92 results about "Milk fat globule" patented technology

The invention provides a nutritional composition and application of the nutritional composition. The nutritional composition comprises medium-chain and long-chain fatty acid triglyceride and a milk fat globule membrane in a mass ratio of (2: 1)-(97: 1), and the medium-chain and long-chain fatty acid triglyceride and the milk fat globule membrane have a synergistic effect in the aspects of promoting skeletal development, especially increasing bone mineral density and / or preventing or treating osteogenesis insufficiency and / or osteoporosis.

A nutritional composition, typically an infant enterically administered nutritional composition, that comprises a milk fat globule membrane component, at least one human milk oligosaccharide and one additional component or a plurality of additional components where the additional component or components include DHA, ARA, Vitamin E, Vitamin C, and sphingomyelin.

The invention provides a nutritional composition and application of the nutritional composition. The nutritional composition comprises medium-chain and long-chain fatty acid triglyceride (MLCT) and milk fat globule membrane (MFGM) in a mass ratio of 2: 1 to 80: 1, and the combination of the two has the effects of synergistically improving diarrhea, inhibiting staphylococcus aureus in vivo or in vitro and / or regulating intestinal flora.

The present application provides a synthetic nutritional composition comprising a milk fat globule membrane (MFGM) in the range of from about 10 [mu] g / 100 kcal to about 1500 mg / 100 kcal for use in improving neurological development in a pediatric subject. During a first year of life, a synthetic nutritional composition is administered to the pediatric subject for at least three months, and the administration of the synthetic nutritional composition improves neural development of the pediatric subject starting from at least two years old.

The invention discloses a composition for regulating intestinal flora and lipid absorption in the early stage of life and application. The composition for regulating intestinal flora and lipid absorption in the early stage of life comprises galactooligosaccharide and a milk fat globule membrane. Compared with the prior art, the composition has the advantages that the milk fat globule membrane and the galactooligosaccharide coordinate to regulate the intestinal flora in the early stage of life and promote intestinal barrier development and lipid absorption.

The present invention discloses a method for separating and preparing milk fat globule membrane, belonging to the technical field of dairy product processing. The method for separating and preparing milk fat globule membrane according to the present invention uses fresh animal milk after centrifugation and sterilization as raw material, and realizes the preparation of buttermilk by controlling the ripening temperature and time of the cream; further, the casein in the buttermilk is removed by using the rennet method, and after regulating the rennet coagulation step, the extraction rates of MFGM protein and phospholipid reach 56.42% and 72.57%; further, after regulating the whey drainage step of the rennet, the flocculation structure of the casein becomes loose, which is beneficial to the recovery of milk fat globule membrane components in the buttermilk whey, and the extraction rates of MFGM protein and phospholipid increase to 68.90% and 80.57% respectively; further, with the assistance of ultrasonic physical extraction, the extraction rates of MFGM protein and phospholipid are further increased to 78.26% and 83.12% respectively.

The present disclosure relates compositions comprising milk fat globule membrane (MFGM) and a mixture of HMOs with at least one fucosylated HMO and at least one HMO selected from neutral core HMOs or sialylated HMOs. The compositions have potential health benefits in terms of improving brain health, immunity and recovery time following exercise, by increasing the formation of glutamic acid.

The invention belongs to the field of functional substance research, and particularly relates to a nutritional composition for promoting absorption of fatty acid and mineral substances and application. The nutritional composition provided by the invention comprises necessary active ingredients shown as the following (I) and (II): (I) 1, 3-dioleic acid-2-palmitic acid triglyceride; (II) a milk fat globule membrane, and / or, 2 '-fucosyllactose; moreover, in the nutritional composition, the mass ratio of the necessary active component shown in (I) to the necessary active component shown in (II) is (5-10): (0.5-10). The combination of OPO and MFGM and / or 2 '-FL provided by the invention can be beneficial to promoting the absorption of the body to fatty acids and mineral substances, and especially can be beneficial to promoting the transmembrane transport capability of intestinal cells of the body to fatty acids and mineral substances, so that the absorption efficiency is improved.

