the feed liquid B and the feed liquid C are mixed in a certain proportion to obtain a second mixed feed liquid;after homogenization and sterilization of the first mixed feed liquid or the second mixed feed liquid, no-added foaming milk is obtained.The foaming milk of the application has excellent foaming performance without adding other ingredients;after steam whipping, the liquid part is perfectly combined with coffee, the bitterness is modified, the smoothness is improved, the milk foam part is soft and delicate, and is stable and easy to whip.

The present invention relates generally to preparative and purification processes relating to whey protein and particularly to the preparation and purification of Whey Protein Concentrate (WPC), also known as Whey Protein Phospholipid Concentrate (WPPC), Milk Fat Globule Membrane (MFGM), procream, Whey Fat Concentrate (WFC) and whey retentate. We describe processes for increasing a protein concentration of a composition containing milk protein and milk fat, and processes for separating milk protein and milk fats in a composition containing milk protein and milk fat. The process includes extracting the composition with a solvent selected from hexane, 2-methyloxolane, ethanol and carbon dioxide, and combinations thereof. The present invention also relates to whey protein compositions, milk fat compositions and phospholipid-rich compositions obtainable or obtained by the processes of the invention.

The invention discloses an antioxidant composition as well as a preparation method and application thereof, and belongs to the technical field of oxidation resistance. The purpose of the invention is to improve the antioxidant ability of probiotics and provide an antioxidant composition. The invention provides an antioxidant composition. The composition comprises a milk fat globule membrane and probiotics. The method is directly applied to functional dairy products, probiotic supplements and other products.

The invention discloses an application of a protein substance in preparation of a composition for inhibiting coronavirus. The coronavirus inhibition comprises the following steps: inhibiting adhesion of the coronavirus on host cells; the invasion of coronavirus to host cells is hindered; the after-cell entry process of coronavirus infection is inhibited. In-vitro verification is carried out on the antiviral effect of the coronavirus GXP2V on various nutritional ingredients (whey protein, milk fat globule membrane, lactoferrin and milk-derived osteopontin), and the result shows that the coronavirus resisting activity of the whey protein, the milk fat globule membrane, the lactoferrin and the milk-derived osteopontin (LPN, short for lactopontin). At present, it is rarely reported that protein substances are used for resisting the coronavirus, the coronavirus GXP2V is a novel coronavirus-like virus, a new thought is developed for resisting the novel coronavirus-like virus, and the application value and prospect are very good.

This invention discloses a method for screening differential protein biomarkers between yak milk and yak / hybrid milk based on proteomics, and its application in identifying yak milk and yak / hybrid milk, relating to the fields of proteomics and food detection technology. A portion of protein samples from whey protein hydrolysis and / or milk fat globule membrane protein hydrolysis from yak milk and yak / hybrid milk are mixed and fractionated by ultra-high performance liquid chromatography (UHPLC) to establish a DDA protein spectrum library. The remaining protein samples are analyzed by UHPLC-high resolution mass spectrometry (HPLC-MS). Through mass spectrometry data analysis, proteins are identified and quantified, and differential protein biomarkers between yak milk and yak / hybrid milk are screened. This method can screen for differential protein biomarkers between yak milk and yak / hybrid milk, which helps to establish a method for identifying yak milk and yak / hybrid milk, thereby achieving accurate, stable, and repeatable differentiation between the two, which is beneficial for ensuring the quality and safety of dairy products and maintaining market order.

The invention relates to a composition for oral or topical human administration and a preparation method thereof. The present invention relates to pentacyclic triterpenoid compounds wherein said triterpenoid compounds are incorporated into lipid vesicles, preferably cream globules, surrounded by three layers of membranes. The triterpenoid is preferably betulinic acid, and / or betulinol, and / or lupenol, and / or oleanolic acid, and / or ursolic acid, most preferably betulinic acid. The incorporation of the triterpenoid compound into the milk fat globules or lipid vesicles at a high payload of at least 10 to at most 50 mg / ml is preferably accomplished with high energy emulsification techniques, most preferably ultrasound treatment. The composition is present as a liquid emulsion formulation in a preferred embodiment. In another preferred embodiment, the composition is a powder, which can be prepared from a liquid embodiment of the composition by, for example, spray drying or freeze drying techniques. The composition can be preferably used as a medicament, a food supplement or a nutraceuticals for the treatment or prevention of cancer, type 2 diabetes, obesity and cardiovascular diseases.

