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Application of irisin in drug for preventing and treating severe acute pancreatitis

A technology for acute pancreatitis and irisin, applied in the field of medicine, can solve the problem of lack of irisin and other problems, and achieve the effects of preventing multiple organ failure syndrome, inhibiting severe disease, and protecting local organs

Active Publication Date: 2018-10-12
崇好科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no report on the application of irisin in severe acute pancreatitis

Method used

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  • Application of irisin in drug for preventing and treating severe acute pancreatitis
  • Application of irisin in drug for preventing and treating severe acute pancreatitis
  • Application of irisin in drug for preventing and treating severe acute pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: 100 micrograms of irisin were dissolved in 10 milliliters of physiological saline to prepare 10 ug / ml injection.

[0021] Take this injection as an example to study the effect of irisin on severe acute pancreatitis.

[0022] Animal experiment.

[0023] 1. Experimental animals: 20-25g male C57BL / 6J mice were randomly divided into 4 groups, 6 in each group:

[0024] Normal control group (Sham);

[0025] Severe acute pancreatitis control group: mice were intraperitoneally injected with 8% L-arginine 4g / kg (Vehicle);

[0026] Severe acute pancreatitis high-dose irisin treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg, and then given 250 μg / kg irisin (H-Irisin) 2 hours later.

[0027] Severe acute pancreatitis low-dose irisin treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg, and then given 50ug / kg irisin (L-Irisin) 2 hours later.

[0028] II: Severe acute pancreatitis model establishment: Vehicle mice ...

Embodiment

[0041] Example: 100 micrograms of irisin were dissolved in 5 milliliters of physiological saline to prepare a 20 ug / ml injection.

[0042] Take this injection as an example to study the effect of irisin on severe acute pancreatitis.

[0043] Animal experiment.

[0044]1. Experimental animals: 20-25g male C57BL / 6J mice were randomly divided into 4 groups, 6 in each group:

[0045] Normal control group (Sham);

[0046] Severe acute pancreatitis control group: mice were intraperitoneally injected with 8% L-arginine 4g / kg (Vehicle);

[0047] Severe acute pancreatitis high-dose irisin treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg, and then given 250 μg / kg irisin (H-Irisin) 2 hours later.

[0048] Severe acute pancreatitis low-dose irisin treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg, and then given 50ug / kg irisin (L-Irisin) 2 hours later.

[0049] II: Severe acute pancreatitis model establishment: Vehicle mice we...

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Abstract

The invention belongs to the field of medicine, and particularly discloses application of irisin in a drug for preventing and treating severe acute pancreatitis. In the mice severe acute pancreatitis,by virtue of the intravenous injection of exogenous irisin, the pancreas function can be significantly improved, the endoplasmic reticulum stress of the pancreas cell can be alleviated, and the pancreas tissue injury and cell death can be reduced, which proves that the irisin can significantly improve the severe accurate pancreatitis; and the irisin is applied to the drug development, when the acute pancreatitis is diagnosed in emergency treatment, the irisin drug is used for intravenous injection, and the local inflammation reaction of pancreatitis is prevented from being developed to the whole-body inflammation reaction syndrome or the whole-body inflammation reaction syndrome chain-type expansion can be inhibited and prevented, so that the worsening of the pancreatitis can be inhibited, and an effect for protecting local internal organs and preventing the multiple organ dysfunction syndrome can be achieved; and by adopting the application of the irisin, a brand new choice and concept can be provided for preventing and treating the severe acute pancreatitis at present.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of irisin in medicines for preventing and treating severe acute pancreatitis. Background technique [0002] Acute pancreatitis (Acute Pancreatitis, AP) is a common acute abdomen in clinical practice, and 20%-25% of the patients are clinically severe, with local or systemic complications, multiple organ failure, and even life-threatening. Severe acute pancreatitis (Severe Acute Pancreatitis, SAP). The etiology of SAP is complex, and its pathogenesis has not yet been fully clarified. According to the World Health Organization, SAP will become the number one cause of death in pancreatic diseases by 2020. After nearly 30 years of research, the treatment effect of severe acute pancreatitis in my country has been significantly improved, and the treatment viewpoint has also reached a consensus in principle, that is, individualized treatment plans for different etiologies and dif...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61P1/18
CPCA61K38/39A61P1/18
Inventor 吴荣谦任一凡吕毅
Owner 崇好科技有限公司
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