62 results about "Milk fat globule" patented technology

A nutritional composition, typically an infant enterically administered nutritional composition, that comprises a milk fat globule membrane component, at least one human milk oligosaccharide and one additional component or a plurality of additional components where the additional component or components include DHA, ARA, Vitamin E, Vitamin C, and sphingomyelin.

The present disclosure relates compositions comprising milk fat globule membrane (MFGM) and a mixture of HMOs with at least one fucosylated HMO and at least one HMO selected from neutral core HMOs or sialylated HMOs. The compositions have potential health benefits in terms of improving brain health, immunity and recovery time following exercise, by increasing the formation of glutamic acid.

The invention belongs to the field of functional substance research, and particularly relates to a nutritional composition for promoting absorption of fatty acid and mineral substances and application. The nutritional composition provided by the invention comprises necessary active ingredients shown as the following (I) and (II): (I) 1, 3-dioleic acid-2-palmitic acid triglyceride; (II) a milk fat globule membrane, and / or, 2 '-fucosyllactose; moreover, in the nutritional composition, the mass ratio of the necessary active component shown in (I) to the necessary active component shown in (II) is (5-10): (0.5-10). The combination of OPO and MFGM and / or 2 '-FL provided by the invention can be beneficial to promoting the absorption of the body to fatty acids and mineral substances, and especially can be beneficial to promoting the transmembrane transport capability of intestinal cells of the body to fatty acids and mineral substances, so that the absorption efficiency is improved.

The invention provides a bifidobacterium animalis subspecies HX-BA21, and the preservation number of the bifidobacterium animalis subspecies HX-BA21 is CGMCC (China General Microbiological Culture Collection Center) NO.32958. The invention discloses bifidobacterium animalis subspecies HX-BA21 containing exosome metabiotics and an exosome-containing fermentation compound obtained by fermenting gastrodia elata through the HX-BA21. The fermentation compound comprises a probiotic protective layer (a core layer), an exosome delivery layer (a shell layer) and a prebiotics sustained release layer (a cocoon layer) from inside to outside. The probiotic protection layer comprises a sodium alginate-milk fat globule membrane compound and animal bifidobacterium subsp.animalis; the exosome delivery layer comprises a gelatin-chitosan compound and a gastrodia elata and probiotic mixed exosome; the prebiotic sustained-release layer comprises an octenyl succinic anhydride starch / polyvinyl alcohol compound and inulin. The compound can start cell repair by improving the cell migration rate, up-regulate DNA helicase and telomere related gene expression, delay premature senescence and delay cell senescence caused by D-galactose by adjusting the oxidative stress level.

This disclosure relates to dairy products, methods for producing dairy products, uses of dairy products, and dairy-based products including dairy products. This disclosure also relates to methods for improving or maintaining physical performance in subjects, and dairy products or dairy-based food products for use in improving or maintaining physical performance in subjects.

The present invention relates to a method for separating and preparing milk fat globule membrane protein from buttermilk, a by-product of butter, comprising: controlling the temperature of the buttermilk, a by-product of butter, at 25 to 30 °C; adjusting the pH value to 4.5 to 4.7 and centrifuging; performing thermal calcium treatment and centrifuging; performing ultrasonic treatment and then cooling to room temperature; performing dialysis treatment; adjusting the pH value to 6-8, and then performing ultrafiltration treatment, and collecting the solution obtained by the ultrafiltration treatment as the milk fat globule membrane protein. The method of the present invention can increase the removal rate of casein to 95%, avoid the effective protein being dialyzed or filtered out, greatly reduce the loss rate of the milk fat globule membrane protein, make the extraction rate reach more than 70%, and the purity of the prepared milk fat globule membrane reaches 87.7%. Moreover, the raw material selected in the method of the present invention is buttermilk, a by-product of industrial butter production, which is usually discarded or made into animal feed. The present invention reasonably utilizes this raw material, which can not only improve the utilization rate of buttermilk, but also save costs.

