31 results about "Multiple organ dysfunction syndrome" patented technology

A compound represented by formula (1):

Q¹-Q²-T⁰-N(R¹)-Q³-N(R²)-T¹-Q⁴  (1)

[wherein R¹ and R² are hydrogen atoms or the like; Q¹ is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q² is a single bond or the like; Q³ represents the following group:

(wherein Q⁵ is an alkylene group having 1 to 8 carbon atoms, or the like); and T⁰ and T¹ are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof.

The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

The invention provides an establishment method of an animal model for acute Stanford A-type aortic dissection (AD) accompanied with MODS (multiple organ dysfunction syndrome), a use of emodin for preparing a medicine for treating acute Stanford A-type AD accompanied with MODS as well as a viscera protective agent for acute Stanford A-type AD accompanied with MODS. In the invention, an AD surgery method is improved and meanwhile manually controlled hypertension is formed by continuously pumping adrenaline into veins so as to promote expansion of the AD stripping range and accelerate disease progression, thus acute Stanford A-type AD accompanied with MODS can be rapidly formed so as to successfully make the model. The animal model for acute Stanford A-type AD accompanied with MODS creates conditions for further deep research in application foundation and intervention treatment.

The present invention provides methods for treating sepsis, systemic inflammatory response syndrome, severe sepsis, septic shock, and multiple organ dysfunction syndrome by modulating NF-κB transcription with ligands that interact with the estrogen receptor, preferably in the absence of classic estrogenic activity. Other aspects of the invention relate to methods for treating sepsis, systemic inflammatory response syndrome, severe sepsis, septic shock, and multiple organ dysfunction syndrome that comprise administering to a patient suffering therefrom an effective amount of a compound of Formula I:

The invention provides a biological reaction device which replaces human kidney, consisting of a biological reactor, a peristaltic pump, a cell culture liquid constant-flow device and a constant temperature box; the biological reactor consists of a plastic shell, a pouring liquid inlet, a pouring liquid outlet, a cell culture liquid inlet, a cell culture liquid outlet, a sulfone film nanometer supporting layer and a hollow fiber pipe; the hollow fiber pipe is arranged in a concentric round; the peristaltic pump is connected with the pouring liquid inlet and the pouring liquid outlet of the biological reactor; the constant-flow device is connected with the cell culture liquid inlet and outlet of the biological reactor; the biological reactor, the peristaltic pump and the constant-flow device are arranged inside the constant temperature box; the biological reaction device has reasonable design and simple and convenient preparation, can replace the kidney function of acute renal failure and multiple organ dysfunction syndrome patient in long-term or leads the similar patients to gradually recover the self-kidney tissue and other functions, thus improving the survival rate of the multiple organ dysfunction syndrome patient and prolonging the survival time of the multiple organ dysfunction syndrome patients.

The invention provides a construction method of an acute pancreatitis animal model. According to the construction method, high-fat feed and alcohol are used for jointly inducing animals to form acute pancreatitis. Obesity caused by high-fat feed and alcohol can synergistically cause pathological damage to pancreas of mice, local inflammatory response of pancreas and inflammatory response of lungs and the whole body. In a basic obesity state, the morbidity condition of a large amount of alcohol drinking of the animal model is closer to human morbidity, pancreatic injury is obvious and accompanied by multiple organ dysfunction syndromes, and the animal model accords with the clinical characteristic that obese acute pancreatitis patients are prone to severe illness. The animal model is simple in modeling method, good in repeatability and high in clinical correlation, the model can be used for studying the pathogenesis of obesity and alcohol-related acute pancreatitis, and an important basis is provided for screening treatment targets and studying medical transformation.

The present invention provides methods, compositions, and kits for treating intestinal hyperpermeability in a subject in need thereof, including conditions such as hyperglycemia and underlying diseases such as diabetes, autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease (GVHD), HIV/ AIDS, multiple organ dysfunction syndrome, irritable bowel syndrome (IBS), celiac disease, eczema, psoriasis, acute pancreatitis, Parkinson's disease, depression, chronic fatigue syndrome, asthma, multiple sclerosis, arthritis, ankylosing spondylitis, nonalcoholic fatty liver disease, alcoholic cirrhosis, environmental enteropathy, or kwashiorkor.

