Liver function and/or pancreatic function improving agent

A technology for improving liver function, which is applied in the functions of food ingredients, resistance to vector-borne diseases, and medical preparations containing active ingredients. It can solve problems such as hypoglycemia and weight gain, achieve high safety and improve liver effect on function and/or pancreatic function

Inactive Publication Date: 2016-05-11
ZERIA PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] As drugs that promote insulin secretion, sulfonylurea drugs, DPPIV inhibitors, GLP-1 analogs, etc. are known, but side effects such as hypoglycemia and weight gain have been reported

Method used

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  • Liver function and/or pancreatic function improving agent
  • Liver function and/or pancreatic function improving agent
  • Liver function and/or pancreatic function improving agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] (experimental method)

[0054] 1) Use animals

[0055] Twenty-four 7-week-old Wistar / Std female rats (Japan SLC Co., Ltd.) were used. They were individually raised in an animal room (temperature 23±2°C, humidity 50±10%RH) with a 12-hour light and dark cycle (bright period: 08:00-20:00) day and night. Before the start of the experiment, they were fed with solid feed for 3 days (F-2 at Funabashi Farm), and then divided into two experimental groups. That is, a substance containing isolated soybean protein (Soyprotein isolate=SPI) and a substance containing porcine liver hydrolysate (PLH) were prepared as a control, and added to an alcohol liquid diet and provided for 14 days.

[0056] 14 hours before execution, the alcohol liquid was removed and fasted, and deionized water was provided instead. Blood was collected into blood collection tubes treated with EDTA-2Na, centrifuged to obtain plasma, and various tissue samples for analysis were stored at -25°C. After a part of the l...

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Abstract

Provided is a drug for improving pancreatic function and/or liver function having been worsened by usual life habits. A liver function improving agent and/or a pancreatic function improving agent, said agents comprising a liver hydrolysate as an active ingredient, for people with high-fat diet and alcohol intake.

Description

Technical field [0001] The present invention relates to an agent for improving liver function and / or an agent for improving pancreatic function. Background technique [0002] The pancreas produces and secretes a variety of digestive enzymes, and secretes insulin and glucagon that control blood sugar levels. Among them, insulin is a hormone that lowers the blood sugar level, and when the secretion of insulin is lowered, diabetes occurs. [0003] As drugs that promote insulin secretion, sulfonylurea drugs, DPPIV inhibitors, GLP-1 analogs, etc. are known, but side effects such as hypoglycemia and weight gain have been reported. [0004] In addition, in addition to the metabolism and storage of nutrients, the liver also has the functions of bile production, detoxification, and excretion. As liver diseases, there are viral hepatitis, alcoholic hepatitis, drug-induced hepatitis, NASH, liver cancer, chronic hepatitis, cirrhosis, etc., and it is difficult to recover if the function of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/407A23L33/10A61P1/16A61P1/18A61P3/10
CPCA61K35/407A23V2002/00A23L33/10A61P1/16A61P1/18A61P5/48A61P3/10A23V2200/3204A23V2200/334
Inventor 驹井三千夫白川仁山田耕太郎樱井英知植田一马普斯波·埃迪·吉里沃诺
Owner ZERIA PHARMA
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