The invention provides a preparation method of a yak milk fat globule membrane and application of the yak milk fat globule membrane in inhibition of pseudomonas aeruginosa, and belongs to the technical field of biology. The preparation method comprises the following steps: centrifuging yak milk to obtain coarsely separated milk fat, washing the milk fat with a potassium phosphate buffer solution and ultrapure water in sequence, refrigerating, grinding with a tissue grinder, further crushing with a cell crusher, and finally performing ultracentrifugation on a sample to obtain the milk fat globule membrane. According to the application, the yak milk fat globule membrane is used for inhibiting pseudomonas aeruginosa, in-vitro inhibition experiments prove that the yak milk fat globule membrane has an inhibition effect on the pseudomonas aeruginosa, and the inhibition effect is better than that of Holstein milk fat globule membrane and buffalo milk fat globule membrane. According to the method, the milk consumption is small, the stability is good, the operation difficulty is low, introduction of chemical impurities in the extraction process and the influence of the chemical impurities on membrane components are reduced, the new function of the yak milk fat globule membrane is developed, and the method has good application and popularization prospects and economic value in the aspects of yak milk fat globule membrane extraction and pseudomonas aeruginosa inhibition research.

The invention discloses a pet food containing probiotic-lactoferrin pellets and a preparation method of the pet food. An immune golden triangle formula is adopted, layered wrapping is carried out, active probiotics, prebiotics, protein for enhancing immunity and antioxidant substances are used as formula raw materials, the probiotics are wrapped by the prebiotics and milk fat globule membrane protein, and then the prebiotics and the milk fat globule membrane protein are wrapped by lactoferrin and shiitake mushroom powder. And finally, coating lactoferrin with a coating solution containing antioxidant substances to prepare pellets, and applying the pellets to preparation of pet food. Functional substances such as probiotics and immune protein are delivered to the intestinal tract through multi-layer wrapping, and various functional components capable of improving immunity in the intestinal tract have a synergistic effect, so that the immunity of pets can be remarkably improved.

The invention discloses a nutritional composition for short-time internal inflammation balance after medium-high-strength resistance training and application of the nutritional composition, and belongs to the technical field of food processing. The composition comprises an inflammation control component composed of a plant inflammation control component and a milk source inflammation control component, the inflammation control component is composed of a plant source component and a milk source component and specifically comprises omega-3 unsaturated fatty acid, curcumin, iron unsaturated lactoferrin and a milk fat globule membrane according to a specific weight ratio, the weight ratio of EPA to DHA in the omega-3 unsaturated fatty acid is not lower than 1.5: 1, and the weight ratio of the curcumin to the iron unsaturated lactoferrin to the milk fat globule membrane is not lower than 1.5: 1. The iron saturation of the iron unsaturated lactoferrin is less than or equal to 30%, and the phospholipid accounts for 4-10% of the milk fat ball membrane. Experimental results show that the composition can effectively regulate and control the level of inflammatory factors within 6 hours after training, and accurate regulation and control of inflammatory response within an inflammatory regulation window period within 6 hours after training are achieved. The invention also relates to application of the composition in preparation of functional food and dairy products.

The invention belongs to the technical field of intestinal health care, and relates to a composition containing a milk fat globular membrane and application of the composition. The composition comprises the following components in parts by weight: 0.1 to 0.4 part of a milk fat ball membrane, 0.4 to 2.4 parts of fructo-oligosaccharide, 0.1 to 1 part of xylooligosaccharide, 0.1 to 0.5 part of stachyose and 0.1 to 0.5 part of metabiotics. The composition can increase beneficial bacteria, inhibit growth of harmful bacteria and increase intestinal peristalsis; the intestinal permeability is regulated; meanwhile, the level of tight junction protein and mucoprotein in the intestinal tract is adjusted, and the intestinal tract barrier is enhanced; the intestinal inflammation level can also be regulated. The composition improves intestinal health through multiple targets, and has a remarkable effect on improving intestinal problems such as constipation and inflammatory bowel diseases; meanwhile, depression and anxiety mood caused by intestinal problems can be relieved, the life quality is improved, and the traditional Chinese medicine composition is more beneficial to overall health of organisms and can be taken for a long time.

The present invention provides a nutritional composition and the use of the nutritional composition. The nutritional composition comprises medium- and long-chain triglycerides (MLCT) and milk fat globule membrane (MFGM) in a mass ratio of 2:1 to 80:1, and the combination of the two has a synergistic effect of improving diarrhea, inhibiting Staphylococcus aureus in vivo or in vitro, and / or regulating the intestinal flora.

The invention relates to the technical field of nata de coco processing, in particular to a method for improving nata de coco processing technology to improve taste and quality, which comprises coconut milk, natural plant juice and coconut water, and further comprises a pretreatment process of raw materials, a fermentation link formula and regulation, a post-treatment and function strengthening process and process and finished product monitoring. According to the present invention, during the raw material pretreatment, the particle size of the coconut milk fat globules can be homogenized to less than or equal to 2 [mu] m through the 800 MPa high-pressure micro-jet homogenization, and the 254 nm ultraviolet ray is matched to cooperate with the 40 DEG C composite sterilization so as to ensure the thorough sterilization of the raw material and the uniform distribution of the fat particles so as to lay the fine and smooth taste foundation for the subsequent fermentation.