The application belongs to the technical field of pharmaceutical compositions, and particularly relates to a composition containing goat milk fat globule membrane and capable of assisting in improving memory and application thereof. The composition comprises goat milk fat globule membrane, L-alpha-glycerophosphocholine, 2'-fucosyllactose, 6'-sialyllactose sodium salt and resveratrol. The composition can reduce the inflammation and oxidative damage level of the body and improve the morphological structure of hippocampus, and has a broad application prospect in the prevention and treatment of memory decline in the elderly.

The invention particularly relates to microbial cell powder for mammals to produce milk rich in primary EPA (eicosapentaenoic acid) and a preparation method. The microbial cell powder is prepared from the following raw materials in percentage by mass: 60%-70% of EPA thalli, 0.2%-0.3% of an emulsifier, 0.03%-0.07% of an antioxidant, 2%-4% of a filler, 5%-8% of a packing material, 0.08%-0.12% of a dispersant and 20%-25% of water. An engineering strain modified by genetic engineering is used as a core raw material, an exogenous EPA synthesis gene cluster is introduced, a metabolic pathway is optimized, efficient synthesis and accumulation of EPA are achieved, EPA exists in microbial cells in the form of triglyceride, the structure is stable, the integrity of the cells is still kept after inactivation treatment, oxidative decomposition of EPA in the processing and storage process is avoided, and the yield of EPA is increased. The preparation process adopts the processes of embedding, emulsifying, homogenizing and the like, so that the microbial cell powder has good dispersity and intestinal tract release performance, after mammals eat the microbial cell powder, EPA is efficiently released and absorbed in intestinal tracts and is integrated into a milk fat globule membrane through in-vivo metabolism, primary enrichment of EPA in milk is realized, and the EPA is easier to absorb and utilize by a human body.

The invention relates to the technical field of biological medicines, in particular to application of a cream globule epidermal growth factor 8 in preparation of a medicine for treating acute heart failure. The milk fat globule epidermal growth factor 8 or the functional fragment, the modified derivative, the expression promoter and the recombinant protein thereof are used for preparing the acute heart failure treatment medicine, myocardial cell systolic dysfunction can be relieved by inhibiting the increase of the acetylation modification level of intracellular tubulin, and then acute heart failure is treated. Particularly, the acute heart failure without basic heart disease can be quickly improved.

The invention discloses a method for analyzing milk fat globule membrane phospholipids of different milk sources based on Q-TOF-MS / MS, and belongs to the technical field of detection. The invention provides a Q-TOF-MS / MS (Quantitative Time of Flight Mass Spectrometry / Mass Spectrometry)-based method for analyzing milk fat globule membrane phospholipids of different milk sources in order to solve the problem of lack of difference of lipid molecules in MFGM of different milk sources based on a lipidomics system in the prior art, and through a Q-TOF-MS / MS analysis technology, full categories of glycerophospholipids and sphingomyelin in MFGM of breast milk, cow milk and goat milk are quantitatively detected at one time; by combining multi-factor statistics-single factor variance analysis, differential phospholipids are accurately screened, a unique lipid molecule fingerprint spectrum of each milk source is established, and the spectrum can directly guide directional addition of infant formula milk powder MFGM, so that the phospholipid composition is close to breast milk on a molecular level, and the lipid molecule fingerprint spectrum has the advantages of high lipid molecule fingerprint spectrum and high lipid molecule fingerprint spectrum. The defects of existing formula phospholipid spectrum mismatch, structure deficiency, data blank and efficacy prediction disjunction are overcome.

The present application belongs to the technical field of pharmaceutical compositions, and particularly relates to a composition containing yak milk fat globule membrane and capable of improving cognitive function decline and application thereof. The composition takes yak milk fat globule membrane as a core active ingredient, and takes taurine, selenium-rich yeast and yam extract as auxiliary active ingredients. Through synergistic effect of the components, the composition can target inhibit acetylcholinesterase activity, relieve oxidative stress damage of brain nerve cells, reduce the level of pro-inflammatory factors in the brain, and then significantly improve cognitive function. The composition takes into account functionality and nutrition, and shows broad application prospects in the development of products related to improving learning and memory ability, delaying cognitive function decline and improving cognitive impairment.

This application relates to compositions comprising polar lipids for maintaining or increasing mobility and vitality. In particular, the invention relates to the use of milk fat globule membrane materials comprising one or more polar lipids in the manufacture of compositions or pharmaceuticals intended for (a) maintaining or increasing lean muscle mass and / or maintaining or decreasing fat mass in human subjects; (b) increasing daily activity and reducing sedentary time in human subjects; and / or (c) after daily administration of the composition or pharmaceuticals for a period of at least three or four months, and wherein the human subjects exercise at least two days per week, compared to the sedentary time and / or low-intensity physical activity time prior to the commencement of daily administration of the composition or pharmaceuticals, a reduction of at least 7 minutes per day in sedentary time and / or an increase of at least 3 minutes per day in low-intensity physical activity time in human subjects.