The invention relates to the technical field of middle-aged and elderly goat milk powder and preparation methods thereof, in particular to total-nutrient low-GI goat milk powder suitable for middle-aged and elderly people and a preparation method and application thereof.The total-nutrient low-GI goat milk powder comprises, by weight, 20-60 parts of raw goat milk, 10-30 parts of demineralized whey powder and 10-30 parts of skimmed milk powder. The formula comprises the following components in parts by weight: 5-20 parts of stachyose composite prebiotics powder, 5-20 parts of powdered oil, 20-30 parts of enzymolysis germinated cereal powder, 5-20 parts of polydextrose, 2-15 parts of whey protein powder (hydrolysis type), 2-15 parts of malt flour, 2-15 parts of whey protein powder (rich in milk fat globule membranes), 0.1-5 parts of taurine, 0.1-5 parts of composite vitamins and 0.1-5 parts of composite minerals. The provided full-nutrient low-GI goat milk powder has the characteristics of low GI, no goaty flavor, easiness in digestion, full nutrition and the like, and is suitable for middle-aged and elderly people.

The invention provides a bifidobacterium animalis subspecies HX-BA21, and the preservation number of the bifidobacterium animalis subspecies HX-BA21 is CGMCC (China General Microbiological Culture Collection Center) NO.32958. The invention discloses bifidobacterium animalis subspecies HX-BA21 containing exosome metabiotics and an exosome-containing fermentation compound obtained by fermenting gastrodia elata through the HX-BA21. The fermentation compound comprises a probiotic protective layer (a core layer), an exosome delivery layer (a shell layer) and a prebiotics sustained release layer (a cocoon layer) from inside to outside. The probiotic protection layer comprises a sodium alginate-milk fat globule membrane compound and animal bifidobacterium subsp.animalis; the exosome delivery layer comprises a gelatin-chitosan compound and a gastrodia elata and probiotic mixed exosome; the prebiotic sustained-release layer comprises an octenyl succinic anhydride starch / polyvinyl alcohol compound and inulin. The compound can start cell repair by improving the cell migration rate, up-regulate DNA helicase and telomere related gene expression, delay premature senescence and delay cell senescence caused by D-galactose by adjusting the oxidative stress level.

This disclosure relates to dairy products, methods for producing dairy products, uses of dairy products, and dairy-based products including dairy products. This disclosure also relates to methods for improving or maintaining physical performance in subjects, and dairy products or dairy-based food products for use in improving or maintaining physical performance in subjects.

The present invention relates to a method for separating and preparing milk fat globule membrane protein from buttermilk, a by-product of butter, comprising: controlling the temperature of the buttermilk, a by-product of butter, at 25 to 30 °C; adjusting the pH value to 4.5 to 4.7 and centrifuging; performing thermal calcium treatment and centrifuging; performing ultrasonic treatment and then cooling to room temperature; performing dialysis treatment; adjusting the pH value to 6-8, and then performing ultrafiltration treatment, and collecting the solution obtained by the ultrafiltration treatment as the milk fat globule membrane protein. The method of the present invention can increase the removal rate of casein to 95%, avoid the effective protein being dialyzed or filtered out, greatly reduce the loss rate of the milk fat globule membrane protein, make the extraction rate reach more than 70%, and the purity of the prepared milk fat globule membrane reaches 87.7%. Moreover, the raw material selected in the method of the present invention is buttermilk, a by-product of industrial butter production, which is usually discarded or made into animal feed. The present invention reasonably utilizes this raw material, which can not only improve the utilization rate of buttermilk, but also save costs.

The invention provides a preparation method of a yak milk fat globule membrane and application of the yak milk fat globule membrane in inhibition of pseudomonas aeruginosa, and belongs to the technical field of biology. The preparation method comprises the following steps: centrifuging yak milk to obtain coarsely separated milk fat, washing the milk fat with a potassium phosphate buffer solution and ultrapure water in sequence, refrigerating, grinding with a tissue grinder, further crushing with a cell crusher, and finally performing ultracentrifugation on a sample to obtain the milk fat globule membrane. According to the application, the yak milk fat globule membrane is used for inhibiting pseudomonas aeruginosa, in-vitro inhibition experiments prove that the yak milk fat globule membrane has an inhibition effect on the pseudomonas aeruginosa, and the inhibition effect is better than that of Holstein milk fat globule membrane and buffalo milk fat globule membrane. According to the method, the milk consumption is small, the stability is good, the operation difficulty is low, introduction of chemical impurities in the extraction process and the influence of the chemical impurities on membrane components are reduced, the new function of the yak milk fat globule membrane is developed, and the method has good application and popularization prospects and economic value in the aspects of yak milk fat globule membrane extraction and pseudomonas aeruginosa inhibition research.