This invention provides an application of a nutritional composition for enhancing immunity. The nutritional composition of this invention comprises medium- and long-chain triglycerides (MLCT) and milk fat globule membrane (MFGM) in a mass ratio of 0.3:1 to 120:1. This nutritional composition can increase the proliferation of immune cells, and is used as a method for improving immunity.

The invention discloses an anthocyanin ingredient containing milk fat globules and a preparation method thereof.The preparation method comprises the specific steps that the milk fat globules are extracted from fresh raw milk, anthocyanin and the milk fat globules are added into deionized water to be emulsified, and the anthocyanin emulsion type ingredient containing the milk fat globules is obtained; wherein anthocyanin in the ingredients and a fat membrane of the milk fat globules form a specific structure, and the specific structure is rich in long-chain unsaturated fatty acid and medium-chain fatty acid in a specific ratio of 1: (7-10) after being digested by in-vitro simulated gastrointestinal fluid. The anthocyanin ingredient containing the milk fat globules is a novel stable emulsion taking the natural milk fat globules as an anthocyanin carrier, is particularly suitable for being used as an ingredient of nutritional and healthy food, and is wide in application range. And the preparation method adopts a probe type ultrasonic combined high-speed shearing technology, so that the obtained emulsion is better in dispersity and stability, simple, efficient, green and safe.

The invention relates to the technical field of milk powder, and particularly discloses infant LMNP combined formula milk powder for caesarean delivery and a preparation method of the infant LMNP combined formula milk powder for caesarean delivery, 100g of formula milk powder comprises an intestinal micro-ecological regulation composition, an immune nutrition synergistic composition, a core nutrition component and a vitamin and mineral composition. The composition has the advantages that the composition is reasonable in formula, beneficial bacteria colonization and proliferation are synergistically promoted, healthy intestinal flora is quickly established, common intestinal flora imbalance of the cesarean delivery infants is effectively improved, the risks of diarrhea, constipation and the like are reduced, and an immune nutrition synergistic system is formed through scientific compatibility of lactoferrin, milk fat globule membranes and compound nucleotide. The composition can enhance immune cell activity, promote immune system development, strengthen mucous membrane defense, make up immune shortages of caesarean section babies in a targeted manner, and reduce allergy and infection risks.

The invention discloses an application of a protein substance in preparation of a composition for inhibiting coronavirus. The coronavirus inhibition comprises the following steps: inhibiting adhesion of the coronavirus on host cells; the invasion of coronavirus to host cells is hindered; the after-cell entry process of coronavirus infection is inhibited. In-vitro verification is carried out on the antiviral effect of the coronavirus GXP2V on various nutritional ingredients (whey protein, milk fat globule membrane, lactoferrin and milk-derived osteopontin), and the result shows that the coronavirus resisting activity of the whey protein, the milk fat globule membrane, the lactoferrin and the milk-derived osteopontin (LPN, short for lactopontin). At present, it is rarely reported that protein substances are used for resisting the coronavirus, the coronavirus GXP2V is a novel coronavirus-like virus, a new thought is developed for resisting the novel coronavirus-like virus, and the application value and prospect are very good.

The invention belongs to the technical field of dairy product processing, and particularly relates to milk fat globule membrane milk protein powder rich in phospholipid as well as a preparation method and application of the milk fat globule membrane milk protein powder. The preparation method of the milk fat globule membrane milk protein powder comprises the following steps: adding chymosin into sweet casein to remove casein so as to obtain casein whey; then sequentially adding whey protein hydrolase and lactase into the casein whey; carrying out ultrafiltration treatment on the hydrolyzed liquid, carrying out percolation treatment on the obtained filtrate, collecting percolate, and drying to obtain a milk fat globule membrane coarse material; and performing CO2 supercritical fluid extraction on the milk fat globule membrane coarse material to obtain the milk fat globule membrane. The phospholipid-rich milk fat globule membrane milk protein powder prepared by the method can be developed into high-polarity lipid food, and especially provides a scientific basis for infant formula milk powder, middle-aged and elderly nutritional food and special functional food.

