6 results about "Multiple organ dysfunction syndrome" patented technology

Methods of preventing and / or treating ischemia, organ dysfunction and / or organ failure, including multiple organ dysfunction syndrome (MODS), and necrosis and apoptosis associated with organ dysfunction / failure, are provided. For instance, the methods involve contacting organ(s) with an oxygenated cholesterol sulfate (OCS), e.g. 5-cholesten-3,25-diol, 3-sulfate (25HC3S). The organ(s) may be in vivo (e.g. in a patient that is treated with the OCS) or ex vivo (e.g. an organ that has been harvested from a donor and is to be transplanted).

The invention discloses application of CLK1 in sepsis, it is determined that an ALKBH5 / m6A / CLK1 signal axis and an ALKBH5 / m6A / CLK1 signal channel targeting macrophages can effectively enhance sepsis immune response, promote macrophage infiltration, reduce bacterial load in abdominal cavity lavage fluid and main organs of lung, spleen, liver and kidney and improve sepsis survival rate, and meanwhile, the ALKBH5 / m6A / CLK1 signal axis and the ALKBH5 / m6A / CLK1 signal channel targeting the macrophages can effectively enhance sepsis immune response, promote macrophage infiltration and improve sepsis survival rate. And pathological changes in main organs such as lung, spleen, liver and kidney are improved. The invention provides a new treatment way for integrating a post-transcriptional modification targeting strategy and an immunotherapy to treat sepsis, and has important significance for treating and preventing sepsis and improving multi-organ dysfunction syndrome caused by sepsis.

The application provides a multiple organ dysfunction syndrome monitoring system and application thereof. The multiple organ dysfunction syndrome monitoring system is used for monitoring tissue-specific methylation genes related to damage of six kinds of tissue organs, i.e. heart, liver, lung, kidney, intestine and pancreas. The bisDNA sequence of each gene and the bisDNA sequence of the internal reference ACTB gene are simultaneously detected, and finally, a multiple combined qMS-PCR method of 6 genes is screened out, which is used for high-sensitivity and high-specificity detection of the methylation sites.

The present invention relates to a compound of formula (I) or a stereoisomer, or tautomer, wherein R1, R2, R3, and R4 have the same meaning as that defined in the claims and the description. The present invention also relates to the use of such compounds for the prevention and / or treatment of a disease associated with ferroptosis and / or oxytosis such as liver disease, chronic kidney disease, ocular surface diseases, wound healing, multiple organ dysfunction syndrome, neurological disease, acute renal failure, ischemia-reperfusion injury, sepsis, prevention of transplant rejection, and iron metabolism-related disease. The present invention also provides pharmaceutical compositions comprising such compounds, as well as the use of the compounds as a medicament.

The invention discloses a Lateococcus-bifidobacterium adolescentis microbial composition and application thereof in preparation of a medicine for preventing and treating liver injury related to multi-organ dysfunction syndrome. Belongs to the field of biomedicine. According to the invention, the microbial combination is composed of the Brawococcus and the Bifidobacterium adolescentis and is applied to prevention and treatment of liver injury related to the multi-organ dysfunction syndrome. According to the composition, effective intervention on the'intestine-liver axis' vicious circle is realized through a precise synergistic mechanism, so that the technical problem that an existing broad-spectrum microecological preparation lacks targeting and synergy under extreme pathological conditions is solved. The specific combination of the Brawococcus and the Bifidobacterium adolescentis, provided by the invention, can remarkably up-regulate the intestinal acetic acid level and effectively relieve liver inflammation and injury, the protection effect of the specific combination is superior to that of a single strain, and a new strategy is provided for developing a targeted microecological preparation.

This invention provides methods for treating or preventing multiple organ dysfunction syndrome. [Solution] A method for treating multiple organ dysfunction syndrome (MODS) in a subject, comprising administering to a subject in need of treatment an effective amount of a phospholipid nanoparticle (PN) composition comprising 0-35% (w / v) of a lipophilic or hydrophobic component, 0.1-60% (w / v) of an amphiphilic emulsifier, a polar liquid carrier, and one or more electrolytes, wherein the PN composition comprises liposomes and / or micelles having a diameter of 1-800 nm.