The invention discloses a pet food containing probiotic-lactoferrin pellets and a preparation method of the pet food. An immune golden triangle formula is adopted, layered wrapping is carried out, active probiotics, prebiotics, protein for enhancing immunity and antioxidant substances are used as formula raw materials, the probiotics are wrapped by the prebiotics and milk fat globule membrane protein, and then the prebiotics and the milk fat globule membrane protein are wrapped by lactoferrin and shiitake mushroom powder. And finally, coating lactoferrin with a coating solution containing antioxidant substances to prepare pellets, and applying the pellets to preparation of pet food. Functional substances such as probiotics and immune protein are delivered to the intestinal tract through multi-layer wrapping, and various functional components capable of improving immunity in the intestinal tract have a synergistic effect, so that the immunity of pets can be remarkably improved.

The invention discloses a nutritional composition for short-time internal inflammation balance after medium-high-strength resistance training and application of the nutritional composition, and belongs to the technical field of food processing. The composition comprises an inflammation control component composed of a plant inflammation control component and a milk source inflammation control component, the inflammation control component is composed of a plant source component and a milk source component and specifically comprises omega-3 unsaturated fatty acid, curcumin, iron unsaturated lactoferrin and a milk fat globule membrane according to a specific weight ratio, the weight ratio of EPA to DHA in the omega-3 unsaturated fatty acid is not lower than 1.5: 1, and the weight ratio of the curcumin to the iron unsaturated lactoferrin to the milk fat globule membrane is not lower than 1.5: 1. The iron saturation of the iron unsaturated lactoferrin is less than or equal to 30%, and the phospholipid accounts for 4-10% of the milk fat ball membrane. Experimental results show that the composition can effectively regulate and control the level of inflammatory factors within 6 hours after training, and accurate regulation and control of inflammatory response within an inflammatory regulation window period within 6 hours after training are achieved. The invention also relates to application of the composition in preparation of functional food and dairy products.

The invention belongs to the technical field of intestinal health care, and relates to a composition containing a milk fat globular membrane and application of the composition. The composition comprises the following components in parts by weight: 0.1 to 0.4 part of a milk fat ball membrane, 0.4 to 2.4 parts of fructo-oligosaccharide, 0.1 to 1 part of xylooligosaccharide, 0.1 to 0.5 part of stachyose and 0.1 to 0.5 part of metabiotics. The composition can increase beneficial bacteria, inhibit growth of harmful bacteria and increase intestinal peristalsis; the intestinal permeability is regulated; meanwhile, the level of tight junction protein and mucoprotein in the intestinal tract is adjusted, and the intestinal tract barrier is enhanced; the intestinal inflammation level can also be regulated. The composition improves intestinal health through multiple targets, and has a remarkable effect on improving intestinal problems such as constipation and inflammatory bowel diseases; meanwhile, depression and anxiety mood caused by intestinal problems can be relieved, the life quality is improved, and the traditional Chinese medicine composition is more beneficial to overall health of organisms and can be taken for a long time.

The present invention provides a nutritional composition and the use of the nutritional composition. The nutritional composition comprises medium- and long-chain triglycerides (MLCT) and milk fat globule membrane (MFGM) in a mass ratio of 2:1 to 80:1, and the combination of the two has a synergistic effect of improving diarrhea, inhibiting Staphylococcus aureus in vivo or in vitro, and / or regulating the intestinal flora.

The invention relates to the technical field of nata de coco processing, in particular to a method for improving nata de coco processing technology to improve taste and quality, which comprises coconut milk, natural plant juice and coconut water, and further comprises a pretreatment process of raw materials, a fermentation link formula and regulation, a post-treatment and function strengthening process and process and finished product monitoring. According to the present invention, during the raw material pretreatment, the particle size of the coconut milk fat globules can be homogenized to less than or equal to 2 [mu] m through the 800 MPa high-pressure micro-jet homogenization, and the 254 nm ultraviolet ray is matched to cooperate with the 40 DEG C composite sterilization so as to ensure the thorough sterilization of the raw material and the uniform distribution of the fat particles so as to lay the fine and smooth taste foundation for the subsequent fermentation.

This invention provides an application of a nutritional composition for enhancing immunity. The nutritional composition of this invention comprises medium- and long-chain triglycerides (MLCT) and milk fat globule membrane (MFGM) in a mass ratio of 0.3:1 to 120:1. This nutritional composition can increase the proliferation of immune cells, and is used as a method for improving immunity.