The present invention provides an application of a composition in the preparation of a product for improving intestinal development; the composition comprises 1 to 10 parts by weight of whey protein powder rich in milk fat globule membrane and 1 part by weight of whey protein powder rich in caseinoglycomacropeptide. The composition of whey protein powder rich in milk fat globule membrane and whey protein powder rich in caseinoglycomacropeptide with a mass ratio of (1-10):1 provided by the present invention has a synergistic effect on promoting intestinal development and can significantly increase the villus height of the intestine and the intestinal villus crypt ratio.

The application discloses application of a silk fibroin nanoparticle hydrogel in treatment of pressure sore ulcers and relates to the technical field of biochemistry.The core points of the technical solution include the following steps: S1, preparation of a silk fibroin solution;S2, preparation of nanoparticles;S3, production and preparation of milk fat globule epidermal growth factor VIII (MFG-E8) in exosomes;S4, purification of MFG-E8 protein;S5, preparation of silk fibroin nanoparticles coated with MFG-E8;S6, preparation of MFG-E8-silk fibroin nanoparticles crosslinked with NGR peptides; and S7, preparation of a collagen / silk fibroin hydrogel.The silk fibroin nanoparticle hydrogel is a non-invasive treatment method and is more easily accepted by patients in clinical application.In addition, the targeted nanoparticle treatment method for pressure sore sites can significantly improve the treatment effect of patients.

The present invention relates to a method for multidimensional evaluation of the similarity of a sample to breast milk, wherein the method is performed in the following steps: (1) establishing a local breast milk phospholipid database; (2) collecting and pretreating a sample to be evaluated; (3) determining the contents of characteristic phospholipid subclasses, the contents of characteristic phospholipid molecules in the sample to be evaluated, and obtaining a microstructural image of milk fat globules in the sample by confocal laser scanning microscopy; (4) calculating the score G for the sample to be evaluated. The present invention evaluates the similarity of samples to breast milk based on phospholipids in three aspects: the composition of characteristic phospholipid subclasses, the composition of characteristic phospholipid molecules, and the morphological similarity evaluation, so that the scheme can better evaluate the simulation quality of infant formulas and their raw and auxiliary materials to breast milk based on phospholipids.

The application provides a composition for promoting growth of Akkermansia and application thereof, and the composition comprises milk fat globule membrane, colostrum basic protein and lacto-N-neotetraose, wherein the concentration ratio of the milk fat globule membrane, the colostrum basic protein and the lacto-N-neotetraose in the composition is (0.1-2):(0.025-0.3):(0.2-0.8). The composition can fully meet the nutritional requirements of Akkermansia bacteria, especially mucinophilic Akkermansia bacteria, can effectively promote the growth of Akkermansia bacteria, can be used for culturing Akkermansia bacteria in vitro, and can promote the growth of mucinophilic Akkermansia bacteria in the human intestinal tract, increase the potential probiotic Akkermansia bacteria in the intestinal tract, and improve intestinal health.

The invention discloses a preparation method of infant formula milk powder. The invention provides a preparation method of milk powder, and raw materials for preparing the milk powder comprise a milk fat globule membrane component, the method comprises the following steps: a first shearing step: carrying out first shearing on at least one part of raw materials except milk fat globule membrane components; a step of homogenizing, namely homogenizing the material obtained in the step of shearing for the first time; and a second shearing step: adding a milk fat globule membrane component into the material obtained in the homogenizing step, and carrying out second shearing. The infant formula milk powder prepared by the preparation method provided by the invention is good in reconstituability, similar to breast milk in interface protein composition and fat globule structure, and good in digestibility.

The present invention relates generally to preparative and purification processes relating to whey protein and particularly to the preparation and purification of Whey Protein Concentrate (WPC), also known as Whey Protein Phospholipid Concentrate (WPPC), Milk Fat Globule Membrane (MFGM), procream, Whey Fat Concentrate (WFC) and whey retentate. We describe processes for increasing a protein concentration of a composition containing milk protein and milk fat, and processes for separating milk protein and milk fats in a composition containing milk protein and milk fat. The process includes extracting the composition with a solvent selected from hexane, 2-methyloxolane, ethanol and carbon dioxide, and combinations thereof. The present invention also relates to whey protein compositions, milk fat compositions and phospholipid-rich compositions obtainable or obtained by the processes of the invention.

The present invention pertains to a new method of producing butter-like products based on warm shearing of liquid, high fat concentrates of milk fat globules, which liquid concentrates contain a significant amount of micellar casein. The invention furthermore pertains to the novel butter-like products as such and uses of the novel butter-like products.