The invention discloses a method for constructing rat model of sepsis with multiple organ dysfunction syndrome, which comprises the following steps: preparing lipopolysaccharide to a corresponding concentration, performing lipopolysaccharide intravenous injection on a rat, pressing the rat, keeping a supine position, exposing the inner side of a hind limb upwards, lightly pulling out hair of a left hind limb, wiping with an alcohol cotton ball, and pressing groin to fill the femoral vein; after disinfection of the alcohol cotton ball, a 1 ml injector is slowly inserted into the blood vessel inparallel, medicine can be pushed after the needle tip is confirmed in the blood vessel, and after medicine pushing is finished, pressing the injection point with a dry cotton ball to stop bleeding; after hemostasis is completed, the rat is fed routinely, and the state of the rat is observed and recorded regularly. The animal model constructed by the method disclosed by the invention has low lipopolysaccharide dosage, the death rate is only 50%-70%, and the method is an ideal method for researching the sepsis with MODS model.

The invention belongs to the field of medicine, and particularly discloses application of irisin in a drug for preventing and treating severe acute pancreatitis. In the mice severe acute pancreatitis,by virtue of the intravenous injection of exogenous irisin, the pancreas function can be significantly improved, the endoplasmic reticulum stress of the pancreas cell can be alleviated, and the pancreas tissue injury and cell death can be reduced, which proves that the irisin can significantly improve the severe accurate pancreatitis; and the irisin is applied to the drug development, when the acute pancreatitis is diagnosed in emergency treatment, the irisin drug is used for intravenous injection, and the local inflammation reaction of pancreatitis is prevented from being developed to the whole-body inflammation reaction syndrome or the whole-body inflammation reaction syndrome chain-type expansion can be inhibited and prevented, so that the worsening of the pancreatitis can be inhibited, and an effect for protecting local internal organs and preventing the multiple organ dysfunction syndrome can be achieved; and by adopting the application of the irisin, a brand new choice and concept can be provided for preventing and treating the severe acute pancreatitis at present.

The invention discloses a novel use of deacidized type glutathione (GSH) in the field of pharmacy, which can be applied for the treatment of systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS), and has the effects of suppression of body temperature rapid decrease, lowering tachypnea and respiratory distress, intensifying leucocyte number, and alleviating heart rate quickening.

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine active ingredient composition and a purpose thereof. The traditional Chinese medicine active ingredient composition is prepared from the following traditional Chinese medicine active ingredients in parts by weight: 30 to 50 parts of geniposide, 25 to 40 parts of scutelloside, 15 to 40 parts of berberine and 6 to 30 parts of palmatine. The traditional Chinese medicine active ingredient composition is applied to preparation of medicine for treating endotoxemia or sepsis, systemic inflammatory response syndrome and multiple organ dysfunction syndrome. After the traditional Chinese medicine active ingredient composition provided by the invention is used for treatment, a patient cannot easily generate recurrence after recovery; and no other toxic and side effects are clinically shown during medication. The traditional Chinese medicine active ingredient composition provided bythe invention has the advantages that the active ingredients are simple; the anti-sepsis effect is strong; the release of inflammatory factors can be well inhibited; the visceral organs are protectedfrom being damaged; the sepsis inflammation cascade reaction is reduced; and the anti-sepsis effect is achieved.

The invention relates to a medicinal preparation for treating and preventing the infectious shock and application thereof. The medicinal preparation is prepared from 8-24 parts of red ginseng, 5-15 parts of radix ophiopogonis, 6-12 parts of rhizoma alismatis, 5-10 parts of flos carthami, 10-25 parts of fructus arctii, 5-10 parts of mint, 5-10 parts of liquorice roots, 8-14 parts of fructus forsythiae, 0.5-5 parts of fructus evodiae, 1-3 parts of clove, 6-13 parts of dogbane leaves, 5-10 parts of herba hyperici perforati and 3-8 parts of caulis sinomenii. According to the theory of traditional Chinese medicine, compatibility is more reasonable, yin and yang are balanced, all medicines have a synergistic effect, and therefore the effects of clearing away heat and toxic materials, strengthening the body resistance and tonifying qi, and promoting blood circulation to remove blood stasis can be more effectively achieved so that the aim of treating the infectious shock complication multiple organ dysfunction syndrome can be achieved, medicine effects and functions are more comprehensive, and both symptoms and root causes are treated; the composition is precise in treatment effect and free of toxic and side effects and has a good treatment effect and potential clinical application value.

The present invention provides methods, compositions, and kits for treating intestinal hyperpermeability in a subject in need thereof, including conditions such as hyperglycemia and underlying diseases such as diabetes, autism, fibromyalgia, inflammatory bowel disease (IBD), graft versus host disease (GVHD), HIV/AIDS, multiple organ dysfunction syndrome, irritable bowel syndrome (IBS), celiac disease, eczema, psoriasis, acute pancreatitis, Parkinson's disease, depression, chronic fatigue syndrome, asthma, multiple sclerosis, arthritis, ankylosing spondylitis, nonalcoholic fatty liver disease, alcoholic cirrhosis, environmental enteropathy, or kwashiorkor.