The utility model relates to the technical field of milk powder production, in particular to a micron-sized milk fat globule homogenizing device for goat milk powder, which is characterized in that milk fat globules are subjected to graded homogenizing treatment, and a milk fat globule solution is subjected to homogenizing treatment by utilizing high pressure and a cutting knife, so that the homogenizing effect of the milk fat globule solution is enhanced; the milk fat globules reach the micron level; comprising a grading mechanism; the device further comprises a pressurizing mechanism, a stirring mechanism, a pressure relief mechanism and a back flushing mechanism, the pressurizing mechanism is installed on the grading mechanism and pressurizes the interior of the grading mechanism, the stirring mechanism is installed on the grading mechanism and cuts and stirs milk fat balls, and the pressure relief mechanism is installed on the grading mechanism and relieves pressure of the grading mechanism. The backflushing mechanism is installed on the pressure relief mechanism and can conduct backflushing cleaning on the grading mechanism.

The invention discloses an application of a protein substance in preparation of a composition for inhibiting coronavirus. The coronavirus inhibition comprises the following steps: inhibiting adhesion of the coronavirus on host cells; the invasion of coronavirus to host cells is hindered; the after-cell entry process of coronavirus infection is inhibited. In-vitro verification is carried out on the antiviral effect of the coronavirus GXP2V on various nutritional ingredients (whey protein, milk fat globule membrane, lactoferrin and milk-derived osteopontin), and the result shows that the coronavirus resisting activity of the whey protein, the milk fat globule membrane, the lactoferrin and the milk-derived osteopontin (LPN, short for lactopontin). At present, it is rarely reported that protein substances are used for resisting the coronavirus, the coronavirus GXP2V is a novel coronavirus-like virus, a new thought is developed for resisting the novel coronavirus-like virus, and the application value and prospect are very good.

Compositions and methods are provided for producing and stabilizing oxidized lipids with anti-inflammatory properties, which are generated from polyunsaturated fatty acids as precursors to these anti-inflammatory oxylipin compounds, using intact milk fat globules extracted from milk. One process has three major steps: 1) isolation of the milk fat globules form milk; 2) incubation of the milk fat globules with polyunsaturated fatty acids; where the polyunsaturated fatty acids are encapsulated into the milk fat globule and subsequently converted to the oxidized forms such as lipid epoxides or hydroxides with potent anti-inflammatory properties, and 3) recovery of the milk fat globules which contain the anti-inflammatory lipids derived from the polyunsaturated fatty acids.

The invention relates to the technical field of cosmetic raw materials, in particular to a preparation method and application of a lactoferrin composite spherical membrane body. The preparation method of the lactoferrin composite globular membrane body, provided by the invention, comprises the following steps of: wrapping lactoferrin by using milk fat globular membrane protein as a carrier to prepare a nano-scale composite globular membrane body, and specifically, reducing the iron saturation of the lactoferrin by adopting a chelate resin iron removal technology, and then preparing the lactoferrin composite globular membrane body by using the milk fat globular membrane protein as the carrier. Constructing a milk fat globule membrane protein / lactoferrin core-shell structure to form colostrum, and injecting the colostrum into a water phase containing 0.1 wt% of lactobionic acid to prepare a composite globule membrane body. The method not only can improve the stability and bacteriostatic activity of the lactoferrin, but also can significantly improve the transdermal rate of the milk iron eggs, enhance the ability of the lactoferrin to specifically bind to keratinocyte lectin receptors, and improve the uptake efficiency of keratinocytes, thereby achieving the effect of improving the bioavailability of the lactoferrin. The composition is an ideal functional cosmetic raw material.

The present application provides a DHA liposome, a suspension thereof and a preparation method thereof and an application thereof in improving or promoting vision health food. The DHA liposome suspension comprises DHA, milk fat globule membrane, phospholipid, sugar and water, the DHA liposome suspension comprises liposome particles, a shell layer of the liposome particles comprises milk fat globule membrane, and at least part of the DHA is embedded in the shell layer. The DHA liposome suspension improves the flavor and stability of the DHA product and improves the absorption and utilization rate thereof. A DHA liposome suspension comprises DHA, milk fat globule membrane, first phospholipid, first sugar and water, the DHA liposome suspension comprises liposome particles, a shell layer of the liposome particles comprises milk fat globule membrane, and at least part of the DHA is embedded in the shell layer.