The invention discloses an anthocyanin ingredient containing milk fat globules and a preparation method thereof.The preparation method comprises the specific steps that the milk fat globules are extracted from fresh raw milk, anthocyanin and the milk fat globules are added into deionized water to be emulsified, and the anthocyanin emulsion type ingredient containing the milk fat globules is obtained; wherein anthocyanin in the ingredients and a fat membrane of the milk fat globules form a specific structure, and the specific structure is rich in long-chain unsaturated fatty acid and medium-chain fatty acid in a specific ratio of 1: (7-10) after being digested by in-vitro simulated gastrointestinal fluid. The anthocyanin ingredient containing the milk fat globules is a novel stable emulsion taking the natural milk fat globules as an anthocyanin carrier, is particularly suitable for being used as an ingredient of nutritional and healthy food, and is wide in application range. And the preparation method adopts a probe type ultrasonic combined high-speed shearing technology, so that the obtained emulsion is better in dispersity and stability, simple, efficient, green and safe.

The invention discloses an anti-inflammatory polypeptide as well as a preparation method and application thereof. The amino acid sequence of the anti-inflammatory polypeptide is Gln-Phe-Gln-Phe (QFQF), and the anti-inflammatory polypeptide is derived from milk fat globule membrane protein and is tetrapeptide capable of being absorbed by intestinal tracts. According to the anti-inflammatory peptide, the amino acid sequence of the anti-inflammatory peptide is analyzed by LC-MS / MS, the anti-inflammatory peptide is synthesized to further verify the anti-inflammatory activity, the sequence of the anti-inflammatory peptide is determined, and the efficiency is improved; the milk fat globule membrane protein-derived anti-inflammatory polypeptide can be used for preparing functional preparations and reducing inflammation in a human body, and has a potential effect of regulating and controlling generation and development of inflammation. The polypeptide has very important significance for developing dairy products, animal feeds, health-care products, health-care foods and medicines with anti-inflammatory functions, and has a wide application prospect.

The invention relates to the technical field of milk powder, and particularly discloses infant LMNP combined formula milk powder for caesarean delivery and a preparation method of the infant LMNP combined formula milk powder for caesarean delivery, 100g of formula milk powder comprises an intestinal micro-ecological regulation composition, an immune nutrition synergistic composition, a core nutrition component and a vitamin and mineral composition. The composition has the advantages that the composition is reasonable in formula, beneficial bacteria colonization and proliferation are synergistically promoted, healthy intestinal flora is quickly established, common intestinal flora imbalance of the cesarean delivery infants is effectively improved, the risks of diarrhea, constipation and the like are reduced, and an immune nutrition synergistic system is formed through scientific compatibility of lactoferrin, milk fat globule membranes and compound nucleotide. The composition can enhance immune cell activity, promote immune system development, strengthen mucous membrane defense, make up immune shortages of caesarean section babies in a targeted manner, and reduce allergy and infection risks.

The invention discloses an application of a protein substance in preparation of a composition for inhibiting coronavirus. The coronavirus inhibition comprises the following steps: inhibiting adhesion of the coronavirus on host cells; the invasion of coronavirus to host cells is hindered; the after-cell entry process of coronavirus infection is inhibited. In-vitro verification is carried out on the antiviral effect of the coronavirus GXP2V on various nutritional ingredients (whey protein, milk fat globule membrane, lactoferrin and milk-derived osteopontin), and the result shows that the coronavirus resisting activity of the whey protein, the milk fat globule membrane, the lactoferrin and the milk-derived osteopontin (LPN, short for lactopontin). At present, it is rarely reported that protein substances are used for resisting the coronavirus, the coronavirus GXP2V is a novel coronavirus-like virus, a new thought is developed for resisting the novel coronavirus-like virus, and the application value and prospect are very good.

The invention belongs to the technical field of dairy product processing, and particularly relates to milk fat globule membrane milk protein powder rich in phospholipid as well as a preparation method and application of the milk fat globule membrane milk protein powder. The preparation method of the milk fat globule membrane milk protein powder comprises the following steps: adding chymosin into sweet casein to remove casein so as to obtain casein whey; then sequentially adding whey protein hydrolase and lactase into the casein whey; carrying out ultrafiltration treatment on the hydrolyzed liquid, carrying out percolation treatment on the obtained filtrate, collecting percolate, and drying to obtain a milk fat globule membrane coarse material; and performing CO2 supercritical fluid extraction on the milk fat globule membrane coarse material to obtain the milk fat globule membrane. The phospholipid-rich milk fat globule membrane milk protein powder prepared by the method can be developed into high-polarity lipid food, and especially provides a scientific basis for infant formula milk powder, middle-aged and elderly nutritional food and special functional food.

