Application of human milk fat globule epidermal growth factor 8 in the preparation of drugs for the prevention/treatment of severe acute pancreatitis

A technology for epidermal growth factor and acute pancreatitis, which is applied in the field of medicine to achieve the effects of inhibiting severe aggravation, protecting local organs, and preventing multiple organ failure syndrome

Active Publication Date: 2022-05-31
崇好科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Currently, there is no report on the application of milk fat globule epidermal growth factor 8 in severe acute pancreatitis

Method used

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  • Application of human milk fat globule epidermal growth factor 8 in the preparation of drugs for the prevention/treatment of severe acute pancreatitis
  • Application of human milk fat globule epidermal growth factor 8 in the preparation of drugs for the prevention/treatment of severe acute pancreatitis
  • Application of human milk fat globule epidermal growth factor 8 in the preparation of drugs for the prevention/treatment of severe acute pancreatitis

Examples

Experimental program
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Effect test

Embodiment 1

[0018] This injection is an example to study the effect of milk fat globule epidermal growth factor 8 on severe acute pancreatitis.

experiment example 2

[0020] One. Experimental animals: 20-25g male C57BL / 6J mice were randomly divided into 3 groups, 6 mice in each group:

[0032] The results show that: milk fat globule epidermal growth factor 8 can reduce the apoptosis of pancreatic cells after severe acute pancreatitis in mice.

[0033] Therefore, the present invention can be used as the preparation of the medicine for the prevention / treatment of severe acute pancreatitis.

[0040] The data are all used mean ± standard error. Statistical method used SNK test, P<0.05 was statistically significant.

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Abstract

The present invention provides a new medical application of human milk fat globule surface growth factor 8 (MFG‑E8), that is, the application of human milk fat globule surface growth factor 8 in preventing / treating severe acute pancreatitis. In mice with severe acute pancreatitis, intravenous injection of exogenous human milk fat globule surface growth factor 8 can significantly improve pancreatic function, reduce pancreatic apoptosis, reduce pancreatic tissue damage and cell death, improve the release of inflammatory mediators and the infiltration of inflammatory cells, Reduce the death rate of mice with severe acute pancreatitis, indicating that human milk fat globule surface growth factor 8 can significantly improve severe acute pancreatitis, human milk fat globule surface growth factor 8 can be developed as a new drug or drug target for the prevention / treatment of severe acute pancreatitis .

Description

Human milk fat globule epidermal growth factor 8 in the preparation of drugs for the prevention / treatment of severe acute pancreatitis applications in technical field The invention belongs to the technical field of medicine, particularly a kind of human milk fat globule epidermal growth factor 8 (MFG-E8) in the manufacture of The application of drugs in the prevention / treatment of severe acute pancreatitis. Background technique Acute pancreatitis (Acute Pancreatitis, AP) is a common clinical acute abdomen, wherein 20%-25% of patients Clinically severe disease, local or systemic complications may occur, multiple organ failure, or even life-threatening, known as severe Acute pancreatitis (Severe Acute Pancreatitis, SAP). The etiology of SAP is complex, and the pathogenesis has not been fully elucidated. The World Health Organization estimates that by 2020 SAP will be the leading cause of death from pancreatic disease. After nearly 30 years of research, my country ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61P1/18
CPCA61K38/1808A61P1/18
Inventor 吴荣谦任一凡吕毅
Owner 崇好科技有限公司
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