The application provides a kind of no-added foaming milk and its preparation method.The preparation method comprises the following steps: separating raw milk to obtain cream and skim milk;optionally, the cream is cooled and crystallized, stirred, filtered to remove part of milk fat globule membrane, and then treated by deacidification to obtain a feed liquid A;the skim milk is micro-filtered to obtain a feed liquid B and a feed liquid C;for UHT milk, the feed liquid A, the feed liquid B and the feed liquid C are mixed in a certain proportion to obtain a first mixed feed liquid;for pasteurized milk, the cream, the feed liquid B and the feed liquid C are mixed in a certain proportion to obtain a second mixed feed liquid;after homogenization and sterilization of the first mixed feed liquid or the second mixed feed liquid, no-added foaming milk is obtained.The foaming milk of the application has excellent foaming performance without adding other ingredients;after steam whipping, the liquid part is perfectly combined with coffee, the bitterness is modified, the smoothness is improved, the milk foam part is soft and delicate, and is stable and easy to whip.

The invention provides application of a milk-derived active component in preparation of an orthopoxvirus inhibitor. The milk-derived active component comprises one or more of lactoferrin, whey protein, milk fat globule membrane and osteopontin. The milk-derived active component has the activity of remarkably inhibiting orthopox virus infection, and is a potential preparation for treating monkey pox and vaccinia virus infectious diseases. The lactoferrin can inhibit virus infection in the whole life cycle of the virus, has important medicinal value, and is a promising candidate preparation for treating infectious diseases of monkey pox virus and other orthopox virus.

The present application provides a method and an apparatus for preparing humanized infant formula milk powder and functional milk powder. The method includes: separating liquid raw milk, calculating and determining a mixing ratio based on the component substance content in the separated fluid to make it humanized or functionalized, and remixing and drying into powder at least one of de-β-lactoglobulin and zero-sugar milk protein fluid, β-lactoglobulin fluid, milk fat globule membrane protein fluid, antibacterial protein fluid, ribonuclease-osteopontin fluid, lactose fluid, sialic acid-lactose fluid, galactooligosaccharide-sialic acid fluid, mineral salt fluid, α-lactalbumin fluid, casein fluid, α-casein fluid, β-casein fluid, and liquid raw milk. This method can maximize the retention of the biological functional activities of various components, each fluid can be directly used for preparing milk powder without excessive processing, a formula calculation model is used to determine the mixing ratio of each fluid component, and milk powder can be made by one-time spray drying.

The present invention relates generally to preparative and purification processes relating to whey protein and particularly to the preparation and purification of Whey Protein Concentrate (WPC), also known as Whey Protein Phospholipid Concentrate (WPPC), Milk Fat Globule Membrane (MFGM), procream, Whey Fat Concentrate (WFC) and whey retentate. We describe processes for increasing a protein concentration of a composition containing milk protein and milk fat, and processes for separating milk protein and milk fats in a composition containing milk protein and milk fat. The process includes extracting the composition with a solvent selected from hexane, 2-methyloxolane, ethanol and carbon dioxide, and combinations thereof. The present invention also relates to whey protein compositions, milk fat compositions and phospholipid-rich compositions obtainable or obtained by the processes of the invention.

The invention discloses an antioxidant composition as well as a preparation method and application thereof, and belongs to the technical field of oxidation resistance. The purpose of the invention is to improve the antioxidant ability of probiotics and provide an antioxidant composition. The invention provides an antioxidant composition. The composition comprises a milk fat globule membrane and probiotics. The method is directly applied to functional dairy products, probiotic supplements and other products.

The invention discloses an application of a protein substance in preparation of a composition for inhibiting coronavirus. The coronavirus inhibition comprises the following steps: inhibiting adhesion of the coronavirus on host cells; the invasion of coronavirus to host cells is hindered; the after-cell entry process of coronavirus infection is inhibited. In-vitro verification is carried out on the antiviral effect of the coronavirus GXP2V on various nutritional ingredients (whey protein, milk fat globule membrane, lactoferrin and milk-derived osteopontin), and the result shows that the coronavirus resisting activity of the whey protein, the milk fat globule membrane, the lactoferrin and the milk-derived osteopontin (LPN, short for lactopontin). At present, it is rarely reported that protein substances are used for resisting the coronavirus, the coronavirus GXP2V is a novel coronavirus-like virus, a new thought is developed for resisting the novel coronavirus-like virus, and the application value and prospect are very good.