The present invention provides an application of a composition in the preparation of a product for improving intestinal development; the composition comprises 1 to 10 parts by weight of whey protein powder rich in milk fat globule membrane and 1 part by weight of whey protein powder rich in caseinoglycomacropeptide. The composition of whey protein powder rich in milk fat globule membrane and whey protein powder rich in caseinoglycomacropeptide with a mass ratio of (1-10):1 provided by the present invention has a synergistic effect on promoting intestinal development and can significantly increase the villus height of the intestine and the intestinal villus crypt ratio.

The application discloses application of a silk fibroin nanoparticle hydrogel in treatment of pressure sore ulcers and relates to the technical field of biochemistry.The core points of the technical solution include the following steps: S1, preparation of a silk fibroin solution;S2, preparation of nanoparticles;S3, production and preparation of milk fat globule epidermal growth factor VIII (MFG-E8) in exosomes;S4, purification of MFG-E8 protein;S5, preparation of silk fibroin nanoparticles coated with MFG-E8;S6, preparation of MFG-E8-silk fibroin nanoparticles crosslinked with NGR peptides; and S7, preparation of a collagen / silk fibroin hydrogel.The silk fibroin nanoparticle hydrogel is a non-invasive treatment method and is more easily accepted by patients in clinical application.In addition, the targeted nanoparticle treatment method for pressure sore sites can significantly improve the treatment effect of patients.

The present invention relates to the technical field of protein micronization preparation, and discloses a preparation method and application of a plant fat substitute based on protein micronization, comprising the following steps: (1) preparing a separated protein solution from plant separated protein, and then performing protein hydration to obtain a hydrated separated protein solution; (2) subjecting the hydrated separated protein solution to ultrasonic heat treatment to obtain a micronized protein dispersion; (3) performing post-treatment to obtain a plant fat substitute based on protein micronization. The present invention utilizes the combined ultrasonic-heat treatment technology to obtain micronized protein particles, endowing them with the texture characteristics of milk fat globules, greatly expanding the application of plant proteins in the food field; adding the plant fat substitute to plant milk can meet the nutritional needs of consumers and the pursuit of more natural and green foods, and the processing technology is green and fast, expanding the practical application of micronized proteins in the field of plant milk.

The present invention relates to a method for multidimensional evaluation of the similarity of a sample to breast milk, wherein the method is performed in the following steps: (1) establishing a local breast milk phospholipid database; (2) collecting and pretreating a sample to be evaluated; (3) determining the contents of characteristic phospholipid subclasses, the contents of characteristic phospholipid molecules in the sample to be evaluated, and obtaining a microstructural image of milk fat globules in the sample by confocal laser scanning microscopy; (4) calculating the score G for the sample to be evaluated. The present invention evaluates the similarity of samples to breast milk based on phospholipids in three aspects: the composition of characteristic phospholipid subclasses, the composition of characteristic phospholipid molecules, and the morphological similarity evaluation, so that the scheme can better evaluate the simulation quality of infant formulas and their raw and auxiliary materials to breast milk based on phospholipids.

The invention discloses a construction method of an animal model with stable intestinal tract four-bound flora and an intestinal tract four-bound core flora used for evaluating the immune regulation function of infant blending powder. According to the method, milk powder base powder containing milk fat globule membranes is used for intervening SD male young rats in the second day of birth in a certain mode, and four flora models with stable intestinal bacteria, fungi, archaea and viruses of the young rats in the lactation period are constructed through metagenome sequencing. The infant blending powder base powder containing the milk fat globule membrane remarkably increases immune related species, and intestinal tract four-boundary core florae remarkably related to immunity are obtained through Spearman correlation analysis. The obtained intestinal tract four-bound flora model of the baby rats in the lactation period can be used for evaluating the immune regulation function of baby blending powder.

The application provides a composition for promoting growth of Akkermansia and application thereof, and the composition comprises milk fat globule membrane, colostrum basic protein and lacto-N-neotetraose, wherein the concentration ratio of the milk fat globule membrane, the colostrum basic protein and the lacto-N-neotetraose in the composition is (0.1-2):(0.025-0.3):(0.2-0.8). The composition can fully meet the nutritional requirements of Akkermansia bacteria, especially mucinophilic Akkermansia bacteria, can effectively promote the growth of Akkermansia bacteria, can be used for culturing Akkermansia bacteria in vitro, and can promote the growth of mucinophilic Akkermansia bacteria in the human intestinal tract, increase the potential probiotic Akkermansia bacteria in the intestinal tract, and improve intestinal health.